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1. 发明申请

WO2005013899A2 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER 审中-公开
标题翻译：肺癌治疗和诊断的组成和方法
公开(公告)号：WO2005013899A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/023085
申请日：2004-07-15
申请人： CORIXA CORPORATION , HENDERSON, Robert, A. , WANG, Tongtong , BANGUR, Chaitanya, S. , PECKHAM, David, W. , RETTER, Marc, W. , FANGER, Gary, R.
发明人： HENDERSON, Robert, A. , WANG, Tongtong , BANGUR, Chaitanya, S. , PECKHAM, David, W. , RETTER, Marc, W. , FANGER, Gary, R.
IPC分类号： A61K
CPC分类号： C07K16/3023 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/5158 , C07K14/47 , C07K14/4748 , C07K14/82 , C07K2317/21 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2319/00 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
摘要翻译：公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。

2. 发明申请

WO2012161809A1 GRADED-INDEX FEW-MODE FIBER DESIGNS FOR SPATIAL MULTIPLEXING 审中-公开
标题翻译：用于空间多路复用的分级索引模式光纤设计
公开(公告)号：WO2012161809A1
公开(公告)日：2012-11-29
申请号：PCT/US2012/026662
申请日：2012-02-24
申请人： OFS FITEL, LLC , GRUNER-NIELSEN, Lars , LINGLE, Robert, L. , MCCURDY, Alan , PECKHAM, David, W. , SUN, Yi
发明人： GRUNER-NIELSEN, Lars , LINGLE, Robert, L. , MCCURDY, Alan , PECKHAM, David, W. , SUN, Yi
IPC分类号： G02B6/02
CPC分类号： G02B6/02042 , G02B6/02 , G02B6/02019 , G02B6/0281 , G02B6/0288 , G02B6/03611 , G02B6/03627 , G02B6/03633 , G02B6/0365 , G02B6/03666 , G02B6/03683 , G02B6/262
摘要： A few-mode optical fiber comprises a core surrounded by a cladding, having a graded index profile that is structured to support propagation of a plurality of desired signal-carrying modes, while suppressing undesired modes. The core and cladding are configured such that the undesired modes have respective effective indices that are close to. or less than, the cladding index such that the undesired modes are leaky modes. The index spacing between the desired mode having the lowest effective index and the leaky mode with the highest effective index is sufficiently large so as to substantially prevent coupling therebetween.
摘要翻译：多模光纤包括由包层围绕的芯，具有渐变的折射率分布，其被构造为支持多个期望的信号承载模式的传播，同时抑制不期望的模式。芯和覆层被配置为使得不期望的模式具有接近的相应的有效索引。或小于包层指数，使得不需要的模式是泄漏模式。具有最低有效指数的期望模式与具有最高有效指数的泄漏模式之间的指数间隔足够大，以便基本上防止它们之间的耦合。

3. 发明申请

WO2005013899A9 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER 审中-公开
公开(公告)号：WO2005013899A9
公开(公告)日：2005-06-16
申请号：PCT/US2004023085
申请日：2004-07-15
申请人： CORIXA CORP , HENDERSON ROBERT A , WANG TONGTONG , BANGUR CHAITANYA S , PECKHAM DAVID W , RETTER MARC W , FANGER GARY R
发明人： HENDERSON ROBERT A , WANG TONGTONG , BANGUR CHAITANYA S , PECKHAM DAVID W , RETTER MARC W , FANGER GARY R
IPC分类号： A61K20060101 , A61K38/00 , A61K39/00 , A61K39/395 , A61K39/40 , A61P35/00 , C07K1/00 , C07K14/47 , C07K14/82 , C07K16/30 , C12N5/08 , C12N15/12 , C12Q1/68 , G01N33/53 , G01N33/574 , A61K
CPC分类号： C07K16/3023 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/5158 , C07K14/47 , C07K14/4748 , C07K14/82 , C07K2317/21 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2319/00 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

4. 发明申请

WO2005013899A3 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER 审中-公开
公开(公告)号：WO2005013899A3
公开(公告)日：2005-08-18
申请号：PCT/US2004023085
申请日：2004-07-15
申请人： CORIXA CORP , HENDERSON ROBERT A , WANG TONGTONG , BANGUR CHAITANYA S , PECKHAM DAVID W , RETTER MARC W , FANGER GARY R
发明人： HENDERSON ROBERT A , WANG TONGTONG , BANGUR CHAITANYA S , PECKHAM DAVID W , RETTER MARC W , FANGER GARY R
IPC分类号： A61K20060101 , A61K38/00 , A61K39/00 , A61K39/395 , A61K39/40 , A61P35/00 , C07K1/00 , C07K14/47 , C07K14/82 , C07K16/30 , C12N5/08 , C12N15/12 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C07K16/3023 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/5158 , C07K14/47 , C07K14/4748 , C07K14/82 , C07K2317/21 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2319/00 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

5. 发明申请

WO2012161810A1 STEP-INDEX FEW-MODE FIBER DEIGNS FOR SPATIAL MULTIPLEXING 审中-公开
标题翻译：用于空间多路复用的步骤指示模式光纤检测
公开(公告)号：WO2012161810A1
公开(公告)日：2012-11-29
申请号：PCT/US2012/026663
申请日：2012-02-24
申请人： OFS FITEL, LLC , GRUNER-NIELSEN, Lars , LINGLE, Robert, L. , MCCURDY, Alan , PECKHAM, David, W. , TOKLE, Torger
发明人： GRUNER-NIELSEN, Lars , LINGLE, Robert, L. , MCCURDY, Alan , PECKHAM, David, W. , TOKLE, Torger
IPC分类号： G02B6/02
CPC分类号： G02B6/02042 , G02B6/02 , G02B6/02019 , G02B6/0281 , G02B6/0288 , G02B6/03611 , G02B6/03627 , G02B6/03633 , G02B6/0365 , G02B6/03666 , G02B6/03683 , G02B6/262
摘要： A few-mode optical fiber comprises a core surrounded by a cladding, having a step index profile that is structured to support propagation of a plurality of desired signal-carrying modes, while suppressing undesired modes. The core and cladding are configured such that the undesired modes have respective effective indices that are close to. or less than, the cladding index such that the undesired modes are leaky modes. The index spacing between the desired mode having the lowest effective index and the leaky mode with the highest effective index is sufficiently large so as to substantially prevent coupling therebetween.
摘要翻译：多模光纤包括由包层围绕的芯，其具有构造成支持多种所需信号承载模式的传播的阶跃折射率分布，同时抑制不期望的模式。芯和覆层被配置为使得不期望的模式具有接近的相应的有效索引。或小于包层指数，使得不需要的模式是泄漏模式。具有最低有效指数的期望模式与具有最高有效指数的泄漏模式之间的指数间隔足够大，以便基本上防止它们之间的耦合。

6. 发明申请

WO0247534A3 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER 审中-公开
公开(公告)号：WO0247534A3
公开(公告)日：2002-08-22
申请号：PCT/US0147576
申请日：2001-11-30
申请人： CORIXA CORP , WANG TONGTONG , WANG AIJUN , SKEIKY YASIR A W , LI SAMUEL X , KALOS MICHAEL D , HENDERSON ROBERT A , MCNEILL PATRICIA D , FANGER NEIL , RETTER MARC W , DURHAM MARGARITA , FANGER GARY R , VEDVICK THOMAS S , CARTER DARRICK , WATANABE YOSHIHIRO , PECKHAM DAVID W , CAI FENG , FOY TERESA M
发明人： WANG TONGTONG , WANG AIJUN , SKEIKY YASIR A W , LI SAMUEL X , KALOS MICHAEL D , HENDERSON ROBERT A , MCNEILL PATRICIA D , FANGER NEIL , RETTER MARC W , DURHAM MARGARITA , FANGER GARY R , VEDVICK THOMAS S , CARTER DARRICK , WATANABE YOSHIHIRO , PECKHAM DAVID W , CAI FENG , FOY TERESA M
IPC分类号： G01N33/574 , A61K31/7088 , A61K35/14 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P37/04 , C07K14/47 , C07K14/82 , C07K16/30 , C07K16/32 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12Q1/68 , C07H21/02 , A01N43/04 , C07H21/04 , C12N15/00 , C12N15/63
CPC分类号： A61K38/17 , A61K39/00 , A61K2039/5154 , C07K14/47 , C07K14/4748 , C07K16/3023 , C07K2317/21 , C07K2317/34 , C07K2319/00 , C12Q1/6809 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

7. 发明申请

WO2013043275A1 OPTIMIZED ULTRA LARGE AREA OPTICAL FIBERS 审中-公开
标题翻译：优化超大面积光纤
公开(公告)号：WO2013043275A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/050562
申请日：2012-08-13
申请人： OFS FITEL, LLC , LINGLE, Robert, L. , PECKHAM, David, W.
发明人： LINGLE, Robert, L. , PECKHAM, David, W.
IPC分类号： G02B6/02 , G02B6/036
CPC分类号： G02B6/03683 , G02B6/02019
摘要： Certain embodiments of the invention may include optimized trench-assisted ultra large area (ULA) optical fibers. According to an example embodiment of the invention, a trench-assisted optical fiber, optimized for microbending and figure -of-merit (FOM) performance is provided. The optical fiber includes a core region having a longitudinal axis, a shelf region surrounding said core region, a cladding region surrounding said shelf region, said core and shelf and cladding regions configured to support and guide the propagation of signal light in a fundamental transverse mode in said core and shelf regions in the direction of said axis, the cladding region including an inner trench and an outer trench. The optical fiber further includes a core effective area (Aeff) of between 135 μιη2 and about 170 μιη2; a figure of merit (FOM) frontier distance less than about 0.8 dB; and a microbend frontier (MBF) distance of less than about 90%.
摘要翻译：本发明的某些实施例可以包括优化的沟槽辅助超大面积（ULA）光纤。根据本发明的一个示例性实施例，提供了针对微弯曲和优异性能（FOM）性能优化的沟槽辅助光纤。光纤包括具有纵向轴线的芯区域，围绕所述芯区域的搁板区域，围绕所述搁板区域的包层区域，所述芯部和搁架以及被配置为支撑和引导基本横向模式的信号光的传播的包层区域在所述芯部和搁板区域中，所述包层区域包括内沟槽和外沟槽。该光纤还包括在135μaeta2和约170μaeta2之间的核心有效面积（Aeff）; 优点（FOM）边界距离小于约0.8 dB; 和微弯边界（MBF）距离小于约90％。

8. 发明申请

WO2013043274A1 OPTIMIZED ULTRA LARGE AREA OPTICAL FIBERS 审中-公开
标题翻译：优化超大面积光纤
公开(公告)号：WO2013043274A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/050555
申请日：2012-08-13
申请人： OFS FITEL, LLC , LINGLE, Robert, L , PECKHAM, David, W.
发明人： LINGLE, Robert, L , PECKHAM, David, W.
IPC分类号： G02B6/02
CPC分类号： G02B6/02019 , G02B6/03683
摘要： Certain embodiments of the invention may include optimized trench-assisted ultra large area (ULA) optical fibers. According to an example embodiment of the invention, a trench- assisted optical fiber, optimized for figure -of-merit (FOM) performance is provided. The optical fiber includes a core region having a longitudinal axis, a shelf region surrounding said core region, a cladding region surrounding said shelf region, said core and shelf and cladding regions configured to support and guide the propagation of signal light in a fundamental transverse mode in said core and shelf regions in the direction of said axis. The optical fiber further includes a core effective area (Aeff) of between 135 μm 2 and about 170 μm 2 ; a relative effective index difference (Neff) of greater than about 0.08%; a loss at 1550 nm of less than 0.185 dB/km; and an index profile having a figure of merit (FOM) frontier distance less than about 0.5 dB.
摘要翻译：本发明的某些实施例可以包括优化的沟槽辅助超大面积（ULA）光纤。根据本发明的一个示例性实施例，提供了针对品质因数（FOM）性能优化的沟槽辅助光纤。光纤包括具有纵向轴线的芯区域，围绕所述芯区域的搁板区域，围绕所述搁板区域的包层区域，所述芯部和搁架以及被配置为支撑和引导基本横向模式的信号光的传播的包层区域在所述芯部和搁板区域中在所述轴线的方向上。光纤还包括135mum2和约170mum2之间的核心有效面积（Aeff）; 相对有效指数差（Neff）大于约0.08％; 在1550nm处的损耗小于0.185dB / km; 以及具有小于约0.5dB的品质因数（FOM）前沿距离的折射率分布。

9. 发明申请

WO2013043273A1 OPTIMIZED ULTRA LARGE AREA OPTICAL FIBERS 审中-公开
标题翻译：优化超大面积光纤
公开(公告)号：WO2013043273A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/050546
申请日：2012-08-13
申请人： OFS FITEL, LLC , LINGLE, Robert, L. , PECKHAM, David, W.
发明人： LINGLE, Robert, L. , PECKHAM, David, W.
IPC分类号： G02B6/02
CPC分类号： G02B6/03683 , G02B6/02019
摘要： Certain embodiments of the invention may include optimized trench-assisted ultra large area (ULA) optical fibers. According to an example embodiment of the invention, a trench- assisted optical fiber, optimized for figure-of-merit (FOM) performance, is provided. The optical fiber includes a core region having a longitudinal axis, a shelf region surrounding said core region, a cladding region surrounding said shelf region, said core and shelf and cladding regions configured to support and guide the propagation of signal light in a fundamental transverse mode in said core and shelf regions in the direction of said axis.. The optical fiber further includes a core effective area (Aeff) of between 135 μm 2 and about 170 μm 2 ; and an index profile having a figure of merit (FOM) frontier distance less than about 0.7 dB.
摘要翻译：本发明的某些实施例可以包括优化的沟槽辅助超大面积（ULA）光纤。根据本发明的示例性实施例，提供了针对品质因数（FOM）性能优化的沟槽辅助光纤。光纤包括具有纵向轴线的芯区域，围绕所述芯区域的搁板区域，围绕所述搁板区域的包层区域，所述芯部和搁架以及被配置为支撑和引导基本横向模式的信号光的传播的包层区域在所述芯和搁板区域中在所述轴线的方向上。所述光纤还包括135mum2和约170mum2之间的芯有效面积（Aeff）; 以及具有小于约0.7dB的品质因数（FOM）边界距离的折射率分布。

10. 发明申请

WO2002000174A3 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER 审中-公开
公开(公告)号：WO2002000174A3
公开(公告)日：2002-01-03
申请号：PCT/US2001/021065
申请日：2001-06-28
申请人： CORIXA CORPORATION , WANG, Tongtong , WANG, Aijun , SKEIKY, Yasir, A., W. , LI, Samuel, X. , KALOS, Michael, D. , HENDERSON, Robert, A. , MCNEILL, Patricia, D. , FANGER, Neil , RETTER, Marc, W. , DURHAM, Margarita , FANGER, Gary, Richard , VEDVICK, Thomas, S. , CARTER, Darrick , WATANABE, Yoshihiro , PECKHAM, David, W.
发明人： WANG, Tongtong , WANG, Aijun , SKEIKY, Yasir, A., W. , LI, Samuel, X. , KALOS, Michael, D. , HENDERSON, Robert, A. , MCNEILL, Patricia, D. , FANGER, Neil , RETTER, Marc, W. , DURHAM, Margarita , FANGER, Gary, Richard , VEDVICK, Thomas, S. , CARTER, Darrick , WATANABE, Yoshihiro , PECKHAM, David, W.
IPC分类号： C12N15/12
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

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