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1. 发明申请

WO2009153683A2 RADIOLOGICAL IMAGING INCORPORATING LOCAL MOTION MONITORING, CORRECTION, AND ASSESSMENT 审中-公开
标题翻译：包含本地运动监测，校正和评估的放射成像
公开(公告)号：WO2009153683A2
公开(公告)日：2009-12-23
申请号：PCT/IB2009052297
申请日：2009-06-01
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , BRINKS RALPH , FISCHER ALEXANDER , MARTIN RECUERO ANA BELEN , GEORGI JENS-CHRISTOPH , SCHWEIZER BERND , PAULUS TIMO MARKUS
发明人： BRINKS RALPH , FISCHER ALEXANDER , MARTIN RECUERO ANA BELEN , GEORGI JENS-CHRISTOPH , SCHWEIZER BERND , PAULUS TIMO MARKUS
IPC分类号： G06T11/00
CPC分类号： G06T11/005 , G06T2211/412
摘要： A radiological imaging method comprises: acquiring radiological lines of response (LOR's) from a subject; grouping the acquired LOR's into time intervals such that each group of LOR's (20) was acquired during a selected time interval; identifying a region of interest (60, 74) for each time interval based on LOR's grouped into that time interval; for each time interval, determining a positional characteristic (102) of the region of interest identified for that time interval based on LOR's grouped into that time interval; for each time interval, spatially adjusting LOR's grouped into that time interval based on the positional characteristic of the region of interest identified for that time interval; and reconstructing at least the spatially adjusted LOR's to generate a motion compensated reconstructed image.
摘要翻译：放射学成像方法包括：从受试者获取放射线响应（LOR）; 将获得的LOR分组成时间间隔，使得在选定的时间间隔内获取每组LOR（20）; 基于分组到该时间间隔中的LOR，为每个时间间隔识别感兴趣区域（60,74）; 对于每个时间间隔，基于分组到该时间间隔中的LOR确定针对该时间间隔标识的兴趣区域的位置特征（102）; 对于每个时间间隔，基于针对该时间间隔识别的感兴趣区域的位置特性，空间调整LOR被分组为该时间间隔; 以及至少重建空间调整的LOR以产生运动补偿重建图像。

2. 发明申请

WO2008015609A2 METHOD OF COMBINING BINARY CLUSTER MAPS INTO A SINGLE CLUSTER MAP 审中-公开
标题翻译：将二进制集群组合成一个单一集群映射的方法
公开(公告)号：WO2008015609A2
公开(公告)日：2008-02-07
申请号：PCT/IB2007/052843
申请日：2007-07-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V., , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WENGLER, Mark Christof , PAULUS, Timo , FISCHER, Alexander
发明人： WENGLER, Mark Christof , PAULUS, Timo , FISCHER, Alexander
IPC分类号： G06T5/50
CPC分类号： G06K9/6253 , G06K9/6218 , G06K9/6292 , G06K9/6293 , G06T7/0012 , G06T7/11 , G06T7/143 , G06T2207/10072 , G06T2207/30004
摘要： This invention relates to a method of combining multiple binary cluster maps into a single cluster map; where each respective binary cluster map represents characteristic information and the single cluster map represent the sum of the characteristic information. Initially, each respective binary cluster map is assigned with a reliability factor for indicating the reliability of the binary cluster map. These factor values are then used to determine a reliability vector comprising reliability factor elements, where each respective reliability factor element is associated to certain cluster map area in the single cluster map and indicates the reliability of the cluster map area. In that way, the single cluster map can be viewed with respect to the reliability.
摘要翻译：本发明涉及将多个二进制簇映射组合成单个簇映射的方法; 其中每个相应的二进制集群映射表示特征信息，并且单个集群映射表示特征信息的和。首先，为每个相应的二进制簇映射图分配用于指示二进制簇映射的可靠性的可靠性因子。然后使用这些因子值来确定包括可靠性因子元素的可靠性向量，其中每个相应的可靠性因素元素与单个集群映射中的某些集群映射区域相关联，并且指示集群映射区域的可靠性。以这种方式，可以相对于可靠性来查看单个集群映射。

3. 发明申请

WO2008004167A2 AUTOMATIC VOXEL SELECTION FOR PHARMACOKINETIC MODELING 审中-公开
标题翻译：用于药物动力学建模的自动VOXEL选择
公开(公告)号：WO2008004167A2
公开(公告)日：2008-01-10
申请号：PCT/IB2007/052533
申请日：2007-06-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , PAULUS, Timo , WENGLER, Mark, C.
发明人： PAULUS, Timo , WENGLER, Mark, C.
CPC分类号： G06T7/0012 , G06T2207/10076 , G06T2207/30004
摘要： This relates to a method of automatically selecting preferred voxels from a group of voxels for pharmacokinetic modeling of a biological system, where the voxels contain data points indicating a change of activity-levels over time. For each respective voxel the changes of the data points over time with at least one noise level value, where the comparing is performed in accordance to a pre-defined selection rule. Then, those voxels where the result of the comparing obeys the selection rule are then selected as preferred voxels.
摘要翻译：这涉及一种自动选择来自一组体素的体素的用于生物系统的药代动力学建模的方法，其中体素包含指示活动水平随时间变化的数据点。对于每个相应的体素，随着时间的推移，数据点随着至少一个噪声水平值的变化，其中根据预定义的选择规则进行比较。然后，将比较结果的选择符合选择规则的体素作为优选体素进行选择。

4. 发明申请

WO2005109343A3 IMAGE DATA PROCESSING SYSTEM FOR COMPARTMENTAL ANALYSIS 审中-公开
标题翻译：用于分析分析的图像数据处理系统
公开(公告)号：WO2005109343A3
公开(公告)日：2006-10-12
申请号：PCT/IB2005051446
申请日：2005-05-03
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , PAULUS TIMO , PELIGRAD DRAGOS-NICOLAE , SPIES LOTHAR
发明人： PAULUS TIMO , PELIGRAD DRAGOS-NICOLAE , SPIES LOTHAR
IPC分类号： G06T7/00 , G06F19/00
CPC分类号： G06T7/0012 , G06F19/321 , G06T2200/04 , G06T2207/10104 , G06T2207/20092 , G06T2207/30004
摘要： The invention relates to a data processing system (1) for the evaluation of image data, particularly of PET-images (I), that represent the time varying concentration of a tracer substance like F-MISO in an object (20). The data processing system (1) comprises a library module (48) with analytical solutions (C j (t)) for several compartment models. Preferably the library also contains the analytical gradients with respect to the parameters of interest. From the library an appropriate solution for each study can be chosen by a user. The use of analytical functions together with the information about the error (s A ( t )) of the input data (either via noise models 43 or via a simulation 44) allows to extract all parameters mandatory to fully understand the kinetics of complex models (more than one tissue compartment) on a per-voxel basis in a robust way in real-time.
摘要翻译：本发明涉及一种用于评价特定于PET图像（I）的图像数据的数据处理系统（1），其表示物体（20）中的示踪物质如F-MISO的时变浓度。数据处理系统（1）包括具有用于几个隔室模型的分析解决方案（C（j））的库模块（48）。优选地，库还包含关于感兴趣的参数的分析梯度。从图书馆，每个研究的适当解决方案可由用户选择。使用分析功能以及关于输入数据的错误（通过噪声模型43或经由模拟44）的错误的信息允许（例如，提取所有必要的参数，以实时的方式，以健壮的方式充分了解复杂模型（多于一个组织室）的动力学。

5. 发明申请

WO2005116647A3 SYSTEM FOR THE EVALUATION OF TRACER CONCENTRATION IN A REFERENCE TISSUE AND A TARGET REGION 审中-公开
公开(公告)号：WO2005116647A3
公开(公告)日：2005-12-08
申请号：PCT/IB2005/051665
申请日：2005-05-23
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , PELIGRAD, Dragos-Nicolae , SPIES, Lothar , PAULUS, Timo
发明人： PELIGRAD, Dragos-Nicolae , SPIES, Lothar , PAULUS, Timo
IPC分类号： G06F19/00
摘要： The invention relates to the estimation of kinetic parameters for a target region (210) utilizing information from a normal (unperturbed) reference region (200). The proposed compartmental model models metabolic pathways for blood, reference and target tissue. The proposed analysis procedure features two alternatives: (A) Extraction of the plasma input in the reference region (200) and its unperturbed kinetic parameters, hereafter utilization of the plasma input and the kinetic parameters of the reference region as initial parameters for the analysis of the target region (210). (B) The system of kinetic equations describing the kinetics of the imaging agent in the target and reference regions is solved for the input function (amount of free imaging agent in the plasma or the total imaging agent S B (t) contained in plasma, blood elements and metabolites) considered to be the same for both regions.

6. 发明申请

WO2005109343A2 DATA PROCESSING SYSTEM FOR COMPARTMENTAL ANALYSIS 审中-公开
标题翻译：数据处理系统进行分析
公开(公告)号：WO2005109343A2
公开(公告)日：2005-11-17
申请号：PCT/IB2005/051446
申请日：2005-05-03
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , PAULUS, Timo , PELIGRAD, Dragos-Nicolae , SPIES, Lothar
发明人： PAULUS, Timo , PELIGRAD, Dragos-Nicolae , SPIES, Lothar
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06F19/321 , G06T2200/04 , G06T2207/10104 , G06T2207/20092 , G06T2207/30004
摘要： The invention relates to a data processing system (1) for the evaluation of image data, particularly of PET-images (I), that represent the time varying concentration of a tracer substance like F-MISO in an object (20). The data processing system (1) comprises a library module (48) with analytical solutions (C,(t)) for several compartment models. Preferably the library also contains the analytical gradients with respect to the parameters of interest. From the library an appropriate solution for each study can be chosen by a user. The use of analytical functions together with the information about the error (6 A ( t )) of the input data (either via noise models 43 or via a simulation 44) allows to extract all parameters mandatory to fully understand the kinetics of complex models (more than one tissue compartment) on a per-voxel basis in a robust way in real-time.
摘要翻译：本发明涉及一种用于评价特定于PET图像（I）的图像数据的数据处理系统（1），其表示物体（20）中的示踪物质如F-MISO的时变浓度。数据处理系统（1）包括具有用于几个隔室模型的分析解决方案（C，（t））的库模块（48）。优选地，库还包含关于感兴趣的参数的分析梯度。从图书馆，每个研究的适当解决方案可由用户选择。使用分析函数以及关于输入数据的错误（6A（t））的信息（通过噪声模型43或通过模拟44）允许提取强制性的所有参数以完全理解复杂模型的动力学（更多比一个组织室）以一个健壮的方式实时地在每个体素基础上。

7. 发明申请

WO2009153683A3 RADIOLOGICAL IMAGING INCORPORATING LOCAL MOTION MONITORING, CORRECTION, AND ASSESSMENT 审中-公开
公开(公告)号：WO2009153683A3
公开(公告)日：2009-12-23
申请号：PCT/IB2009/052297
申请日：2009-06-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BRINKS, Ralph , FISCHER, Alexander , MARTIN RECUERO, Ana, Belen , GEORGI, Jens-Christoph , SCHWEIZER, Bernd , PAULUS, Timo, Markus
发明人： BRINKS, Ralph , FISCHER, Alexander , MARTIN RECUERO, Ana, Belen , GEORGI, Jens-Christoph , SCHWEIZER, Bernd , PAULUS, Timo, Markus
IPC分类号： G06T11/00
摘要： A radiological imaging method comprises: acquiring radiological lines of response (LOR's) from a subject; grouping the acquired LOR's into time intervals such that each group of LOR's (20) was acquired during a selected time interval; identifying a region of interest (60, 74) for each time interval based on LOR's grouped into that time interval; for each time interval, determining a positional characteristic (102) of the region of interest identified for that time interval based on LOR's grouped into that time interval; for each time interval, spatially adjusting LOR's grouped into that time interval based on the positional characteristic of the region of interest identified for that time interval; and reconstructing at least the spatially adjusted LOR's to generate a motion compensated reconstructed image.

8. 发明申请

WO2007010440A8 AUTOMATIC INPUT FUNCTION ESTIMATION FOR PHARMACOKINETIC MODELING 审中-公开
标题翻译：用于药物动力学建模的自动输入函数估计
公开(公告)号：WO2007010440A8
公开(公告)日：2007-05-18
申请号：PCT/IB2006052345
申请日：2006-07-11
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP , FISCHER ALEXANDER , PAULUS TIMO
发明人： FISCHER ALEXANDER , PAULUS TIMO
IPC分类号： G06F19/00
CPC分类号： G06F17/18 , G16H50/50
摘要： This system ( 200 ), apparatus ( 300 ), and method ( 100 ) of the present invention provide an analytic way to solve the (input) estimation problem of pharmacokinetic modeling: estimating parameters of a kinetic model from a series of tracer (radioactively labeled imaging agent) activity measurements (e.g. by positron emission tomography). Since the model describes a biological process its parameters have a direct functional interpretation (e.g. hypoxia for the tracer FMISO) that can be of diagnostic value. The measurements represent the activity distribution in time and space in the form of a 4D data set d(t, x, y, z), t=1, . . . , T. The kinetic parameter estimation procedure ( 205 ) requires knowledge of the tracer input activity. This input activity can either be measured invasively or it can be estimated from the data in a preprocessing step. The estimation problem can be solved efficiently if the model and its input are described analytically. Typically parameterized functions (often sums of exponential terms) ( 204 ) are fitted to the averaged data over a region of interest (ROI) (e.g. an artery or the left ventricular blood pool) in order to obtain an analytical input representation. The input function representation (functional form) ( 204 ) and its initial parameter values ( 205 ) have to be selected/specified prior to the fitting procedure 206 ). The present invention thereby reduces the amount of manual interaction and operator dependence in the evaluation of dynamic procedures.

9. 发明申请

WO2009019535A1 A METHOD, APPARATUS, COMPUTER-READABLE MEDIUM AND USE FOR PHARMACOKINETIC MODELING 审中-公开
标题翻译：方法，装置，计算机可读介质和用于药物动力学建模
公开(公告)号：WO2009019535A1
公开(公告)日：2009-02-12
申请号：PCT/IB2007/053065
申请日：2007-08-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , PAULUS, Timo , FISCHER, Alexander , SPIES, Lothar
发明人： PAULUS, Timo , FISCHER, Alexander , SPIES, Lothar
IPC分类号： G06T7/00
CPC分类号： G06T7/0016 , G06T7/207 , G06T2207/10076 , G06T2207/10104 , G06T2207/20016 , G06T2207/20021 , G06T2207/30004
摘要： An advantageous method, apparatus, computer-readable medium, and use for improving the estimation of relevant initial parameters for parameter reconstruction processes in molecular imaging are disclosed, resulting in shorter process times and more robust results with small confidence intervals.
摘要翻译：公开了一种有利的方法，装置，计算机可读介质和用于改进分子成像中参数重建过程的相关初始参数的估计的用途，导致较短的处理时间和更小的置信区间的更稳健的结果。

10. 发明申请

WO2008015609A3 METHOD OF COMBINING BINARY CLUSTER MAPS INTO A SINGLE CLUSTER MAP 审中-公开
标题翻译：将二进制集群映射合并到单个集群映射中的方法
公开(公告)号：WO2008015609A3
公开(公告)日：2008-12-31
申请号：PCT/IB2007052843
申请日：2007-07-17
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , WENGLER MARK CHRISTOF , PAULUS TIMO , FISCHER ALEXANDER
发明人： WENGLER MARK CHRISTOF , PAULUS TIMO , FISCHER ALEXANDER
IPC分类号： G06T7/00
CPC分类号： G06K9/6253 , G06K9/6218 , G06K9/6292 , G06K9/6293 , G06T7/0012 , G06T7/11 , G06T7/143 , G06T2207/10072 , G06T2207/30004
摘要： This invention relates to a method of combining multiple binary cluster maps into a single cluster map; where each respective binary cluster map represents characteristic information and the single cluster map represent the sum of the characteristic information. Initially, each respective binary cluster map is assigned with a reliability factor for indicating the reliability of the binary cluster map. These factor values are then used to determine a reliability vector comprising reliability factor elements, where each respective reliability factor element is associated to certain cluster map area in the single cluster map and indicates the reliability of the cluster map area. In that way, the single cluster map can be viewed with respect to the reliability.
摘要翻译：本发明涉及一种将多个二进制簇映射组合成单个簇映射的方法; 其中每个相应的二进制聚类地图表示特征信息，并且单个聚类地图表示特征信息的总和。最初，为每个相应的二进制簇映射分配用于指示二进制簇映射的可靠性的可靠性因子。然后使用这些因子值来确定包括可靠性因素元素的可靠性向量，其中每个相应的可靠性因素元素与单个聚类地图中的某个聚类地图区域相关联并且指示聚类地图区域的可靠性。这样，就可靠性而言，可以查看单个聚类地图。

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