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    • 3. 发明申请
    • SUSPENDED PARTICLE CHARACTERIZATION SYSTEM
    • 悬浮粒子特征系统
    • WO2016066992A1
    • 2016-05-06
    • PCT/GB2015/053010
    • 2015-10-13
    • MCCAFFREY, JohnDAHL, KevinBENNETT, PeterPATIL, VishalLEWIS, E. NeilMALVERN INSTRUMENTS LIMITED
    • MCCAFFREY, JohnDAHL, KevinBENNETT, PeterPATIL, VishalLEWIS, E. Neil
    • G01N15/14G01N21/88G01N21/65B01L3/00
    • G01N15/1456B01L3/508B01L2200/0668B01L2300/0681B01L2300/0819B01L2300/0822B01L2300/0829B01L2300/0851B01L2300/0877B01L2400/0457B01L2400/049G01N21/65G01N2021/651
    • An apparatus (10) for characterizing particles, comprising: a microscope objective with an optical axis and a depth of field; a holder cell (22) configured to position the particles in a generally planar volume below the microscope objective, the planar volume being substantially normal to the optical axis and having a depth that is less than or equal to the depth of field, wherein a portion of the cell holder (22) for positioning in the optical axis of the microscope objective is substantially free of significant spectral features in a Raman spectral range; an x-y stage (20) to move the microscope objective relative to the holder cell (22) in x and y directions to align particles with the optical axis of the microscope objective while the particles are held by the holder cell (22), a detector ( 18) for acquiring an image of a particle through the microscope objective, a laser operable to illuminate a particle held by the holder cell (22), a Raman spectrometer ( 16) arranged to obtain a spectrum including the Raman spectral range from the illuminated particle, and characterizing logic operative to characterize the particle based on image processing operations performed on the acquired image and based on the Raman spectrum. The holder cell (22) comprises a first plate (34) and a second plate (36) that are separated by a predetermined distance defining the planar volume depth.
    • 一种用于表征颗粒的装置(10),包括:具有光轴和景深的显微镜物镜; 保持器单元(22),其构造成将所述颗粒定位在所述显微镜物镜下方的大致平坦的体积中,所述平面体积基本上垂直于所述光轴并且具有小于或等于所述景深的深度,其中, 用于在显微镜物镜的光轴上定位的电池座(22)在拉曼光谱范围内基本上没有显着的光谱特征; 一个xy平台(20),用于在x和y方向上相对于保持器单元(22)移动显微镜物镜,以使颗粒与显微镜物镜的光轴对准,同时颗粒被保持电池(22)保持;检测器 (18),用于通过所述显微镜物镜获取颗粒的图像,可操作以照亮由所述保持器单元(22)保持的颗粒的激光;拉曼光谱仪(16),布置成获得包括来自所述照明的拉曼光谱范围的光谱 粒子和表征逻辑,用于基于对所获取的图像执行的图像处理操作并基于拉曼光谱来表征粒子。 保持器单元(22)包括以限定平面体积深度的预定距离分开的第一板(34)和第二板(36)。
    • 7. 发明申请
    • PHARMACEUTICAL COMPOSITION COMPRISING METFORMIN AND PIOGLITAZONE
    • 包含METFORMIN和PIOGLITAZONE的药物组合物
    • WO2012028934A1
    • 2012-03-08
    • PCT/IB2011/002001
    • 2011-08-31
    • LUPIN LIMITEDKULKARNI, ShirishkumarDALAL, Satish, KumarJAHAGIRDAR, HarshalPATIL, Vishal
    • KULKARNI, ShirishkumarDALAL, Satish, KumarJAHAGIRDAR, HarshalPATIL, Vishal
    • A61K31/155A61K31/4439A61K9/20
    • A61K31/4439A61K9/2013A61K9/2027A61K9/2054A61K9/209A61K31/155A61K2300/00
    • A pharmaceutical composition comprising metformin or pharmaceutically acceptable salts, esters, solvates, hydrates, metabolites, prodrugs or isomers thereof in extended release form and pioglitazone or pharmaceutically acceptable salts, esters, solvates, hydrates, metabolites, prodrugs or isomers thereof in immediate release form is provided. More particularly a pharmaceutical composition comprising extended release metformin core comprising metformin, extended release polymer and other pharmaceutically acceptable excipients; and immediate release pioglitazone layer comprising pioglitazone, high viscosity polymer, and other pharmaceutically acceptable excipients. Further a pharmaceutical composition comprising extended release metformin core comprising metformin, extended release polymer and other pharmaceutically acceptable excipients; and immediate release pioglitazone layer comprising pioglitazone, polyvinyl alcohol, surfactant and other pharmaceutically acceptable excipients
    • 药物组合物,其包含二甲双胍或其药学上可接受的盐,酯,溶剂化物,水合物,代谢产物,前药或其延迟释放形式,吡格列酮或其药学上可接受的盐,酯,溶剂化物,水合物,代谢产物,前药或异构体, 提供。 更具体地,包含包含二甲双胍,延长释放聚合物和其它药学上可接受的赋形剂的延长释放二甲双胍核心的药物组合物; 并且立即释放吡格列酮层,其包含吡格列酮,高粘度聚合物和其它药学上可接受的赋形剂。 此外,还包含药物组合物,其包含延长释放的二甲双胍核心,其包含二甲双胍,延长释放聚合物和其它药学上可接受的赋形剂; 和速释吡格列酮层,其包含吡格列酮,聚乙烯醇,表面活性剂和其它药学上可接受的赋形剂