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    • 2. 发明申请
    • BENZAMIDE COMPOUNDS
    • 苯酰胺化合物
    • WO2008073450A2
    • 2008-06-19
    • PCT/US2007025390
    • 2007-12-12
    • UNIV GEORGETOWNSAMARITAN PHARMACEUTICALS INCLECANU LAURENTGREESON JANETPAPADOPOULOS VASSILIOSXU JING
    • LECANU LAURENTGREESON JANETPAPADOPOULOS VASSILIOSXU JING
    • A61K31/497
    • A61K31/497C07D209/20
    • The invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal, such as a human, wherein the infectivity of a pathogen toward mammalian cells is implicated and inhibition of its infectivity is desired comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof that inhibits pathogenic infectivity, including pharmaceutically acceptable salts thereof, wherein the pathogen is Avian Influenza, Avian Influenza A, Influenza A, Influenza B, hepatitis B virus, or hepatitis C virus. The invention also provides a therapeutic method for preventing or treating a neuropathological condition or symptom in a mammal, such as human, comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof, including pharmaceutically acceptable salts thereof.
    • 本发明提供了用于预防或治疗哺乳动物例如人的病理状态或症状的治疗方法,其中涉及病原体对哺乳动物细胞的感染性并且需要抑制其感染性,包括对需要 这种疗法是有效量的抑制病原性感染性的氨基酸哌嗪酰胺的N-苯甲酰胺衍生物,包括其药学上可接受的盐,其中病原体是禽流感,甲型禽流感,甲型流感,甲型流感,乙型肝炎 B病毒或丙型肝炎病毒。 本发明还提供了用于预防或治疗哺乳动物(例如人)的神经病理状况或症状的治疗方法,其包括向需要这种治疗的哺乳动物施用有效量的本发明的哌嗪基酰胺的N-苯甲酰胺衍生物 其氨基酸,包括其药学上可接受的盐。