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1. 发明申请

WO2012125811A1 MULTI-MODAL MEDICAL IMAGING 审中-公开
标题翻译：多模式医学成像
公开(公告)号：WO2012125811A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/029203
申请日：2012-03-15
申请人： SIEMENS CORPORATION , PALADINI, Gianluca
发明人： PALADINI, Gianluca
IPC分类号： A61B8/08 , A61B6/03 , A61N7/00 , G01T1/166 , A61B6/00 , A61B8/00
CPC分类号： A61B8/4416 , A61B6/037 , A61B6/4258 , A61B6/4405 , A61B6/4417 , A61B6/4458 , A61B6/481 , A61B6/5247 , A61B6/547 , A61B8/08 , A61B8/145 , A61B8/4218 , A61B8/4245 , A61B8/4444 , A61B8/4483 , A61B8/483 , A61B8/486 , A61B8/5261 , A61B34/20 , A61B34/30 , A61B90/37 , A61B2034/2048 , A61B2034/2051 , A61B2034/2065 , A61B2090/378 , A61N7/00 , A61N7/02 , A61N2007/0052 , G01T1/161
摘要： A nuclear probe (12) and ultrasound transducer (14) are interconnected, such as being in a same hand-held housing (11). The interconnection (16) aligns the coordinate systems in a known spatial relationship. The ultrasound data is used to detect transducer (14) offset or change in position without a tracking sensor. The radiation detected by the nuclear probe (12) may be reconstructed into an image based on the detected transducer (14) position since the nuclear probe (12) moves with the ultrasound transducer (14). Both anatomical and functional imaging may be provided together without the complications of calibration and tracking. Where a therapeutic transducer (14) is included, therapy may also be provided. The anatomical and functional information identifies the regions for treatment. The same device, already positioned correctly based on the functional and anatomical imaging, is then used for treatment with high intensity focused ultrasound.
摘要翻译：核探针（12）和超声换能器（14）相互连接，例如在相同的手持壳体（11）中。互连（16）以已知的空间关系对准坐标系。超声数据用于检测换能器（14）偏移或位置改变而没有跟踪传感器。由核探针（12）与超声换能器（14）一起移动，由核探针（12）检测到的辐射可以基于检测到的换能器（14）位置被重建成图像。解剖学和功能成像可以一起提供，而不需要校准和跟踪的并发症。在包括治疗换能器（14）的情况下，还可以提供治疗。解剖和功能信息确定治疗区域。已经基于功能和解剖学成像正确定位的相同装置然后被用于用高强度聚焦超声波治疗。

2. 发明申请

WO2010056409A1 MICROSCOPIC AND MACROSCOPIC DATA FUSION FOR BIOMEDICAL IMAGING 审中-公开
标题翻译：用于生物医学成像的微观和宏观数据融合
公开(公告)号：WO2010056409A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/054832
申请日：2009-08-25
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , LADIC, Lance, Anthony , PALADINI, Gianluca
发明人： LADIC, Lance, Anthony , PALADINI, Gianluca
IPC分类号： A61B5/00 , G06T7/00
CPC分类号： A61B5/00 , G06T7/33 , G06T7/38 , G06T2207/10056 , G06T2207/30024
摘要： Macroscopic imaging data, such as CT, MR, PET, or SPECT, is obtained. Microscopic imaging data of at least a portion of the same tissue is obtained. The microscopic imaging data is spatially aligned with the macroscopic imaging data. The spatial alignment allows calculation and/or imaging using both types of data as a multi-resolution data set. A given image may include information about the relative position of the microscopically imaged tissue to the macroscopically imaged body portion. This positional relationship may allow viewing of affects or changes at cellular levels as well as less detailed tissue structure or organism levels and may allow determination of any correlation between changes in both levels.
摘要翻译：获得宏观成像数据，如CT，MR，PET或SPECT。得到至少一部分相同组织的显微成像数据。显微成像数据与宏观成像数据在空间上对齐。空间对准允许使用两种类型的数据作为多分辨率数据集的计算和/或成像。给定的图像可以包括关于微观成像的组织相对于宏观成像的身体部分的相对位置的信息。这种位置关系可以允许查看细胞水平的影响或变化以及较不详细的组织结构或生物体水平，并且可以允许确定两个水平的变化之间的任何相关性。

3. 发明申请

WO2013142072A3 LUGGAGE VISUALIZATION AND VIRTUAL UNPACKING 审中-公开
标题翻译：行货可视化和虚拟解包
公开(公告)号：WO2013142072A3
公开(公告)日：2014-11-20
申请号：PCT/US2013029494
申请日：2013-03-07
申请人： SIEMENS CORP , LI WEI , PALADINI GIANLUCA
发明人： LI WEI , PALADINI GIANLUCA
IPC分类号： G06T19/00
CPC分类号： G06T15/08 , G01N23/046 , G01N2223/419 , G01N2223/42 , G01N2223/639 , G01N2223/643 , G06T19/00 , G06T2207/10072 , G06T2207/30112
摘要： Methods and systems for luggage visualization perform virtual unpacking by visually moving an object image away from its original pose. A scanned 3D volume is segmented guided by a confidence measure to create a label volume whose voxels specify the detected object IDs. The luggage dataset and the label volume are visualized by volume rendering. Using an automatic coloring algorithm, any pair of objects whose projections are adjacent in an image are assigned distinct hues. A layered framework efficiently renders a scene mixed with packed luggage, animated unpacking objects, and already unpacked objects put aside for further inspection. A GPU is used to automatically select objects that are not blocked by others and can be unpacked.
摘要翻译：用于行李可视化的方法和系统通过视觉上将物体图像远离其原始姿态进行虚拟拆包。扫描的3D体积由置信度量度引导，以创建体素，其体素指定检测到的对象ID。行李数据集和标签卷可通过体积渲染来显示。使用自动着色算法，其投影在图像中相邻的任何一对对象被分配不同的色调。分层框架有效地将场景与包装的行李，动画的拆包对象以及已经打包的对象放在一起进行进一步检查。 GPU用于自动选择未被其他人阻止的对象，并可以解压缩。

4. 发明申请

WO2012027259A3 SYSTEM AND METHOD FOR INTERACTIVE SEGMENTATION ON MOBILE DEVICES IN A CLOUD COMPUTING ENVIRONMENT 审中-公开
公开(公告)号：WO2012027259A3
公开(公告)日：2012-03-01
申请号：PCT/US2011/048590
申请日：2011-08-22
申请人： SIEMENS CORPORATION , FANG, Ruogu , GRADY, Leo , PALADINI, Gianluca
发明人： FANG, Ruogu , GRADY, Leo , PALADINI, Gianluca
IPC分类号： G06F19/00
摘要： A mobile device (160) for medical image analysis is disclosed. The mobile device (160) includes a display (162), a communication module (218), a memory (204) configured to store processor-executable instructions (224) and a processor (202) in communication with the display (162), the communication module (218) and the memory (204). The processor (202) being configured to execute the processor-executable instructions (224) to implement a compression routine to generate a compressed representation of a medical image stored in the memory (204), transmit the compressed representation to a remote device (110) via the communication module (218), receive segmented results from the remote device (110), wherein the segmented results are derived from a reconstruction of the compressed representation generated at the remote device (110), and present, via the display (162), a segmented medical image based on the received segmented results.

5. 发明申请

WO2012027259A2 SYSTEM AND METHOD FOR INTERACTIVE SEGMENTATION ON MOBILE DEVICES IN A CLOUD COMPUTING ENVIRONMENT 审中-公开
标题翻译：云计算环境中移动设备交互分段的系统与方法
公开(公告)号：WO2012027259A2
公开(公告)日：2012-03-01
申请号：PCT/US2011048590
申请日：2011-08-22
申请人： SIEMENS CORP , FANG RUOGU , GRADY LEO , PALADINI GIANLUCA
发明人： FANG RUOGU , GRADY LEO , PALADINI GIANLUCA
IPC分类号： G06F19/00
CPC分类号： G06T7/0012 , G06F19/321 , G06T7/10 , H04N19/60 , H04N19/80 , H04N19/85
摘要： A mobile device (160) for medical image analysis is disclosed. The mobile device (160) includes a display (162), a communication module (218), a memory (204) configured to store processor-executable instructions (224) and a processor (202) in communication with the display (162), the communication module (218) and the memory (204). The processor (202) being configured to execute the processor-executable instructions (224) to implement a compression routine to generate a compressed representation of a medical image stored in the memory (204), transmit the compressed representation to a remote device (110) via the communication module (218), receive segmented results from the remote device (110), wherein the segmented results are derived from a reconstruction of the compressed representation generated at the remote device (110), and present, via the display (162), a segmented medical image based on the received segmented results.
摘要翻译：公开了一种用于医学图像分析的移动设备（160）。移动设备（160）包括显示器（162），通信模块（218），被配置为存储与显示器（162）通信的处理器可执行指令（224）和处理器（202）的存储器（204）通信模块（218）和存储器（204）。处理器（202）被配置为执行处理器可执行指令（224）以实现压缩例程以生成存储在存储器（204）中的医学图像的压缩表示，将压缩表示传送到远程设备（110）经由所述通信模块（218）接收来自所述远程设备（110）的分段结果，其中所述分段结果是从在所述远程设备（110）处生成的所述压缩表示的重建导出的，并且经由所述显示器（162）呈现，基于接收到的分段结果的分段医学图像。

6. 发明申请

WO2013142072A2 LUGGAGE VISUALIZATION AND VIRTUAL UNPACKING 审中-公开
标题翻译：行货可视化和虚拟解包
公开(公告)号：WO2013142072A2
公开(公告)日：2013-09-26
申请号：PCT/US2013/029494
申请日：2013-03-07
申请人： SIEMENS CORPORATION , LI, Wei , PALADINI, Gianluca
发明人： LI, Wei , PALADINI, Gianluca
IPC分类号： G06T15/00
CPC分类号： G06T15/08 , G01N23/046 , G01N2223/419 , G01N2223/42 , G01N2223/639 , G01N2223/643 , G06T19/00 , G06T2207/10072 , G06T2207/30112
摘要： Methods and systems for luggage visualization perform virtual unpacking by visually moving an object image away from its original pose. A scanned 3D volume is segmented guided by a confidence measure to create a label volume whose voxels specify the detected object IDs. The luggage dataset and the label volume are visualized by volume rendering. Using an automatic coloring algorithm, any pair of objects whose projections are adjacent in an image are assigned distinct hues. A layered framework efficiently renders a scene mixed with packed luggage, animated unpacking objects, and already unpacked objects put aside for further inspection. A GPU is used to automatically select objects that are not blocked by others and can be unpacked.
摘要翻译：用于行李可视化的方法和系统通过视觉上将物体图像远离其原始姿态进行虚拟拆包。扫描的3D体积由置信度量度引导，以创建体素，其体素指定检测到的对象ID。行李数据集和标签卷可通过体积渲染来显示。使用自动着色算法，其投影在图像中相邻的任何一对对象被分配不同的色调。分层框架有效地将场景与包装的行李，动画的包装物品以及已经打包的物品混合在一起，放在一边进行进一步的检查。使用GPU来自动选择不被其他人阻止的对象，并且可以解压缩。

7. 发明申请

WO2013028762A1 METHOD AND SYSTEM FOR INTEGRATED RADIOLOGICAL AND PATHOLOGICAL INFORMATION FOR DIAGNOSIS, THERAPY SELECTION, AND MONITORING 审中-公开
标题翻译：用于诊断，治疗选择和监测的综合放射学和病理学信息的方法和系统
公开(公告)号：WO2013028762A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/051869
申请日：2012-08-22
申请人： SIEMENS CORPORATION , KAMEN, Ali , GRADY, Leo , PALADINI, Gianluca , KHURD, Parmeshwar , KUTTER, Oliver , COMANICIU, Dorin
发明人： KAMEN, Ali , GRADY, Leo , PALADINI, Gianluca , KHURD, Parmeshwar , KUTTER, Oliver , COMANICIU, Dorin
IPC分类号： A61B6/00 , A61B8/00 , G06F19/00 , A61B10/00
CPC分类号： G06T7/0012 , A61B6/12 , A61B6/463 , A61B6/467 , A61B8/0841 , A61B8/463 , A61B8/465 , A61B8/467 , A61B10/02 , G06F19/00 , G06F19/3481 , G06T2207/30004 , G16H50/20
摘要： A method and system for integrating radiological and pathological information for cancer diagnosis, therapy selection, and monitoring is disclosed. A radiological image of a patient, such as a magnetic resonance (MR), computed tomography (CT), positron emission tomography (PET), or ultrasound image, is received. A location corresponding to each of one or more biopsy samples is determined in the at least one radiological image. An integrated display is used to display a histological image corresponding to the each biopsy samples, the radiological image, and the location corresponding to each biopsy samples in the radiological image. Pathological information and radiological information are integrated by combining features extracted from the histological images and the features extracted from the corresponding locations in the radiological image for cancer grading, prognosis prediction, and therapy selection.
摘要翻译：公开了用于整合放射学和病理学信息用于癌症诊断，治疗选择和监测的方法和系统。接收患者的放射学图像，例如磁共振（MR），计算机断层摄影（CT），正电子发射断层摄影（PET）或超声图像。在至少一个放射图像中确定与一个或多个活检样本中的每一个对应的位置。使用集成显示器来显示对应于每个活检样本，放射图像和对应于放射图像中的每个活检样本的位置的组织学图像。通过组合图像提取的特征和从放射图像中相应位置提取的特征，进行癌症分级，预后预测和治疗选择，整合病理信息和放射学信息。

8. 发明申请

WO2012064917A1 ROBOTIC NAVIGATED NUCLEAR PROBE IMAGING 审中-公开
标题翻译：机动航海导弹探测成像
公开(公告)号：WO2012064917A1
公开(公告)日：2012-05-18
申请号：PCT/US2011/060091
申请日：2011-11-10
申请人： SIEMENS CORPORATION , PALADINI, Gianluca , KAMEN, Ali , KUTTER, Oliver
发明人： PALADINI, Gianluca , KAMEN, Ali , KUTTER, Oliver
IPC分类号： A61B6/00 , A61B5/00 , A61B17/34 , G01T1/166 , G01T1/29 , A61B19/00
CPC分类号： A61B6/4458 , A61B5/0064 , A61B6/037 , A61B6/4057 , A61B6/4258 , A61B6/4417 , A61B6/4464 , A61B6/466 , A61B6/481 , A61B6/5223 , A61B6/5229 , A61B6/5247 , A61B34/30
摘要： Robotic navigation is provided for nuclear probe imaging. Using a three-dimensional scanner (19), the surface of a patient is determined (42). A calibrated robotic system positions (48) a nuclear probe about the patient based on the surface. The positioning (48) may be without contacting the patient and the surface may be used in reconstruction to account for spacing of the probe from the patient. By using the robotic system for positioning (48), the speed, resolution and/or quality of the reconstructed image may be predetermined, user settable, and/or improved compared to manual scanning. The reconstruction (52) may be more computationally efficient by providing for regular spacing of radiation detection locations within the volume
摘要翻译：提供机器人导航用于核探针成像。使用三维扫描器（19），确定患者的表面（42）。校准的机器人系统基于表面定位（48）关于患者的核探针。定位（48）可以不与患者接触，并且可以在重建中使用表面以考虑探针与患者的间隔。通过使用用于定位的机器人系统（48），与手动扫描相比，重建图像的速度，分辨率和/或质量可以是预定的，用户可设置的和/或改进的。通过提供体积内的辐射检测位置的规则间隔，重建（52）可以更有计算效率

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