专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008111096A2 NOVEL PRODRUGS 审中-公开
标题翻译：新的PRODRUGS
公开(公告)号：WO2008111096A2
公开(公告)日：2008-09-18
申请号：PCT/IN2008/000147
申请日：2008-03-14
申请人： SUN PHARMA ADVANCED RESEARCH COMPANY LTD , THENNATI, Rajamannar , SAMANTA, Biswajit , PAL, Ranjan Kumar , KILARU, Srinivasu , JIVANI, Jignesh , KUMBHANI, Savajibhai Anil , ADHYAPAK, Jay Prakashchandra
发明人： THENNATI, Rajamannar , SAMANTA, Biswajit , PAL, Ranjan Kumar , KILARU, Srinivasu , JIVANI, Jignesh , KUMBHANI, Savajibhai Anil , ADHYAPAK, Jay Prakashchandra
IPC分类号： C07C251/60
CPC分类号： C07C271/60 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/34 , C07D277/40 , C07D295/185 , C07D401/12
摘要： The present invention describes novel prodrugs of formula (I) or their salts, process of preparation and uses thereof.
摘要翻译：本发明描述了式（I）的新型前药或其盐，其制备方法和用途。

2. 发明申请

WO2006123355A3 NOVEL STATIN DERIVATIVES 审中-公开
公开(公告)号：WO2006123355A3
公开(公告)日：2006-11-23
申请号：PCT/IN2006/000043
申请日：2006-02-02
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED , KUMBHANI, Anil Savajibhai , DIPCHANDANI, Jitendra Gopaldas , PAL, Ranjan Kumar , SAMANTA, Biswajit , THENNATI, Rajamannar
发明人： KUMBHANI, Anil Savajibhai , DIPCHANDANI, Jitendra Gopaldas , PAL, Ranjan Kumar , SAMANTA, Biswajit , THENNATI, Rajamannar
IPC分类号： C07D309/30 , A61K31/351 , A61P3/06
摘要： The present invention provides novel statin derivatives and a facile process for preparation thereof selected from a group consisting of a compound of formula (I), wherein R is selected from a group consisting of -OH, -OR 1 , OCOR 1 , -OCHO, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, alkylaryl, heteroaryl, aralkyl, heterocycle having ring size between 3 to 6, -CN, -COOH, -COOR 1 , -CONHR 1 , -CONR 1 R 2 , -NH 2 , -NHR 1 , -NR 1 R 2 halogen, -SH and -SR 1 ; wherein R 1 and R 2 are independently selected from C 1 -C 6 alkyl, alkylaryl, heteroaryl, aralkyl, heterocycle having ring size between 3 to 6, C 2 -C 6 alkenyl and C 2 -C 6 alkynyl, or R 1 and R 2 together with the carbon atom to which they are attached from a heterocycle with a ring size from 3 to 6, ------ represents either α or β-susbstituent, and pharmaceutically acceptable salt thereof. The compounds have anti-hyperlipidimic anti-hypercholesterolemic and antiinflammatory activity.

3. 发明申请

WO2009116067A3 NOVEL DERIVATIVES OF ACYL CYANOPYRROLIDINES 审中-公开
标题翻译： ACYL CYANOPRROLIDINES的新型衍生物
公开(公告)号：WO2009116067A3
公开(公告)日：2010-09-10
申请号：PCT/IN2009000029
申请日：2009-01-09
申请人： SUN PHARMA ADVANCED RES CO LTD , AKOLKAR NAKUL PRAMOD , ADHYAPAK JAY PRAKASHCHANDRA , ARADHYE JAYRAJ DILIPBHAI , KUMBHANI ANIL SAVAJIHAI , PANCHAL BHAVESH MOHANBHAI , JIVANI JIGNESH KANTILAL , SAMANTA BISWAJIT , PAL RANJAN KUMAR , THENNATI RAJAMANNAR
发明人： AKOLKAR NAKUL PRAMOD , ADHYAPAK JAY PRAKASHCHANDRA , ARADHYE JAYRAJ DILIPBHAI , KUMBHANI ANIL SAVAJIHAI , PANCHAL BHAVESH MOHANBHAI , JIVANI JIGNESH KANTILAL , SAMANTA BISWAJIT , PAL RANJAN KUMAR , THENNATI RAJAMANNAR
IPC分类号： C07H19/04 , A61K31/7052 , C07D211/06 , C07D401/06
CPC分类号： C07D493/04 , A61K31/7052 , A61K31/706 , A61K45/06 , C07D493/14 , C07H13/00 , C07H13/08 , C07H19/04 , A61K2300/00
摘要： A compound of formula (I) or a tautomeric form, regioisomer, stereoisomer, solvate, N-oxide or pharmaceutically acceptable salts thereof; wherein 'a' - is selected from the group consisting of substituted or unsubstituted heterocycloalkyl ring and substituted or unsubstituted carbohydrate moiety y is a member selected from -O-, -CO-, -S02-, aminoalkyl or formula (II) wherein, Rw is hydrogen, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl; x is a member selected from -0-, -S-, -SO-, -S02-, CONR10, NR10CO and -NRd-, or x and y together represent a chemical bond; Z is selected from -CH-, -N-. t is an integer selected from O to 4; with the provisos that when 'a' is substituted or unsubstituted heterocycloalkyl ring then 't' is not O and when y = -CO-, x is not NRd.
摘要翻译：式（I）化合物或互变异构体，区域异构体，立体异构体，溶剂合物，N-氧化物或其药学上可接受的盐; 其中'a'选自取代或未取代的杂环烷基环和取代或未取代的碳水化合物部分y是选自-O - ， - CO - ， - SO 2 - ，氨基烷基或式（II）的成员，其中，Rw 是氢，取代或未取代的烷基，烯基，炔基，环烷基，芳基，杂芳基; x是选自-O - ， - S-，-SO-，-SO 2 - ，CONR 10，NR 10 CO和-NR d - 的成员，或x和y一起代表化学键; Z选自-CH-，-N-。 t是选自O至4的整数; 条件是当'a'为取代或未取代的杂环烷基环时，则't'不为O，当y = -CO-时，x不为NRd。

4. 发明申请

WO2008152149A1 NOVEL DICARBOXYLIC ACID DERIVATIVES AS S1P1 RECEPTOR AGONISTS 审中-公开
标题翻译：新型二羧酸衍生物作为S1P1受体激动剂
公开(公告)号：WO2008152149A1
公开(公告)日：2008-12-18
申请号：PCT/EP2008/057571
申请日：2008-06-16
申请人： BIOPROJET , SUN PHARMA ADVANCED RESEARCH COMPANY LTD , CAPET, Marc , LEVOIN, Nicolas , BERREBI-BERTRAND, Isabelle , ROBERT, Philippe , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie , ARADHYE, Jayraj Dilipbhai , PILLAI, Muthukumaran Natarajan , PANCHAL, Bhavesh Mohanbhai , JIVANI, Jignesh Kantilal , SAMANTA, Biswajit , PAL, Ranjan Kumar , THENNATI, Rajamannar
发明人： CAPET, Marc , LEVOIN, Nicolas , BERREBI-BERTRAND, Isabelle , ROBERT, Philippe , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie , ARADHYE, Jayraj Dilipbhai , PILLAI, Muthukumaran Natarajan , PANCHAL, Bhavesh Mohanbhai , JIVANI, Jignesh Kantilal , SAMANTA, Biswajit , PAL, Ranjan Kumar , THENNATI, Rajamannar
IPC分类号： C07D271/06 , C07D413/10 , C07D413/14 , A61K31/4245 , A61P29/00 , A61P37/06
CPC分类号： C07D413/10 , C07D271/06 , C07D413/14
摘要： The present invention relates to new compounds of formula (I) possessing agonistic activity at sphingosine-1 -phosphate (S1 P) receptors, their process of preparation and their use as immunosuppressive agents. The invention is also directed to pharmaceutical compositions containing these compounds and use of these compounds for treatment/prevention of immune mediated diseases and conditions or inflammatory diseases and conditions.
摘要翻译：本发明涉及在鞘氨醇-1-磷酸（S1P）受体，其制备方法及其作为免疫抑制剂的用途中具有激动作用的式（I）化合物。本发明还涉及含有这些化合物的药物组合物和这些化合物用于治疗/预防免疫介导的疾病和病症或炎性疾病和病症的药物组合物。

5. 发明申请

WO2012140020A1 NOVEL PIPERIDINYL MONOCARBOXYLIC ACIDS AS S1P1 RECEPTOR AGONISTS 审中-公开
标题翻译：新型PIPERIDINYL单羧酸作为S1P1受体激动剂
公开(公告)号：WO2012140020A1
公开(公告)日：2012-10-18
申请号：PCT/EP2012/056470
申请日：2012-04-10
申请人： BIOPROJET , SUN PHARMA ADVANCED RESEARCH COMPANY LTD , CAPET, Marc , BERREBI-BERTRAND, Isabelle , ROBERT, Philippe , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie , THENNATI, Rajamannar , PAL, Ranjan, Kumar , SAMANTA, Biswajit , PILLAI, Muthukumaran, Natarajan , DESAI, Japan, Nitinkumar , RANA, Dijixa, Chandubhai , PRAJAPATI, Kaushik, Dhanjubhai , PATHAK, Sandeep, Pankajbhai , PANCHAL, Bhavesh, M. , ARADHYE, Jayraj, D.
发明人： CAPET, Marc , BERREBI-BERTRAND, Isabelle , ROBERT, Philippe , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie , THENNATI, Rajamannar , PAL, Ranjan, Kumar , SAMANTA, Biswajit , PILLAI, Muthukumaran, Natarajan , DESAI, Japan, Nitinkumar , RANA, Dijixa, Chandubhai , PRAJAPATI, Kaushik, Dhanjubhai , PATHAK, Sandeep, Pankajbhai , PANCHAL, Bhavesh, M. , ARADHYE, Jayraj, D.
IPC分类号： C07D413/10 , A61K31/454 , A61P9/10 , A61P29/00 , A61P37/06 , A61P35/00 , C07D413/14 , A61K31/5377
CPC分类号： C07D413/10 , A61K31/454 , A61K45/06 , C07D271/06
摘要： The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation.
摘要翻译：本发明涉及作为S1P（鞘氨醇-1-磷酸）受体的激动剂的新化合物，含有这些化合物的组合物，这些化合物在医药中的应用及其制备方法。

6. 发明申请

WO2008111096A3 NOVEL PRODRUGS 审中-公开
标题翻译：新的PRODRUGS
公开(公告)号：WO2008111096A3
公开(公告)日：2009-09-03
申请号：PCT/IN2008000147
申请日：2008-03-14
申请人： SUN PHARMA ADVANCED RES CO LTD , THENNATI RAJAMANNAR , SAMANTA BISWAJIT , PAL RANJAN KUMAR , KILARU SRINIVASU , JIVANI JIGNESH , KUMBHANI SAVAJIBHAI ANIL , ADHYAPAK JAY PRAKASHCHANDRA
发明人： THENNATI RAJAMANNAR , SAMANTA BISWAJIT , PAL RANJAN KUMAR , KILARU SRINIVASU , JIVANI JIGNESH , KUMBHANI SAVAJIBHAI ANIL , ADHYAPAK JAY PRAKASHCHANDRA
IPC分类号： C07C251/60
CPC分类号： C07C271/60 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/34 , C07D277/40 , C07D295/185 , C07D401/12
摘要： The present invention describes novel prodrugs of formula (I) or their salts, process of preparation and uses thereof.
摘要翻译：本发明描述了式（I）的新型前药或其盐，其制备方法和用途。

7. 发明申请

WO2006123355A2 NOVEL STATIN DERIVATIVES 审中-公开
标题翻译：新型不动产衍生物
公开(公告)号：WO2006123355A2
公开(公告)日：2006-11-23
申请号：PCT/IN2006000043
申请日：2006-02-02
申请人： SUN PHARMACEUTICAL IND LTD , KUMBHANI ANIL SAVAJIBHAI , DIPCHANDANI JITENDRA GOPALDAS , PAL RANJAN KUMAR , SAMANTA BISWAJIT , THENNATI RAJAMANNAR
发明人： KUMBHANI ANIL SAVAJIBHAI , DIPCHANDANI JITENDRA GOPALDAS , PAL RANJAN KUMAR , SAMANTA BISWAJIT , THENNATI RAJAMANNAR
IPC分类号： C07D309/30
CPC分类号： C07D309/30
摘要： The present invention provides novel statin derivatives and a facile process for preparation thereof selected from a group consisting of a compound of formula (I), wherein R is selected from a group consisting of -OH, -OR 1 , OCOR 1 , -OCHO, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, alkylaryl, heteroaryl, aralkyl, heterocycle having ring size between 3 to 6, -CN, -COOH, -COOR 1 , -CONHR 1 , -CONR 1 R 2 , -NH 2 , -NHR 1 , -NR 1 R 2 halogen, -SH and -SR 1 ; wherein R 1 and R 2 are independently selected from C 1 -C 6 alkyl, alkylaryl, heteroaryl, aralkyl, heterocycle having ring size between 3 to 6, C 2 -C 6 alkenyl and C 2 -C 6 alkynyl, or R 1 and R 2 together with the carbon atom to which they are attached from a heterocycle with a ring size from 3 to 6, ------ represents either a or ß-susbstituent, and pharmaceutically acceptable salt thereof. The compounds have anti-hyperlipidimic anti-hypercholesterolemic and antiinflammatory activity.
摘要翻译：本发明提供新的他汀类衍生物和其制备方法，其选自式（I）化合物，其中R选自-OH，-OR 1， OCOR 1，-OCHO，C 1 -C 6烷基，C 2 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基，烯基，C 2 -C 6炔基，烷基芳基，杂芳基，芳烷基，环大小在3至6之间的杂环，-CN，-COOH，-COOR -CONHR 1，-CONR 1，R 2，-NH 2，，-NHR 1，-NR 1 R 2 2卤素，-SH和-SR 1 N; 其中R 1和R 2独立地选自C 1 -C 6烷基，烷基芳基，杂芳基，芳烷基，环大小为3至6的杂环，C 2 -C 6 - 烯基和C 2 -C 6 - 炔基或R 1和R 2与它们与环的大小为3至6的杂环连接的碳原子一起，代表一种或另一种β-取代物及其药学上可接受的盐。该化合物具有抗高脂血症的抗高胆固醇血症和抗炎活性。

8. 发明申请

WO2006043149A9 NOVEL DICARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：新型的二羧酸衍生物
公开(公告)号：WO2006043149A9
公开(公告)日：2006-08-10
申请号：PCT/IB2005003113
申请日：2005-10-18
申请人： BIOPROJET SOC CIV , SUN PHARMACEUTICAL IND LTD , CAPET MARC , LEVOIN NICOLAS , BERREBI-BERTRAND ISABELLE , POUPARDIN OLIVIA , ROBERT PHILIPPE , SCHWARTZ JEAN-CHARLES , LECOMTE JEANNE-MARIE , RAJAMANNAR THENNATI , PAL RANJAN KUMAR , SAMANTA BISWAJIT , JIVANI JIGNESH K , PANCHAL BHAVESH M , BHATT ISHA H , ARADHYE JAYRAJ D
发明人： CAPET MARC , LEVOIN NICOLAS , BERREBI-BERTRAND ISABELLE , POUPARDIN OLIVIA , ROBERT PHILIPPE , SCHWARTZ JEAN-CHARLES , LECOMTE JEANNE-MARIE , RAJAMANNAR THENNATI , PAL RANJAN KUMAR , SAMANTA BISWAJIT , JIVANI JIGNESH K , PANCHAL BHAVESH M , BHATT ISHA H , ARADHYE JAYRAJ D
IPC分类号： C07C229/30 , A61K31/10 , A61K31/165 , A61K31/196 , A61K31/197 , A61K31/216 , A61P37/06 , C07C229/48 , C07C237/24 , C07C323/12
CPC分类号： C07C237/24 , C07C229/30 , C07C229/48 , C07C323/12 , C07C2601/08
摘要： The present patent application concerns new compounds of formula (I): displaying agonistic activity at sphingosine-1-phosphate (S1P) receptors, their process of preparation and their use as immunosuppressive agents.
摘要翻译：本专利申请涉及式（I）的新化合物：显示对1-磷酸鞘氨醇（S1P）受体的激动活性，其制备过程及其作为免疫抑制剂的用途。

9. 发明申请

WO2003087059A3 (E)-OXIME ETHER DERIVATIVE OF 5,6-DIHYDRO-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-ONE 审中-公开
公开(公告)号：WO2003087059A3
公开(公告)日：2003-10-23
申请号：PCT/IN2003/000150
申请日：2003-04-08
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED , BHATT, Isha, Harshang , SAMANTA, Biswajit , PAL, Ranjan, kumar , CHITTURI, Trinadha, Rao , THENNATI, Rajamannar
发明人： BHATT, Isha, Harshang , SAMANTA, Biswajit , PAL, Ranjan, kumar , CHITTURI, Trinadha, Rao , THENNATI, Rajamannar
IPC分类号： C07D221/16
摘要： ( E)- oxime ether derivative of 5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, compound of formula (I): wherein R in formula (I) is selected from formula (a, b, c, d, e, f, g, h, i) and their pharmaceutically acceptable salts useful as antihistaminic compounds.

10. 发明申请

WO2003087059A2 ANTIHISTAMINIC COMPOUNDS 审中-公开
标题翻译：抗组胺药
公开(公告)号：WO2003087059A2
公开(公告)日：2003-10-23
申请号：PCT/IN2003/000150
申请日：2003-04-08
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED , BHATT, Isha, Harshang , SAMANTA, Biswajit , PAL, Ranjan, kumar , CHITTURI, Trinadha, Rao , THENNATI, Rajamannar
发明人： BHATT, Isha, Harshang , SAMANTA, Biswajit , PAL, Ranjan, kumar , CHITTURI, Trinadha, Rao , THENNATI, Rajamannar
IPC分类号： C07D221/16
CPC分类号： C07D221/16
摘要： ( E)- oxime ether derivative of 5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, compound of formula (I): wherein R in formula (I) is selected from formula (a, b, c, d, e, f, g, h, i) and their pharmaceutically acceptable salts useful as antihistaminic compounds.
摘要翻译：（E） - 5,6-二氢 - 苯并[5,6]环庚并[1,2-b]吡啶-11-酮的肟醚衍生物，化合物其中式（I）中的R选自式（a，b，c，d，e，f，g，h，i）及其药学上可接受的盐，其可用作抗组胺药。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式