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1. 发明申请

WO2010065443A1 SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-(PYRROLIDIN-3-YLVINYL)PYRIMIDINE 审中-公开
标题翻译：（R）-5 - （（E）-2-（吡咯烷-3-基）乙基）嘧啶的合成和新型盐形式
公开(公告)号：WO2010065443A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066078
申请日：2009-11-30
申请人： TARGACEPT, INC. , AKIREDDY, Srinivisa Rao , BHATTI, Balwinder, Singh , CUTHBERTSON, Timothy, J. , DULL, Gary, Maurice , MILLER, Craig, Harrison , MITCHENER, JR., Joseph, Pike , MUNOZ, Julio, A. , OTTEN, Pieter, Albert
发明人： AKIREDDY, Srinivisa Rao , BHATTI, Balwinder, Singh , CUTHBERTSON, Timothy, J. , DULL, Gary, Maurice , MILLER, Craig, Harrison , MITCHENER, JR., Joseph, Pike , MUNOZ, Julio, A. , OTTEN, Pieter, Albert
IPC分类号： C07D403/06 , A61K31/505 , A61P25/00
CPC分类号： C07D403/06
摘要： The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.
摘要翻译：本发明涉及（R）-5 - （（E）-2-吡咯烷-3-基乙烯基）嘧啶的立体有择合成，其盐形式和这些盐的新颖多晶形式。

2. 发明申请

WO1990004803A1 OPTICAL SWITCH 审中-公开
标题翻译：光开关
公开(公告)号：WO1990004803A1
公开(公告)日：1990-05-03
申请号：PCT/AU1989000459
申请日：1989-10-23
申请人： AUSTRALIAN OPTICAL FIBRE RESEARCH PTY LIMITED , BRUNSWICK, Robert , OTTEN, Pieter, Albert
发明人： AUSTRALIAN OPTICAL FIBRE RESEARCH PTY LIMITED
IPC分类号： G02B26/02
CPC分类号： G02B6/3516 , G02B6/3552 , G02B6/3572
摘要： An optical switch includes a body (14) for locating an end of an optical fibre, and a member (20) providing a reflective face (21) disposed to reflect at least a proportion of light received from the end of the fibre back along the fibre. This member (20) is movable by an externally applied magnetic, electric or electromagnetic field, relative to the fibre location body (14), to in turn relatively move the reflective face (21) between two different positions relative to the end of the fibre. In a method of assembling such a switch, the member (20) is adjusted to vary the displacement of the reflective face (21) from the end (13) of the fibre (12) until a desired higher value of reflected signal is monitored in the fibre. A second member (22) is then placed on the fibre location body (14) with a spring or the like to bias the reflective face (21) to maintain the aforesaid higher value. An external magnetic, electric or electromagnetic field is applied to move the reflective face (21) to a new position with respect to the end (13) of the fibre, and the second member (22) is adjusted relative to the fibre location body (14) to vary this new position until a desired lower value of reflected signal is monitored in the fibre.
摘要翻译：一种光学开关包括用于定位光纤端部的本体（14），以及提供反射面（21）的构件（20），该反射面设置成反射从光纤的端部接收的至少一部分光沿纤维。该构件（20）可通过相对于纤维定位体（14）的外部施加的磁，电或电磁场移动，从而相对于纤维端部在两个不同位置之间相对移动反射面（21）。在组装这种开关的方法中，调节构件（20）以改变反射面（21）与光纤（12）的端部（13）的位移，直到在纤维。然后用弹簧等将第二构件（22）放置在纤维定位体（14）上，以偏压反射面（21）以维持上述较高的值。施加外部磁，电或电磁场以使反射面（21）相对于纤维的端部（13）移动到新位置，并且第二构件（22）相对于纤维定位体（ 14）改变这个新的位置，直到在光纤中监视所需的较低的反射信号值。

3. 发明申请

WO2010065449A1 (R) -3- (E) -2- (PYRR0LIDIN-3-YL) VINYL) -5- (TETRAHYDR0PYRAN-4-YL0XY) PYRIDINE, ITS SALTS, ITS SYNTHESIS AND ITS USE AS LIGAND FOR NICOTINIC ACETYLCHOLINERGIC RECEPTORS 审中-公开
标题翻译：（R）-3-（E）-2-（PYRR0LIDIN-3-YL）VINYL）-5-（四氢吡喃-4-基）吡啶，其盐，其合成及其用作NICOTINIC乙酰胆碱受体的配体
公开(公告)号：WO2010065449A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066092
申请日：2009-11-30
申请人： TARGACEPT, INC. , AKIREDDY, Srinivisa, Rao , BREINING, Scott, R. , CUTHBERTSON, Timothy, J. , DULL, Gary, Maurice , GATTO, Gregory, J. , GENUS, John , HAMMOND, Philip, S. , MITCHENER, Joseph, Pike, Jr. , MUNOZ, Julio, A. , OTTEN, Pieter, Albert , YOHANNES, Daniel , FEDOROV, Nikolai
发明人： AKIREDDY, Srinivisa, Rao , BREINING, Scott, R. , CUTHBERTSON, Timothy, J. , DULL, Gary, Maurice , GATTO, Gregory, J. , GENUS, John , HAMMOND, Philip, S. , MITCHENER, Joseph, Pike, Jr. , MUNOZ, Julio, A. , OTTEN, Pieter, Albert , YOHANNES, Daniel , FEDOROV, Nikolai
IPC分类号： C07D405/14 , A61P25/00 , A61K31/4439
CPC分类号： A61K31/4439 , C07D405/14
摘要： The present invention relates to (R) -3- ( (E) -2- (pyrrolidin-3-yl) vinyl) -5- (tetrahydropyran-4-yloxy) pyridine, its salt forms, and to processes for the commercial-scale production of these compounds in sufficient purity and quality for use in pharmaceutical compositions. The present invention relates also the use of this compound in the manufacture of a medicament for the treatment of CNS related disorders.
摘要翻译：本发明涉及（R）-3 - （（E）-2-（吡咯烷-3-基）乙烯基）-5-（四氢吡喃-4-基氧基）吡啶及其盐形式，这些化合物的大规模生产具有足够的纯度和质量用于药物组合物。本发明还涉及该化合物在制备用于治疗CNS相关疾病的药物中的用途。

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