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1. 发明申请

WO1990002119A1 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES 审中-公开
标题翻译： 1,2,3,4-四氢喹啉衍生物
公开(公告)号：WO1990002119A1
公开(公告)日：1990-03-08
申请号：PCT/JP1989000825
申请日：1989-08-15
申请人： BANYU PHARMACEUTICAL CO., LTD. , ISHIKAWA, Kiyofumi , HAYAMA, Takashi , FUKAMI, Takehiro , TAKAHASHI, Ikuko , MIURA, Keiko , OKUYAMA, Akira
发明人： BANYU PHARMACEUTICAL CO., LTD.
IPC分类号： C07D217/14
CPC分类号： C07D217/04 , C07D217/16 , C07D217/20
摘要： The invention relates to 1,2,3,4-tetrahydroisoquinoline derivatives represented by following general formula (I) and antitumor effect potentiators containing said compounds as active ingredients. In the said formula, R represents a lower alkyl group or, when combined with R or R , represents a methylene group, one of R and R represents a lower alkyl group or, when combined with R , represents a methylene group, and the other represents a lower alkenyl group, a substituted or unsubstituted aryl-lower alkenyl group, a substituted or unsubstituted aryl-lower alkyl group (provided that an unsubstituted phenyl group is omitted), a substituted or unsubstituted aryl group (provided that an unsubstituted phenyl group is omitted) or a group represented by -(CH2)m-A (wherein A represents a halogen atom, a lower alkylthio group, a lower alkylsulfinyl group, a lower alkylsulfonyl group, a substituted or unsubstituted aryl-lower alkylthio group, a substituted or unsubstituted aryl-lower alkylsulfinyl group, a substituted or unsubstituted aryl-lower alkylsulfonyl group, a substituted or unsubstituted arylthio group, a substituted or unsubstituted arylsulfinyl group, a substituted or unsubstituted arylsulfonyl group, a substituted or unsubstituted alkyloxy group or a substituted or unsubstituted aryloxy group, an N-benzyl-N-(lower alkyl)amino group, an N-phenyl-N-(lower alkyl)amino group, an N,N-di(lower alkyl)amino group, a di(lower alkyloxy)phosphinoyl group or a dibenzyloxyphosphinoyl group, and m represents 2 to 4), R represents a lower alkyl group, Ar represents a phenyl group optionally substituted by 1 to 3 lower alkyloxy groups, and n represents 0 to 2.
摘要翻译：本发明涉及由以下通式（I）表示的1,2,3,4-四氢异喹啉衍生物和含有所述化合物作为活性成分的抗肿瘤作用增强剂。在所述式中，R 2表示低级烷基，或者当与R 1或R 3结合时，表示亚甲基，R 1和R 3之一表示低级烷基或者当与R 2结合时，表示亚甲基，另一个表示低级烯基，取代或未取代的芳基 - 低级烯基，取代或未取代的芳基 - 低级烷基（条件是未取代的苯基（其中A表示卤素原子，低级烷硫基，低级烷基亚磺酰基，低级烷基亚磺酰基）表示的基团，烷基磺酰基，取代或未取代的芳基 - 低级烷硫基，取代或未取代的芳基 - 低级烷基亚磺酰基，取代或未取代的芳基 - 低级烷基磺酰基，取代或未取代的芳硫基，取代或未取代的芳基亚磺酰基，取代基取代或未取代的烷氧基或取代或未取代的芳氧基，N-苄基-N-（低级烷基）氨基，N-苯基-N-（低级烷基）氨基，N ，N-二（低级烷基）氨基，二（低级烷氧基）膦酰基或二苄氧基膦酰基，m表示2〜4），R 4表示低级烷基，Ar表示任选被 1〜3个低级烷氧基，n表示0〜2。

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