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1. 发明申请

WO1998011118A1 LEWIS X DERIVATIVES 审中-公开
标题翻译： LEWIS X衍生物
公开(公告)号：WO1998011118A1
公开(公告)日：1998-03-19
申请号：PCT/JP1997003247
申请日：1997-09-12
申请人： DAIKIN INDUSTRIES, LTD. , OHIRA, Yutaka , IIDA, Takao
发明人： DAIKIN INDUSTRIES, LTD.
IPC分类号： C07H15/04
CPC分类号： C07H5/02 , C07H15/04 , C07H19/044 , Y02P20/55
摘要： Novel fluorine-containing Lewis X derivatives represented by general formula (I) wherein R represents hydrogen, a hydroxy-protective group, -PO(OH)2, -SO3H or sialate; R represents hydrogen, hydroxy, aliphatic acyloxy, aromatic acyloxy, lower alkylthio, optionally substituted phenylthio, lower alkoxy, branched long chain alkoxy, optionally substituted phenylmethoxy or sphingosyl; R represents hydrogen or -O-C(=NH)CC13, provided that when R is -O-C(=NH)CC13, then R is hydrogen; R and R are the same or different and each represents hydrogen, aliphatic acyl, aromatic acyl or optionally substituted phenylmethyl; and R represents hydroxy, aliphatic acyloxy, aromatic acyloxy, aliphatic acylamino or aromatic acylamino.
摘要翻译：由通式（I）表示的新型含氟路易斯X衍生物，其中R表示氢，羟基保护基，-PO（OH）2，-SO 3 H或唾液酸酯; R 1表示氢，羟基，脂族酰氧基，芳族酰氧基，低级烷硫基，任选取代的苯硫基，低级烷氧基，支链长链烷氧基，任选取代的苯基甲氧基或鞘糖基; R 10表示氢或-O-C（= NH）CC 13，条件是当R 10为-O-C（= NH）CCl 3时，则R 9为氢; R 2和R 3相同或不同，各自代表氢，脂族酰基，芳族酰基或任选取代的苯甲基; R 4表示羟基，脂族酰氧基，芳香族酰氧基，脂肪族酰基氨基或芳香族酰氨基。

2. 发明申请

WO1998017674A1 GANGLIOSIDES HAVING FLUORESCENT-TAGGED CERAMIDE MOIETIES 审中-公开
标题翻译：具有荧光标记的陶瓷制品的胶体蛋白
公开(公告)号：WO1998017674A1
公开(公告)日：1998-04-30
申请号：PCT/JP1997003810
申请日：1997-10-22
申请人： DAIKIN INDUSTRIES, LTD. , IIDA, Takao , OHIRA, Yutaka
发明人： DAIKIN INDUSTRIES, LTD.
IPC分类号： C07H15/04
CPC分类号： C07H15/04 , G01N33/56983 , Y02P20/55 , Y10S435/975 , Y10S436/80 , Y10S436/811 , Y10S436/818
摘要： Compounds useful as a reagent for detecting influenza virus and represented by general formula (I), wherein m is an integer of 2 to 15; n is an integer of 0 to 12; R represents a sugar chain or a derivative thereof; R' represents a group represented by general formula (II), (wherein p is an integer of 0 to 4; q is an integer of 0 to 5; r is an integer of 2 to 5; and R and R may be the same or different and each represents hydrogen, lower alkyl, aliphatic acyl, nitro or cyano); R represents hydrogen or a carboxyl protective group; R , R and R may be the same or different and each represents hydrogen, aliphatic acyl or aromatic acyl; and R represents acetyl, glycolyl or trifluoroacetyl.
摘要翻译：用作检测流感病毒并由通式（I）表示的试剂的化合物，其中m为2至15的整数; n为0〜12的整数。 R代表糖链或其衍生物; R'表示由通式（II）表示的基团，其中p为0〜4的整数，q为0〜5的整数，r为2〜5的整数，R 12和R 10为氢， 13>可以相同或不同，各自代表氢，低级烷基，脂族酰基，硝基或氰基）; R 1表示氢或羧基保护基; R 2，R 4和R 5可以相同或不同，各自代表氢，脂族酰基或芳族酰基; R 3表示乙酰基，乙酰基或三氟乙酰基。

3. 发明申请

WO1995032211A1 GANGLIOSIDE HAVING FLUORESCENCE-LABELLED CERAMIDE PORTION AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：具有荧光标记陶瓷部分的甘油三酯及其制造方法
公开(公告)号：WO1995032211A1
公开(公告)日：1995-11-30
申请号：PCT/JP1995000951
申请日：1995-05-18
申请人： DAIKIN INDUSTRIES LTD. , IIDA, Takao , OHIRA, Yutaka
发明人： DAIKIN INDUSTRIES LTD.
IPC分类号： C07H15/04
CPC分类号： C07H15/24 , C07H15/10 , Y02P20/55
摘要： A ganglioside having a fluorescence-labelled ceramide portion and represented by general formula (I), wherein -O-R-O- represents a sugar chain constituting a ganglioside; R' represents an ether, sulfide, amide, urethane, thiourea or amino group having a fluorescent dye; one of R and R represents a single bond and the other represents hydrogen; 1 represents an integer of 1 to 8; m represents an integer of 2 or above; and n represents an integer of 0 to 12. This derivative, having the recognition characteristics of the sugar chain portion thereof and the labelling function of the fluorescent dye introduced into the ceramide portion, is utilizable as a reagent which can trace dynamic behaviors of glycolipid receptors, a reagent for laboratory diagnosis of bacteria and viruses, and so forth.
摘要翻译：具有荧光标记的神经酰胺部分并由通式（I）表示的神经节苷脂，其中-O-R-O-表示构成神经节苷脂的糖链; R'表示具有荧光染料的醚，硫醚，酰胺，氨基甲酸酯，硫脲或氨基; R 5和R 6之一表示单键，另一个表示氢; 1表示1〜8的整数， m表示2以上的整数， n表示0〜12的整数。该衍生物具有糖链部分的识别特性和引入神经酰胺部分的荧光染料的标记功能，可用作可以跟踪糖脂受体的动态行为的试剂，用于细菌和病毒的实验室诊断的试剂等。

4. 发明申请

WO1998011083A1 4-SUBSTITUTED-2,7-DIDEOXY-7-FLUORO-2,3-DIDEHYDROSIALIC ACIDS 审中-公开
标题翻译： 4-取代-2,7-二去甲基-7-氟-2,3-二取代苯甲酸
公开(公告)号：WO1998011083A1
公开(公告)日：1998-03-19
申请号：PCT/JP1997003184
申请日：1997-09-10
申请人： DAIKIN INDUSTRIES, LTD. , OHIRA, Yutaka
发明人： DAIKIN INDUSTRIES, LTD.
IPC分类号： C07D309/28
CPC分类号： C07D209/28 , C07D309/28
摘要： Compounds represented by general formula (I) and salts thereof useful as non-tolerance-inducing antiviral agents, wherein A is O, CH2 or S; R is lower alkoxycarbonyl, COOH or the like; R is H, OR , F, Cl, Br, CN, NHR or SR (wherein R is H, C1-C6 lower alkyl or the like); one of R and R is H and the other thereof is H, CN, a nitrogenous group such as amino, or the like; R is -NHR or -N=CHR ; and R is CH2CH2XR or CH(XR )CH2XR (wherein X is O, S or NH).
摘要翻译：由通式（I）表示的化合物及其盐可用作非耐受性抗病毒剂，其中A为O，CH 2或S; R 1是低级烷氧基羰基，COOH等; R 2是H，OR 6，F，Cl，Br，CN，NHR 6或SR 6（其中R 6是H，C 1 -C 6低级烷基等）; R 3和R 3'之一是H，另一个是H，CN，含氮基团如氨基等; R 4是-NHR 6或-N = CHR 6; 和R 5是CH 2 CH 2 XR 6或CH（XR 6）CH 2 XR 6（其中X是O，S或NH）。

5. 发明申请

WO1997008207A1 FLUORINATED SIALYL-LEWIS X DERIVATIVES AND INTERMEDIATES FOR SYNTHESIS THEREOF 审中-公开
标题翻译：氟化SIALYL-LEWIS X衍生物及其合成中间体
公开(公告)号：WO1997008207A1
公开(公告)日：1997-03-06
申请号：PCT/JP1996002250
申请日：1996-08-08
申请人： DAIKIN INDUSTRIES LTD. , IIDA, Takao , OHIRA, Yutaka
发明人： DAIKIN INDUSTRIES LTD.
IPC分类号： C08B37/00
CPC分类号： C07H13/04 , C07H3/06 , C07H13/08 , C07H15/10 , C07H15/14 , C07H15/18 , C07H15/203
摘要： Sialyl-Lewis X derivatives wherein the 2-hydroxyl group of fucose has been substituted by a fluorine atom as represented by general formula (I-1) and intermediates for use in synthesizing the derivatives.
摘要翻译：唾液酸 - 路易斯X衍生物，其中岩藻糖的2-羟基已经被通式（I-1）所示的氟原子取代，以及用于合成衍生物的中间体。

6. 发明申请

WO1996005211A1 GANGLIOSIDE GM3 ANALOG HAVING SIALIC ACID RESIDUE FLUORINATED AT THE 9-POSITION AND INTERMEDIATE THEREFOR 审中-公开
标题翻译： GANGLIOSIDE GM3模拟具有在9位和中间的氟化钠残留
公开(公告)号：WO1996005211A1
公开(公告)日：1996-02-22
申请号：PCT/JP1995001598
申请日：1995-08-10
申请人： DAIKIN INDUSTRIES LTD. , IIDA, Takao , OHIRA, Yutaka
发明人： DAIKIN INDUSTRIES LTD.
IPC分类号： C07H15/04
CPC分类号： C07H15/10
摘要： A ganglioside GM3 analog having the sialic acid residue fluorinated at the 9-position, represented by general formula (I), and an intermediate therefor, wherein R represents lower aliphatic acyl; R represents hydrogen or lower alkyl; R through R represent each independently hydrogen, lower aliphatic acyl or aromatic acyl; R represents linear or branched, saturated or unsaturated C1-C30 aliphatic hydrocarbyl; and n represents an integer of 0 to 20. It is useful as medicines such as an inhibitor for influenza virus and an inhibitor for cancer cell growth or metastasis.
摘要翻译：具有由通式（I）表示的9-位被氟化的唾液酸残基的神经节苷脂GM3类似物及其中间体，其中R表示低级脂肪族酰基; R 1表示氢或低级烷基; R 2至R 5各自独立地表示氢，低级脂族酰基或芳族酰基; R 11表示直链或支链，饱和或不饱和的C 1 -C 30脂族烃基; n表示0〜20的整数。作为流感病毒用抑制剂和癌细胞生长或转移抑制剂等药物是有用的。

7. 发明申请

WO1995032955A1 7-FLUORO-2, 3-DIDEHYDROSIALIC ACID AND INTERMEDIATE FOR SYNTHESIS THEREOF 审中-公开
标题翻译： 7-氟-2,3-二硬脂酸及其合成中间体
公开(公告)号：WO1995032955A1
公开(公告)日：1995-12-07
申请号：PCT/JP1995000820
申请日：1995-04-26
申请人： DAIKIN INDUSTRIES LTD. , IIDA, Takao , OHIRA, Yutaka
发明人： DAIKIN INDUSTRIES LTD.
IPC分类号： C07D309/14
CPC分类号： C07H13/04 , C07D309/14 , C07D309/28 , C07D309/30
摘要： 2, 7-Deoxy-7-fluoro-2, 3-didehydrosialic acid of general formula (IV) and intermediates therefor of general formulae (II) and (III); in formula (II), R represents aliphatic acyl; R represents lower alkyl; R s represent each independently aliphatic or aromatic acyl; and R represents halogen; in formula (III), R represents aliphatic acyl; R represents lower alkyl; R s represent each independently halogen, or aliphatic or aromatic acyl; and R represents thioacyl, thioalkyl or thioaryl; each being useful for developing practical medicines such as antiviral agents and preventives for viral diseases, and also as anticancer drugs and immunoregulators.
摘要翻译：通式（Ⅳ）的2-脱甲基-7-氟-2,3-二氢唾液酸及其通式（Ⅱ）和（Ⅲ）的中间体; 在式（II）中，R表示脂肪族酰基; R 1表示低级烷基; R 2各自独立地表示脂族或芳族酰基; R 3表示卤素; 在式（III）中，R表示脂肪族酰基; R 1表示低级烷基; R 2各自独立地表示卤素，或脂族或芳族酰基; R 4表示硫代酰基，硫代烷基或硫代芳基; 每种用于开发诸如抗病毒剂和病毒性疾病预防剂的实用药物，也用作抗癌药物和免疫调节剂。

8. 发明申请

WO1995007302A1 GANGLIOSIDE GM3 DERIVATIVE HAVING FLUORINATED CERAMIDE MOIETY 审中-公开
标题翻译：具有氟化物的GM3衍生物
公开(公告)号：WO1995007302A1
公开(公告)日：1995-03-16
申请号：PCT/JP1994001495
申请日：1994-09-09
申请人： DAIKIN INDUSTRIES LTD. , IIDA, Takao , OHIRA, Yutaka
发明人： DAIKIN INDUSTRIES LTD.
IPC分类号： C08B37/00
CPC分类号： C07H15/10
摘要： A ganglioside GM3 derivative having a fluorinated ceramide moiety, represented by general formula (I), wherein R represents alkyl or fluoroalkyl; m represents an integer of 2 or above; and n represents an integer of 0 to 7, provided m is greater than n.
摘要翻译：具有氟化神经酰胺部分的神经节苷脂GM3衍生物，由通式（I）表示，其中R表示烷基或氟代烷基; m表示2以上的整数， n表示0〜7的整数，m大于n。

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