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1. 发明申请

WO1994010125A1 GLYCERIN DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：甘氨酸衍生物及其用途
公开(公告)号：WO1994010125A1
公开(公告)日：1994-05-11
申请号：PCT/EP1993002917
申请日：1993-10-21
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , NAGAHAMA, Shizuo , OCHIAI, Keiko , OHBA, Setsuya , TOMITA, Takako , WAKABAYASHI, Toshio
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C07C69/587
CPC分类号： C07C69/587
摘要： A compound of formula (I) wherein R1 and R2 are acyl groups derived from different unsaturated fatty acids, both R1 groups being identical, one acyl group of R1 and R2 is an acyl group derived from eicosapentaenoic acid or docosahexaenoic acid, and theother acyl group is an acyl group derived from linoleic acid, gamma -linolenic acid, eicosapentaenoic acid or docosahexaenoic acid, and which is preferably in pure form comprising at least 90 % of the compound, has platelet aggregation inhibition activity and can be effectively used not only as a medicine for the therapy or prevention of thrombotic inflammation and platelet aggregation-induced arterial sclerosis, but also as a well-balanced nutrient clysis. Also certain compounds of formula (I), in particular the compound in which R1 is an eicosapentaenoyl residue and R2 is a gamma -linolenoyl residue, have anti-hypertriglyceridemic activity and are useful for the therapeutic treatment or prevention of diseases caused by hypertriglyceridemic such as cardiac infarction or arteriosclerosis.
摘要翻译：式（I）的化合物，其中R 1和R 2是衍生自不同不饱和脂肪酸的酰基，两个R 1基团相同，R 1和R 2的一个酰基是衍生自二十碳五烯酸或二十二碳六烯酸的酰基，以及其它酰基是衍生自亚油酸，γ-亚麻酸，二十碳五烯酸或二十二碳六烯酸的酰基，其优选为包含至少90％的化合物的纯形式，具有血小板聚集抑制活性，并且可以有效地用作用于治疗或预防血栓形成炎症和血小板聚集诱导的动脉硬化的药物，还可以作为平衡的营养物质溶解。还有某些式（I）化合物，特别是其中R 1为二十碳五烯酰基残基且R 2为γ-亚苄基酰基残基的化合物具有抗高甘油三酯血症活性，并且可用于治疗或预防由高甘油三酯血症引起的疾病，例如心肌梗塞或动脉硬化。

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