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1. 发明申请

WO2006121943A3 METHOD FOR THE TREATMENT OF MAGNESIUM AND POTASSIUM DEFICIENCIES 审中-公开
标题翻译：用于治疗镁和钾缺乏症的方法
公开(公告)号：WO2006121943A3
公开(公告)日：2009-04-30
申请号：PCT/US2006017562
申请日：2006-05-05
申请人： NICHE PHARMACEUTICALS INC , OFFEN CHRISTOPHER , BRANDON STEPHEN , HARRISON CHARLES , WHITE CHARLES , KLUGER JEFFREY
发明人： OFFEN CHRISTOPHER , BRANDON STEPHEN , HARRISON CHARLES , WHITE CHARLES , KLUGER JEFFREY
IPC分类号： A61K31/33
CPC分类号： A61K45/06 , A61K31/19 , A61K33/06 , A61K2300/00
摘要： A method for the treatment of depleted intracellular and serum magnesium levels by administration of a highly bioavailable magnesium salt is disclosed. A prescription dispensing system is also disclosed. The highly bioavailable magnesium salt can be administered alone or as adjunctive therapy in conjunction with various medications that cause or exacerbate depleted intracellular magnesium levels, such as renal magnesium wasting medications, including diuretics, immunosuppressants, chemotherapeutic agents, and antibiotics. The highly bioavailable magnesium salt can also be used as adjunctive therapy in conjunction with Class III anti-arrhythmic drugs to attenuate the QTc interval and reduce the risk of fatal arrhythmias, which are a common risk associated with Class III anti-arrhythmic drugs. The administration of a highly bioavailable magnesium salt in accordance with the present invention also serves to restore intracellular potassium levels to normal ranges in patients who remain hypokalemic despite potassium therapy.
摘要翻译：公开了一种通过施用高度生物可利用的镁盐来治疗贫化的细胞内和血清镁水平的方法。还公开了处方分配系统。高度生物利用的镁盐可以单独施用或作为辅助治疗，连同引起或加剧耗尽的细胞内镁水平的各种药物，例如肾镁消耗药物，包括利尿剂，免疫抑制剂，化学治疗剂和抗生素。高度生物利用的镁盐也可以作为辅助治疗与III类抗心律失常药联用，以减轻QTc间期，降低致命性心律失常的风险，这是与III类抗心律失常药物相关的常见风险。根据本发明的高度生物利用度的镁盐的给药还用于尽管钾治疗仍然存在低钾血症的患者中将细胞内钾水平恢复到正常范围。

2. 发明申请

WO2006121943A2 METHOD FOR THE TREATMENT OF MAGNESIUM AND POTASSIUM DEFICIENCIES 审中-公开
标题翻译：用于治疗镁和钾缺乏症的方法
公开(公告)号：WO2006121943A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/017562
申请日：2006-05-05
申请人： NICHE PHARMACEUTICALS, INC. , OFFEN, Christopher , BRANDON, Stephen , HARRISON, Charles , WHITE, Charles , KLUGER, Jeffrey
发明人： OFFEN, Christopher , BRANDON, Stephen , HARRISON, Charles , WHITE, Charles , KLUGER, Jeffrey
IPC分类号： A61K31/19
CPC分类号： A61K45/06 , A61K31/19 , A61K33/06 , A61K2300/00
摘要： A method for the treatment of depleted intracellular and serum magnesium levels by administration of a highly bioavailable magnesium salt is disclosed. A prescription dispensing system is also disclosed. The highly bioavailable magnesium salt can be administered alone or as adjunctive therapy in conjunction with various medications that cause or exacerbate depleted intracellular magnesium levels, such as renal magnesium wasting medications, including diuretics, immunosuppressants, chemotherapeutic agents, and antibiotics. The highly bioavailable magnesium salt can also be used as adjunctive therapy in conjunction with Class III anti-arrhythmic drugs to attenuate the QTc interval and reduce the risk of fatal arrhythmias, which are a common risk associated with Class III anti-arrhythmic drugs. The administration of a highly bioavailable magnesium salt in accordance with the present invention also serves to restore intracellular potassium levels to normal ranges in patients who remain hypokalemic despite potassium therapy.
摘要翻译：公开了一种通过施用高度生物可利用的镁盐来治疗贫化的细胞内和血清镁水平的方法。还公开了处方分配系统。高度生物利用的镁盐可以单独施用或作为辅助治疗，连同引起或加剧耗尽的细胞内镁水平的各种药物，例如肾镁消耗药物，包括利尿剂，免疫抑制剂，化学治疗剂和抗生素。高度生物利用的镁盐也可以作为辅助治疗与III类抗心律失常药联用，以减轻QTc间期，降低致命性心律失常的风险，这是与III类抗心律失常药物相关的常见风险。根据本发明的高度生物利用度的镁盐的给药还用于尽管钾治疗仍然存在低钾血症的患者中将细胞内钾水平恢复到正常范围。

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