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1. 发明申请

WO9909965A3 ANTI-INFLAMMATORY AGENT 审中-公开
标题翻译：抗炎剂
公开(公告)号：WO9909965A3
公开(公告)日：1999-05-20
申请号：PCT/JP9803692
申请日：1998-08-20
申请人： TAKEDA CHEMICAL INDUSTRIES LTD , ODAKA HIROYUKI , MOMOSE YU
发明人： ODAKA HIROYUKI , MOMOSE YU
IPC分类号： A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/42 , A61K31/44
CPC分类号： A61K31/4439 , A61K31/422 , A61K31/427
摘要： An anti-inflammatory agent which affects by way of a TNF- alpha inhibitory action and comprises a compound of formula (I) wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula -CO-, -CH(OH)-, or -NR - where R represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R ; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond or a salt thereof.
摘要翻译：一种通过TNF-α抑制作用起作用的抗炎剂，包含式（I）化合物，其中R表示可被取代的烃基或可被取代的杂环基; Y表示式-CO - ， - CH（OH） - 或-NR 3 - 的基团，其中R 3表示可以被取代的烷基; m是0或1; n是0,1或2; X代表CH或N; A表示具有1至7个碳原子的化学键或二价脂族烃基; Q代表氧或硫; R 1表示氢或烷基; 环E可以进一步具有1至4个取代基，其可以与R 1组合形成环; L和M分别表示氢或可以相互结合形成化学键或其盐。

2. 发明申请

WO03099793A8 1,2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY 审中-公开
标题翻译：具有高血压和高血压活性的1,2-AZO衍生物
公开(公告)号：WO03099793A8
公开(公告)日：2004-12-29
申请号：PCT/JP0306389
申请日：2003-05-22
申请人： TAKEDA PHARMACEUTICAL , MAEKAWA TSUYOSHI , HARA RYOMA , ODAKA HIROYUKI , KIMURA HIROYUKI , MIZUFUNE HIDEYA , FUKATSU KOHJI
发明人： MAEKAWA TSUYOSHI , HARA RYOMA , ODAKA HIROYUKI , KIMURA HIROYUKI , MIZUFUNE HIDEYA , FUKATSU KOHJI
IPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D261/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/12 , C07D417/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/4439
CPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D261/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/12 , C07D417/04
摘要： A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, - O -, - S - and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents -OR4 (R4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.

3. 发明申请

WO03099793A9 1,2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY 审中-公开
标题翻译：具有高血压和高血压活性的1,2-AZO衍生物
公开(公告)号：WO03099793A9
公开(公告)日：2005-02-10
申请号：PCT/JP0306389
申请日：2003-05-22
申请人： TAKEDA PHARMACEUTICAL , MAEKAWA TSUYOSHI , HARA RYOMA , ODAKA HIROYUKI , KIMURA HIROYUKI , MIZUFUNE HIDEYA , FUKATSU KOHJI
发明人： MAEKAWA TSUYOSHI , HARA RYOMA , ODAKA HIROYUKI , KIMURA HIROYUKI , MIZUFUNE HIDEYA , FUKATSU KOHJI
IPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D261/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/12 , C07D417/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/4439
CPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D261/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/12 , C07D417/04
摘要： A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, - O -, - S - and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents -OR (R is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.
摘要翻译：由式（1）表示的化合物，其中环A是任选具有1至3个取代基的环; 环B是可以进一步具有1至3个取代基的1,2-吡咯环; Xa，Xb和Xc相同或不同，各自为键，-O - ， - S-等; Ya是具有1至20个碳原子的二价脂族烃残基; Yb和Yc相同或不同，各自为键或碳原子数1〜20的二价脂肪族烃残基; 环C是可以进一步具有1至3个取代基的单环芳环; R表示-OR 4（R 4为氢原子或任意取代的烃基）等，或其盐或其前药可用作预防或治疗糖尿病等的药剂。

4. 发明申请

WO2003099793A1 1,2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY 审中-公开
标题翻译：具有高分子和低分子活性的1,2-AZO衍生物
公开(公告)号：WO2003099793A1
公开(公告)日：2003-12-04
申请号：PCT/JP2003/006389
申请日：2003-05-22
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , MAEKAWA, Tsuyoshi , HARA, Ryoma , ODAKA, Hiroyuki , KIMURA, Hiroyuki , MIZUFUNE, Hideya , FUKATSU, Kohji
发明人： MAEKAWA, Tsuyoshi , HARA, Ryoma , ODAKA, Hiroyuki , KIMURA, Hiroyuki , MIZUFUNE, Hideya , FUKATSU, Kohji
IPC分类号： C07D231/12
CPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D261/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/12 , C07D417/04
摘要： A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, - O -, - S - and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents -OR 4 (R 4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.
摘要翻译：由下式表示的化合物其中环A是任选具有1至3个取代基的环; 环B是可以进一步具有1至3个取代基的1,2-吡咯环; Xa，Xb和Xc相同或不同，各自为键，-O - ， - S-等; Ya是具有1至20个碳原子的二价脂族烃残基; Yb和Yc相同或不同，各自为键或碳原子数1〜20的二价脂肪族烃残基; 环C是可以进一步具有1至3个取代基的单环芳环; 和R表示-OR4（R4是氢原子或任选取代的烃基）等，或其盐或其前药可用作预防或治疗糖尿病等的药剂。

5. 发明申请

WO1997036882A1 OXAZOLE DERIVATIVES, THEIR PRODUCTION AND USE 审中-公开
标题翻译：奥沙唑衍生物，其生产和使用
公开(公告)号：WO1997036882A1
公开(公告)日：1997-10-09
申请号：PCT/JP1997001146
申请日：1997-04-02
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. , MOMOSE, Yu , ODAKA, Hiroyuki
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD.
IPC分类号： C07D263/38
CPC分类号： C07D263/34 , C07D263/38 , C07D263/46 , C07D263/48 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14
摘要： A novel compound of formula (I), wherein R is a halogen atom, an optionally substituted heterocyclic, hydroxy, thiol or amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, or an optionally esterified or amidated carboxy group; B is an optionally substituted aromatic group; Y is a divalent aliphatic hydrocarbon group, or a salt thereof, which have an excellent insulin secretion-promoting and blood sugar-depressing effect, and useful in agents for diabetes.
摘要翻译：式（I）的新型化合物，其中R 1是卤素原子，任选取代的杂环，羟基，硫醇或氨基; A是任选取代的酰基，任选取代的杂环基，任选取代的羟基或任选酯化或酰胺化的羧基; B是任选取代的芳基; Y是具有优异的胰岛素分泌促进作用和降低血糖的效果的二价脂肪族烃基或其盐，可用于糖尿病药。

6. 发明申请

WO0061127A3 USE OF INSULIN SENSITISERS FOR IMPROVING KETOSIS 审中-公开
标题翻译：胰岛素敏感剂用于改善KETOSIS的使用
公开(公告)号：WO0061127A3
公开(公告)日：2001-09-07
申请号：PCT/JP0002413
申请日：2000-04-13
申请人： TAKEDA CHEMICAL INDUSTRIES LTD , ODAKA HIROYUKI , SUZUKI MASAMI
发明人： ODAKA HIROYUKI , SUZUKI MASAMI
IPC分类号： A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/425 , A61P3/10
CPC分类号： A61K31/427 , A61K31/422 , A61K31/426 , A61K31/4439 , Y10S514/866
摘要： An agent for improving ketosis which comprises an insulin sensitizer, which has an excellent action and low toxicity.
摘要翻译：用于改善酮症的药剂，其包含胰岛素敏化剂，其具有优异的作用和低毒性。

7. 发明申请

WO1996005186A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE 审中-公开
标题翻译：噻唑烷二酮衍生物及其生产和使用
公开(公告)号：WO1996005186A1
公开(公告)日：1996-02-22
申请号：PCT/JP1995001579
申请日：1995-08-09
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. , SOHDA, Takashi , ODAKA, Hiroyuki , MOMOSE, Yu
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD.
IPC分类号： C07D277/34
CPC分类号： C07D417/12 , C07D277/34
摘要： A 2,4-thiazolidinedione derivative of formula (I), wherein R is an optionally substituted hydrocarbon group or heterocyclic group which may be attached through a hydrocarbon chain; n is 0 or 1; X is CH or N; Y is a bivalent hydrocarbon group; R and R are the same or different and are a hydrogen atom, a halogen atom, an optionally substituted hydroxyl group or an optionally substituted hydrocarbon group, and either R or R and a part of Y may be linked together to form a ring; and L and M are a hydrogen atom, or L and M are linked together to form a bond; or a salt thereof. A pharmaceutical composition comprising the compound (I) and a process for producing the compound (I) are also provided.
摘要翻译：式（I）的2,4-噻唑烷二酮衍生物，其中R是可以通过烃链连接的任选取代的烃基或杂环基; n为0或1; X是CH或N; Y为二价烃基; R 1和R 2相同或不同，为氢原子，卤素原子，任选取代的羟基或任选取代的烃基，R 1或R 2和一部分的Y可以连接在一起形成环; L和M是氢原子，或L和M连接在一起形成键; 或其盐。还提供了包含化合物（I）和制备化合物（I）的方法的药物组合物。

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