专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011075822A8 IMMUNOGENIC COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：免疫原性组合物和相关方法
公开(公告)号：WO2011075822A8
公开(公告)日：2011-08-25
申请号：PCT/CA2010001975
申请日：2010-12-20
申请人： SANOFI PASTEUR LTD , HARPER KEVIN , LJUTIC BELMA , GALLICHAN SCOTT , OCHS MARTINA OCHS , MOREFIELD GARRY , AUSAR FERNANDO , SALHA MARIE-DANIELLE
发明人： HARPER KEVIN , LJUTIC BELMA , GALLICHAN SCOTT , OCHS MARTINA OCHS , MOREFIELD GARRY , AUSAR FERNANDO , SALHA MARIE-DANIELLE
IPC分类号： A61K39/39 , A61K39/02 , A61K39/09 , A61P31/04 , A61P37/04
CPC分类号： A61K39/39 , A61K9/0019 , A61K39/092 , A61K47/26 , A61K2039/55505
摘要： This disclosure relates to adjuvants for use in immunogenic compositions comprising at least one antigen and an aluminum compound comprising hydroxyl groups that has been treated with phosphate, carboxylate, carbonate, sulfate diphosphonate or a mixture of two or more of these compounds and methods of using these compositions for preventing and treating diseases are also provided.
摘要翻译：本公开涉及用于免疫原性组合物中的佐剂，所述免疫原性组合物包含至少一种抗原和已用磷酸盐，羧酸盐，碳酸盐，硫酸二膦酸盐或两种或更多种这些化合物的混合物处理过的含羟基的铝化合物，以及使用这些佐剂还提供了用于预防和治疗疾病的组合物。

2. 发明申请

WO0218595A3 MORAXELLA POLYPEPTIDES AND CORRESPONDING DNA FRAGMENTS AND USES THEREOF 审中-公开
标题翻译：莫拉赛尔多糖和相应的DNA片段及其用途
公开(公告)号：WO0218595A3
公开(公告)日：2002-10-03
申请号：PCT/CA0101221
申请日：2001-08-28
申请人： AVENTIS PASTEUR , LOOSMORE SHEENA , WANG JOE , BRADLEY BILL , OCHS MARTINA , YANG YAN-PING
发明人： LOOSMORE SHEENA , WANG JOE , BRADLEY BILL , OCHS MARTINA , YANG YAN-PING
IPC分类号： A61K39/00 , C07K14/21 , C12N1/21 , C12N7/01 , C12N15/31 , A61K39/02 , A61K39/40 , A61K48/00 , C07K16/12 , C07K19/00 , C12N15/62 , C12Q1/68 , G01N33/569
CPC分类号： C07K14/212 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K2319/00 , C12N2799/023
摘要： The present invention provides nucleic acids, proteins and vectors for immunization of a host, including humans, against disease caused by infection by a strain of Moraxella, specifically M. catarrhalis. The invention includes DNA vaccination methods which employ a vector containing a nucleotide sequence encoding a protein of a strain of Moraxella, specifically M. catarrhalis, and a promoter to effect expression of the protein gene product in the host. The nucleotide sequences include those which encode: a major anaerobically induced OMP, rare lipoprotein A proteins, component proteins of the adhesin complex, a potential lipoprotein OMP, a putative oxidoreductase, OprM, collagenase, outer membrane phopholipase A, lipoproteins, OmpA, NADH:ubiquinone oxidoreductase subunit, pilQ fimbriae, invasin protein, a 36 kDa secreted protein, OMP, Outer membrane esterase, pyridine nucleotide transhydrogenase, HecB, a putative virulence factor, heme receptor, ompC, heme receptor, and porin.
摘要翻译：本发明提供用于免疫宿主（包括人）的核酸，蛋白质和载体，其针对由莫拉氏菌菌株，特别是卡他莫拉菌感染引起的疾病。本发明包括DNA疫苗接种方法，其使用含有编码莫拉氏菌菌株，特别是卡他莫拉菌的蛋白质的核苷酸序列的载体，以及在宿主中实现蛋白质基因产物表达的启动子。核苷酸序列包括编码：主要的厌氧诱导的OMP，罕见的脂蛋白A蛋白，粘附素复合物的组分蛋白，潜在的脂蛋白OMP，推定的氧化还原酶，OprM，胶原酶，外膜磷脂酶A，脂蛋白，OmpA，NADH：泛醌氧化还原酶亚基，pilQ菌毛，invasin蛋白，36kDa分泌蛋白，OMP，外膜酯酶，吡啶核苷酸转氢酶，HecB，推定的毒力因子，血红素受体，ompC，血红素受体和孔蛋白。

3. 发明申请

WO2011075823A1 IMMUNOGENIC COMPOSITIONS 审中-公开
标题翻译：免疫组化
公开(公告)号：WO2011075823A1
公开(公告)日：2011-06-30
申请号：PCT/CA2010/001977
申请日：2010-12-20
申请人： SANOFI PASTEUR LIMITED , GALLICHAN, Scott , HARPER, Kevin , LJUTIC, Belma , OCHS, Martina, Ochs , MOREFIELD, Garry , AUSAR, Fernando , SALHA, Marie-Danielle
发明人： GALLICHAN, Scott , HARPER, Kevin , LJUTIC, Belma , OCHS, Martina, Ochs , MOREFIELD, Garry , AUSAR, Fernando , SALHA, Marie-Danielle
IPC分类号： A61K39/09 , A61P31/04 , A61P37/04
CPC分类号： A61K39/092 , A61K2039/55505 , C07K16/1275
摘要： This disclosure relates to immunogenic compositions comprising an isolated immunogenic S. pneumoniae PcpA polypeptide and at least one additional antigen (such as for example, an isolated immunogenic S. pneumoniae polypeptide selected from the group consisting of the polyhistidine triad family of proteins (e g. PhtD) and methods of using these compositions for preventing and treating diseases caused by S. pneumoniae.
摘要翻译：本公开涉及包含分离的免疫原性肺炎链球菌PcpA多肽和至少一种另外的抗原（例如分离的免疫原性肺炎链球菌多肽的免疫原性组合物，其选自蛋白质的多组氨酸三联体家族（例如， PhtD）和使用这些组合物预防和治疗由肺炎链球菌引起的疾病的方法。

4. 发明申请

WO2009094779A1 ASSAY FOR DIAGNOSING STREPTOCOCCUS PNEUMONIAE 审中-公开
标题翻译：诊断STREPTOCOCCUS PNEUMONIAE的测定
公开(公告)号：WO2009094779A1
公开(公告)日：2009-08-06
申请号：PCT/CA2009/000119
申请日：2009-02-02
申请人： SANOFI PASTEUR LIMITED , OCHS, Martina , BROOKES, Roger , SIEGREST, Claire-Anne
发明人： OCHS, Martina , BROOKES, Roger , SIEGREST, Claire-Anne
IPC分类号： G01N33/543 , G01N33/564 , G01N33/569
CPC分类号： G01N33/56944 , G01N33/53 , G01N33/569 , G01N2333/3156
摘要： Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.
摘要翻译：本文描述了使用一种或多种链球菌抗原在生物样品中检测抗链球菌抗体的测定法。抗原的各种组合可用于测定。例如，可以使用Ply，PhtD，PhtE，LytB和PcpA中的一种或多种。还可以使用额外的链球菌抗原。测定也可以与检测链球菌核酸的测定结合使用。

5. 发明申请

WO0218595A9 MORAXELLA POLYPEPTIDES AND CORRESPONDING DNA FRAGMENTS AND USES THEREOF 审中-公开
标题翻译：莫拉赛尔多糖和相应的DNA片段及其用途
公开(公告)号：WO0218595A9
公开(公告)日：2007-08-23
申请号：PCT/CA0101221
申请日：2001-08-28
申请人： AVENTIS PASTEUR , LOOSMORE SHEENA , WANG JOE , BRADLEY BILL , OCHS MARTINA , YANG YAN-PING
发明人： LOOSMORE SHEENA , WANG JOE , BRADLEY BILL , OCHS MARTINA , YANG YAN-PING
IPC分类号： A61K39/00 , C07K14/21 , C12N1/21 , C12N7/01 , C12N15/31
CPC分类号： C07K14/212 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K2319/00 , C12N2799/023
摘要： The present invention provides nucleic acids, proteins and vectors for immunization of a host, including humans, against disease caused by infection by a strain of Moraxella, specifically M. catarrhalis. The invention includes DNA vaccination methods which employ a vector containing a nucleotide sequence encoding a protein of a strain of Moraxella, specifically M. catarrhalis, and a promoter to effect expression of the protein gene product in the host. The nucleotide sequences include those which encode: a major anaerobically induced OMP, rare lipoprotein A proteins, component proteins of the adhesin complex, a potential lipoprotein OMP, a putative oxidoreductase, OprM, collagenase, outer membrane phopholipase A, lipoproteins, OmpA, NADH:ubiquinone oxidoreductase subunit, pilQ fimbriae, invasin protein, a 36 kDa secreted protein, OMP, Outer membrane esterase, pyridine nucleotide transhydrogenase, HecB, a putative virulence factor, heme receptor, ompC, heme receptor, and porin.
摘要翻译：本发明提供用于免疫宿主（包括人）的核酸，蛋白质和载体，其针对由莫拉氏菌菌株，特别是卡他莫拉菌感染引起的疾病。本发明包括DNA疫苗接种方法，其使用含有编码莫拉氏菌菌株，特别是卡他莫拉菌的蛋白质的核苷酸序列的载体，以及在宿主中影响蛋白质基因产物表达的启动子。核苷酸序列包括编码：主要的厌氧诱导的OMP，罕见的脂蛋白A蛋白，粘附素复合物的组分蛋白，潜在的脂蛋白OMP，推定的氧化还原酶，OprM，胶原酶，外膜磷脂酶A，脂蛋白，OmpA，NADH：泛醌氧化还原酶亚基，pilQ菌毛，invasin蛋白，36kDa分泌蛋白，OMP，外膜酯酶，吡啶核苷酸转氢酶，HecB，推定的毒力因子，血红素受体，ompC，血红素受体和孔蛋白。

6. 发明申请

WO2011075822A1 IMMUNOGENIC COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：免疫组化及相关方法
公开(公告)号：WO2011075822A1
公开(公告)日：2011-06-30
申请号：PCT/CA2010/001975
申请日：2010-12-20
申请人： SANOFI PASTEUR LIMITED , HARPER, Kevin , LJUTIC, Belma , GALLICHAN, Scott , OCHS, Martina, Ochs , MOREFIELD, Garry , AUSAR, Fernando , SALHA, Marie-Danielle
发明人： HARPER, Kevin , LJUTIC, Belma , GALLICHAN, Scott , OCHS, Martina, Ochs , MOREFIELD, Garry , SALHA, Marie-Danielle
IPC分类号： A61K39/39 , A61K39/02 , A61K39/09 , A61P31/04 , A61P37/04
CPC分类号： A61K39/39 , A61K9/0019 , A61K39/092 , A61K47/26 , A61K2039/55505
摘要： This disclosure relates to adjuvants for use in immunogenic compositions comprising at least one antigen and an aluminum compound comprising hydroxyl groups that has been treated with phosphate, carboxylate, carbonate, sulfate diphosphonate or a mixture of two or more of these compounds and methods of using these compositions for preventing and treating diseases are also provided.
摘要翻译：本公开涉及用于免疫原性组合物的佐剂，其包含至少一种抗原和包含用磷酸盐，羧酸盐，碳酸盐，硫酸二膦酸盐或两种或更多种这些化合物的混合物处理的羟基的铝化合物及其使用方法还提供了用于预防和治疗疾病的组合物。

7. 发明申请

WO2010071986A1 MODIFIED STEPTOCOCCUS PNEUMONIA PNEUMOLYSIN (PLY) POLYPEPTIDES 审中-公开
标题翻译：改良型肺炎支原体（PLY）多肽
公开(公告)号：WO2010071986A1
公开(公告)日：2010-07-01
申请号：PCT/CA2009/001843
申请日：2009-12-22
申请人： SANOFI PASTEUR LIMITED , OLOO, Eliud , COMEN, Raymond , OCHS, Martina , YETHON, Jeremy
发明人： OLOO, Eliud , COMEN, Raymond , OCHS, Martina , YETHON, Jeremy
IPC分类号： C07K14/315 , A61K39/09 , A61P31/04 , C07K16/12 , C12N15/31
CPC分类号： C07K14/3156 , A61K39/092 , A61K2039/505 , A61K2039/55505 , C07K14/315 , C07K16/1275 , C07K2317/76
摘要： This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided
摘要翻译：本公开涉及缺乏溶血活性并可用作免疫原性组合物或针对由肺炎链球菌引起的侵袭性肺炎链球菌疾病的疫苗的免疫原的改良型肺炎链球菌肺炎球菌（PLY）蛋白。经修饰的肺炎球菌蛋白包括在苏氨酸65处的氨基酸取代，甘氨酸 293和半胱氨酸428也提供了核酸，由此编码的多肽，含有其的组合物，使用这些核酸，多肽和组合物的方法

8. 发明申请

WO2009012588A1 IMMUNOGENIC POLYPEPTIDES AND MONOCLONAL ANTIBODIES 审中-公开
标题翻译：免疫多聚体和单克隆抗体
公开(公告)号：WO2009012588A1
公开(公告)日：2009-01-29
申请号：PCT/CA2008/001353
申请日：2008-07-23
申请人： Sanofi Pasteur Limited , OCHS, Martina , BROOKES, Roger , CHARLEBOIS, Robert , YETHON, Jeremy
发明人： OCHS, Martina , BROOKES, Roger , CHARLEBOIS, Robert , YETHON, Jeremy
IPC分类号： C12N15/31 , A61K39/09 , A61K39/395 , A61K9/72 , A61P31/04 , A61P37/04 , C07K14/315 , C07K16/10 , C12N15/63 , C12P21/08 , G01N33/577 , G01N33/68
CPC分类号： C07K16/1275 , A61K38/00 , A61K39/09 , A61K2039/505 , A61K2039/507 , C07K14/3156 , G01N33/56944
摘要： Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
摘要翻译：本文提供了用于引发针对肺炎链球菌的免疫应答的组合物和方法。更具体地，组合物和方法涉及免疫原性多肽，包括PhtD及其变体的片段，以及编码或表达多肽的核酸，载体和转染细胞。还描述了制备和使用免疫原性多肽的方法。

9. 发明申请

WO2005076696A2 PNEUMOLYSIN DERIVATIVES 审中-公开
标题翻译：气泡衍生物
公开(公告)号：WO2005076696A2
公开(公告)日：2005-08-25
申请号：PCT/IB2005001052
申请日：2005-02-11
申请人： SANOFI PASTEUR LTD , OCHS MARTINA , FEGARAS FOTULA , WANG SHAOJIU , CARPICK BRUCE , QI WEI-WEI , YUAN TAO , MYERS LISA E , TARTAGLIA JAMES , CHAWLA DAVINDER , PERSON ROY , JAMES OLIVE , MATHESON KIMBERLY , PEDYCZAK ARTUR , MILLAR AMAMDA
发明人： OCHS MARTINA , FEGARAS FOTULA , WANG SHAOJIU , CARPICK BRUCE , QI WEI-WEI , YUAN TAO , MYERS LISA E , TARTAGLIA JAMES , CHAWLA DAVINDER , PERSON ROY , JAMES OLIVE , MATHESON KIMBERLY , PEDYCZAK ARTUR , MILLAR AMAMDA
IPC分类号： A61K39/00 , A61K39/09 , C07K14/315
CPC分类号： C07K14/3156 , A61K39/00 , A61K39/092 , A61K2039/53 , C07K14/315 , C07K16/1275
摘要： The present invention relates to vaccines against bacterial pathogens. particular, the invention relates to modified epitopes of bacterial antigens.
摘要翻译：本发明涉及抗细菌病原体的疫苗。具体地，本发明涉及细菌抗原的修饰表位。

10. 发明申请

WO2005076696A3 PNEUMOLYSIN DERIVATIVES 审中-公开
公开(公告)号：WO2005076696A3
公开(公告)日：2005-08-25
申请号：PCT/IB2005/001052
申请日：2005-02-11
申请人： SANOFI PASTEUR LIMITED , OCHS, Martina , FEGARAS, Fotula , WANG, Shaojiu , CARPICK, Bruce , QI, Wei-Wei , YUAN, Tao , MYERS, Lisa, E. , TARTAGLIA, James , CHAWLA, Davinder , PERSON, Roy , JAMES, Olive , MATHESON, Kimberly , PEDYCZAK, Artur , MILLAR, Amamda
发明人： OCHS, Martina , FEGARAS, Fotula , WANG, Shaojiu , CARPICK, Bruce , QI, Wei-Wei , YUAN, Tao , MYERS, Lisa, E. , TARTAGLIA, James , CHAWLA, Davinder , PERSON, Roy , JAMES, Olive , MATHESON, Kimberly , PEDYCZAK, Artur , MILLAR, Amamda
IPC分类号： C12N15/31
摘要： The present invention relates to recombinant DLA molecules encoding pneumolysin or derivatives thereof, polypeptides produced therefrom, and pharmaceutically acceptable compositions thereof.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式