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1. 发明申请

WO2009112995A2 MULTI-ELEMENT PIEZOELECTRIC TRANSDUCERS 审中-公开
标题翻译：多元素压电传感器
公开(公告)号：WO2009112995A2
公开(公告)日：2009-09-17
申请号：PCT/IB2009/050953
申请日：2009-03-08
申请人： ULTRASHAPE LTD. , NUDELMAN, Igor , RYBYANETS, Andrey
发明人： NUDELMAN, Igor , RYBYANETS, Andrey
IPC分类号： H01L41/04 , H01L41/047 , H01L41/22
CPC分类号： B06B1/0637 , Y10T29/42
摘要： A piezoelectric transducer formed of a body of piezoelectric material having first and second opposed sides and first and second electrically conductive layers on the first and second sides respectively of the piezoelectric body, wherein the piezoelectric body and the electrically conductive layers are so constructed that they form a plurality of separate adjacent series- connected transducer elements. A method of manufacturing such a transducer is also disclosed. The piezoelectric body may have a substantially uniform direction of polarization, or alternating zones of opposite polarization. The conductive layers may be continuous or discontinuous, together forming isolated electrode pairs to define the individual transducer elements. The elements can be hard wired or connected through a switching circuit to display either circumferential or axial or other ultrasonic focal patterns, and may be connected in a parallel, rather than a series configuration. When connected in series, advantageously higher impedance can be obtained, compared to the parallel configuration.
摘要翻译：一种由压电材料体形成的压电换能器，其具有在压电体的第一和第二侧上具有第一和第二相对侧以及第一和第二导电层的压电体，其中压电体和导电层的构造使得它们形成多个单独的相邻的串联连接的换能器元件。还公开了制造这种换能器的方法。压电体可以具有基本上均匀的偏振方向，或具有相反极化的交替区域。导电层可以是连续的或不连续的，一起形成隔离的电极对以限定各个换能器元件。元件可以通过开关电路进行硬连线或连接，以显示圆周或轴向或其他超声波焦点图案，并且可以以并联而不是串联配置连接。当串联连接时，与并行配置相比，可以获得更高的阻抗。

2. 发明申请

WO2007113841A3 NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS 审中-公开
标题翻译：新型氨基酸类及其在遗传性疾病治疗中的应用
公开(公告)号：WO2007113841A3
公开(公告)日：2007-11-29
申请号：PCT/IL2007000463
申请日：2007-04-10
申请人： TECHNION RES & DEV FOUNDATION , BAASOV TIMOR , BEN-YOSEF TAMAR , NUDELMAN IGOR , REBIBO-SABBAH ANNIE , SHALLOM-SHEZIFI DALIA , HAINRICHSON MARIANA
发明人： BAASOV TIMOR , BEN-YOSEF TAMAR , NUDELMAN IGOR , REBIBO-SABBAH ANNIE , SHALLOM-SHEZIFI DALIA , HAINRICHSON MARIANA
IPC分类号： C07H5/06 , A61K31/7008
CPC分类号： A61K31/7036 , A61K9/0053 , B65D25/205 , C07H5/06
摘要： A new class of paromomycin-derived aminoglycosides (Formula I), which exhibit efficient stop-codon mutation suppression activity, low cytotoxicity and selectivity towards eukaryotic cells are provided. Also provided are processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
摘要翻译：提供了一类新型的巴霉素衍生的氨基糖苷（式I），其表现出有效的终止密码子突变抑制活性，对真核细胞的细胞毒性和选择性低。还提供了制备这些巴布霉素衍生的氨基糖苷类及其中间体的方法，以及含有它们的药物组合物及其在治疗遗传疾病中的用途。

3. 发明申请

WO2012011106A1 PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS 审中-公开
标题翻译：制备17-去氧角质素的方法
公开(公告)号：WO2012011106A1
公开(公告)日：2012-01-26
申请号：PCT/IL2011/000580
申请日：2011-07-20
申请人： TARO PHARMACEUTICAL INDUSTRIES LTD. , CHERNIAK, Simon , CYJON, Rosa , OZER, Ilana , NUDELMAN, Igor
发明人： CHERNIAK, Simon , CYJON, Rosa , OZER, Ilana , NUDELMAN, Igor
IPC分类号： C07J3/00 , C07J1/00 , C07J7/00 , C07J43/00
CPC分类号： C07J7/009 , C07J5/0023 , C07J5/0038 , C07J5/0076 , C07J7/008 , C07J71/0015 , C07J75/00
摘要： The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone or Desoximetasone.
摘要翻译：本发明提供了在单一化学步骤中通过使17-羟基起始原料与过量的三甲基甲硅烷基碘反应制备17-脱氧皮质类固醇衍生物的改进方法。本发明特别有利于制备在皮质类固醇如2,6或7或9位具有一个或多个卤素基团的脱氧皮质类固醇衍生物，例如Clocortolone或脱邻雄酮。

4. 发明申请

WO2009112995A3 MULTI-ELEMENT PIEZOELECTRIC TRANSDUCERS 审中-公开
标题翻译：多元素压电传感器
公开(公告)号：WO2009112995A3
公开(公告)日：2009-12-23
申请号：PCT/IB2009050953
申请日：2009-03-08
申请人： ULTRASHAPE LTD , NUDELMAN IGOR , RYBYANETS ANDREY
发明人： NUDELMAN IGOR , RYBYANETS ANDREY
IPC分类号： H01L41/00
CPC分类号： B06B1/0637 , Y10T29/42
摘要： A piezoelectric transducer formed of a body of piezoelectric matepal having first and second opposed sides and first and second electrically conductive layers on the first and second sides respectively of the piezoelectric body, wherein the piezoelectric body and the electncally conductive layers are so constructed that they form a plurality of separate adjacent sepes connected transducer elements The piezoelectric body may have a substantially uniform direction of polarization, or alternating zones of opposite polarization The conductive layers may be continuous or discontinuous, together forming isolated electrode pairs to define the individual transducer elements The elements can be hard wired or connected through a switching circuit to display either circumferential or axial or other ultrasonic focal patterns, and may be connected in a parallel, rather than a sepes configuration When connected in series, advantageously higher impedance can be obtained, compared to the parallel configuration.
摘要翻译：一种压电传感器，其由压电材料体形成，所述压电材料体在所述压电体的第一和第二侧上具有第一和第二相对侧以及第一和第二导电层，其中所述压电体和所述电导体层被构造成使得它们形成多个独立的相邻的隔片连接的换能器元件压电体可以具有基本上均匀的偏振方向或相反极化的交替区域。导电层可以是连续的或不连续的，一起形成隔离的电极对以限定各个换能器元件。通过开关电路进行硬接线或连接，以显示圆周或轴向或其他超声波焦点图案，并且可以并联连接，而不是隔离结构。当串联连接时，有利地可以获得更高的阻抗，与平行 CONF iguration。

5. 发明申请

WO2009098606A3 ULTRASOUND TREATMENT OF ADIPOSE TISSUE WITH VACUUM FEATURE 审中-公开
标题翻译：具有真空功能的超声波治疗脂肪组织
公开(公告)号：WO2009098606A3
公开(公告)日：2009-12-23
申请号：PCT/IB2009050307
申请日：2009-01-26
申请人： ULTRASHAPE LTD , RYBYANETS ANDREY , NUDELMAN IGOR
发明人： RYBYANETS ANDREY , NUDELMAN IGOR
IPC分类号： A61B18/18
CPC分类号： A61N7/00 , A61B2017/308 , A61B2090/036 , A61H9/0057 , A61H23/0245 , A61M37/0092 , A61N2007/0008
摘要： There is provided herein, an apparatus for lysing of adipose tissue comprising a transducer adapted to transmit ultrasound to a target area tissue of a subject body; and a vacuum system adapted to suck a surface of the target area tissue into the transducer to facilitate acoustic contact between the surface of the target area tissue and the transducer.
摘要翻译：在此提供了一种用于溶解脂肪组织的设备，该设备包括适于向对象身体的目标区域组织发送超声波的换能器; 以及真空系统，其适于将目标区域组织的表面吸入换能器中以促进目标区域组织的表面与换能器之间的声学接触。

6. 发明申请

WO2009098606A2 ULTRASOUND TREATMENT OF ADIPOSE TISSUE WITH VACUUM FEATURE 审中-公开
标题翻译：具有真空特征的ADIPOSE组织的超声处理
公开(公告)号：WO2009098606A2
公开(公告)日：2009-08-13
申请号：PCT/IB2009/050307
申请日：2009-01-26
申请人： ULTRASHAPE LTD. , RYBYANETS, Andrey , NUDELMAN, Igor
发明人： RYBYANETS, Andrey , NUDELMAN, Igor
IPC分类号： A61N7/02
CPC分类号： A61N7/00 , A61B2017/308 , A61B2090/036 , A61H9/0057 , A61H23/0245 , A61M37/0092 , A61N2007/0008
摘要： There is provided herein, an apparatus for lysing of adipose tissue comprising a transducer adapted to transmit ultrasound to a target area tissue of a subject body; and a vacuum system adapted to suck a surface of the target area tissue into the transducer to facilitate acoustic contact between the surface of the target area tissue and the transducer.
摘要翻译：本文提供了一种用于裂解脂肪组织的装置，包括适于将超声波传送到被检体的靶区域组织的换能器; 以及适于将目标区域组织的表面吸入换能器以促进目标区域组织的表面与换能器之间的声学接触的真空系统。

7. 发明申请

WO2007113841A2 NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS 审中-公开
标题翻译：新型氨基酸类及其在遗传性疾病治疗中的应用
公开(公告)号：WO2007113841A2
公开(公告)日：2007-10-11
申请号：PCT/IL2007/000463
申请日：2007-04-10
申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. , BAASOV, Timor , BEN-YOSEF, Tamar , NUDELMAN, Igor , REBIBO-SABBAH, Annie , SHALLOM-SHEZIFI, Dalia , HAINRICHSON, Mariana
发明人： BAASOV, Timor , BEN-YOSEF, Tamar , NUDELMAN, Igor , REBIBO-SABBAH, Annie , SHALLOM-SHEZIFI, Dalia , HAINRICHSON, Mariana
IPC分类号： C07H5/06 , A61K31/7008
CPC分类号： A61K31/7036 , A61K9/0053 , B65D25/205 , C07H5/06
摘要： A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low cytotoxicity and selectivity towards eukaryotic cells are provided. Also provided are processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
摘要翻译：提供了一类新型的巴霉素衍生的氨基糖苷类，其表现出有效的终止密码子突变抑制活性，对真核细胞的细胞毒性和选择性低。还提供了制备这些巴布霉素衍生的氨基糖苷类及其中间体的方法，以及含有它们的药物组合物及其在治疗遗传疾病中的用途。

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