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1. 发明申请

WO2005040159A1 4-(PYRAZOL-3-YLAMINO) PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译： 4-（PYRAZOL-3-YLAMINO）吡嗪衍生物用于治疗癌症
公开(公告)号：WO2005040159A1
公开(公告)日：2005-05-06
申请号：PCT/GB2004/004307
申请日：2004-10-11
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , NOWAK, Thorsten , THOMAS, Andrew, Peter
发明人： NOWAK, Thorsten , THOMAS, Andrew, Peter
IPC分类号： C07D413/14
CPC分类号： C07D413/14 , C07D417/14 , C07D471/10
摘要： A compound of Formula (I); wherein the substituents are as defined in the text for use in modulating insulin-like growth factor 1 receptor activity in a warm blooded animal such as man.
摘要翻译：式（I）的化合物; 其中取代基如文中所定义，用于在温血动物如人中调节胰岛素样生长因子1受体活性。

2. 发明申请

WO0117955A3 HYDROXYACETAMIDOBENZENESULPHONAMIDE DERIVATIVES 审中-公开
标题翻译：羟基乙酰氨基苯磺酰胺衍生物
公开(公告)号：WO0117955A3
公开(公告)日：2001-06-21
申请号：PCT/GB0003303
申请日：2000-08-30
申请人： ASTRAZENECA AB , ASTRAZENECA UK LTD , BUTLIN ROGER JOHN , PEASE JANET ELIZABETH , BLOCK MICHAEL HOWARD , NOWAK THORSTEN , BURROWS JEREMY NICHOLAS
发明人： BUTLIN ROGER JOHN , PEASE JANET ELIZABETH , BLOCK MICHAEL HOWARD , NOWAK THORSTEN , BURROWS JEREMY NICHOLAS
IPC分类号： C07D295/22 , A61K31/18 , A61K31/40 , A61K31/44 , A61K31/4406 , A61K31/445 , A61K31/5375 , A61P3/10 , A61P9/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C311/46 , C07C323/67 , C07D207/12 , C07D211/46 , C07D211/96 , C07D213/76 , C07D295/26 , A61P5/48
CPC分类号： C07D213/76 , C07C311/46 , C07C323/67 , C07C2601/14 , C07D207/12 , C07D211/46 , C07D295/26
摘要： A compound of formula (I) wherein: R , R , R , R , R , R and R are as defined within; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.
摘要翻译：式（I）的化合物，其中：R 1，R 2，R 3，R 4，R 5，R 6和R 7如上所定义; 或其药学上可接受的盐或体内可水解的酯。还描述了在温血动物如人中产生式（I）化合物在产生PDH活性升高中的用途。详细描述了制备式（I）化合物的药物组合物，方法和方法。

3. 发明申请

WO2008117051A1 S-6-METH0XY-2- (2- (3- (PYRIMID-2-YL) IS0XAZ0L-5-YL) PYRROLIDIN-1-YL) -4- (5-METHYL-IH-PYRAZOL-S-YLAMINO) PYRIMIDINE AND POLYMORPHIC FORMS THEREOF AS MODULATORS OF THE INSULIN-LIKE GROWTH 审中-公开
标题翻译： S-6-甲氧基-2-（2-（3-（吡啶-2-基）异吲哚啉-1-基）吡咯烷-1-基）-4-（5-甲基-1H-吡唑-3-磺酰胺）吡嗪和作为胰岛素样生长调节剂的多形态
公开(公告)号：WO2008117051A1
公开(公告)日：2008-10-02
申请号：PCT/GB2008/001047
申请日：2008-03-26
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , NOWAK, Thorsten , PURKISS, Stuart, Charles , THOMAS, Andrew, Peter
发明人： NOWAK, Thorsten , PURKISS, Stuart, Charles , THOMAS, Andrew, Peter
IPC分类号： C07D413/14 , A61K31/506 , A61P35/00
CPC分类号： C07D413/14
摘要： There is provided novel pyrimidine derivatives of formula (I) or pharmaceutically acceptable salsts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：提供式（I）的新型嘧啶衍生物或其药学上可接受的盐，其制备方法，含有它们的药物组合物及其在治疗中的用途。

4. 发明申请

WO2008093075A3 5,6,7,8-TETRAHYDROPTERIDINE DERIVATIVES AS HSP90 INHIBITORS 审中-公开
标题翻译：作为HSP90抑制剂的5,6,7,8-四氢喹啉衍生物
公开(公告)号：WO2008093075A3
公开(公告)日：2008-10-02
申请号：PCT/GB2008000303
申请日：2008-01-31
申请人： ASTRAZENECA AB , ASTRAZENECA UK LTD , NOWAK THORSTEN
发明人： NOWAK THORSTEN
IPC分类号： C07D475/00 , A61K31/519 , A61P35/00
CPC分类号： C07D475/00
摘要： The present invention relates to compounds that inhibit HSP90 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm blooded animals such as humans of diseases such as for the treatment of solid tumours.
摘要翻译：本发明涉及抑制HSP90功能的化合物，其制备方法，含有它们作为活性成分的药物组合物，其作为药物的用途及其用于制备用于治疗温血动物如人类的疾病如治疗实体肿瘤。

5. 发明申请

WO2006109026A1 4-(PYRID-2-YL) AMINO SUBSTITUTED PYRIMIDINE AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译： 4-（PYRID-2-YL）氨基取代的吡咯胺作为蛋白激酶抑制剂
公开(公告)号：WO2006109026A1
公开(公告)日：2006-10-19
申请号：PCT/GB2006/001283
申请日：2006-04-07
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , THOMAS, Andrew, Peter , NOWAK, Thorsten
发明人： THOMAS, Andrew, Peter , NOWAK, Thorsten
IPC分类号： C07D413/14 , C07D417/14 , A61K31/4427 , A61P35/00
CPC分类号： C07D413/14 , C07D417/14
摘要： A compound of formula (I): wherein the substituents are as defined in the text for use in inhibiting insulin-like growth factor 1 receptor activity in a warm-blooded animal such as man.
摘要翻译：式（I）的化合物：其中取代基如文中所定义，用于在温血动物如人中抑制胰岛素样生长因子1受体活性。

6. 发明申请

WO2006100461A1 2-AZETIDINYL-4-(lH-PYRAZOL-3-YLAMINO)PYRIMIDINES AS INHIBITORS OF INSULIN-LIKE GROWTH FACTOR-I RECEPTOR ACTIVITY 审中-公开
标题翻译：作为胰岛素样生长因子-1受体活性的抑制剂的2-亚氨基-4-（1H-吡唑-3-基）氨基嘧啶
公开(公告)号：WO2006100461A1
公开(公告)日：2006-09-28
申请号：PCT/GB2006/001013
申请日：2006-03-21
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , THOMAS, Andrew, Peter , NOWAK, Thorsten
发明人： THOMAS, Andrew, Peter , NOWAK, Thorsten
IPC分类号： C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： C07D417/14 , C07D413/14
摘要： A compound of formula (I): wherein the substituents are as defined in the text for use in inhibiting insulin-like growth factor 1 receptor activity in a warm blooded animal such as man.
摘要翻译：式（I）的化合物：其中取代基如文中所定义，用于在温血动物如人中抑制胰岛素样生长因子1受体活性。

7. 发明申请

WO2006106307A1 PYRIMIDINE DERIVATIVES FOR USE AS ANTICANCER AGENTS 审中-公开
标题翻译：用作反应剂代谢物的吡咯烷酮衍生物
公开(公告)号：WO2006106307A1
公开(公告)日：2006-10-12
申请号：PCT/GB2006/001195
申请日：2006-03-31
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , THOMAS, Andrew, Peter , NOWAK, Thorsten
发明人： THOMAS, Andrew, Peter , NOWAK, Thorsten
IPC分类号： C07D413/14 , A61K31/495 , A61P35/00
CPC分类号： C07D413/14
摘要： A compound of formula (I), wherein the substituents are as defined in the text for use in inhibiting insulin-like growth factor 1 receptor activity in a warm blooded animal such as man.
摘要翻译：式（I）的化合物，其中取代基如文中所定义，用于在温血动物如人中抑制胰岛素样生长因子1受体活性。

8. 发明申请

WO2006064189A1 OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS 审中-公开
标题翻译：氧化氮衍生物作为DGAT抑制剂
公开(公告)号：WO2006064189A1
公开(公告)日：2006-06-22
申请号：PCT/GB2005/004726
申请日：2005-12-09
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BIRCH, Alan, Martin , BOWKER, Suzanne, Saxon , BUTLIN, Roger, John , DONALD, Craig, Samuel , MCCOULL, William , NOWAK, Thorsten , PLOWRIGHT, Alleyn
发明人： BIRCH, Alan, Martin , BOWKER, Suzanne, Saxon , BUTLIN, Roger, John , DONALD, Craig, Samuel , MCCOULL, William , NOWAK, Thorsten , PLOWRIGHT, Alleyn
IPC分类号： C07D271/10 , C07D413/12 , A61K31/4245 , A61P3/04 , A61P3/10
CPC分类号： C07D271/113 , C07D413/12
摘要： Compounds of formula (I), and salts and pro-drugs thereof: Formula (I) wherein for example R 1 is optionally substituted aryl or heteroaryl; Y is a linking group selected from, for example, a direct bond, and a (substituted) alkyl chain; R 2 is an optionally substituted aryl, an optionally substituted cycloalkyl or an optionally substituted heterocyclic group; are described. Processes to make such compounds and their use as DGAT inhibitors, for example in the treatment of obesity, are also described.
摘要翻译：式（I）化合物及其盐和前药：式（I）其中例如R 1为任选取代的芳基或杂芳基; Y是选自例如直接键和（取代的）烷基链的连接基团; R 2是任选取代的芳基，任选取代的环烷基或任选取代的杂环基; 被描述。还描述了制备这些化合物的方法及其作为DGAT抑制剂的用途，例如用于治疗肥胖症。

9. 发明申请

WO2013127427A1 APPARATUS AND METHOD FOR ENERGIZING A TRANSCEIVER TAG 审中-公开
标题翻译：一种收发器标签的装置和方法
公开(公告)号：WO2013127427A1
公开(公告)日：2013-09-06
申请号：PCT/EP2012/053291
申请日：2012-02-27
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. , OTTO, Stephan , NOWAK, Thorsten , MAYORDOMO, Iker
发明人： OTTO, Stephan , NOWAK, Thorsten , MAYORDOMO, Iker
IPC分类号： G06K7/00 , G06K7/10
CPC分类号： G06K7/10168 , G06K7/0008 , G06K7/10079 , G06K7/10217
摘要： A wireless location system for energizing and/or determining location information indicative of a location of at least one transceiver tag (2) of a plurality of transceiver tags distributed within a tracking area, the transceiver tags being operable to wirelessly transmit an identification signal when an energizing electromagnetic signal is present at the location of the transceiver tag, comprises at least one mobile energizer node (4) comprising a transmitter (24) operable to transmit the energizing electromagnetic signal for the at least one transceiver tag (2). The mobile energizer node (4) is mounted on a movable device (6). At least one receiver (10) is operable to receive the identification signal from the transceiver tags and at least one location evaluator (14) is operable to determine the location information using a location of the mobile energizing node (4) and/or a signal characteristic of the received identification signal of the at least one transceiver tag (2).
摘要翻译：一种无线定位系统，用于激励和/或确定指示分布在跟踪区域内的多个收发器标签的至少一个收发信机标签（2）的位置的位置信息，所述收发机标签可操作以在识别信号当无线地发送识别信号时激励电磁信号存在于收发信机标签的位置处，包括至少一个移动激励器节点（4），该移动激励器节点（4）包括可操作以传送至少一个收发信机标签（2）的激励电磁信号的发射机（24）。移动式激励器节点（4）安装在可动装置（6）上。至少一个接收器（10）可操作以从收发器标签接收识别信号，并且至少一个位置评估器（14）可操作以使用移动通电节点（4）的位置和/或信号来确定位置信息所述至少一个收发信机标签（2）的所接收的识别信号的特性。

10. 发明申请

WO2008093075A2 5,6,7,8-TETRAHYDROPTERIDINE DERIVATIVES AS HSP90 INHIBITORS 审中-公开
标题翻译：作为HSP90抑制剂的5,6,7,8-四氢喋啶衍生物
公开(公告)号：WO2008093075A2
公开(公告)日：2008-08-07
申请号：PCT/GB2008/000303
申请日：2008-01-31
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , NOWAK, Thorsten
发明人： NOWAK, Thorsten
IPC分类号： C07D475/00 , A61K31/519 , A61P35/00
CPC分类号： C07D475/00
摘要： The present invention relates to compounds that inhibit HSP90 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm blooded animals such as humans of diseases such as for the treatment of solid tumours.
摘要翻译：本发明涉及抑制HSP90功能的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途以及它们在制备用于在温血动物例如人类中治疗诸如用于治疗实体瘤的疾病。

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