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1. 发明申请

WO2022232088A1 TRANSCRIPTIONAL ENHANCED ASSOCIATED DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF 审中-公开
公开(公告)号：WO2022232088A1
公开(公告)日：2022-11-03
申请号：PCT/US2022/026268
申请日：2022-04-26
申请人： DANA-FARBER CANCER INSTITUTE, INC. , GRAY, Nathanael, S. , ZHANG, Tinghu , FAN, Mengyang , CHE, Jianwei , LU, Wenchao , DHE-PAGANON, Sirano , KWIATKOWSKI, Nicholas, Paul
发明人： GRAY, Nathanael, S. , ZHANG, Tinghu , FAN, Mengyang , CHE, Jianwei , LU, Wenchao , DHE-PAGANON, Sirano , KWIATKOWSKI, Nicholas, Paul
IPC分类号： C07D403/12 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/12 , A61P35/00 , A61K31/506
摘要： Provided herein are compounds of Formula (I'), Formula (II), Formula (III), Formula (IV), Formula (V), Formula (VI), Formula (VII), or Formula (VIII) and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, or prodrugs thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers, such as carcinoma, sarcoma, lung cancer, thyroid cancer, skin cancer, ovarian cancer, colorectal cancer, prostate cancer, pancreatic cancer, esophageal cancer, liver cancer, breast cancer)) in a subject. Provided are methods of inhibiting a TEAD transcription factors (e.g., TEAD1, TEAD2, TEAD3, TEAD4) in a subject.

2. 发明申请

WO2021247634A1 INHIBITORS OF TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) AND USES THEREOF 审中-公开
公开(公告)号：WO2021247634A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/035343
申请日：2021-06-02
申请人： DANA-FARBER CANCER INSTITUTE, INC. , GRAY, Nathanael, S. , ZHANG, Tinghu , KWIATKOWSKI, Nicholas, Paul , FAN, Mengyang , CHE, Jianwei , LU, Wenchao
发明人： GRAY, Nathanael, S. , ZHANG, Tinghu , KWIATKOWSKI, Nicholas, Paul , FAN, Mengyang , CHE, Jianwei , LU, Wenchao
IPC分类号： A61P35/00 , C07D213/64 , C07D233/64 , C07D237/08 , C07D239/26 , C07D239/34 , C07D257/04 , C07D271/10 , C07D277/28 , C07D401/04 , C07D403/04 , C07D405/12 , C07D513/04 , A61K31/505 , A61K31/41 , A61K31/4174 , A61K31/4245 , A61K31/437 , A61K31/4412 , A61K31/50 , A61K31/513 , A61K31/506 , A61K31/426
摘要： Provided herein are compounds of Formula (I''), Formula (I'), Formula (I), Formula (II'), and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are methods, uses, and kits involving the disclosed compounds and pharmaceutical compositions thereof for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers), inflammatory diseases (e.g., fibrosis), autoimmune diseases (e.g., sclerosis)) in a subject. Provided are methods of inhibiting the activity of a transcription factor (e.g., TEAD, such as TEAD1, TEAD2, TEAD3, TEAD4) and/or inhibiting the transcription of a gene (e.g., a gene controlled or regulated by a transcription factor (e.g., TEAD)) in a subject.

3. 发明申请

WO2018027196A2 MULTI-AXIS ROTARY PISTON ACTUATOR 审中-公开
标题翻译：多轴旋转活塞执行器
公开(公告)号：WO2018027196A2
公开(公告)日：2018-02-08
申请号：PCT/US2017/045631
申请日：2017-08-04
申请人： SHAHROUDI, Kamran Eftekhari , GENDRON, Tom , SNYDER, Larry , POLLEY, Nolan , BRINKS, Barry , KIM, Joseph H. , SOBOLEWSKI, Pawel A. , GERHART, Robert A. , NICHOLAS, Paul
发明人： SHAHROUDI, Kamran Eftekhari , GENDRON, Tom , SNYDER, Larry , POLLEY, Nolan , BRINKS, Barry , KIM, Joseph H. , SOBOLEWSKI, Pawel A. , GERHART, Robert A. , NICHOLAS, Paul
IPC分类号： F15B15/12
摘要： The subject matter of this specification can be embodied in, among other things, a multi-axis rotary actuator that includes a first rotary piston actuator configured to controllably actuate a first pivotal joint between a first linkage to a second linkage about a first axis, and a second rotary piston actuator configured to controllably actuate a second pivotal joint connecting the second linkage to a third linkage about a second axis.
摘要翻译：本说明书的主题可以包括多轴旋转致动器，该多轴旋转致动器包括第一旋转活塞致动器，该第一旋转活塞致动器构造成可控制地致动第一连杆与第一连杆之间的第一枢转接头围绕第一轴线的第二连杆以及配置成可控制地致动将第二连杆连接到第三连杆的第二枢轴连接关于第二轴线的第二旋转活塞致动器。

4. 发明申请

WO2018027194A3 MULTI-CHAMBER ROTARY PISTON ACTUATOR 审中-公开
公开(公告)号：WO2018027194A3
公开(公告)日：2018-02-08
申请号：PCT/US2017/045628
申请日：2017-08-04
申请人： SHAHROUDI, Kamran Eftekhari , GENDRON, Tom , SNYDER, Larry , POLLEY, Nolan , BRINKS, Barry , KIM, Joseph H. , SOBOLEWSKI, Pawel A. , GERHART, Robert A. , NICHOLAS, Paul
发明人： SHAHROUDI, Kamran Eftekhari , GENDRON, Tom , SNYDER, Larry , POLLEY, Nolan , BRINKS, Barry , KIM, Joseph H. , SOBOLEWSKI, Pawel A. , GERHART, Robert A. , NICHOLAS, Paul
IPC分类号： F15B15/12
摘要： The subject matter of this specification can be embodied in, among other things, a fluid actuator including a housing defining a first chamber having a first cavity and a first open end, a first piston assembly including a tubular first piston defining a second chamber having a second cavity and a second open end, disposed in said first housing for reciprocal movement in the first chamber through the first open end, wherein a first seal, the first cavity, and the first piston define a first pressure chamber, and a second piston assembly having an second piston disposed in said first piston assembly for reciprocal movement in the second chamber through the second open end, wherein a second seal, the second cavity, and the second piston define a second pressure chamber, and a first portion of the second piston contacts a first end effector.

5. 发明申请

WO2018027194A2 MULTI-CHAMBER ROTARY PISTON ACTUATOR 审中-公开
标题翻译：多室旋转活塞执行机构
公开(公告)号：WO2018027194A2
公开(公告)日：2018-02-08
申请号：PCT/US2017/045628
申请日：2017-08-04
申请人： SHAHROUDI, Kamran Eftekhari , GENDRON, Tom , SNYDER, Larry , POLLEY, Nolan , BRINKS, Barry , KIM, Joseph H. , SOBOLEWSKI, Pawel A. , GERHART, Robert A. , NICHOLAS, Paul
发明人： SHAHROUDI, Kamran Eftekhari , GENDRON, Tom , SNYDER, Larry , POLLEY, Nolan , BRINKS, Barry , KIM, Joseph H. , SOBOLEWSKI, Pawel A. , GERHART, Robert A. , NICHOLAS, Paul
IPC分类号： F15B15/12
摘要： The subject matter of this specification can be embodied in, among other things, a fluid actuator including a housing defining a first chamber having a first cavity and a first open end, a first piston assembly including a tubular first piston defining a second chamber having a second cavity and a second open end, disposed in said first housing for reciprocal movement in the first chamber through the first open end, wherein a first seal, the first cavity, and the first piston define a first pressure chamber, and a second piston assembly having an second piston disposed in said first piston assembly for reciprocal movement in the second chamber through the second open end, wherein a second seal, the second cavity, and the second piston define a second pressure chamber, and a first portion of the second piston contacts a first end effector.
摘要翻译：本说明书的主题可以体现为流体致动器，流体致动器包括限定具有第一空腔和第一开口端的第一腔室的壳体，包括管状的第一活塞组件第一活塞限定具有第二空腔和第二开口端的第二腔室，所述第二腔室设置在所述第一壳体中，用于通过所述第一开口端在所述第一腔室中往复运动，其中第一密封件，所述第一腔室和所述第一活塞限定第一所述第二活塞组件具有布置在所述第一活塞组件中的第二活塞，用于通过所述第二开口端在所述第二腔室中往复运动，其中第二密封件，所述第二腔室和所述第二活塞限定第二压力腔室，并且第二活塞的第一部分接触第一端部执行器。

6. 发明申请

WO2012140437A1 LUMINESCENT COMPOUNDS, COMPLEXES AND THEIR USES 审中-公开
标题翻译：发光化合物，复合物及其用途
公开(公告)号：WO2012140437A1
公开(公告)日：2012-10-18
申请号：PCT/GB2012/050818
申请日：2012-04-13
申请人： LONDON METROPOLITAN UNIVERSITY , BLIGH, Sim-Wan Annie , CHATTERTON, Nicholas Paul , WARDLE, Nicholas James , SARRIS, Jason Lee , CHEN, Gaoyun
发明人： BLIGH, Sim-Wan Annie , CHATTERTON, Nicholas Paul , WARDLE, Nicholas James , SARRIS, Jason Lee , CHEN, Gaoyun
IPC分类号： C09K9/02 , C09K11/06 , G01N21/64 , G01N21/80
CPC分类号： G01N21/77 , C07D403/06 , C07D403/14 , C07F5/00 , C09K9/02 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , C09K2211/182
摘要： A method of changing the fluorescent properties of a complex, the method comprising: providing a first complex comprising a multidentate ligand that is coordinated to a lanthanide ion, wherein the lanthanide is selected from europium and terbium and the multidentate ligand has at least one optionally substituted phthalimide group coordinated to the lanthanide ion, contacting the complex with an aqueous liquid medium under appropriate conditions, such that at least one phthalimide group is hydrolysed to a phthalamate group, to form a second complex. Complexes and compounds are also disclosed.
摘要翻译：一种改变络合物的荧光性质的方法，所述方法包括：提供包含与镧系元素离子配位的多齿配体的第一配合物，其中所述镧系元素选自铕和铽，所述多齿配体具有至少一个任选取代的与镧系元素离子配位的邻苯二甲酰亚胺基团，在合适的条件下使络合物与水性液体介质接触，使得至少一个邻苯二甲酰亚胺基团被水解成邻苯二甲酸酯基团，形成第二配合物。还公开了配合物和化合物。

7. 发明申请

WO2011110575A1 DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES 审中-公开
标题翻译： 2- [2-（苯并或吡啶-2-基）噻唑啉氨基] -6-氨基吡啶的衍生物，用于治疗呼吸道感染，过敏或炎症性疾病
公开(公告)号：WO2011110575A1
公开(公告)日：2011-09-15
申请号：PCT/EP2011/053499
申请日：2011-03-09
申请人： GLAXO GROUP LIMITED , ALDER, Catherine Mary , BALDWIN, Ian Robert , BARTON, Nicholas Paul , CAMPBELL, Amanda Jennifer , CHAMPIGNY, Aurelie Cecile , HARLING, John David , MAXWELL, Aoife Caitriona , SIMPSON, Juliet Kay , SMITH, Ian Edward David , TAME, Christopher John , WILSON, Caroline , WOOLVEN, James Michael
发明人： ALDER, Catherine Mary , BALDWIN, Ian Robert , BARTON, Nicholas Paul , CAMPBELL, Amanda Jennifer , CHAMPIGNY, Aurelie Cecile , HARLING, John David , MAXWELL, Aoife Caitriona , SIMPSON, Juliet Kay , SMITH, Ian Edward David , TAME, Christopher John , WILSON, Caroline , WOOLVEN, James Michael
IPC分类号： C07D417/04 , C07D417/14 , C07D513/04 , A61K31/427 , A61K31/428 , A61P11/00 , A61P19/00 , A61P37/00
CPC分类号： C07D417/04 , C07D417/14 , C07D513/04
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular Itk activity.
摘要翻译：本发明涉及某些新型化合物。具体地，本发明涉及式（I）的化合物及其盐。本发明的化合物是激酶活性的抑制剂，特别是Itk活性。

8. 发明申请

WO2010080712A3 PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS 审中-公开
标题翻译：吡咯二酮 - 激素激酶类化合物和治疗疾病的方法
公开(公告)号：WO2010080712A3
公开(公告)日：2010-11-11
申请号：PCT/US2010000050
申请日：2010-01-06
申请人： DANA FARBER CANCER INST INC , GRAY NATHANAEL S , DENG XIANMING , KWIATKOWSKI NICHOLAS PAUL
发明人： GRAY NATHANAEL S , DENG XIANMING , KWIATKOWSKI NICHOLAS PAUL
IPC分类号： C07D487/04 , A61K31/4985 , A61P29/00 , A61P35/00 , C07D487/12
CPC分类号： C07D487/04 , C07C2601/08 , C07C2601/14 , C07D471/14 , C07D487/14 , C07D491/14 , C07D495/14 , C07D498/04 , C07D498/14 , C07D513/04
摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPSl (TTK), ERK5 (BMKl, MAPK7), polo kinase 1,2,3, or 4, Ackl, Ack2, AbI, DCAMKLl, ABLl, AbI mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNKl, PLKl, ULK2, PLK4, PRKDl, PRKD2, PRKD3, ROS l, RPS6KA6, TAOKl, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, AxI, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rskl, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
摘要翻译：本发明涉及新的嘧啶二氮杂酮化合物，调节蛋白激酶的方法，包括MPS1（TTK），ERK5（BMK1，MAPK7），polo激酶1,2,3或4，Ack1，Ack2，AbI，DCAMKL1，ABL1 ，AbI突变体，DCAMKL2，ARK5，BRK，MKNK2，FGFR4，TNK1，PLK1，ULK2，PLK4，PRKD1，PRKD2，PRKD3，ROS1，RPS6KA6，TAOK1，TAOK3，TNK2，Bcr-Abl，GAK，cSrc，TPR-Met ，Tie2，MET，FGFR3，Aurora，AxI，Bmx，BTK，c-kit，CHK2，Flt3，MST2，p70S6K，PDGFR，PKB，PKC，Raf，ROCK-H，Rsk1，SGK，TrkA，TrkB和TrkC，使用这些化合物治疗各种疾病，病症或病症。

9. 发明申请

WO2005084271A3 ARTICULATING HINGE 审中-公开
标题翻译：文字兴趣
公开(公告)号：WO2005084271A3
公开(公告)日：2006-11-16
申请号：PCT/US2005006416
申请日：2005-02-28
申请人： SOUTHCO , BENNETT NICHOLAS PAUL
发明人： BENNETT NICHOLAS PAUL
IPC分类号： E05D3/06 , E05F1/12 , E06B3/12
CPC分类号： E05D3/16 , E05F1/1269 , Y10T16/5323 , Y10T16/5383 , Y10T16/547 , Y10T16/5474 , Y10T16/5475
摘要： An articulated hinge is provided which is capable of supporting a panel member and permitting the panel member to be moved away from an opening and at the same time permit the panel member to be rotated approximately 90 degrees. As seen in Figure 2, the hinge has a scissor arm mechanism which provides for smooth opening and closing of the hinge thereby eliminating a possible sticking of the hinge during opening.
摘要翻译：提供铰接铰链，其能够支撑面板构件并允许面板构件从开口移开，同时允许面板构件旋转大约90度。如图2所示，铰链具有剪刀臂机构，其提供铰链的平滑打开和关闭，从而消除铰链在打开过程中可能的粘着。

10. 发明申请

WO2005093989A1 DIGITAL LICENSE SHARING SYSTEM AND METHOD 审中-公开
标题翻译：数字许可证共享系统和方法
公开(公告)号：WO2005093989A1
公开(公告)日：2005-10-06
申请号：PCT/AU2005/000449
申请日：2005-03-29
申请人： SMART INTERNET TECHNOLOGY CRC PTY LIMITED , LIU, Qiong , SAFAVI-NAINI, Reihaneh , SHEPPARD, Nicholas, Paul
发明人： LIU, Qiong , SAFAVI-NAINI, Reihaneh , SHEPPARD, Nicholas, Paul
IPC分类号： H04L9/00
CPC分类号： G06F21/105 , G06F21/10 , G06F2221/0706 , G06Q10/10 , H04L63/0442 , H04L2463/101
摘要： A digital license sharing method, system and apparatus is provided for use in a digital rights management system. Usage rights in respect of digital content are transferred between content player devices or applications by associating with each player a status indication. Transfer is carried out by transmitting a request to obtain the usage rights from a player requiring usage rights to a player currently holding the rights. The transferring player sets a first status indication to indicate that it is no longer entitled to exercise the rights, and transmits a response to the requesting player to transfer the usage rights. The requesting player then sets a second status indication to indicate that it is henceforth entitled to exercise the rights. Methods and apparatus for creating transferable licenses are also provided that employ a sharable license format including a validated portion and an unvalidated portion. The validated portion, which may be, for example, digitally signed by a license issuing authority, includes characteristic information of a digital content decryption key required to access the digital content controlled by the license. The unvalidated portion includes the digital content key itself, encrypted using an encryption key associated with a player entitled to use the license.
摘要翻译：提供数字许可证共享方法，系统和装置用于数字版权管理系统。关于数字内容的使用权利通过与每个播放器相关联的状态指示在内容播放器设备或应用之间传送。通过从当前持有权利的玩家发送要求使用权的玩家获得使用权的请求来进行转移。转移玩家设置第一状态指示以指示其不再有权行使权限，并且向请求方发送响应以转移使用权。然后，请求玩家设置第二状态指示以指示其以后有权行使权利。还提供了用于创建可转让许可证的方法和设备，其采用可共享许可证格式，包括经过验证的部分和未验证的部分。验证部分可以例如由许可证颁发机构数字签名，包括访问由许可证控制的数字内容所需的数字内容解密密钥的特征信息。未验证部分包括使用与有权使用许可证的玩家相关联的加密密钥加密的数字内容密钥本身。

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