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1. 发明申请

WO9907839A3 IMMUNOPROTECTIVE INFLUENZA ANTIGEN AND ITS USE IN VACCINATION 审中-公开
标题翻译：免疫保护性流感抗原及其在疫苗接种中的应用
公开(公告)号：WO9907839A3
公开(公告)日：1999-05-14
申请号：PCT/EP9805106
申请日：1998-08-05
申请人： VLAAMS INTERUNIV INST BIOTECH , NEIRYNCK SABINE , MIN JOU WILLY , FIERS WALTER
发明人： NEIRYNCK SABINE , MIN JOU WILLY , FIERS WALTER
IPC分类号： C12N15/09 , A61K38/00 , A61K39/145 , A61P31/16 , C07K14/02 , C07K14/11 , C07K14/47 , C12N1/21 , C12N15/00 , C07K19/00 , A61K39/385
CPC分类号： C07K14/005 , A61K38/00 , C07K14/472 , C07K2319/00 , C07K2319/02 , C12N2730/10122 , C12N2760/16122
摘要： The present invention relates to an influenza antigen, comprising a fusion product of at least the extracellular part of a conserved influenza membrane protein or a functional fragment thereof and a presenting carrier, which may be a presenting (poly)peptide or a non-peptidic structure, such as glycans, peptide mimetics, synthetic polymers. The invention further relates to a vaccine against influenza, comprising at least an antigen of the invention, optionally in the presence of one or more excipients. The invention also relates to use of the antigen, a method for preparing the antigen and acceptor cells expressing the antigen.
摘要翻译：本发明涉及流感抗原，其包含至少保守的流感病毒膜蛋白的细胞外部分或其功能片段和呈递载体的融合产物，其可以是呈递（多）肽或非肽结构，如聚糖，肽模拟物，合成聚合物。本发明进一步涉及抗流感疫苗，其中至少包含本发明的抗原，任选地在一种或多种赋形剂的存在下。本发明还涉及抗原的用途，制备抗原的方法和表达抗原的受体细胞。

2. 发明申请

WO2008084115A2 LACTOCOCCUS PROMOTERS AND USES THEREOF 审中-公开
标题翻译： LACTOCOCCUS促销者及其用途
公开(公告)号：WO2008084115A2
公开(公告)日：2008-07-17
申请号：PCT/EP2008/050352
申请日：2008-01-14
申请人： ACTOGENIX N.V. , STEIDLER, Lothar , VANDENBROUCKE, Klaas , NEIRYNCK, Sabine
发明人： STEIDLER, Lothar , VANDENBROUCKE, Klaas , NEIRYNCK, Sabine
IPC分类号： C12N15/74 , C07K14/315
CPC分类号： C12N15/746 , A61K38/00 , C07K14/5428 , C07K14/575 , C07K14/605
摘要： The invention is in the field of molecular biology, and relates to recombinant engineering and protein expression. More in particular, the invention relates to nucleic acids for recombinant expression of proteins comprising sequences derived from Lactococcus and useful as promoters. The invention further relates to vectors comprising the said nucleic acids and host cells transformed therewith. The invention also covers the use of host cells comprising the said nucleic acids or vectors for expressing heterologous or homologous proteins; and also for delivery, especially therapeutic delivery, of the said proteins to subjects.
摘要翻译：本发明涉及分子生物学领域，涉及重组工程和蛋白质表达。更具体地，本发明涉及用于重组表达蛋白质的核酸，其包含源自乳球菌的序列并且可用作启动子。本发明还涉及包含所述核酸的载体和用其转化的宿主细胞。本发明还涵盖了包含所述核酸或载体的宿主细胞用于表达异源或同源蛋白质的用途; 并且还用于将所述蛋白质递送，特别是治疗性递送给受试者。

3. 发明申请

WO2005111194A1 SELF-CONTAINING LACTOBACILLUS STRAIN 审中-公开
标题翻译：自含乳酸杆菌菌株
公开(公告)号：WO2005111194A1
公开(公告)日：2005-11-24
申请号：PCT/EP2005/052296
申请日：2005-05-18
申请人： VIB VZW , UNIVERSITEIT GENT , UNIVERSITY COLLEGE CORK , STEIDLER, Lothar , NEIRYNCK, Sabine
发明人： STEIDLER, Lothar , NEIRYNCK, Sabine
IPC分类号： C12N1/00
CPC分类号： C12N9/1007 , A61K2035/11 , C12R1/225
摘要： The invention relates to a recombinant Lactobacillus strain, with limited growth and viability in the environment. More particularly, it relates to a recombinant Lactobacillus that can only survive in a medium, where thymidine is present. By this strict dependency upon thymidine, thymidine less death is rapidly induced in this recombinant strain. A preferred embodiment is a Lactobacillus that may only survive in a host organism, where thymidine is present, but cannot survive outside the host organism in absence of this medium compound. Moreover, said Lactobacillus strain can be transformed with prophylactic and/or therapeutic molecules and can, as such, be used to treat diseases such as, but not limited to, inflammatory bowel diseases.
摘要翻译：本发明涉及一种在环境中生长和生存有限的重组乳杆菌菌株。更具体地说，本发明涉及一种只能存在胸腺嘧啶存在的培养基中的重组乳杆菌。通过严格依赖胸苷，在该重组菌株中迅速诱导胸苷少死亡。优选的实施方案是乳杆菌，其可以仅在存在胸苷的宿主生物体中存活，但在不存在该培养基化合物的情况下不能在宿主生物体的外部存活。此外，所述乳杆菌属菌株可以用预防和/或治疗分子转化，因此可以用于治疗诸如但不限于炎性肠病的疾病。

4. 发明申请

WO2010124855A1 CRYOPROTECTANTS FOR FREEZE DRYING OF LACTIC ACID BACTERIA 审中-公开
标题翻译：冻干酸乳杆菌冻干试验
公开(公告)号：WO2010124855A1
公开(公告)日：2010-11-04
申请号：PCT/EP2010/002604
申请日：2010-04-28
申请人： ACTOGENIX NV , CORVELEYN, Sam , DHAESE, Patrick , NEIRYNCK, Sabine , STEIDLER, Lothar
发明人： CORVELEYN, Sam , DHAESE, Patrick , NEIRYNCK, Sabine , STEIDLER, Lothar
IPC分类号： C12N1/04
CPC分类号： A61K35/744 , A23K20/10 , A23L33/10 , A23L33/135 , A23V2002/00 , A23Y2240/41 , A61K47/10 , A61K47/12 , A61K47/36 , C12N1/04 , C12N1/20
摘要： The present invention comprises the discovery and development of an effective cryoprotectant composition, without containing skim milk or any other animal-derived compounds, to achieve long-term stability of freeze-dried lactic acid bacteria (LAB), at different temperatures, whereby the retention of viability of the freeze-dried LAB after 6 months of storage, preferably after 9 months of storage, more preferably after 12 months of storage is more than 50%. The invention is in the field of producing freeze dried bacteria, in particular Lactic acid bacteria. More in particular, the invention relates to the use of a novel combination of cryoprotectants for increasing the viability of bacteria after freeze drying, improving the texture of the lyofilized cake for easy grinding and improving the long term stability of the freeze dried bacteria at different temperature conditions. The invention further relates to such freeze dried bacteria for use in food industry or in human or animal health applications. More in particular, the invention relates to the increased viability and long-term storage of recombinant bacteria capable of expressing heterologous proteins or peptides and administered to humans or animals for therapeutic or vaccination purposes.
摘要翻译：本发明包括在不同温度下发现和开发有效的冷冻保护剂组合物，不含脱脂乳或任何其它动物衍生化合物以达到冷冻干燥的乳酸菌（LAB）的长期稳定性，从而保留冷冻干燥的LAB在储存6个月后的存活率，优选储存9个月后，更优选储存12个月后超过50％。本发明涉及生产冷冻干燥细菌，特别是乳酸菌的领域。更具体地，本发明涉及使用冷冻保护剂的新型组合来增加冷冻干燥后细菌的存活力，改善裂解饼的质地以便于研磨，并提高冷冻干燥细菌在不同温度下的长期稳定性条件。本发明还涉及用于食品工业或人或动物健康应用的这种冷冻干燥细菌。更具体地，本发明涉及能够表达异源蛋白质或肽并且施用于人或动物用于治疗或疫苗接种目的的重组细菌的增加的活力和长期储存。

5. 发明申请

WO2008084115A3 LACTOCOCCUS PROMOTERS AND USES THEREOF 审中-公开
标题翻译： LACTOCOCCUS促销者及其用途
公开(公告)号：WO2008084115A3
公开(公告)日：2009-04-09
申请号：PCT/EP2008050352
申请日：2008-01-14
申请人： ACTOGENIX NV , STEIDLER LOTHAR , VANDENBROUCKE KLAAS , NEIRYNCK SABINE
发明人： STEIDLER LOTHAR , VANDENBROUCKE KLAAS , NEIRYNCK SABINE
IPC分类号： C12N15/74 , A61K38/19 , A61K38/20 , A61K38/22
CPC分类号： C12N15/746 , A61K38/00 , C07K14/5428 , C07K14/575 , C07K14/605
摘要： The invention is in the field of molecular biology, and relates to recombinant engineering and protein expression. More in particular, the invention relates to nucleic acids for recombinant expression of proteins comprising sequences derived from Lactococcus and useful as promoters. The invention further relates to vectors comprising the said nucleic acids and host cells transformed therewith. The invention also covers the use of host cells comprising the said nucleic acids or vectors for expressing heterologous or homologous proteins; and also for delivery, especially therapeutic delivery, of the said proteins to subjects.
摘要翻译：本发明涉及分子生物学领域，涉及重组工程和蛋白质表达。更具体地，本发明涉及用于重组表达蛋白质的核酸，其包含源自乳球菌的序列并且可用作启动子。本发明还涉及包含所述核酸的载体和用其转化的宿主细胞。本发明还涵盖了包含所述核酸或载体的宿主细胞用于表达异源或同源蛋白质的用途; 并且还用于将所述蛋白质递送，特别是治疗性递送给受试者。

6. 发明申请

WO2004056850A3 MUTANT PROTEINS SHOWING INCREASED SECRETION 审中-公开
标题翻译：突变蛋白表达增加分泌
公开(公告)号：WO2004056850A3
公开(公告)日：2004-09-30
申请号：PCT/EP0351050
申请日：2003-12-18
申请人： VIB VZW , UNIV GENT , STEIDLER LOTHAR , NEIRYNCK SABINE
发明人： STEIDLER LOTHAR , NEIRYNCK SABINE
IPC分类号： C07K14/54 , C12N15/24 , C12N15/74 , C12P21/02
CPC分类号： C07K14/5428 , C12N15/746 , C12P21/02
摘要： The present invention relates to proteins that carry a mutation in the amino terminal part of the mature protein, which causes an improved secretion of the mutated protein form in gram-positive bacteria, without affecting the biological activity. More particularly, it relates to a protein where a proline has been replaced in the first (10) amino acids of the mature protein. In a preferred embodiment, the invention relates to hypersecreting mutants of interleukin (6) and interleukin (10).
摘要翻译：本发明涉及在成熟蛋白质的氨基末端部分具有突变的蛋白质，其在革兰氏阳性细菌中导致改变的突变蛋白质形式的分泌，而不影响生物活性。更具体地说，本发明涉及在成熟蛋白质的第一（10）个氨基酸中替代脯氨酸的蛋白质。在优选的实施方案中，本发明涉及白细胞介素（6）和白细胞介素（10）的高通量突变体。

7. 发明申请

WO2004056850A2 MUTANT PROTEINS WITH INCREASED SECRETION 审中-公开
标题翻译：突变蛋白质增加分泌
公开(公告)号：WO2004056850A2
公开(公告)日：2004-07-08
申请号：PCT/EP2003/051050
申请日：2003-12-18
申请人： VIB VZW , UNIVERSITEIT GENT , STEIDLER, Lothar , NEIRYNCK, Sabine
发明人： STEIDLER, Lothar , NEIRYNCK, Sabine
IPC分类号： C07K14/00
CPC分类号： C07K14/5428 , C12N15/746 , C12P21/02
摘要： The present invention relates to proteins that carry a mutation in the amino terminal part of the mature protein, which causes an improved secretion of the mutated protein form in gram-positive bacteria, without affecting the biological activity. More particularly, it relates to a protein where a proline has been replaced in the first (10) amino acids of the mature protein. In a preferred embodiment, the invention relates to hypersecreting mutants of interleukin (6) and interleukin (10).
摘要翻译：本发明涉及在成熟蛋白质的氨基末端部分具有突变的蛋白质，其在革兰氏阳性细菌中导致改变的突变蛋白质形式的分泌，而不影响生物活性。更具体地说，本发明涉及在成熟蛋白质的第一（10）个氨基酸中替代脯氨酸的蛋白质。在优选的实施方案中，本发明涉及白细胞介素（6）和白细胞介素（10）的高通量突变体。

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