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1. 发明申请

WO2019173246A1 LIQUID CRYSTAL THERMOMETER FOR MRI 审中-公开
公开(公告)号：WO2019173246A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/020622
申请日：2019-03-04
申请人： QALIBRE MD, INC. , NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
发明人： MIROWSKI, Elizabeth , SNOW, Michael , KEENAN, Kathryn
IPC分类号： G01K11/16 , A61B5/055
摘要： Provided herein are novel liquid crystal based devices for the facile measurement of temperature in an MRI system. The thermometers comprise a plurality of vessels wherein each vessel contains a liquid crystal composition having a unique phase transition temperature. By scanning with appropriate techniques, the state of the liquid crystals in each vessel can be assessed, and the temperature at the time of the scan can be determined by the state of the liquid crystal compositions. Also provided are novel vessels and assemblies of vessels that can be used as MRI thermometers and which are compatible with MRI phantoms.

2. 发明申请

WO2011035260A4 DISTRIBUTED ION SOURCE ACCELERATION COLUMN 审中-公开
公开(公告)号：WO2011035260A4
公开(公告)日：2011-03-24
申请号：PCT/US2010/049525
申请日：2010-09-20
申请人： FEI COMPANY , UNITED STATES OF AMERICA as respresented by THE SECRETARY OF COMMERCE, THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY , MCCLELLAND, Jabez, J. , KNUFFMAN, Brenton, J. , STEELE, Adam, V. , ORLOFF, Jonathan, H.
发明人： MCCLELLAND, Jabez, J. , KNUFFMAN, Brenton, J. , STEELE, Adam, V. , ORLOFF, Jonathan, H.
IPC分类号： H01J27/02 , H01J37/04
摘要： An ion beam system uses a separate accelerating electrode, such as a resistive tube, to accelerate the ions while maintaining a low electric field at an extended, that is, distributed, ion source, thereby improving resolution. A magneto-optical trap can be used as the ion source.

3. 发明申请

WO2022051692A1 METHOD AND SYSTEM FOR DETERMINING AT LEAST ONE PROPERTY OF MAGNETIC MATTER 审中-公开
公开(公告)号：WO2022051692A1
公开(公告)日：2022-03-10
申请号：PCT/US2021/049176
申请日：2021-09-04
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , UNIVERSITY OF CALIFORNIA- SAN DIEGO , NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
发明人： SHAW, Justin, M. , SILVA, Thomas, J. , NEMBACH, Hans Toya , RILEY, Grant A.
IPC分类号： G01R33/032 , G01B11/02 , G01N23/202 , G01R33/09 , G01R33/12
摘要： A method for determining at least one property of magnetic matter includes: applying a magnetic field to magnetic matter; directing first light on the magnetic matter at a first set of incident angles; receiving a first set of signatures associated with the first light scattered from the magnetic matter; varying orientation of the magnetic matter with respect to the magnetic field; directing second light on the magnetic matter at a second set of incident angles; receiving a second set of signatures associated with the second light scattered from the magnetic matter; determining, by processing the first set and the second set of signatures according to a dispersion relation, at least one property of the magnetic matter.

4. 发明申请

WO2015163954A2 DUAL-FREQUENCY OPTICAL SOURCE 审中-公开
标题翻译：双频光源
公开(公告)号：WO2015163954A2
公开(公告)日：2015-10-29
申请号：PCT/US2015/012962
申请日：2015-01-26
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY , LI, Jiang , VAHALA, Kerry , DIDDAMS, Scott , YI, Xu , LEE, Hansuek
发明人： LI, Jiang , VAHALA, Kerry , DIDDAMS, Scott , YI, Xu , LEE, Hansuek
IPC分类号： H01S3/091
CPC分类号： H04B10/2507 , H03B17/00 , H03L7/08 , H03L7/16 , H04B10/2504 , H04B10/2575 , H04B10/503 , H04B2210/006 , H04L7/0075 , H04L7/0091
摘要： A dual-frequency optical source comprises: (a) first and second pump laser sources arranged to generate optical pump power at respective first and second pump laser frequencies v pump1 and v pump2 ; and (b) an optical resonator characterized by a Brillouin shift frequency v B and a free spectral range that is substantially equal to an integer submultiple of the Brillouin shift frequency. Each one of the first and second pump laser sources is frequency-locked to a corresponding resonant optical mode of the optical resonator. First and second optical output signals of the dual-frequency optical reference source at respective first and second output frequencies v 1 =v pump1 -v B and v 2 =v pump2 -v B comprise stimulated Brillouin laser output generated by simultaneous optical pumping of the optical resonator by the first and second pump laser sources, respectively. An output difference frequency v 2 - v 1 is greater than about 300 GHz.
摘要翻译：双频光源包括：（a）第一和第二泵浦激光源，被布置成在相应的第一和第二泵浦激光频率v泵1和v泵2处产生光泵浦功率; 和（b）以布里渊移动频率v B为特征的光学谐振器和基本上等于布里渊移动频率的整数倍的自由光谱范围。第一和第二泵浦激光源中的每一个被频率锁定到光学谐振器的相应的谐振光学模式。在相应的第一和第二输出频率v 1 = v泵1 -v B和v 2 = v pump 2 -v B处的双频光学参考源的第一和第二光学输出信号包括通过同时光学泵浦产生的受激布里渊激光输出光学谐振器分别由第一和第二泵激光源。输出差频率v 2 -v 1大于约300GHz。

5. 发明申请

WO2020028412A1 DETERMINING TILT ANGLE IN PATTERNED ARRAYS OF HIGH ASPECT RATIO STRUCTURES 审中-公开
公开(公告)号：WO2020028412A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/044216
申请日：2019-07-30
申请人： LAM RESEARCH CORPORATION , GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
发明人： THOMPSON, William Dean , KLINE, Regis Joseph , SUNDAY, Daniel F. , WU, Wenli , SORKHABI, Osman , ZHANG, Jin , CHEN, Xiaoshu
IPC分类号： H01L21/66 , H01L21/67 , G03F7/20 , G01N23/04 , G01N21/95
摘要： Provided herein are methods and apparatus for characterizing high aspect ratio (HAR) structures of fabricated or partially fabricated semiconductor devices. The methods involve using small angle X-ray scattering (SAXS) to determine average parameters of an array of HAR structures. In some implementations, SAXS is used to analyze symmetry of HAR structures in a sample and may be referred to as tilted structural symmetry analysis - SAXS (TSSA-SAXS) or TSSA. Analysis of parameters such as tilt, sidewall angle, bowing, and the presence of multiple tilts in HAR structures may be performed.

6. 发明申请

WO2015160413A2 STABILIZED MICROWAVE-FREQUENCY SOURCE 审中-公开
标题翻译：稳定的微波频率源
公开(公告)号：WO2015160413A2
公开(公告)日：2015-10-22
申请号：PCT/US2015/012964
申请日：2015-01-26
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY , VAHALA, Kerry , DIDDAMS, Scott , LI, Jiang , YI, Xu , LEE, Hansuek
发明人： VAHALA, Kerry , DIDDAMS, Scott , LI, Jiang , YI, Xu , LEE, Hansuek
IPC分类号： H01S3/10
CPC分类号： H04B10/2507 , H03B17/00 , H03L7/08 , H03L7/16 , H04B10/2504 , H04B10/2575 , H04B10/503 , H04B2210/006 , H04L7/0075 , H04L7/0091
摘要： A microwave-frequency source at frequency f M comprises: a dual optical- frequency reference source, an electro-optic sideband generator, an optical bandpass filter, an optical detector, a reference oscillator, an electrical circuit, and a voltage-controlled oscillator (VCO). The sideband generator modulates dual optical reference signals at v 2 and v 1 to generate sideband signals at v 1 ±n f M and v 2 ±n 2 f M . The bandpass filter transmits sideband signals at v 1 +N 1 f M and v 2 -N 2 f M . The optical detector generates a beat note at (v 2 -N 2 f M )-(v 1 +N 1 f M )- The beat note and a reference oscillator signal are processed by the circuit to generate a loop- filtered error signal to input to the VCO. Output of the VCO at f M drives the sideband generator and forms the microwave-frequency output signal. The resultant frequency division results in reduced phase noise on the microwave- frequency signal.
摘要翻译：在频率f M处的微波频率源包括：双光频参考源，电光边带生成器，光纤带通滤波器，光学检测器，参考振荡器，电路和压控振荡器（VCO）。边带发生器在v 2和v 1调制双光学参考信号以在v ＆nbsp;＆nbsp;＆nbsp;＆lt; 2＆gt;＆lt; m＆gt; M＆lt; / i＆gt; 带通滤波器在v 1 1 + N 1 f M 。光学检测器在（v 2，...，sub 2，2，f 2）处产生拍音， M 1） - （v 1 +1）N 1 > - > - 拍子音符和参考振荡器信号由电路处理以产生经环路滤波的误差信号以输入到 VCO。 fCO处的VCO输出驱动边带发生器并形成微波频率输出信号。由此产生的分频可以降低微波频率信号的相位噪声。

7. 发明申请

WO2015017733A1 METHODS AND APPARATUS FOR TRANSPLANTATION OF NUCLEIC ACID MOLECULES 审中-公开
标题翻译：用于转运核酸分子的方法和装置
公开(公告)号：WO2015017733A1
公开(公告)日：2015-02-05
申请号：PCT/US2014/049305
申请日：2014-07-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , J. CRAIG VENTER INSTITUTE, INC. , GOVERNMENT OF U.S.A AS REP. BY THE SEC. OF COMMERCE, THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
发明人： MERSHIN, Andreas , PELLETIER, James , GERSHENFELD, Neil , GLASS, John , STRYCHALSKI, Elizabeth
IPC分类号： C12N5/02
CPC分类号： C12M35/08 , C12N15/87
摘要： In exemplary implementations, transplantation of nucleic acids into cells occurs in microfluidic chambers. The nucleic acids may be large nucleic acid molecules with more than 100 kbp. In some cases, the microfluidic chambers have only one orifice that opens to a flow channel. In some cases, flow through a microfluidic chamber temporarily ceases due to closing one or more valves. Transplantation occurs during a period in which the contents of the chambers are shielded from shear forces. Diffusion, centrifugation, suction from a vacuum channel, or dead-end loading may be used to move cells or buffers into the chambers.
摘要翻译：在示例性实施方案中，将核酸移植到细胞中发生在微流体室中。核酸可以是大于100kbp的大核酸分子。在一些情况下，微流体室仅具有一个通向流动通道的孔口。在一些情况下，由于关闭一个或多个阀门，流过微流体室的流动暂时停止。移植发生在室内容物被剪切力屏蔽的期间。可以使用扩散，离心，真空通道抽吸或死端装载将细胞或缓冲液移动到腔室中。

8. 发明申请

WO2020180977A1 SYSTEMS, DEVICES, AND METHODS FOR RESISTANCE METROLOGY USING GRAPHENE WITH SUPERCONDUCTING COMPONENTS 审中-公开
公开(公告)号：WO2020180977A1
公开(公告)日：2020-09-10
申请号：PCT/US2020/020969
申请日：2020-03-04
申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK , GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE, NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
发明人： ELMQUIST, Randolph , RIGOSI, Albert , KRUSKOPF, Mattias
IPC分类号： G01R33/07 , H01L43/14 , H01L43/04 , H01L43/06
摘要： A quantum Hall resistance apparatus is to improve resistance standards and includes a substrate, a graphene epitaxially grown on the substrate and having a plurality of first contact patterns at edges of the graphene, a plurality of contacts, each including a second contact pattern and configured to connect to a corresponding first contact pattern, and a protective layer configured to protect the graphene and to increase adherence between the first contact patterns and the second contact patterns. The contacts become a superconductor at a temperature lower than or equal to a predetermined temperature and under up to a predetermined magnetic flux density.

9. 发明申请

WO2016164530A1 COMPOSITIONS AND METHODS FOR HIGH THROUGHPUT PROTEIN SEQUENCING 审中-公开
标题翻译：用于高通量蛋白质测序的组合物和方法
公开(公告)号：WO2016164530A1
公开(公告)日：2016-10-13
申请号：PCT/US2016/026354
申请日：2016-04-07
申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK , NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
发明人： LI, Shuwei , MARINO, John , FUERST, Thomas
IPC分类号： C07K1/00 , C07K1/12 , G01N33/68
CPC分类号： C07K1/00 , C07K1/12 , C07K1/128 , C07K1/13 , C07K14/00 , G01N33/6824
摘要： Provided are compositions and methods for elucidating the amino acid sequences of a plurality of polypeptides in high-throughput approaches. The compositions include unique binding partners that have specificity for N-terminal amino acids. The methods include using the unique binding partners in processes that involves obtaining a plurality of polypeptides, binding detectably labeled N-terminal amino acid binding agents to the N-terminal amino acid of the polypeptides, detecting the N-terminal amino acid binding agents to identify the N-terminal amino acid for some or all of the polypeptides, removing the N-terminal amino acid binding agents, liberating the N-terminal amino acid to reveal the next amino acid in the polypeptides in the N->C terminal direction, and repeating the process to determine some or all of the amino acid sequence of the polypeptides. The approaches be used to analyze polypeptides from a wide diversity of sources, and for detecting proteins of low abundance from any particular source.
摘要翻译：提供了用于在高通量方法中阐明多个多肽的氨基酸序列的组合物和方法。组合物包括对N-末端氨基酸具有特异性的独特结合配偶体。所述方法包括在涉及获得多个多肽的方法中使用独特的结合配偶体，将可检测地标记的N-末端氨基酸结合试剂结合到多肽的N-末端氨基酸，检测N-末端氨基酸结合剂以鉴定一些或所有多肽的N-末端氨基酸，去除N末端氨基酸结合剂，释放N末端氨基酸以显示多肽中N-末端方向的下一个氨基酸，以及重复该过程以确定多肽的部分或全部氨基酸序列。这些方法用于分析来自各种来源的多肽，以及用于从任何特定来源检测低丰度的蛋白质。

10. 发明申请

WO1996041154A1 OPTICAL TRAP FOR DETECTION AND QUANTITATIONS OF SUBZEPTOMOLAR QUANTITIES OF ANALYTES 审中-公开
标题翻译：用于检测和分析分析员的次分子量的光学陷阱
公开(公告)号：WO1996041154A1
公开(公告)日：1996-12-19
申请号：PCT/US1996010007
申请日：1996-06-07
申请人： NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY , WEETALL, Howard, Hayyam , HELMERSON, Kristian, Peter , KISHORE, Roni, Bakhru
发明人： NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
IPC分类号： G01N21/39
CPC分类号： H05H3/04 , G01N33/54313 , G01N33/54373
摘要： Tightly focused beams of laser light are used as "optical tweezers" to trap and manipulate polarizable objects such as microspheres of glass or latex with diameters on the order of 4.5 mu m. When analytes are allowed to adhere to the microspheres, small quantities of these analytes can be manipulated, thus allowing their detection and quantitation even when amounts and concentrations of the analytes are extremely small. Illustrative examples include measuring the strength needed to break antibody-antigen bonds and the detection of DNA sequences.
摘要翻译：紧密聚焦的激光束被用作“光学镊子”以捕获和操纵可极化物体，例如直径为4.5μm的玻璃或胶乳微球。当允许分析物粘附到微球时，可以操纵少量的这些分析物，从而即使当分析物的量和浓度非常小时也能够进行检测和定量。示例性实例包括测量断裂抗体 - 抗原键所需的强度和DNA序列的检测。

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