专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008043046A3 MICROFLUIDIC CHECK VALVES 审中-公开
标题翻译：微流感检查阀
公开(公告)号：WO2008043046A3
公开(公告)日：2008-08-07
申请号：PCT/US2007080489
申请日：2007-10-04
申请人： FLUIDIGM CORP , WANG JING , NASSEF HANY R
发明人： WANG JING , NASSEF HANY R
IPC分类号： F16K1/00 , F16K15/00
CPC分类号： F16K99/0026 , B01L3/502738 , B01L2200/12 , B01L2300/0887 , B01L2400/0605 , B01L2400/0638 , F16K99/0001 , F16K99/0057 , F16K2099/0078 , F16K2099/008
摘要： A microfluidic check valve and a method of using the check valve In microfluidic devices includes a check valve comprising two stacked chambers that are separated by a pore-containing membrane. The membrane is composed of an elastomeric material and can be configured in normally open or normally closed state. The normally open check valve can be implemented so that the degree of back pressure necessary to close the valve can be set.
摘要翻译：微流体止回阀和使用止回阀的方法在微流体装置中包括止回阀，其包括由含孔膜隔开的两个堆叠室。膜由弹性体材料构成，可以配置成常开或常闭状态。可以实现常开止回阀，使得可以设定关闭阀所需的背压程度。

2. 发明申请

WO2004000721A3 RECIRCULATING FLUIDIC NETWORK AND METHODS FOR USING THE SAME 审中-公开
标题翻译：循环流体网络及其使用方法
公开(公告)号：WO2004000721A3
公开(公告)日：2005-02-03
申请号：PCT/US0319775
申请日：2003-06-23
申请人： FLUIDIGM CORP , MANGER IAN D , BARCO JOSEPH W , NASSEF HANY R
发明人： MANGER IAN D , BARCO JOSEPH W , NASSEF HANY R
IPC分类号： B01L3/00 , B81C20060101 , F04B19/00 , F04B43/02 , G01N21/00 , G01N33/53 , G01N33/543 , G01N33/566 , G01N37/00
CPC分类号： B81B3/00 , B01L3/5025 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/088 , B01L2300/0887 , B01L2400/0415 , B01L2400/0481 , B01L2400/0655 , F04B19/006 , F04B43/02 , F16K99/0001 , F16K99/0003 , F16K99/0026 , F16K99/0036 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , G01N33/5304 , G01N33/54366 , Y10T436/2575
摘要： The present invention provides microfluidic devices comprising elastomeric components and solid substrate component for attaching ligands and methods for conducting a variety of assays and high throughput screening. The elastomeric components comprise a plurality of first and second flow channels forming a plurality of intersecting areas, further capable of forming looped flow channels, and in fluid communication with the solid substrate surface, a plurality of control channels, a plurality of first and second control valves, and a plurality of loop forming control valves.
摘要翻译：本发明提供了包含弹性体组分和用于附着配体的固体底物组分和用于进行各种测定和高通量筛选的方法的微流体装置。弹性体部件包括形成多个相交区域的多个第一和第二流动通道，其还能够形成环形流动通道，并且与固体基板表面流体连通，多个控制通道，多个第一和第二控制阀和多个回路成形控制阀。

3. 发明申请

WO2008043046A2 MICROFLUIDIC CHECK VALVES 审中-公开
标题翻译：微流感检查阀
公开(公告)号：WO2008043046A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/080489
申请日：2007-10-04
申请人： FLUIDIGM CORPORATION , WANG, Jing , NASSEF, Hany, R.
发明人： WANG, Jing , NASSEF, Hany, R.
IPC分类号： B01J19/00
CPC分类号： F16K99/0026 , B01L3/502738 , B01L2200/12 , B01L2300/0887 , B01L2400/0605 , B01L2400/0638 , F16K99/0001 , F16K99/0057 , F16K2099/0078 , F16K2099/008
摘要： The present invention is a robust, microfluidic check valve and a method of using the check valve in microfluidic devices. The check valve is comprised two stacked chambers that are separated by a pore-containing membrane. The membrane is composed of an elastomeric material and can be configured in normally open or normally closed state. The normally open check valve can be implemented so that the degree of back pressure necessary to close the valve can be set. The normally closed embodiment can maintain a closed state with essentially no back pressure. Both the normally open and the normally closed version can be readily produced by multilayer soft lithographic techniques and may retain effective functioning through many thousands of opening and closing cycles without failure. Such check valves can substitute for active valve structures in microfluidic devices and, when appropriately implemented, can simplify the design, manufacture, and/or operation of the devices containing them.
摘要翻译：本发明是一种坚固的微流体止回阀和在微流体装置中使用止回阀的方法。止回阀包括由含孔膜隔开的两个堆叠室。膜由弹性体材料构成，并且可以构造成常开或常闭状态。可以实现常开止回阀，使得可以设定关闭阀所需的背压程度。常闭实施例可以保持基本上没有背压的关闭状态。常开和常闭型都可以通过多层软平版印刷技术轻松生产，并可通过数千个开闭周期保持有效的功能，而不会发生故障。这种止回阀可以替代微流体装置中的主动阀结构，并且当适当实施时，可以简化包含它们的装置的设计，制造和/或操作。

4. 发明申请

WO2004000721A2 RECIRCULATING FLUIDIC NETWORK AND METHODS FOR USING THE SAME 审中-公开
标题翻译：循环流体网络及其使用方法
公开(公告)号：WO2004000721A2
公开(公告)日：2003-12-31
申请号：PCT/US2003/019775
申请日：2003-06-23
申请人： FLUIDIGM CORPORATION , MANGER, Ian, D. , BARCO, Joseph, W. , NASSEF, Hany, R.
发明人： MANGER, Ian, D. , BARCO, Joseph, W. , NASSEF, Hany, R.
IPC分类号： B81C
CPC分类号： B81B3/00 , B01L3/5025 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/088 , B01L2300/0887 , B01L2400/0415 , B01L2400/0481 , B01L2400/0655 , F04B19/006 , F04B43/02 , F16K99/0001 , F16K99/0003 , F16K99/0026 , F16K99/0036 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , G01N33/5304 , G01N33/54366 , Y10T436/2575
摘要： The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and solid substrate component for attaching ligand(s) on its surface. The elastomeric layer comprises (a) a plurality of first flow channels; (b) a plurality of second flow channels each intersecting and crossing each of said first flow channels thereby providing a plurality of intersecting areas formed at intersections between said first flow channels and said second flow channels, wherein said plurality of first flow channels and said plurality of second flow channels are adapted to allow the flow of a solution therethrough, and wherein said solid substrate surface is in fluid communication with at least said intersecting areas of said plurality of first flow channels and said plurality of second flow channels, and wherein said plurality of first flow channels and/or said plurality of second flow channels are capable of forming a plurality of looped flow channels; (c) a plurality of control channels; (d) a plurality of first control valves each operatively disposed with respect to each of said first flow channel to regulate flow of the solution through said first flow channels, wherein each of said first control valves comprises a first control channel and an elastomeric segment that is deflectable into or retractable from said first flow channel upon which said first control valve operates in response to an actuation force applied to said first control channel, the elastomeric segment when positioned in said first flow channel restricting solution flow therethrough; (e) a plurality of second control valves each operatively disposed with respect to each of said second flow channel to regulate flow of the solution through said second flow channels, wherein each of said second control valves comprises a second control channel and an elastomeric segment that is deflectable into or retractable from said second flow channel upon which said second control valve operates in response to an actuation force applied to said second control channel, the elastomeric segment when positioned in said second flow channel restricting solution flow therethrough; (f) a plurality of loop forming control valves each operatively disposed with respect to each of said first and/or said second flow channels to form said plurality of looped flow channels, wherein each of said loop forming control valves comprises a loop forming control channel and an elastomeric segment that is deflectable into or retractable from said first and/or said second flow channels upon which said loop forming control valve operates in response to an actuation force applied to said loop forming control channel, the elastomeric segment when positioned in said first and/or said second flow channels restricting solution flow therethrough thereby forming said looped flow channel; and (g) a plurality of recirculating pumps, and wherein each recirculating pump is operatively disposed with respect to one of said looped flow channels such that circulation of solution through each of said looped flow channels can be regulated by one of said recirculating pumps.
摘要翻译：本发明提供微流体装置及其使用方法。特别地，本发明的微流体装置可用于进行各种测定和高通量筛选。本发明的微流体装置包括用于在其表面上附着配体的弹性体组分和固体底物组分。弹性体层包括（a）多个第一流动通道; （b）多个第二流动通道，每个第二流动通道与每个所述第一流动通道相交并交叉，从而提供在所述第一流动通道和所述第二流动通道之间的交叉处形成的多个相交区域，其中所述多个第一流动通道和所述多个第二流动通道适于允许溶液流过其中，并且其中所述固体基底表面与所述多个第一流动通道和所述多个第二流动通道中的至少所述相交区域流体连通，并且其中所述多个的第一流动通道和/或所述多个第二流动通道能够形成多个环形流动通道; （c）多个控制通道; （d）多个第一控制阀，每个第一控制阀相对于每个所述第一流动通道操作地设置，以调节溶液通过所述第一流动通道的流动，其中每个所述第一控制阀包括第一控制通道和弹性体段，响应于施加到所述第一控制通道的致动力，所述弹性段在所述第一流动通道中被限制溶液流动通过其中时，可偏转到所述第一流动通道中或从所述第一流动通道缩回。（e）多个第二控制阀，每个第二控制阀相对于每个所述第二流动通道操作地设置以调节溶液通过所述第二流动通道的流动，其中每个所述第二控制阀包括第二控制通道和弹性体段，响应于施加到所述第二控制通道的致动力，所述弹性体段定位在所述第二流动通道中以限制溶液流过其中时，可偏转到所述第二流动通道中或从所述第二流动通道缩回所述第二控制阀。（f）多个回路成形控制阀，每个操作地相对于每个所述第一和/或所述第二流动通道设置，以形成所述多个环形流动通道，其中每个所述回路成形控制阀包括回路成形控制通道以及弹性体段，其可偏转到所述第一和/或所述第二流动通道中或从所述第二和/或所述第二流动通道中缩回，所述环形成控制阀响应于施加到所述环形成控制通道的致动力而操作，所述弹性体段在定位在所述第一和/或所述第二流动通道限制溶液流过其中从而形成所述环形流动通道; 和（g）多个循环泵，并且其中每个循环泵相对于所述环形流动通道中的一个可操作地设置，使得循环

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式