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1. 发明申请

WO2007133197A1 PLASMON RESONANT BASED EYE PROTECTION 审中-公开
标题翻译：基于共聚物共聚物的眼睛保护
公开(公告)号：WO2007133197A1
公开(公告)日：2007-11-22
申请号：PCT/US2006/018023
申请日：2006-05-10
申请人： NANOSPECTRA BIOSCIENCES, INC. , PAYNE, J. Donald , JACKSON, Joseph, B.
发明人： PAYNE, J. Donald , JACKSON, Joseph, B.
IPC分类号： G02C7/02 , G02C7/10 , A61B3/10
CPC分类号： G02C7/04 , A61F9/022 , B29D11/00038
摘要： A contact lens is provided in which tunable nanoparticles are embedded or otherwise coated on the lens to extinguish near-infrared energy. In one preferred embodiment, the tunable nanoparticles are nanoshells consisting of a dielectric core and a metal shell, wherein the plasmon resonance frequency is determined by the relative size of the core and the metal shell. With the capability to alter the relative size of the core and the metal shell, nanoshells are uniquely tunable nanoparticles, allowing a range of optical extinctions. In another embodiment, the nanoshells are tuned to extinguish energy from other parts of the energy spectrum. In one desired embodiment of the invention, these plasmon resonant structures are introduced into the lens polymer prior to formation or manufacturing of a lens. In another embodiment of the invention, these nanoshells are coated on a contact lens after formation of the lens.
摘要翻译：提供了一种隐形眼镜，其中可调谐纳米颗粒被嵌入或以其他方式涂覆在透镜上以熄灭近红外能量。在一个优选实施方案中，可调谐纳米颗粒是由介电芯和金属壳组成的纳米壳，其中等离子体共振频率由芯和金属壳的相对尺寸确定。具有改变芯和金属壳的相对尺寸的能力，纳米壳是唯一可调谐的纳米颗粒，允许一定范围的光学消光。在另一个实施例中，纳米壳被调谐以从能量谱的其他部分熄灭能量。在本发明的一个期望的实施方案中，在形成或制造透镜之前将这些等离子体共振结构引入透镜聚合物。在本发明的另一个实施方案中，在形成透镜之后，将这些纳米壳涂覆在隐形眼镜上。

2. 发明申请

WO2009117124A1 NARROWBAND IMAGING USING NEAR-INFRARED ABSORBING NANOPARTICLES 审中-公开
标题翻译：使用近红外吸收纳米粒子的窄带成像
公开(公告)号：WO2009117124A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/001736
申请日：2009-03-19
申请人： NANOSPECTRA BIOSCIENCES, INC. , TUNNELL, James, W. , SCHWARTZ, Jon, A , PARK, Jaesook , PUVANAKRISHNAN, Priyaveena , PAYNE, J. Donald
发明人： TUNNELL, James, W. , SCHWARTZ, Jon, A , PARK, Jaesook , PUVANAKRISHNAN, Priyaveena , PAYNE, J. Donald
IPC分类号： A61B5/05
CPC分类号： A61B5/0059 , A61K49/0065
摘要： Devices and methods are provided for image identification of contrast agents comprising nanoparticles. The imaging devices and methods may also be configured to identify target tissues from surrounding tissues such as disease conditions (e.g. cancer tumors) through narrowband imaging of tissue. Contrast agents such as near-infrared absorbing nanoparticles may be introduced to an organism to distinguish target cells, tissues, or structures from normal tissue. The contrast agent is allowed to preferentially accumulate in the target cells, tissues or structures. As the contrast agents are adapted to preferentially absorb one or more wavelengths of light, the reflection of one wavelength or band of wavelengths by the contrast agents is compared to a separate wavelength or band of wavelengths to identify the target cells, tissues, or structures. In this way, the comparisons identify the presence of the preferential accumulation of the contrast agent in the target cells, tissues or structures.
摘要翻译：提供了用于包含纳米颗粒的造影剂的图像识别的装置和方法。成像装置和方法还可以被配置为通过组织的窄带成像从周围组织识别目标组织，例如疾病状况（例如癌症肿瘤）。可以将对比剂例如近红外吸收纳米颗粒引入生物体以将靶细胞，组织或结构与正常组织区分开。使造影剂优先积聚在靶细胞，组织或结构中。由于造影剂适于优先吸收一个或多个波长的光，所以将造影剂的一个波长或波长波段的反射与波长的单独波长或波段进行比较，以识别靶细胞，组织或结构。以这种方式，比较确定造影剂在靶细胞，组织或结构中的优先积累的存在。

3. 发明申请

WO2009091597A2 TREATMENTS OF DISEASE OR DISORDERS USING NANOPARTICLES FOR FOCUSED HYPERTHERMIA TO INCREASE THERAPY EFFICACY 审中-公开
标题翻译：治疗使用纳米颗粒治疗聚焦性高热的疾病或病症以提高治疗效果
公开(公告)号：WO2009091597A2
公开(公告)日：2009-07-23
申请号：PCT/US2009/000315
申请日：2009-01-16
申请人： NANOSPECTRA BIOSCIENCES, INC.
发明人： KRISHNAN, Sunil , DIAGARADJANE, Parmeswaran , SCHWATRZ, Jon, Alexander , WANG, James, Chunjay
IPC分类号： G02F1/15
CPC分类号： A61N2/002 , A61K41/0052 , A61K47/60 , A61N1/406 , A61N5/062 , A61N5/0625 , A61N5/1077 , A61N7/00 , A61N2005/0659 , A61N2005/067 , A61N2005/1088 , A61N2005/1098
摘要： Methods are provided for the treatment of diseases and disorders using systematically-introduced nanoparticles to create a focused localized hyperthermia in a target area to enhance the effect of additional treatment therapies such as ionizing radiation. Advantages include an enhancement of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia in the treatment area, further, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as chemotherapy and radiation therapy. Methods for treating a target area may comprise systemically introducing nanoparticles into an organism; allowing the nanoparticles to preferentially accumulate in the target area, applying an external energy where the nanoparticles are adapted to transduce at least a portion of the external energy into a heal energy so as to create a focused localized hyperthermia; and applying a subsequent additional therapy.
摘要翻译：提供了使用系统引入的纳米颗粒治疗疾病和病症的方法，以在目标区域中产生聚焦的局部高温以增强额外的治疗疗法例如电离辐射的效果。优点包括通过增加灌注或减少治疗区域中的缺氧来增强其他疗法的治疗效果，此外，本文的方法还可能导致脉管系统的破坏，其为这些治疗单独地并且与常规疗法，如化疗和放疗。用于治疗目标区域的方法可以包括将纳米颗粒系统地引入生物体中; 允许纳米粒子优先积聚在目标区域中，施加外部能量，其中纳米粒子适于将至少一部分外部能量转换成治疗能量，从而产生聚焦局部高温; 并应用后续的额外治疗。

4. 发明申请

WO2009091597A8 TREATMENTS OF DISEASE OR DISORDERS USING NANOPARTICLES FOR FOCUSED HYPERTHERMIA TO INCREASE THERAPY EFFICACY 审中-公开
标题翻译：使用纳米颗粒治疗焦虑性高血压以增加治疗效果的疾病或病症治疗
公开(公告)号：WO2009091597A8
公开(公告)日：2009-11-05
申请号：PCT/US2009000315
申请日：2009-01-16
申请人： NANOSPECTRA BIOSCIENCES INC
发明人： KRISHNAN SUNIL , DIAGARADJANE PARMESWARAN , SCHWATRZ JON ALEXANDER , WANG JAMES CHUNJAY
IPC分类号： G02F1/15
CPC分类号： A61N2/002 , A61K41/0052 , A61K47/48215 , A61K47/60 , A61N1/406 , A61N5/062 , A61N5/0625 , A61N5/1077 , A61N7/00 , A61N2005/0659 , A61N2005/067 , A61N2005/1088 , A61N2005/1098
摘要： Methods are provided for the treatment of diseases and disorders using systematically-introduced nanoparticles to create a focused localized hyperthermia in a target area to enhance the effect of additional treatment therapies such as ionizing radiation. Advantages include an enhancement of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia in the treatment area, further, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as chemotherapy and radiation therapy. Methods for treating a target area may comprise systemically introducing nanoparticles into an organism; allowing the nanoparticles to preferentially accumulate in the target area, applying an external energy where the nanoparticles are adapted to transduce at least a portion of the external energy into a heal energy so as to create a focused localized hyperthermia; and applying a subsequent additional therapy.
摘要翻译：提供了使用系统引入的纳米颗粒治疗疾病和病症的方法，以在目标区域中产生聚焦的定位性热疗，以增强额外的治疗疗法如电离辐射的作用。优点包括通过增加灌注或减少治疗区域中的缺氧来增强其他疗法的治疗效果，此外，本文的方法还可导致脉管系统的破坏，这为进行这种治疗提供了进一步的动力，并且与常规疗法如化疗和放射治疗。用于治疗靶区域的方法可以包括将纳米颗粒系统地引入生物体中; 允许纳米颗粒优先地在目标区域中积累，施加外部能量，其中纳米颗粒适于将至少一部分外部能量转换成愈合能量，以产生聚焦的局部热疗; 并应用随后的额外疗法。

5. 发明申请

WO03047633A2 TREATMENT OF DISEASE STATES CHARACTERIZED BY EXCESSIVE OR INAPPROPRIATE ANGIOGENESIS 审中-公开
标题翻译：疾病状态的治疗由过度或不明确的血管生成特征
公开(公告)号：WO03047633A2
公开(公告)日：2003-06-12
申请号：PCT/US0238695
申请日：2002-12-03
申请人： NANOSPECTRA BIOSCIENCES INC
发明人： WEST JENNIFER L , PAYNE J DONALD
IPC分类号： A61K9/10 , A61F9/007 , A61K9/14 , A61K9/51 , A61K33/24 , A61K33/44 , A61K39/395 , A61K41/00 , A61K47/20 , A61K47/34 , A61K47/42 , A61K47/48 , A61N5/06 , A61P17/02 , A61P27/02 , A61P35/00 , A61P43/00
CPC分类号： B82Y5/00 , A61K41/0042 , A61K41/0052 , A61K47/6923
摘要： Disclosed is a method for reducing excessive or inappropriate neovasculature, including nevasculature in the eye which interferes with or has potential to interfere with vision, for example, that associated with diabetic retinopathy or macular degeneration. The regions of the neovasculature are targeted with nanoparticles, including metal nanoshells, which are then irradiated, preferably with a laser, to heat them and ablate the undesired blood vessels. The nanoparticles are targeted to the neovasculature by linking them with a targeting agent, including, for example, antibodies, antibody fragments, receptor biding proteins or other proteins or molecules including growth factors.
摘要翻译：公开了一种减少过度或不适当的新血管系统的方法，包括眼睛中的血管系统干扰或可能干扰视力，例如与糖尿病性视网膜病变或黄斑变性相关的新血管。新血管系统的区域靶向纳米颗粒，包括金属纳米壳，然后用激光照射，以加热它们并消融不想要的血管。通过将它们与靶向剂（包括例如抗体，抗体片段，受体结合蛋白或包括生长因子的其它蛋白质或分子）连接起来将纳米颗粒靶向新血管。

6. 发明申请

WO2018112261A1 DEVICES AND THE USE THEREOF IN METHODS FOR ABLATION THERAPY 审中-公开
公开(公告)号：WO2018112261A1
公开(公告)日：2018-06-21
申请号：PCT/US2017/066522
申请日：2017-12-14
申请人： NANOSPECTRA BIOSCIENCES, INC.
发明人： GOODRICH, Glenn, Patrick , SCHWARTZ, Jon, Alexander , MURPHY, Andrew, Mark
IPC分类号： A61B18/00 , A61B18/18 , A61B18/20 , A61B18/22 , A61B18/24 , A61N5/06
摘要： Various methods, systems, and devices for treating tissue ablation are disclosed. Some embodiments disclosed herein pertain to methods of treating tumors, systems used for irradiating tissue and tumors with electromagnetic radiation, components and devices of that system, and kits for providing systems used for irradiating tissue and tumors with electromagnetic radiation. In some embodiments, the system provides sub-ablative infrared radiation that is absorbed by nanoparticles. In some embodiments, the nanoparticles absorb the radiation converting it into heat energy. In some embodiments, though the infrared radiation itself may be sub-ablative, the heat energy generated by the nanoparticles is sufficient to cause thermal coagulation, hyperthermia, and/or tissue ablation.

7. 发明申请

WO2009091597A3 TREATMENTS OF DISEASE OR DISORDERS USING NANOPARTICLES FOR FOCUSED HYPERTHERMIA TO INCREASE THERAPY EFFICACY 审中-公开
标题翻译：使用纳米颗粒治疗焦虑性高血压以增加治疗效果的疾病或病症治疗
公开(公告)号：WO2009091597A3
公开(公告)日：2009-12-30
申请号：PCT/US2009000315
申请日：2009-01-16
申请人： NANOSPECTRA BIOSCIENCES INC , KRISHNAN SUNIL , DIAGARADJANE PARMESWARAN , SCHWATRZ JON ALEXANDER , WANG JAMES CHUNJAY
发明人： KRISHNAN SUNIL , DIAGARADJANE PARMESWARAN , SCHWATRZ JON ALEXANDER , WANG JAMES CHUNJAY
IPC分类号： A61N5/02
CPC分类号： A61N2/002 , A61K41/0052 , A61K47/48215 , A61K47/60 , A61N1/406 , A61N5/062 , A61N5/0625 , A61N5/1077 , A61N7/00 , A61N2005/0659 , A61N2005/067 , A61N2005/1088 , A61N2005/1098
摘要： The present invention generally relates to methods for the treatment of a variety of diseases and disorders utilizing systemically- introduced nanoparticles to create focused hyperthermia of a target area so as to enhance the efficacy of additional therapies. Generally, the present invention describes a method for treating tumors or target tissues using localized hyperthermia to enhance the effect of other therapies such as drug treatments and radiation treatments. Advantages of the methods herein include an increase of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia, in the treatment area. Further, in certain embodiments, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as anti-hypoxic agents.
摘要翻译：本发明一般涉及使用全身导入的纳米颗粒来治疗各种疾病和病症的方法，以产生目标区域的聚焦热疗，从而增强额外疗法的功效。通常，本发明描述了使用局部高热治疗肿瘤或靶组织以增强其它治疗如药物治疗和放射治疗的效果的方法。本文方法的优点包括在治疗区域中通过增加灌注或减少缺氧来增加其它疗法的治疗效果。此外，在某些实施方案中，本文的方法还可导致脉管系统的破坏，这为这种治疗提供了进一步的动力，单独地并结合常规疗法如抗缺氧剂。

8. 发明申请

WO2003047633A3 TREATMENT OF ANGIOGENESIS DISORDERS USING TARGETED NANOPARTICLES 审中-公开
公开(公告)号：WO2003047633A3
公开(公告)日：2003-06-12
申请号：PCT/US2002/038695
申请日：2002-12-03
申请人： NANOSPECTRA BIOSCIENCES, INC.
发明人： WEST, Jennifer, L. , PAYNE, J., Donald
IPC分类号： A61K47/48
摘要： Disclosed is a method for reducing excessive or inappropriate neovasculature, including nevasculature in the eye which interferes with or has potential to interfere with vision, for example, that associated with diabetic retinopathy or macular degeneration. The regions of the neovasculature are targeted with nanoparticles, including metal nanoshells, which are then irradiated, preferably with a laser, to heat them and ablate the undesired blood vessels. The nanoparticles are targeted to the neovasculature by linking them with a targeting agent, including, for example, antibodies, antibody fragments, receptor biding proteins or other proteins or molecules including growth factors.

9. 发明申请

WO2011127061A1 ENHANCEMENT OF RADIATION THERAPY BY TARGETED HIGH-Z NANOPARTICLES 审中-公开
标题翻译：通过目标高Z纳米粒子进行辐射治疗的增强
公开(公告)号：WO2011127061A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/031262
申请日：2011-04-05
申请人： NANOSPECTRA BIOSCIENCES, INC. , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , KRISHNAN, Sunil , DIAGARDJANE, Parmeswaran , GOODRICH, Glenn, P. , PAYNE, J., Donald
发明人： KRISHNAN, Sunil , DIAGARDJANE, Parmeswaran , GOODRICH, Glenn, P. , PAYNE, J., Donald
IPC分类号： A61K41/00 , A61K47/48 , A61P35/00 , B82Y5/00
CPC分类号： A61K41/0085 , A61K41/0038 , A61K47/551 , A61K47/64 , A61K47/6849 , A61K47/6923 , A61K47/6929 , A61N5/10 , A61N5/1001
摘要： A method for the design, manufacturing, and use of a high-Z particle to enhance the effects of ionizing radiation. In particular, the use of a targeting molecule to enable cellular uptake by the target cells (tumor cells or endothelial cells proximate to the tumor) will enhance the dose effect.
摘要翻译：一种用于设计，制造和使用高Z粒子以增强电离辐射效果的方法。特别地，靶向分子使靶细胞（肿瘤细胞或靠近肿瘤的内皮细胞）能够摄取能够增强剂量效应。

10. 发明申请

WO2008108980A3 DEVICES AND METHODS FOR EXTRACORPOREAL ABLATION OF CIRCULATING CELLS 审中-公开
标题翻译：用于循环细胞的体外消融的装置和方法
公开(公告)号：WO2008108980A3
公开(公告)日：2008-12-04
申请号：PCT/US2008002691
申请日：2008-02-29
申请人： NANOSPECTRA BIOSCIENCES INC , KORBLING MARTIN , PAYNE J DONALD , COLEMAN CHRISTOPHER L , SCHWARTZ JON A
发明人： KORBLING MARTIN , PAYNE J DONALD , COLEMAN CHRISTOPHER L , SCHWARTZ JON A
IPC分类号： A61B17/52 , A61B8/00 , A61B8/14 , A61K38/00 , A61K39/00 , A61K39/395 , A61N2/00
CPC分类号： A61M1/3681 , A61M1/3618 , A61M1/3683 , A61M1/369
摘要： Methods and devices are provided for the extracorporeal ablation of target cells circulating in blood of an organism. Exogenous material introduced into the blood preferentially associates with target cells (e.g. cancer cells, bacteria, viruses) in the blood. An extracorporeal continuous flow pathway accesses the patient's blood to apply an external energy source to the blood at an ex vivo ablation device in a portion of the extracorporeal continuous flow pathway. The exogenous material interact with the applied energy so as to result in the damage or death of the target cells. The blood is then returned to the body in a continuous-flow pattern. By applying the energy while the blood is in the ex vivo ablation device, shielding of the target cells by the body is reduced and detrimental effects on the organs and tissues of the body are avoided or mitigated.
摘要翻译：提供了用于在生物体的血液中循环的靶细胞的体外消融的方法和装置。引入血液中的外源物质优先与血液中的靶细胞（例如癌细胞，细菌，病毒）相关联。体外连续流动路径访问患者的血液以在体外连续流动路径的一部分中的离体消融装置处将外部能量源应用于血液。外源物质与施加的能量相互作用，从而导致靶细胞的损伤或死亡。然后血液以连续流动模式返回到身体。通过在血液在体外消融装置中时施加能量，减少了身体对靶细胞的屏蔽，并且避免或减轻了对身体的器官和组织的有害影响。

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