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1. 发明申请

WO2010064435A8 METHOD FOR MEASURING CYSTATIN C IN HUMAN BODY FLUID 审中-公开
标题翻译：测定人体液中胱氨酸C的方法
公开(公告)号：WO2010064435A8
公开(公告)日：2010-09-16
申请号：PCT/JP2009006590
申请日：2009-12-03
申请人： SEKISUI MEDICAL CO LTD , NAKAYAMA SHINYA , TAKAHASHI HIROSHI , NAKAMURA YASUSHI , SHIMIZU TOMO
发明人： NAKAYAMA SHINYA , TAKAHASHI HIROSHI , NAKAMURA YASUSHI , SHIMIZU TOMO
IPC分类号： G01N33/53 , G01N33/543 , G01N33/577
CPC分类号： G01N33/543 , G01N33/6893 , G01N2333/8139
摘要： Disclosed is a particle-enhanced immunoassay method for cystatin C in a human body fluid, which has higher specificity, is more inexpensive, and can be automated more readily compared with conventional assay methods in which polyclonal antibodies having low specificity or monoclonal antibodies having high specificity but having poor aggregability have been used in large quantities. The particle-enhanced immunoassay method utilizes a combination of an antibody-sensitized particle comprising an insoluble carrier particle and an anti-human cystatin C monoclonal antibody having higher affinity and bound to the particle and an antibody-sensitized particle comprising the insoluble carrier particle and an anti-human cystatin C monoclonal antibody having a different recognition site from that of the aforementioned monoclonal antibody and having a relatively lower affinity, wherein the quantity of each of the human cystatin C monoclonal antibodies bound to the insoluble carrier particle is less than 5 wt% relative to the weight of the antibody-sensitized particle.
摘要翻译：公开了一种人体液中半胱氨酸蛋白酶抑制剂C的颗粒增强免疫测定方法，与特异性低的多克隆抗体或特异性高的单克隆抗体的常规测定方法相比，该方法具有更高的特异性，更便宜，并且可以更容易自动化但具有较差的可聚合性已被大量使用。颗粒增强免疫测定方法利用包含不溶性载体颗粒的抗体敏化颗粒和具有较高亲和力且结合于颗粒的抗人半胱氨酸蛋白酶抑制剂C单克隆抗体的组合以及包含不溶性载体颗粒和抗体敏化颗粒与上述单克隆抗体具有不同识别位点并具有相对较低亲和力的抗人半胱氨酸蛋白酶抑制剂C单克隆抗体，其中与不溶性载体颗粒结合的每种人半胱氨酸蛋白酶抑制剂C单克隆抗体的量小于5重量％相对于抗体致敏颗粒的重量。

2. 发明申请

WO2003023369A3 APPARATUS FOR MEASURING A SURFACE PROFILE 审中-公开
公开(公告)号：WO2003023369A3
公开(公告)日：2003-03-20
申请号：PCT/JP2002/009058
申请日：2002-09-05
申请人： OLYMPUS OPTICAL CO., LTD. , NAGAIKE, Yasunari , NAKAMURA, Yasushi , ITO, Yoshiaki
发明人： NAGAIKE, Yasunari , NAKAMURA, Yasushi , ITO, Yoshiaki
IPC分类号： G01N19/00
摘要： An apparatus for measuring a surface profile of an object to be measured, comprising a measuring probe (6) positioned to contact the surface of the object (2) to be measured, guide means (4) for supporting and guiding the measuring probe (6) in an axis direction of the measuring probe, tilt angle adjustment means (3) for tilting the guide means (4) at a predetermined tile angle to a horizontal direction so that the measuring probe (6) contact the surface of the object (2) to be measured with a predetermined contact force, and drive means for relatively driving at least one of the measuring probe (6) and the object (2) to scan the surface of the object (2) to be measured with the measuring probe (6), the contact force being derived from a tilt direction component of the gravity of the measuring probe (6) generated when the measuring probe (6) is tilted.

3. 发明申请

WO1995013539A1 METHOD OF ASSAYING ANTI-INTERFERON ANTIBODY AND REAGENT FOR USE THEREIN 审中-公开
标题翻译：测定抗干扰素抗体的方法及其用途
公开(公告)号：WO1995013539A1
公开(公告)日：1995-05-18
申请号：PCT/JP1993001657
申请日：1993-11-12
申请人： DAIICHI PURE CHEMICALS CO., LTD. , NAKAMURA, Yasushi , USHIZAWA, Koji
发明人： DAIICHI PURE CHEMICALS CO., LTD.
IPC分类号： G01N33/53
CPC分类号： G01N33/6866
摘要： A method of assaying an anti-interferon antibody and an interferon/anti-interferon antibody complex present in a liquid specimen by utilizing the immuno-reaction between a solid-supported antigen and a liquid specimen, wherein the solid-supported antigen comprises a solid-supported antigen/antibody complex prepared by sequentially binding an anti-interferon antibody and interferon to a solid-phase support. The invention enables unpurified interferon, even if used, to be purified in the step of preparing the solid phase and both of an anti-interferon antibody and an interferon/anti-interferon antibody complex present in the serum to be assayed readily and accurately.
摘要翻译：一种通过利用固体支持的抗原和液体样本之间的免疫反应来测定存在于液体标本中的抗干扰素抗体和干扰素/抗 - 干扰素抗体复合物的方法，其中所述固体支持的抗原包含固体 - 通过将抗干扰素抗体和干扰素依次结合到固相载体上制备的支持的抗原/抗体复合物。本发明使即使使用的未纯化的干扰素能够在制备固相的步骤中被纯化，并且容易且准确地测定血清中存在的抗干扰素抗体和干扰素/抗 - 干扰素抗体复合物。

4. 发明申请

WO1992011800A1 RADIATION SENSING CLINICAL THERMOMETER 审中-公开
标题翻译：辐射传感临床温度计
公开(公告)号：WO1992011800A1
公开(公告)日：1992-07-23
申请号：PCT/JP1991001775
申请日：1991-12-26
申请人： OMRON CORPORATION , MAKITA, Shigeru , SANO, Yoshihiko , OTA, Hiroyuki , NAKAMURA, Yasushi
发明人： OMRON CORPORATION
IPC分类号： A61B05/00
CPC分类号： G01J5/02 , G01J5/021 , G01J5/04 , G01J5/049
摘要： A radiation sensing clinical thermometer in which a cylindrical support part (2) outwardly projecting at forward end thereof is fixed to a support frame (11) formed integrally with the case proper (1) of the thermometer and a radiant temperature sensor (3) to detect heat rays emitted from the external ear is fixed to the forward end surface of said cylindrical support part. A cylindrical probe (4) is slidably supported by the cylindrical support part (2) and outwardly energized by a spring (42). When the forward end of the cylindrical probe (4) is inserted and pushed into the ear hole, said probe (4) recedes relative to the ear and signals are emitted from a microswitch (5). Such signals are inputted as trigger signals to a temperature measuring circuit provided in the case proper (1) and, thereby, said circuit starts measuring a temperature based on the output of said temperature sensor (3).

5. 发明申请

WO03023369A2 APPARATUS FOR MEASURING A SURFACE PROFILE 审中-公开
标题翻译：测量表面轮廓的设备
公开(公告)号：WO03023369A2
公开(公告)日：2003-03-20
申请号：PCT/JP0209058
申请日：2002-09-05
申请人： OLYMPUS OPTICAL CO , NAGAIKE YASUNARI , NAKAMURA YASUSHI , ITO YOSHIAKI
发明人： NAGAIKE YASUNARI , NAKAMURA YASUSHI , ITO YOSHIAKI
IPC分类号： G01B21/20 , G01B3/00 , G01B5/004 , G01B5/008 , G01B5/20 , G01N19/08 , G01N19/00
CPC分类号： G01B5/008 , G01B3/008 , G01B5/004 , G01B5/20
摘要： An apparatus for measuring a surface profile of an object to be measured, comprising a measuring probe (6) positioned to contact the surface of the object (2) to be measured, guide means (4) for supporting and guiding the measuring probe (6) in an axis direction of the measuring probe, tilt angle adjustment means (3) for tilting the guide means (4) at a predetermined tile angle to a horizontal direction so that the measuring probe (6) contact the surface of the object (2) to be measured with a predetermined contact force, and drive means for relatively driving at least one of the measuring probe (6) and the object (2) to scan the surface of the object (2) to be measured with the measuring probe (6), the contact force being derived from a tilt direction component of the gravity of the measuring probe (6) generated when the measuring probe (6) is tilted.
摘要翻译：一种用于测量待测量物体的表面轮廓的装置，包括定位成与待测物体（2）的表面接触的测量探针（6），用于支撑和引导测量探针（6）的引导装置（4））在所述测量探头的轴线方向上倾斜的倾斜角度调节装置（3），用于使所述引导装置（4）以预定的平铺角倾斜到水平方向，使得所述测量探头（6）接触所述物体（2）的表面）以预定的接触力测量;以及驱动装置，用于相对驱动测量探针（6）和物体（2）中的至少一个以利用测量探针扫描待测量物体（2）的表面（接触力是由测量探针（6）倾斜时产生的测量探针（6）的重力的倾斜方向分量导出的。

6. 发明申请

WO1996033301A1 METHOD AND EQUIPMENT FOR GROWING SINGLE CRYSTALS 审中-公开
标题翻译：用于生长单晶的方法和设备
公开(公告)号：WO1996033301A1
公开(公告)日：1996-10-24
申请号：PCT/JP1996001089
申请日：1996-04-22
申请人： SHIN-ETSU HANDOTAI CO., LTD. , IINO, Eiichi , NAKAMURA, Yasushi , OTSUKA, Seiichiro , MIDZUISHI, Koji , KIMURA, Masanori , YAMAGISHI, Hirotoshi
发明人： SHIN-ETSU HANDOTAI CO., LTD.
IPC分类号： C30B15/30
CPC分类号： C30B15/30 , C30B15/22 , Y10S117/90 , Y10S117/911 , Y10T117/1032
摘要： A method and equipment for growing single crystals according to the so-called Czochralski process. The method comprises attaching a seed crystal (12) to the tip of a wire (41a) of a lifting device (41), pulling up a single crystal portion (15) for crystal growth while engaging an arm-shaped member (44a) of a supporting device (44) with a recess (16) of unevennesses (14) formed on the side of the single crystal portion (15), synchronizing the pulling rate of the member (44a) with that of the wire (41a) to smoothen the cooperation of the both, and pulling up the single crystal portion (15) at a constant pulling rate. Heavy single crystals can safely be pulled up without causing dislocation while minimizing the shock to the growing crystals.
摘要翻译：根据所谓的Czochralski工艺生长单晶的方法和设备。该方法包括将晶种（12）附接到升降装置（41）的导线（41a）的尖端，拉动用于晶体生长的单晶部分（15），同时将臂状构件（44a）具有形成在所述单晶部分（15）侧的不平坦凹部（14）的支撑装置（44），使所述部件（44a）与所述导线（41a）的拉拔速度同步以使所述线两者的协调，并且以恒定的拉伸速率拉起单晶部分（15）。重的单晶可以安全地拉起而不会发生错位，同时最小化生长晶体的冲击。

7. 发明申请

WO1993019662A1 SPECULUM COVER, METHOD OF MANUFACTURING SAME AND CASE FOR HOUSING COVER 审中-公开
标题翻译： SPECIAL CO COVER，其制造方法和壳体外壳
公开(公告)号：WO1993019662A1
公开(公告)日：1993-10-14
申请号：PCT/JP1993000406
申请日：1993-03-31
申请人： OMRON CORPORATION , MAKITA, Shigeru , SANO, Yoshihiko , OTA, Hiroyuki , NAKAMURA, Yasushi
发明人： OMRON CORPORATION
IPC分类号： A61B05/00
CPC分类号： G01J5/02 , A61B1/00142 , A61B1/32 , A61B46/10 , A61B2017/00057 , A61B2017/00084 , A61B2017/00907 , G01J5/021
摘要： A sensor probe cover (20) is constituted by two sheets of transparent film (21) and (22) each being of a generally square shape and a ring (23) having a hole (23a) suitable for fitting over a sensor probe (12). A hole (21a) is formed in the center of the first film (21) and a ring (23) is welded to the peripheral edge of this hole (21a) in the inner surface of the first film (21). The ring (23) is formed of a material harder than that of the film. The first film (21) and the second film (22) are hot-welded to each other at four corners thereof. The positions of hot welding are designated by reference numerals (20a). The second film (22) is formed of a material which can transmit infrared rays therethrough when it is used for a cover of a probe in an infrared ray clinical thermometer. When the forward end of the probe (12) is pushed into the ring (23) from above the second film (22), the second film (22) covers the probe (12) while the second film (22) is turned over. When the ring (23) is fitted into an annular groove (12a) of the probe (12), the mounting of the cover is completed.
摘要翻译：传感器探针盖（20）由两片透明膜（21）和（22）构成，每片透明膜（21）和（22）均为大致正方形，并且环（23）具有适于安装在传感器探头（12）上的孔）。在第一膜（21）的中心形成有孔（21a），并且在第一膜（21）的内表面上，在该孔（21a）的周缘焊接有环（23）。环（23）由比膜的材料硬的材料形成。第一膜（21）和第二膜（22）在其四个角处彼此热焊接。热焊接的位置用附图标记（20a）表示。第二膜（22）由用于红外线体温计中的探针的盖的能够透过红外线的材料形成。当探针（12）的前端从第二膜（22）的上方推入环（23）时，第二膜（22）在第二膜（22）翻转时覆盖探针（12）。当环（23）装配到探针（12）的环形槽（12a）中时，盖的安装完成。

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