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1. 发明申请

WO2009087081A3 NOVEL INSULIN DERIVATIVES HAVING AN EXTREMELY DELAYED TIME-ACTION PROFILE 审中-公开
标题翻译：极端TIME新的胰岛素衍生物延迟/ EFFECT简介
公开(公告)号：WO2009087081A3
公开(公告)日：2009-09-17
申请号：PCT/EP2009000017
申请日：2009-01-06
申请人： SANOFI AVENTIS DEUTSCHLAND , HABERMANN PAUL , SEIPKE GERHARD , KURRLE ROLAND , MUELLER GUENTER , SOMMERFELD MARK , TENNAGELS NORBERT , TSCHANK GEORG , WERNER ULRICH
发明人： HABERMANN PAUL , SEIPKE GERHARD , KURRLE ROLAND , MUELLER GUENTER , SOMMERFELD MARK , TENNAGELS NORBERT , TSCHANK GEORG , WERNER ULRICH
IPC分类号： C07K14/62
CPC分类号： C07K14/62 , A61K38/00
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.
摘要翻译：本发明涉及新的胰岛素类似物与基础时间/操作简档，其特征在于在于：a）有一个酰胺化碱性氨基酸残基如赖氨酸或精氨酸酰胺，b）加入的胰岛素的N-末端氨基酸残基的A-的B链端的特征链是一个赖氨酸或精氨酸残基，c）中的氨基酸位置A8是由组氨酸残基占据时，由甘氨酸残基d）中的氨基酸位置已被占用A21，和e）一个或多个取代和/或负电荷的氨基酸残基的添加在位置A5，A15 是携带A18，B1，B0，B1，B2，B3和B4。

2. 发明申请

WO2005111018A1 PYRIDAZINONE DERIVATIVES, METHODS FOR PRODUCING THEM AND THEIR USE AS PHARMACEUTICALS 审中-公开
标题翻译：吡咯烷酮衍生物，其生产方法及其作为药物的用途
公开(公告)号：WO2005111018A1
公开(公告)日：2005-11-24
申请号：PCT/EP2005/005346
申请日：2005-05-17
申请人： AVENTIS PHARMA DEUTSCHLAND GMBH , HOELDER, Swen , MUELLER, Guenter , SCHOENAFINGER, Karl , WILL, David, William , MATTER, Hans , BOSSART, Martin
发明人： HOELDER, Swen , MUELLER, Guenter , SCHOENAFINGER, Karl , WILL, David, William , MATTER, Hans , BOSSART, Martin
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , C07D403/04 , C07D471/04
摘要： The present invention relates to compounds according to the general formula (I), with the definitions of the substituents X, R 1 and R 2 given below in the text, as well as their physiologically acceptable salts, methods for producing these compounds and their use as pharmaceuticals. Formula (I) These compounds are kinase inhibitors, in particular inhibitors of the kinase GSK15 30 (glycogen synthase kinase-3ß).
摘要翻译：本发明涉及根据通式（I）的化合物，其定义如下文中给出的取代基X，R 1和R 2以及它们的生理上可接受的盐，制备这些的方法化合物及其作为药物的用途。式（I）这些化合物是激酶抑制剂，特别是激酶GSK1530（糖原合成酶激酶-3β）的抑制剂。

3. 发明申请

WO2010028754A2 DESCALING DEVICE 审中-公开
标题翻译：除垢
公开(公告)号：WO2010028754A2
公开(公告)日：2010-03-18
申请号：PCT/EP2009006278
申请日：2009-08-31
申请人： SMS SIEMAG AG , NEUMANN LUC , BILGEN CHRISTIAN , BAEUMER KLAUS , MUELLER GUENTER , IGELHORST WOLFGANG
发明人： NEUMANN LUC , BILGEN CHRISTIAN , BAEUMER KLAUS , MUELLER GUENTER , IGELHORST WOLFGANG
CPC分类号： B21B45/08 , B21B15/0035 , B21B15/005 , B21B45/0278 , Y10T29/4544
摘要： The invention relates to a descaling device which can be operated in an optimal manner with respect to the efficiency, descaling quality, energy and water consumption and is readily available. The aim of the invention is achieved such that the spray nozzles (12), which are instrumental in descaling the steel material (2) in the descaling device (8), are designed as static nozzles and as dynamic or rotating nozzles. The static nozzles form, together with the spray bars, pairs of spray bars (13) and the dynamic or rotating nozzles form, together with spray units, rows of pairs of spray units (23).
摘要翻译：本发明的目的是提供一种除鳞装置，其可操作最佳在它们的性能，除鳞，能量和水的消耗方面，并且其具有高可用性。该目的创造性地实现，即在除鳞装置的钢材料（2）的去氧化皮（8）实现所述喷嘴（12）被设计为静态喷嘴和动态或旋转喷嘴，静态喷嘴（带有喷射棒一起喷射杆对 13）和动态的或旋转的喷嘴（带有喷射单元喷射单元行对23）一起形成。

4. 发明申请

WO2007135687A3 DEVICES FOR TRAPPING INSECTS 审中-公开
标题翻译：用于追捕的设备
公开(公告)号：WO2007135687A3
公开(公告)日：2009-04-23
申请号：PCT/IL2007000631
申请日：2007-05-24
申请人： WESTHAM LTD , SIMCHONI-BARAK MIRI , SCHLEIN YOSEF , MUELLER GUENTER
发明人： SIMCHONI-BARAK MIRI , SCHLEIN YOSEF , MULLER GUNTER
IPC分类号： A01M1/02 , A01M1/04 , A01M1/06 , A01M1/08 , A01M1/22 , A01N65/00
CPC分类号： A01N37/36 , A01M1/023 , A01M1/08 , A01N31/02 , A01N35/02 , A01N37/44
摘要： The present invention discloses trapping devices for biting (e.g. mosquitoes, sand flies, black flies, and biting midges) and nuisance flies (e.g. houseflies, filth flies, and fruit flies). The outdoor solution for biting flies includes a solar panel, a housing, a bag, and a ventilator located in the housing. The ventilator creates a capture zone having an airflow toward the bag. A CO2 generator, chemical attractants, a heat source, and a UV light attract mosquitoes to the capture zone. The chemical attractants are released continuously, the CO2 is released in pulses, and the ventilator and UV are operated in independent programmable intervals. The device is efficient in energy consumption and CO2 production. Other trapping devices are disclosed having a combination of insect-attracting mechanisms including a ventilator. Novel insect zappers including a ventilator are disclosed as well. Indoor and outdoor solutions for insects including biting and nuisance flies.
摘要翻译：本发明公开了用于咬（例如蚊子，沙蝇，黑蝇和咬iting）和滋扰蝇（例如家蝇，fil蝇和果蝇）的诱捕装置。用于叮咬苍蝇的户外解决方案包括位于壳体中的太阳能电池板，壳体，袋子和呼吸机。呼吸机产生具有朝向袋子的气流的捕获区域。 CO2发生器，化学引诱剂，热源和紫外线吸引蚊子到捕获区域。化学引诱剂连续释放，二氧化碳以脉冲形式释放，呼吸机和紫外线以独立的可编程间隔运行。该设备在能源消耗和二氧化碳生产方面效率高。公开了具有包括呼吸机在内的昆虫吸引机构的组合的其它捕获装置。还公开了包括呼吸机在内的新型昆虫卡片机。用于昆虫的室内和室外解决方案，包括咬伤和滋扰苍蝇。

5. 发明申请

WO2008096352A2 METHODS AND DEVICES FOR ATTRACTING AND TRAPPING INSECTS 审中-公开
标题翻译：吸引和追踪药物的方法和装置
公开(公告)号：WO2008096352A2
公开(公告)日：2008-08-14
申请号：PCT/IL2008000157
申请日：2008-02-05
申请人： WESTHAM LTD , SIMCHONI-BARAK MIRI , SCHLEIN YOSEF , MUELLER GUENTER
发明人： SIMCHONI-BARAK MIRI , SCHLEIN YOSEF , MULLER GUNTER
IPC分类号： A01M1/10
CPC分类号： A01M1/145 , A01M1/02 , A01M1/023
摘要： Trapping devices for biting and nuisance flies, and fleas are disclosed. Device optionally include: a trap housing; a trapping surface, positioned in the trap housing, for trapping insects, the trapping surface having an exposed sticky side; a light-emission module, positioned in the trapping surface, having at least one LED light source; a light-transmitting casing for covering the light-emission module, a heating film for emitting heat in a vicinity of the trapping surface, an attractant compartment in the trap housing; an attractant drawer configured to be inserted into the attractant compartment, and configured to hold at least one insect attractant; and at least one attractant-dispersant aperture configured to emit at least one insect attractant in front of the trapping surface. Other disclosed devices include a trapping ramp for catching fleas, and a shadow mode for enhancing insect attraction. Other disclosed devices include an attractant combined with a sticky sheet.
摘要翻译：披露叮咬和滋扰苍蝇的捕获装置和跳蚤。设备可选地包括：陷阱壳体; 捕获表面，位于捕集器壳体中，用于捕获昆虫，捕集表面具有暴露的粘性侧; 位于捕集表面中的发光模块具有至少一个LED光源; 用于覆盖发光模块的透光壳体，用于在捕获表面附近发热的加热膜，在陷阱壳体中的引诱室; 引诱剂抽屉，其构造成插入到引诱室中，并且构造成保持至少一个昆虫引诱剂; 以及至少一个引诱剂 - 分散剂孔，其构造成在捕获表面前方发射至少一种昆虫引诱剂。其他公开的装置包括用于捕捉跳蚤的捕获斜坡和用于增强昆虫吸引力的阴影模式。其他公开的装置包括与粘性片组合的引诱剂。

6. 发明申请

WO2006074957A9 SUBSTITUTED AMINOMETHYLENE SULPHONAMIDES, PRODUCTION AND USE THEREOF AS MEDICAMENTS 审中-公开
标题翻译：取代的N- AMINOMETHYLENSULFONAMIDE，生产与应用，药物
公开(公告)号：WO2006074957A9
公开(公告)日：2007-07-12
申请号：PCT/EP2006000313
申请日：2006-01-16
申请人： SANOFI AVENTIS DEUTSCHLAND , SCHOENAFINGER KARL , PETRY STEFAN , MUELLER GUENTER , BARINGHAUS KARL-HEINZ
发明人： SCHOENAFINGER KARL , PETRY STEFAN , MUELLER GUENTER , BARINGHAUS KARL-HEINZ
IPC分类号： C07C311/60 , A61K31/18 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61P3/10 , A61P5/50 , C07D211/16 , C07D295/096 , C07D295/32
CPC分类号： C07C311/51 , C07C2601/08 , C07C2601/14 , C07D211/16 , C07D295/096 , C07D295/32
摘要： The invention relates to compounds of general formula (I), wherein the definition of the substituents R 1 - R 5 , A and X are cited in the description, and to the physiologically compatible salts thereof. The invention also relates to a method for producing said compounds and to the use thereof as medicaments. Said inventive compounds are hormone sensitive lipase (HSL) inhibitors.
摘要翻译：本发明涉及通式（I）的化合物，其中取代基R 1定义^{1 至R ^{5 ，A和X在以下文本中列出的，以及它们的生理学上可接受的盐，该化合物的制备方法以及它们作为药物的用途。这些化合物是激素敏感性脂肪酶（HSL）的抑制剂。}}

7. 发明申请

WO2006074957A1 SUBSTITUIERTE N-AMINOMETHYLENSULFONAMIDE, IHRE HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL 审中-公开
标题翻译：取代的N- AMINOMETHYLENSULFONAMIDE，生产与应用，药物
公开(公告)号：WO2006074957A1
公开(公告)日：2006-07-20
申请号：PCT/EP2006/000313
申请日：2006-01-16
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , SCHOENAFINGER, Karl , PETRY, Stefan , MUELLER, Guenter , BARINGHAUS, Karl-Heinz
发明人： SCHOENAFINGER, Karl , PETRY, Stefan , MUELLER, Guenter , BARINGHAUS, Karl-Heinz
IPC分类号： C07C311/60 , C07D211/16 , C07D295/096 , C07D295/32 , A61K31/18 , A61K31/495 , A61K31/4453 , A61K31/5375 , A61P3/10 , A61P5/50
CPC分类号： C07C311/51 , C07C2601/08 , C07C2601/14 , C07D211/16 , C07D295/096 , C07D295/32
摘要： Die Erfindung betrifft Verbindungen der allgemeinen Formel (I), wobei die Definition der Substituenten R 1 bis R 5 , A und X im nachfolgenden Text aufgeführt sind, sowie deren physiologisch verträglichen Salze, Verfahren zur Herstellung dieser Verbindung und deren Verwendung als Arzneimittel. Diese Verbindungen sind Inhibitoren der hormonsensitiven Lipase (HSL).
摘要翻译：本发明涉及通式（I）的化合物，其中取代基R 1定义^{1 至R ^{5 ，A和X在以下文本中列出的，以及它们的生理学上可接受的盐，该化合物的制备方法以及它们作为药物的用途。这些化合物是激素敏感性脂肪酶（HSL）的抑制剂。}}

8. 发明申请

WO2005111019A1 NOVEL PYRIDAZINONE DERIVATIVES AS INHIBITORS OF CDK2 审中-公开
标题翻译：作为CDK2的抑制剂的新型吡咯烷酮衍生物
公开(公告)号：WO2005111019A1
公开(公告)日：2005-11-24
申请号：PCT/EP2005/006046
申请日：2005-05-17
申请人： AVENTIS PHARMA S.A. , HOELDER, Swen , MUELLER, Guenter , SCHOENAFINGER, Karl , WILL, David William , MATTER, Hans
发明人： HOELDER, Swen , MUELLER, Guenter , SCHOENAFINGER, Karl , WILL, David William , MATTER, Hans
IPC分类号： C07D401/14
CPC分类号： C07D403/04 , C07D401/14
摘要： The present invention relates to compounds according to the general formula (I), with the definitions of the substituents X, R1 and R2 given below in the text, as well as their physiologically acceptable salts, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).
摘要翻译：本发明涉及根据通式（I）的化合物，其定义如下文中给出的取代基X，R 1和R 2及其生理上可接受的盐，制备这些化合物的方法及其作为药物的用途。这些化合物是激酶抑制剂，特别是激酶CDK2（细胞周期蛋白依赖性激酶2）的抑制剂。

9. 发明申请

WO2005080587A3 GLIMEPIRIDE- AND INSULIN-INDUCED GLYCOSYLPHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C REGULATION 审中-公开
公开(公告)号：WO2005080587A3
公开(公告)日：2005-09-01
申请号：PCT/EP2005/001553
申请日：2005-02-16
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , MUELLER, Guenter , FRICK, Wendelin , SCHNEIDER, Rudolf
发明人： MUELLER, Guenter , FRICK, Wendelin , SCHNEIDER, Rudolf
IPC分类号： C12Q1/02 , C07F9/6571
摘要： The present invention refers to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC wherein a] a mammalian cell is incubated with glimepiride; b] hcDlGs of the cells of a] are prepared; c] the hcDlGs from b] are incubated with a chemical compound; d] the activity of the GPI-PLC from the hcDlGs of c] is determined.

10. 发明申请

WO2009087082A3 NOVEL INSULIN DERIVATIVES HAVING AN EXTREMELY DELAYED TIME-ACTION PROFILE 审中-公开
标题翻译：极端TIME新的胰岛素衍生物延迟/ EFFECT简介
公开(公告)号：WO2009087082A3
公开(公告)日：2009-09-24
申请号：PCT/EP2009000018
申请日：2009-01-06
申请人： SANOFI AVENTIS DEUTSCHLAND , HABERMANN PAUL , SEIPKE GERHARD , KURRLE ROLAND , MUELLER GUENTER , SOMMERFELD MARK , TENNAGELS NORBERT , TSCHANK GEORG , WERNER ULRICH
发明人： HABERMANN PAUL , SEIPKE GERHARD , KURRLE ROLAND , MUELLER GUENTER , SOMMERFELD MARK , TENNAGELS NORBERT , TSCHANK GEORG , WERNER ULRICH
IPC分类号： C07K14/62
CPC分类号： C07K14/62
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
摘要翻译：本发明涉及用基础时间/动作模板新型胰岛素类似物，胰岛素A链的特征为带负电和带正电的氨基酸残基添加和/或取代，以及C-末端羧基的B链的，和组氨酸的酰胺化在第8位置，其制备方法和用途。

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