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1. 发明申请

WO2008036688A3 OPTIMIZED ANTIBODIES THAT TARGET HM1.24 审中-公开
标题翻译：目标HM1.24的优化抗体
公开(公告)号：WO2008036688A3
公开(公告)日：2009-09-24
申请号：PCT/US2007078800
申请日：2007-09-18
申请人： XENCOR INC , BERNETT MATTHEW J , DESJARLAIS JOHN R , KARKI SHER BAHADUR , LAZAR GREGORY ALAN , MUCHHAL UMESH S , NGUYEN DUC-HANH THI , RICHARDS JOHN O
发明人： BERNETT MATTHEW J , DESJARLAIS JOHN R , KARKI SHER BAHADUR , LAZAR GREGORY ALAN , MUCHHAL UMESH S , NGUYEN DUC-HANH THI , RICHARDS JOHN O
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , A61K31/454 , A61K31/573 , A61K31/69 , A61K39/3955 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/92
摘要： The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibodythat alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.
摘要翻译：本公开描述了靶向HM1.24的抗体。在各个方面，抗体具有特异性CDR，可变或全长序列，与亲本抗体具有修饰，或者相对于母体抗体包括至少一个修饰，改变对FcγR的亲和力或改变效应子功能，与亲本抗体。还公开了编码抗体的核酸和使用抗体的方法。

2. 发明申请

WO2007032778A2 ANALYSIS OF MHC-PEPTIDE BINDING INTERACTIONS 审中-公开
标题翻译： MHC-PEPTIDE结合相互作用的分析
公开(公告)号：WO2007032778A2
公开(公告)日：2007-03-22
申请号：PCT/US2006/010809
申请日：2006-03-23
申请人： XENCOR, INC. , MUCHHAL, Umesh, S. , DESJARLAIS, John, R. , MOORE, Gregory, L.
发明人： MUCHHAL, Umesh, S. , DESJARLAIS, John, R. , MOORE, Gregory, L.
IPC分类号： G01N33/541 , G01N33/68
CPC分类号： G01N33/56977 , B01J2219/00725 , G01N33/541 , G01N33/6845 , G01N2333/70539
摘要： Methods, apparatuses, and compounds for screening or detecting binding of candidate peptides to an MHC protein is provided. A first component including at least one candidate peptides and a second component including at least one MHC protein are contacted. One of the components is immobilized on a solid support. The presence, absence, or quantity of binding of the peptide and said MHC protein is then determined.
摘要翻译：提供了用于筛选或检测候选肽与MHC蛋白的结合的方法，装置和化合物。接触包含至少一种候选肽的第一组分和包含至少一种MHC蛋白的第二组分。其中一个组分固定在固体支持物上。然后确定肽和所述MHC蛋白的结合的存在，不存在或数量。

3. 发明申请

WO2008036688A2 OPTIMIZED ANTIBODIES THAT TARGET HM1.24 审中-公开
标题翻译：目标HM1.24的优化抗体
公开(公告)号：WO2008036688A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/078800
申请日：2007-09-18
申请人： XENCOR, INC. , BERNETT, Matthew J. , DESJARLAIS, John R. , KARKI, Sher Bahadur , LAZAR, Gregory Alan , MUCHHAL, Umesh S. , NGUYEN, Duc-hanh Thi , RICHARDS, John O.
发明人： BERNETT, Matthew J. , DESJARLAIS, John R. , KARKI, Sher Bahadur , LAZAR, Gregory Alan , MUCHHAL, Umesh S. , NGUYEN, Duc-hanh Thi , RICHARDS, John O.
CPC分类号： C07K16/2896 , A61K31/454 , A61K31/573 , A61K31/69 , A61K39/3955 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/92
摘要： The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibodythat alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.
摘要翻译：本公开描述了靶向HM1.24的抗体。在各个方面，抗体具有特异性CDR，可变或全长序列，与亲本抗体具有修饰，或者相对于母体抗体包括至少一个修饰，其改变对FcγR的亲和力或改变效应子功能，与亲本抗体。还公开了编码抗体的核酸和使用抗体的方法。

4. 发明申请

WO2007032778A3 ANALYSIS OF MHC-PEPTIDE BINDING INTERACTIONS VIA POPULATION SPECIFIC MHC-ARRAYS 审中-公开
标题翻译：通过人口特异性MHC阵列分析MHC-肽结合相互作用
公开(公告)号：WO2007032778A3
公开(公告)日：2007-05-10
申请号：PCT/US2006010809
申请日：2006-03-23
申请人： XENCOR INC , MUCHHAL UMESH S , DESJARLAIS JOHN R , MOORE GREGORY L
发明人： MUCHHAL UMESH S , DESJARLAIS JOHN R , MOORE GREGORY L
IPC分类号： G01N33/541 , G01N33/68
CPC分类号： G01N33/56977 , B01J2219/00725 , G01N33/541 , G01N33/6845 , G01N2333/70539
摘要： Methods, apparatuses, and compounds for screening or detecting binding of candidate peptides to an MHC protein is provided. A first component including at least one candidate peptides and a second component including at least one MHC protein are contacted. One of the components is immobilized on a solid support. The presence, absence, or quantity of binding of the peptide and said MHC protein is then determined.
摘要翻译：提供了用于筛选或检测候选肽与MHC蛋白的结合的方法，装置和化合物。接触包含至少一种候选肽的第一组分和包含至少一种MHC蛋白的第二组分。其中一个组分固定在固体支持物上。然后确定肽和所述MHC蛋白的结合的存在，不存在或数量。

5. 发明申请

WO1998004701A1 METHODS AND COMPOSITIONS FOR IMPROVING A PLANT'S ABILITY TO TAKE IN PHOSPHATE FROM SOIL 审中-公开
标题翻译：改善植物从土壤中吸收磷酸盐的能力的方法和组合物
公开(公告)号：WO1998004701A1
公开(公告)日：1998-02-05
申请号：PCT/US1997013458
申请日：1997-07-29
申请人： PURDUE RESEARCH FOUNDATION , RAGHOTHAMA, K., G. , MUCHHAL, Umesh, S.
发明人： PURDUE RESEARCH FOUNDATION
IPC分类号： C12N15/29
CPC分类号： C12N15/8261 , C07K14/415 , Y02A40/146
摘要： The present invention relates to methods and materials in the field of molecular biology and the regulation of protein synthesis through plant genetic engineering. More particularly, the invention relates to newly-isolated nucleotide sequences, nucleotide sequences having substantial identity thereto and proteins encoded thereby. The invention also involves the introduction of foreign nucleotide sequences into a plant genome, wherein the introduction of the nucleotide sequence effects an increase in the plant's ability to transport phosphate. Plant transformants harboring a DNA construct comprising a promoter operably linked to an inventive nucleotide sequence demonstrate increased levels of phosphate transporter proteins, rendering the plant better able to sustain growth in a phosphate-deficient substrate.
摘要翻译：本发明涉及分子生物学领域的方法和材料以及通过植物遗传工程调节蛋白质合成。更具体地，本发明涉及新分离的核苷酸序列，与其具有实质同一性的核苷酸序列及其编码的蛋白质。本发明还涉及将外源核苷酸序列引入植物基因组中，其中引入核苷酸序列会影响植物运输磷酸盐的能力。携带包含可操作地连接到本发明核苷酸序列的启动子的DNA构建体的植物转化体表现出增加的磷酸转运蛋白水平，使得植物能够更好地维持磷酸盐缺乏的底物中的生长。

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