专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010030811A3 CARBACEPHEM ß-LACTAM ANTIBIOTICS 审中-公开
标题翻译： CARBACEPHEMβ-内酰胺抗生素
公开(公告)号：WO2010030811A3
公开(公告)日：2010-08-12
申请号：PCT/US2009056555
申请日：2009-09-10
申请人： ACHAOGEN INC , WAGMAN ALLAN SCOTT , MOSER HEINZ ERNST
发明人： WAGMAN ALLAN SCOTT , MOSER HEINZ ERNST
IPC分类号： C07D463/22 , A61K31/4353 , A61P31/04
CPC分类号： C07D463/22
摘要： Carbacephem -lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar1, Ar2, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
摘要翻译：公开了具有结构（I）的碳水化合物 - 内酰胺抗菌素，包括其立体异构体，药学上可接受的盐，酯和前药，其中Ar 1，Ar 2，R 1和R 2如本文所定义。该化合物可用于治疗细菌感染，特别是由耐甲氧西林葡萄球菌属引起的感染。

2. 发明申请

WO2010030811A2 CARBACEPHEM β-LACTAM ANTIBIOTICS 审中-公开
标题翻译： CARBACEPHEMß-LACTAM抗生素
公开(公告)号：WO2010030811A2
公开(公告)日：2010-03-18
申请号：PCT/US2009/056555
申请日：2009-09-10
申请人： ACHAOGEN, INC. , WAGMAN, Allan, Scott , MOSER, Heinz, Ernst
发明人： WAGMAN, Allan, Scott , MOSER, Heinz, Ernst
IPC分类号： C07D463/22 , A61K31/4353 , A61P31/04
CPC分类号： C07D463/22
摘要： Carbacephem -lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar 1 , Ar 2 , R 1 and R 2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
摘要翻译：公开了具有结构（I）的碳水化合物β-内酰胺抗生素，包括立体异构体，其药学上可接受的盐，酯和前药，其中Ar1，Ar2，R1和R2如本文所定义。这些化合物可用于治疗细菌感染，特别是由耐甲氧西林葡萄球菌引起的细菌感染。

3. 发明申请

WO2009137130A2 ANTIBACTERIAL FLUOROQUINOLONE ANALOGS 审中-公开
标题翻译：抗生素荧光素类似物
公开(公告)号：WO2009137130A2
公开(公告)日：2009-11-12
申请号：PCT/US2009033946
申请日：2009-02-12
申请人： ACHAOGEN INC , WAGMAN ALLAN SCOTT , MOSER HEINZ ERNST , MCENROE GLENN A , AGGEN JAMES , LINSELL MARTIN S , GOLDBLUM ADAM AARON , GRIFFIN JOHN H , SIMONS LLOYD J , BELLIOTTI THOMAS R , HARRIS CHRISTINA R , POEL TONI-JO , MELNICK MICHAEL J , GASTON RICKY D
发明人： WAGMAN ALLAN SCOTT , MOSER HEINZ ERNST , MCENROE GLENN A , AGGEN JAMES , LINSELL MARTIN S , GOLDBLUM ADAM AARON , GRIFFIN JOHN H , SIMONS LLOYD J , BELLIOTTI THOMAS R , HARRIS CHRISTINA R , POEL TONI-JO , MELNICK MICHAEL J , GASTON RICKY D
IPC分类号： C07D487/22
CPC分类号： C07D471/14 , C07D498/14 , C07D513/14
摘要： Compounds having antibacterial activity are disclosed. The compunds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译：公开了具有抗细菌活性的化合物。该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中A，B，D，E，G，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

4. 发明申请

WO1997047636A2 INTERMEDIATES FOR OLIGONUCLEOTIDE SYNTHESIS 审中-公开
标题翻译：寡核苷酸合成的中间体
公开(公告)号：WO1997047636A2
公开(公告)日：1997-12-18
申请号：PCT/GB1997001490
申请日：1997-06-03
申请人： NOVARTIS AG , COLLINGWOOD, Stephen, Paul , MOSER, Heinz, Ernst , ALTMANN, Karl-Heinz , DOUGLAS, Mark, Edward
发明人： NOVARTIS AG
IPC分类号： C07H19/04
CPC分类号： C07H19/04 , Y02P20/55
摘要： A compound of formula (I) where B is a radical of a nucleoside base, R is hydrogen or a hydroxy-protecting group, R is hydrogen, hydroxy or a 2' nucleoside-modifying atom or group, R is an unsubstituted or substituted C1 to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, and Z is halogen or a group of formula (II) where R and R are each independently an unsubstituted or substituted C1 to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, or R is said group and R is hydrogen, or R and R together with the nitrogen atom to which they are attached denote a five- to thirteen-membered heterocyclic ring, or Z is a group of formula (III): Nuc-O-, where Nuc is the residue of a natural or synthetic nucleoside or oligonucleotide after removal of a 5'-hydroxyl group therefrom attached through a 5' methylene thereof to the indicated oxygen atom.
摘要翻译：式（I）的化合物，其中B 1是核苷碱基，R 1是氢或羟基保护基，R 2是氢，羟基或2'核苷修饰原子或基团，R 3是未取代或取代的C1至C10烷基，C2至C10烯基，C4至C10环烷基烷基，C6至C10芳基或C7至C13芳烷基，Z为卤素或式（II） R 4和R 5各自独立地为未取代或取代的C 1至C 10烷基，C 2至C 10烯基，C 4至C 10环烷基烷基，C 6至C 10芳基或C 7至C 13芳烷基，或R 4为所述基团和R 5是氢，或者R 4和R 5与它们所连接的氮原子一起表示5至13元杂环，或Z是式（III）的基团： Nuc-O-，其中Nuc是去除通过其5'亚甲基连接到指定氧原子上的5'-羟基后天然或合成核苷或寡核苷酸的残基。

5. 发明申请

WO2011031744A1 ANTIBACTERIAL FLUOROQUINOLONE ANALOGS 审中-公开
标题翻译：抗生素荧光素类似物
公开(公告)号：WO2011031744A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048109
申请日：2010-09-08
申请人： ACHAOGEN, INC. , WAGMAN, Allan, Scott , MOSER, Heinz, Ernst , MCENROE, Glenn, A. , AGGEN, James, Bradley , LINSELL, Martin, Sheringham , GOLDBLUM, Adam, Aaron , GASTON, Ricky, D. , GRIFFIN, John, H.
发明人： WAGMAN, Allan, Scott , MOSER, Heinz, Ernst , MCENROE, Glenn, A. , AGGEN, James, Bradley , LINSELL, Martin, Sheringham , GOLDBLUM, Adam, Aaron , GASTON, Ricky, D. , GRIFFIN, John, H.
IPC分类号： C07D471/14 , C07D487/14 , C07D498/14 , C07D513/14 , C07D455/02 , A61K31/437 , A61K31/4375 , A61K31/4985 , A61K31/5383 , A61K31/5415 , A61P31/04
CPC分类号： C07D471/14 , C07D455/02 , C07D487/14 , C07D498/14 , C07D513/14
摘要： Compounds having antibacterial activity are disclosed. The compounds have one of the following structures (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, D, E, G, W, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译：公开了具有抗菌活性的化合物。该化合物具有下列结构（I）或（II）之一：包括其立体异构体，药学上可接受的盐和前药，其中A，D，E，G，W，R 1，R 2，R 3，R 4，R 5，R 6和R 7 如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

6. 发明申请

WO2010042851A1 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS 审中-公开
标题翻译：抗菌胺类化合物
公开(公告)号：WO2010042851A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060212
申请日：2009-10-09
申请人： ACHAOGEN, INC. , AGGEN, James, Bradley , LINSELL, Martin, Sheringham , GOLDBLUM, Adam, Aaron , HILDEBRANDT, Darin, James , KANE, Timothy, Robert , DOZZO, Paola , GLIEDT, Micah, James , MOSER, Heinz, Ernst
发明人： AGGEN, James, Bradley , LINSELL, Martin, Sheringham , GOLDBLUM, Adam, Aaron , HILDEBRANDT, Darin, James , KANE, Timothy, Robert , DOZZO, Paola , GLIEDT, Micah, James , MOSER, Heinz, Ernst
IPC分类号： C07H15/232 , A61K31/7036 , A61P31/04
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译：公开了具有抗细菌活性的化合物。所述化合物具有以下结构（I）：（I），其包括其立体异构体，药学上可接受的盐和前药，其中Q1，Q2，R1，R2和R3如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

7. 发明申请

WO2010042850A1 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS 审中-公开
标题翻译：抗菌胺类化合物
公开(公告)号：WO2010042850A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060211
申请日：2009-10-09
申请人： ACHAOGEN, INC. , AGGEN, James, Bradley , LINSELL, Martin, Sheringham , GOLDBLUM, Adam, Aaron , HILDEBRANDT, Darin, James , KANE, Timothy, Robert , DOZZO, Paola , GLIEDT, Micah, James , MOSER, Heinz, Ernst
发明人： AGGEN, James, Bradley , LINSELL, Martin, Sheringham , GOLDBLUM, Adam, Aaron , HILDEBRANDT, Darin, James , KANE, Timothy, Robert , DOZZO, Paola , GLIEDT, Micah, James , MOSER, Heinz, Ernst
IPC分类号： C07H15/232 , A61K31/7036 , A61P31/04
CPC分类号： C07H15/232
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I):(I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译：公开了具有抗菌活性的化合物。所述化合物具有以下结构（I）：（I），其包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，R1，R2和R3如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

8. 发明申请

WO2010030810A1 CARBACEPHEM BETA-LACTAM ANTIBIOTICS 审中-公开
标题翻译： CARBACEPHEM BETA-LACTAM抗生素
公开(公告)号：WO2010030810A1
公开(公告)日：2010-03-18
申请号：PCT/US2009/056554
申请日：2009-09-10
申请人： ACHAOGEN, INC. , WAGMAN, Allan, Scott , MOSER, Heinz, Ernst
发明人： WAGMAN, Allan, Scott , MOSER, Heinz, Ernst
IPC分类号： C07D463/22 , A61K31/4353 , A61P31/04
CPC分类号： C07D463/22
摘要： Carbacephem β-lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar 2 , X, R 1 and R 2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
摘要翻译：公开了具有结构（I）的碳纤维β-内酰胺抗生素，包括立体异构体，其药学上可接受的盐，酯和前药，其中Ar 2，X，R 1和R 2如本文所定义。这些化合物可用于治疗细菌感染，特别是由耐甲氧西林葡萄球菌引起的细菌感染。

9. 发明申请

WO2011031743A1 ANTIBACTERIAL FLUOROQUINOLONE ANALOGS 审中-公开
标题翻译：抗生素荧光素类似物
公开(公告)号：WO2011031743A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048107
申请日：2010-09-08
申请人： ACHAOGEN, INC. , WAGMAN, Allan, Scott , MOSER, Heinz, Ernst , AGGEN, James, Bradley , LINSELL, Martin, Sheringham , GOLDBLUM, Adam, Aaron , POEL, Toni-Jo , MELNICK, Michael, J. , GRIFFIN, John, H.
发明人： WAGMAN, Allan, Scott , MOSER, Heinz, Ernst , AGGEN, James, Bradley , LINSELL, Martin, Sheringham , GOLDBLUM, Adam, Aaron , POEL, Toni-Jo , MELNICK, Michael, J. , GRIFFIN, John, H.
IPC分类号： C07D471/14 , C07D491/14 , A61K31/55 , A61P31/04
CPC分类号： C07D491/14 , C07D471/14
摘要： Compounds having antibacterial activity are disclosed. The compounds have one of the following structures (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, J, D, E, G, W, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译：公开了具有抗菌活性的化合物。所述化合物具有以下结构（I）或（II）之一：其包括立体异构体，其药学上可接受的盐和前药，其中A，B，J，D，E，G，W，R 1，R 2，R 3，R 4，R 5 R6和R7如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

10. 发明申请

WO9747636A3 INTERMEDIATES FOR OLIGONUCLEOTIDE SYNTHESIS 审中-公开
标题翻译：寡核苷酸合成的中间体
公开(公告)号：WO9747636A3
公开(公告)日：1998-02-12
申请号：PCT/GB9701490
申请日：1997-06-03
申请人： NOVARTIS AG , COLLINGWOOD STEPHEN PAUL , MOSER HEINZ ERNST , ALTMANN KARL-HEINZ , DOUGLAS MARK EDWARD
发明人： COLLINGWOOD STEPHEN PAUL , MOSER HEINZ ERNST , ALTMANN KARL-HEINZ , DOUGLAS MARK EDWARD
IPC分类号： C07H19/06 , C07H19/04 , C07H19/16 , C07H21/00
CPC分类号： C07H19/04 , Y02P20/55
摘要： A compound of formula (I) where B is a radical of a nucleoside base, R is hydrogen or a hydroxy-protecting group, R is hydrogen, hydroxy or a 2' nucleoside-modifying atom or group, R is an unsubstituted or substituted C1 to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, and Z is halogen or a group of formula (II) where R and R are each independently an unsubstituted or substituted C1 to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, or R is said group and R is hydrogen, or R and R together with the nitrogen atom to which they are attached denote a five- to thirteen-membered heterocyclic ring, or Z is a group of formula (III): Nuc-O-, where Nuc is the residue of a natural or synthetic nucleoside or oligonucleotide after removal of a 5'-hydroxyl group therefrom attached through a 5' methylene thereof to the indicated oxygen atom. 00000
摘要翻译：式（I）的化合物，其中B 1是核苷碱基的基团，R 1是氢或羟基保护基，R 2是氢，羟基或2'核苷修饰原子或基团，R 3为未取代或取代的C1至C10烷基，C2至C10烯基，C4至C10环烷基烷基，C6至C10芳基或C7至C13芳烷基，Z为卤素或式（II）基团，其中 R 4和R 5各自独立地为未取代或取代的C 1至C 10烷基，C 2至C 10烯基，C 4至C 10环烷基烷基，C 6至C 10芳基或C 7至C 13芳烷基，或R 4为所述基团和R 5是氢，或者R 4和R 5与它们所连接的氮原子一起表示5至13元杂环，或Z是式（III）的基团： Nuc-O-，其中Nuc是除去其中5'羟基之后的天然或合成核苷或寡核苷酸的残基，其中5'羟基通过其5'亚甲基连接到指定的氧原子上。 00000

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式