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1. 发明申请

WO2005058834A2 QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE 审中-公开
标题翻译：喹诺酮可用于治疗心血管疾病
公开(公告)号：WO2005058834A2
公开(公告)日：2005-06-30
申请号：PCT/US2004/041399
申请日：2004-12-10
申请人： WYETH , COLLINI, Michael, D. , SINGHAUS, Robert, R., Jr. , HU, Baihua , JETTER, James, W. , MORRIS, Robert, L. , KAUFMAN, David, H. , MILLER, Christopher, P. , ULLRICH, John, W. , UNWALLA, Rayomand, J. , WROBEL, Jay, E. , QUINET, Elaine , NAMBI, Ponnal , BERNOTAS, Ronald, C. , ELLOSO, Merle
发明人： COLLINI, Michael, D. , SINGHAUS, Robert, R., Jr. , HU, Baihua , JETTER, James, W. , MORRIS, Robert, L. , KAUFMAN, David, H. , MILLER, Christopher, P. , ULLRICH, John, W. , UNWALLA, Rayomand, J. , WROBEL, Jay, E. , QUINET, Elaine , NAMBI, Ponnal , BERNOTAS, Ronald, C. , ELLOSO, Merle
IPC分类号： C07D215/00
CPC分类号： C07D401/04 , C07D215/14 , C07D215/54 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12
摘要： This invention provides compounds of formula (I) that are useful in the treatment or inhibition of LXR mediated diseases.
摘要翻译：本发明提供了用于治疗或抑制LXR介导的疾病的式（I）化合物。

2. 发明申请

WO2006007503A1 TETRACYCLIC COMPOUNDS AS ESTROGEN LIGANDS 审中-公开
标题翻译：四氢化合物作为雌激素配体
公开(公告)号：WO2006007503A1
公开(公告)日：2006-01-19
申请号：PCT/US2005/023044
申请日：2005-06-29
申请人： WYETH , MILLER, Christopher, P. , COLLINI, Michael, D. , MORRIS, Robert, L. , SINGHAUS, Robert, R., Jr.
发明人： MILLER, Christopher, P. , COLLINI, Michael, D. , MORRIS, Robert, L. , SINGHAUS, Robert, R., Jr.
IPC分类号： C07D307/77
CPC分类号： C07D493/04 , C07D307/77 , C07D307/93
摘要： This invention provides estrogen receptor modulators having the structure: (I) wherein R 1 , R 2 , R 3 , R 4 , Q, n, R 8 , R 9 , R 10 , and R 11 have been defined in the specification; or a pharmaceutically acceptable salt thereof. The invention further provides methods for the preparation and use of the compounds.
摘要翻译：本发明提供具有以下结构的雌激素受体调节剂：（I）其中R 1，R 2，R 3，R 4， / SUB>，Q，n，R 8，R 9，R 10和R 11已经被<！ - SIPO

3. 发明申请

WO1995000146A1 AMINO BI- AND TRI-CARBOCYCLIC ALKANE BIS-ARYL SQUALENE SYNTHASE INHIBITORS 审中-公开
标题翻译：氨基双 - 和三 - 碳环烷烃双 - 亚芳基磺酰基合成酶抑制剂
公开(公告)号：WO1995000146A1
公开(公告)日：1995-01-05
申请号：PCT/US1994007030
申请日：1994-06-23
申请人： RHONE-POULENC RORER PHARMACEUTICALS INC. , MORRIS, Robert, L. , NEUENSCHWANDER, Kent, W. , LEARN, Keith, S. , SCOTESE, Anthony, C.
发明人： RHONE-POULENC RORER PHARMACEUTICALS INC.
IPC分类号： A61K31/42
CPC分类号： C07D263/57
摘要： This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and tri-carbocyclic alkane ring contains an amino group and the ring is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
摘要翻译：本发明涉及一类具有双芳基取代的新型氨基双 - 和三 - 碳环烷烃化合物，其表现出角鲨烯合酶抑制性质。双 - 和三 - 碳环烷烃环包含一个氨基，并且该环进一步连接或桥连至两个单环和/或双环。本发明化合物降低体内血清胆固醇水平，而不显着降低甲羟戊酸代谢物合成。本发明还涉及使用本发明化合物降低血清胆固醇水平的药物组合物和治疗方法。

4. 发明申请

WO1992015579A1 MULTICYCLIC TERTIARY AMINE POLYAROMATIC SQUALENE SYNTHETASE INHIBITORS 审中-公开
标题翻译：多元醇胺多磺酸合成酶抑制剂
公开(公告)号：WO1992015579A1
公开(公告)日：1992-09-17
申请号：PCT/US1992001773
申请日：1992-03-03
申请人： RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. , NEUENSCHWANDER, Kent , AMIN, Dilip , SCOTESE, Anthony, C. , MORRIS, Robert, L.
发明人： RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC.
IPC分类号： C07D451/00
CPC分类号： C07D453/02
摘要： This invention relates to polycyclic compounds containing two mono and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
摘要翻译：本发明涉及含有两个单环和/或双环的多环化合物和能够在生物pH下形成铵离子的碱性叔氨基并且能降低体内血清胆固醇水平而不显着降低甲羟戊酸代谢物合成。本发明还涉及使用本发明化合物降低血清胆固醇水平的药物组合物和治疗方法。

5. 发明申请

WO2005058834A3 QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE 审中-公开
标题翻译：喹诺酮用于治疗心血管疾病
公开(公告)号：WO2005058834A3
公开(公告)日：2005-11-17
申请号：PCT/US2004041399
申请日：2004-12-10
申请人： WYETH CORP , COLLINI MICHAEL D , SINGHAUS ROBERT R JR , HU BAIHUA , JETTER JAMES W , MORRIS ROBERT L , KAUFMAN DAVID H , MILLER CHRISTOPHER P , ULLRICH JOHN W , UNWALLA RAYOMAND J , WROBEL JAY E , QUINET ELAINE , NAMBI PONNAL , BERNOTAS RONALD C , ELLOSO MERLE
发明人： COLLINI MICHAEL D , SINGHAUS ROBERT R JR , HU BAIHUA , JETTER JAMES W , MORRIS ROBERT L , KAUFMAN DAVID H , MILLER CHRISTOPHER P , ULLRICH JOHN W , UNWALLA RAYOMAND J , WROBEL JAY E , QUINET ELAINE , NAMBI PONNAL , BERNOTAS RONALD C , ELLOSO MERLE
IPC分类号： A61K31/47 , A61K31/4709 , C07D215/14 , C07D215/54 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12
CPC分类号： C07D401/04 , C07D215/14 , C07D215/54 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12
摘要： This invention provides compounds of formula (I) that are useful in the treatment or inhibition of LXR mediated diseases.
摘要翻译：本发明提供了可用于治疗或抑制LXR介导的疾病的式（I）化合物。

6. 发明申请

WO1995031458A1 3-HYDROXYQUINUCLIDIN-3-YLPHENYLQUINOLINES AS SQUALENE SYNTHASE INHIBITORS 审中-公开
标题翻译： 3-羟基喹啉-3-基苯乙烯醇作为平均合成酶抑制剂
公开(公告)号：WO1995031458A1
公开(公告)日：1995-11-23
申请号：PCT/US1994005451
申请日：1994-05-12
申请人： RHONE-POULENC RORER PHARMACEUTICALS INC. , NEUENSCHWANDER, Kent, W. , GRONEBERG, Robert, D. , MORRIS, Robert, L. , SCOTESE, Anthony, C. , MAGUIRE, Martin, P.
发明人： RHONE-POULENC RORER PHARMACEUTICALS INC.
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： This invention relates to a class of novel compounds useful in the treatment of diseases associated with undesirable cholesterol levels in the body, and particularly diseases of the cardiovascular system, such as atherosclerosis. The compounds of this invention are novel quinolinyl phenyl 3-hydroxyquinuclidines which may be linked directly or through a chain linking the quinolinyl to the phenyl and/or the phenyl to the quinuclidine. Compounds of this invention exhibit squalene synthase inhibition properties and reduce levels of serum cholesterol without significantly reducing mevalonic metabolite synthesis and thus provide a therapeutic agent having fewer side effects than agents which act by inhibiting the HMG-CoA reductase enzyme. Compounds of the present invention may also be useful in treating fungal infections. This invention further relates to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
摘要翻译：本发明涉及一类可用于治疗与身体不良胆固醇水平有关的疾病，特别是心血管系统疾病如动脉粥样硬化的新型化合物。本发明的化合物是可以直接或通过将喹啉基与苯基和/或苯基连接到奎宁环的链连接的新的喹啉基苯基3-羟基奎宁子。本发明的化合物显示出角鲨烯合成酶抑制性质并降低血清胆固醇水平，而不显着降低甲羟戊酸代谢物的合成，从而提供与通过抑制HMG-CoA还原酶起作用的药物相比具有较少副作用的治疗剂。本发明的化合物也可用于治疗真菌感染。本发明还涉及使用本发明化合物降低血清胆固醇水平的药物组合物和治疗方法。

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