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1. 发明申请

WO9907352A3 METHOD FOR PROMOTING EXPRESSION OF LDL RECEPTOR GENE 审中-公开
标题翻译：促进低密度脂蛋白受体基因表达的方法
公开(公告)号：WO9907352A3
公开(公告)日：1999-05-14
申请号：PCT/JP9803595
申请日：1998-08-12
申请人： SUMITOMO PHARMA , TULARIK INC , UENO YOSHIHIDE , MORISHITA KOJI , MURAOKA MASAMI , OHASHI NAOHITO , SHAN BEI
发明人： UENO YOSHIHIDE , MORISHITA KOJI , MURAOKA MASAMI , OHASHI NAOHITO , SHAN BEI
IPC分类号： C07D253/06 , A61K31/53 , A61P3/06 , A61P43/00 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14
CPC分类号： C07D253/07 , A61K31/53 , C07D401/04
摘要： Method of promoting expression of LDL receptor gene and an agent therefor, which comprises as an active ingredient a 1,2,4-triazin-5-one derivative of formula (I), wherein R is unsubstituted or substituted phenyl, unsubstituted or substituted heterocycle; R is unsubstituted or substituted phenyl, unsubstituted or substituted naphthyl, unsubstituted or substituted aralkyl, unsubstituted or substituted 5- to 6-membered aromatic heteromonocycle, unsubstituted or substituted C1-C6alkyl, or unsubstituted or substituted C2-C6alkenyl, or pharmaceutically acceptable salt thereof, said active compound (I) increasing the LDL receptor amount by promoting expression of LDL receptor gene (amount of mRNA), by which showing activity of reducing cholesterol level in the blood, and therefore being useful in the prophylaxis or treatment of hyperlipidemia.
摘要翻译：促进LDL受体基因表达的方法及其制剂，其包含作为活性成分的式（I）的1,2,4-三嗪-5-酮衍生物，其中R 1为未取代或取代的苯基，未取代的或取代的杂环; R 2是未取代或取代的苯基，未取代或取代的萘基，未取代或取代的芳烷基，未取代或取代的5至6元芳族杂单环，未取代或取代的C 1 -C 6烷基，或未取代或取代的C 2 -C 6烯基或药学上可接受的其盐，所述活性化合物（I）通过促进LDL受体基因的表达（mRNA的量）增加LDL受体量，通过其显示降低血液中胆固醇水平的活性，因此可用于预防或治疗高脂血症。

2. 发明申请

WO1993021497A1 APPARATUS FOR MEASURING DISTANCE 审中-公开
标题翻译：测量距离的装置
公开(公告)号：WO1993021497A1
公开(公告)日：1993-10-28
申请号：PCT/JP1993000462
申请日：1993-04-12
申请人： OMRON CORPORATION , MORISHITA, Koji , HIRAO, Iichi , HORII, Takayoshi , INOUE, Yuichi
发明人： OMRON CORPORATION
IPC分类号： G01C03/06
CPC分类号： G01C3/08 , G01S17/46
摘要： In an apparatus for measuring a distance by triangulation, according to the light-reception signal outputted from a position sensing device (PSD) (5), a computing circuit (11) generates a light quantity signal (A) representing an incident light quantity and a signal (B) representing the distance to an objective body. According to the light quantity signal (A), a circuit (13) for determining the light quantity generates signals (A1, A2) representing that the light quantity is an appropriate light quantity, an insufficient light quantity or an excessive light quantity. According to the distance signal (B), a circuit (14) for determining the distance generates signals (B1, B2, B3, B4) representing that the distance is in a measurement central region, a short-distance measurable region, a long-distance measurable region, a short-distance unmeasurable region, or a long-distance unmeasurable region. These signals (A1, A2, B1-B4) are given to a decoder and driver (15), and LEDs (7, 17, 8, 18) are driven. Thereby, displayed are the respective operational states of an appropriate light quantity in the central measuring region, an appropriate light quantity in the short distance or long-distance measurable region, an appropriate light quantity in the short-distance or long-distance unmeasurable region, and an abnormal light quantity.
摘要翻译：在通过三角测量测量距离的装置中，根据从位置检测装置（PSD）（5）输出的光接收信号，计算电路（11）产生表示入射光量的光量信号（A）表示到物体的距离的信号（B）。根据光量信号（A），用于确定光量的电路（13）产生表示光量是适当光量，光量不足或过量光量的信号（A1，A2）。根据距离信号（B），用于确定距离的电路（14）产生表示距离在测量中心区域中的信号（B1，B2，B3，B4），短距离可测量区域，距离可测量区域，短距离不可测量区域或远距离不可测量区域。这些信号（A1，A2，B1-B4）被提供给解码器和驱动器（15），并且驱动LED（7,17,8,18）。由此，显示中心测量区域中的适当光量，短距离或长距离可测量区域中的适当光量，短距离或长距离不可测量区域中的适当光量的各自的操作状态，和异常光量。

3. 发明申请

WO2011057082A2 A METHOD TO ENHANCE ENDURANCE 审中-公开
标题翻译：一种增强耐力的方法
公开(公告)号：WO2011057082A2
公开(公告)日：2011-05-12
申请号：PCT/US2010055638
申请日：2010-11-05
申请人： KYOWA HAKKO BIO CO LTD , OCHIAI MASAYUKI , MORISHITA KOJI , KOMATSU MIHO , HOFFMAN JAY R , RATAMESS NICHOLAS , KANG JIE , SUGIMURA KENTARO
发明人： OCHIAI MASAYUKI , MORISHITA KOJI , KOMATSU MIHO , HOFFMAN JAY R , RATAMESS NICHOLAS , KANG JIE , SUGIMURA YOICHIRO
IPC分类号： A61K31/198 , A61P3/00 , A61P3/04
CPC分类号： A61K38/05 , A61K31/198
摘要： The present invention relates to a method of enhancing endurance of a human subject through administration of alanyl-glutamine or alanyl-glutamine salt.
摘要翻译：本发明涉及一种通过施用丙氨酰 - 谷氨酰胺或丙氨酰 - 谷氨酰胺盐来增强人受试者耐力的方法。

4. 发明申请

WO2011057082A9 A METHOD TO ENHANCE ENDURANCE 审中-公开
公开(公告)号：WO2011057082A9
公开(公告)日：2011-05-12
申请号：PCT/US2010/055638
申请日：2010-11-05
申请人： KYOWA HAKKO BIO CO., LTD. , OCHIAI, Masayuki , MORISHITA, Koji , KOMATSU, Miho , HOFFMAN, Jay, R. , RATAMESS, Nicholas , KANG, Jie , SUGIMURA, Kentaro
发明人： OCHIAI, Masayuki , MORISHITA, Koji , KOMATSU, Miho , HOFFMAN, Jay, R. , RATAMESS, Nicholas , KANG, Jie
IPC分类号： A61K31/198 , A61P3/04 , A61P3/00

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