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1. 发明申请

WO2007049843A1 BIO-CHIP SCANNER 审中-公开
标题翻译：生物芯片扫描仪
公开(公告)号：WO2007049843A1
公开(公告)日：2007-05-03
申请号：PCT/KR2006/000921
申请日：2006-03-15
申请人： GOODGENE INC. , MOON, Woo-Chul
发明人： MOON, Woo-Chul
IPC分类号： C12Q1/68
CPC分类号： G01N21/6428 , G01N21/6452
摘要： There is provided a bio-chip scanner. A light source unit irradiates light of a specific wavelength onto a detecting position. A transfer unit transfers the bio-chip so that the light is irradiated onto a plurality of reference points separated by a predetermined distance from each other on the bio-chip. A detection unit is located above the detecting position and detects the light irradiated onto the reference points to output a plurality of images corresponding to the reference points. A focusing unit determines a focal length by averaging light intensities obtained from the images corresponding to the reference points input from the detection unit, and adjusts a focus corresponding to the bio-chip by transferring the detection unit upwardly or downwardly in accordance with the focal length. Accordingly, in the bio-chip scanner of the present invention, an automatic focus adjustment can be carried out to samples mounted on the bio-chip which has various surface tilt.
摘要翻译：提供了一个生物芯片扫描仪。光源单元将特定波长的光照射到检测位置。传送单元传送生物芯片，使得光在生物芯片上照射到彼此间隔开预定距离的多个参考点。检测单元位于检测位置上方，并且检测照射到参考点上的光以输出与参考点对应的多个图像。聚焦单元通过平均从与从检测单元输入的参考点相对应的图像获得的光强来确定焦距，并且通过根据焦距向上或向下传送检测单元来调整与生物芯片相对应的焦点。因此，在本发明的生物芯片扫描器中，可以对安装在具有各种表面倾斜的生物芯片上的样品进行自动聚焦调整。

2. 发明申请

WO2007049844A1 MULTI-CHANNEL BIO-CHIP SCANNER 审中-公开
标题翻译：多通道生物芯片扫描仪
公开(公告)号：WO2007049844A1
公开(公告)日：2007-05-03
申请号：PCT/KR2006/000949
申请日：2006-03-16
申请人： GOODGENE INC. , MOON, Woo-chul
发明人： MOON, Woo-chul
IPC分类号： C12Q1/68
CPC分类号： G01N21/6428 , G01N21/6452 , G01N2021/6419
摘要： There is provided a multi-channel bio-chip scanner using two or more excitation wavelengths. The bio-chip scanner includes: a glass holder unit mounted with a bio-chip in which a target DNA pre-marked by a fluorescent material is hybridized with a probe DNA; a light source unit irradiating a laser beam onto the bio-chip; a transfer unit transferring the bio-chip from the glass holder unit; and a detection unit detecting and analyzing fluorescent light expressed by the bio-chip with irradiation of the laser beam, wherein the light source unit generates two or more laser beams having different wavelengths.
摘要翻译：提供了使用两个或更多个激发波长的多通道生物芯片扫描器。生物芯片扫描器包括：安装有生物芯片的玻璃保持器单元，其中由荧光材料预先标记的靶DNA与探针DNA杂交; 将激光束照射到所述生物芯片上的光源单元; 转移单元，从所述玻璃保持器单元转移所述生物芯片; 以及检测单元，其通过所述激光束的照射来检测和分析由所述生物芯片表示的荧光，其中所述光源单元产生具有不同波长的两个或更多个激光束。

3. 发明申请

WO2010062001A1 DNA CHIP, KIT FOR DETECTING OR GENOTYPING BACTERIA CAUSING SEXUALLY TRANSMITTED DISEASES, GENOTYPING ANTIBACTERIAL DRUG RESISTANCE AND DETECTING OR GENOTYPING METHOD USING THE SAME 审中-公开
标题翻译： DNA芯片，用于检测或基因治疗细菌引起多发性疾病的基因组，基因治疗抗生素耐药性及使用其的检测或基因治疗方法
公开(公告)号：WO2010062001A1
公开(公告)日：2010-06-03
申请号：PCT/KR2008/007492
申请日：2008-12-17
申请人： GOODGENE INC. , MOON, Woo Chul
发明人： MOON, Woo Chul
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6837 , C12Q2600/156 , C12Q2600/16
摘要： Disclosed are a DNA chip and a kit capable of quickly and accurately detecting or genotyping the highly prevalent and important eleven microbes causing sexually transmitted diseases (STD) Neisseria gonorrhoeae , Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma genitalium, Mycoplasma hominis , syphilis-causing t reponema, pallidum, chancroid-causing Haemophilus ducreyi , genital herpes-causing herpes simplex virus 1 and 2, human papillomavirus (HPV) and Trichomonas vaginalis and three related organisms Candida albicans, Gardnerella vaginalis and coliform bacteria and analyzing antibiotic resistance against tetracycline and lactam antibiotics, and a method for detecting or genotyping using the same. According to the present invention, the presence, genotype and antibiotic resistance of the fourteen organisms can be analyzed quickly and accurately from a DNA sample. With excellent sensitivity, specificity, reproducibility and accuracy of the 14 STD-causing and related microorganisms may be automatically identified quickly and accurately from multiple samples, and selection of antibiotics may be aided.
摘要翻译：公开了能够快速准确地检测或基因分型引起性传播疾病（STD）淋病奈瑟氏球菌，沙眼衣原体，解脲支原体，生殖支原体，人支原体，引起梅毒的梅毒螺旋体的DNA芯片和试剂盒，苍白球，致引起流感嗜血杆菌，生殖器疱疹单纯疱疹病毒1和2，人乳头状瘤病毒（HPV）和阴道毛滴虫和三种相关生物体白色念珠菌，阴道加德纳菌和大肠杆菌，分析抗四环素和内酰胺抗生素的抗生素抗性，一种使用其检测或基因分型的方法。根据本发明，可以从DNA样品中快速准确地分析14种生物体的存在，基因型和抗生素抗性。具有良好的灵敏度，特异性，重现性和14 STD引起和相关微生物的准确性可以从多个样品中快速准确地自动识别，并且可以帮助选择抗生素。

4. 发明申请

WO2009123373A1 NEW SKIN SAMPLING KIT WHICH STORES NUCLEIC ACIDS IN STABLE STATUS, GENETIC TEST METHODS BY USING THE KIT AND THEIR PRACTICAL APPLICATION 审中-公开
标题翻译：新型皮肤采样工具，以稳定的状态存储核酸，通过使用试剂盒及其实际应用的遗传测试方法
公开(公告)号：WO2009123373A1
公开(公告)日：2009-10-08
申请号：PCT/KR2008/001917
申请日：2008-04-04
申请人： GOODGENE INC. , MOON, Woo Chul , LEE, Jin yung , PARK, Keun Yang , SHIN, Jung Sik
发明人： MOON, Woo Chul , LEE, Jin yung , PARK, Keun Yang , SHIN, Jung Sik
IPC分类号： C12Q1/68
CPC分类号： A61B10/02
摘要： The present invention relates to a new skin gene card for genetic test, a method for acquiring DNA and RNA and performing various genetic tests using the same, and practical applications thereof. More specifically, the inventors of the present invention have developed a skin gene card capable of acquiring samples from human skin, hair or mucosa simply, safely and quickly and enabling stable long-term storage and transport of DNA and RNA included in the acquired sample at room temperature. Various genetic tests may performed using the acquired DNA and RNA, including polymerase chain reaction (PCR), reverse transcription (RT)-PCR, real-time PCR, sequencing, hybridization, DNA chip analysis, single-nucleotide polymorphism (SNP) assay, gene mutation assay, promoter methylation assay, gene expression assay, etc. The genetic skin test result may be utilized for disease prognosis, nutrigenomic test, pharmacogenomic test, forensic test such as personal identification, diagnosis of genetic diseases, diagnosis of skin diseases, or the like. In addition, through an objective evaluation of the skin or hair condition, a personalized cosmetic and skin care system may be established for practical application in beauty care, cosmetology, dermatology, and clinical practice.
摘要翻译：本发明涉及一种用于遗传检测的新皮肤基因卡，一种获取DNA和RNA并使用该皮肤基因卡进行各种遗传检测的方法及其实际应用。更具体地说，本发明的发明人开发出能够简单，安全，快速地从人体皮肤，毛发或粘膜中获取样品的皮肤基因卡，并使获得的样品中包含的DNA和RNA能够稳定地长期储存和转运室内温度。使用获得的DNA和RNA进行各种遗传检测，包括聚合酶链反应（PCR），逆转录（RT）-PCR，实时PCR，测序，杂交，DNA芯片分析，单核苷酸多态性（SNP）基因突变测定，启动子甲基化测定，基因表达测定等。遗传性皮肤试验结果可用于疾病预后，营养基因组检测，药物基因组学检测，法医鉴定，遗传疾病诊断，皮肤病诊断或类似。此外，通过对皮肤或毛发状况的客观评价，可以建立个性化的化妆品和皮肤护理系统，用于美容护理，美容，皮肤病学和临床实践中的实际应用。

5. 发明申请

WO2006038752A1 PROBE OF BACTERIA CAUSING SEXUALLY TRANSMITTED DISEASES, DNA CHIP AND GENOTYPING KIT 审中-公开
标题翻译：引起细菌性传染性疾病的细菌探针，DNA芯片和基因工具包
公开(公告)号：WO2006038752A1
公开(公告)日：2006-04-13
申请号：PCT/KR2005/000773
申请日：2005-03-17
申请人： GOODGENE INC. , MOON, Woo-Chul , OH, Myung-Ryurl , KO, Jung-Eun , PARK, Min-Koo , LEE, Jin-Sun , JANG, Eun-Ju
发明人： MOON, Woo-Chul , OH, Myung-Ryurl , KO, Jung-Eun , PARK, Min-Koo , LEE, Jin-Sun , JANG, Eun-Ju
IPC分类号： C12N15/11
CPC分类号： C12Q1/6883 , C12Q1/689 , C12Q2600/16
摘要： A DNA chip and a genotyping kit for diagnosis with quickness and accuracy of infection with the four most frequent outbreaks among sexually transmitted disease (STD) pathogens such as Neisseria gonorrhoeae, Chlamydiae trachomatis, Ureaplasma urealyticum, Mycoplasma genitalium, and an oligonucleotide probe used therein are provided. The DNA chip and the genotyping kit is excellent in sensitivity, specificity and reproducibility in diagnosis of STD, and they are effective in automated analysis with quickness of four types of bacteria in various samples.
摘要翻译：性传播疾病（STD）病原体如淋病奈瑟氏球菌，沙眼衣原体，解脲支原体，生殖支原体及其中使用的寡核苷酸探针等四种最常见的病原体感染的快速和准确性的DNA芯片和基因分型试剂盒。提供。 DNA芯片和基因分型试剂盒在STD诊断中的灵敏度，特异性和重复性都很好，它们在各种样品中四种细菌的快速自动化分析中都是有效的。

6. 发明申请

WO2006038753A1 PROBE OF HUMAN PAPILLOMAVIRUS AND DNA CHIP COMPRISING THE SAME 审中-公开
标题翻译：人乳头瘤病毒探针和包含其的DNA芯片
公开(公告)号：WO2006038753A1
公开(公告)日：2006-04-13
申请号：PCT/KR2005/000775
申请日：2005-03-18
申请人： GOODGENE INC. , MOON, Woo-Chul , OH, Myung-Ryurl , YIM, Su-Bin , EUM, Tae-Han , JUNG, Eun-Hae , KO, Jung-Eun , BAE, Jae-Han
发明人： MOON, Woo-Chul , OH, Myung-Ryurl , YIM, Su-Bin , EUM, Tae-Han , JUNG, Eun-Hae , KO, Jung-Eun , BAE, Jae-Han
IPC分类号： C12N15/11
CPC分类号： C12Q1/708
摘要： Oligonucleotide probes for analyzing 40 types of HPV were synthesized, and DNA chips were produced by using the oligonucleotide probes. The synthesis of the oligonucleotide probes is based on clones of Ll and E6/E7 genes of 35 types of HPV obtained from cervical cell specimens from 4,898 Korean adult women and tissue specimens from 68 cervical cancer cases in addition to information based on American and European cases. The DNA chips can analyze the 40 types of HPV found in cervical, diagnose complex infection by at least one type of HPV, and have excellent diagnostic sensitivity and specificity on HPV genetic type up to 100% and reproducibility. Also, the DAN chips are superior to conventional analytic method, and very economical, since they can analyze numerous specimens in shortest time. Accordingly, the DNA chips are useful for predicting cervical cancer and precancerous lesion.
摘要翻译：合成分析40种HPV的寡核苷酸探针，并用寡核苷酸探针制备DNA芯片。寡核苷酸探针的合成基于来自4,898名韩国成年妇女的宫颈细胞标本获得的35种HPV的L1和E6 / E7基因的克隆，以及来自68个宫颈癌病例的组织标本以及基于美国和欧洲病例的信息。 DNA芯片可以分析宫颈发现的40种HPV，通过至少一种HPV诊断复杂感染，对HPV遗传型的诊断敏感性和特异性高达100％，具有重复性。此外，DAN芯片优于常规分析方法，非常经济，因为它们可以在最短时间内分析多个样品。因此，DNA芯片可用于预测子宫颈癌和癌前病变。

7. 发明申请

WO2006028323A1 METHOD FOR STORING DNA BY USING CHITOSAN, AND PRODUCTS USING THE METHODS 审中-公开
标题翻译：通过使用壳聚糖和使用该方法的产品来储存DNA的方法
公开(公告)号：WO2006028323A1
公开(公告)日：2006-03-16
申请号：PCT/KR2005/000774
申请日：2005-03-18
申请人： GOODGENE INC. , MOON, Woo-Chul , OH, Myung-Ryurl , YIM, Su-Bin , EUM, Tae-Han , LEE, Mi-Ae , JEON, Bu-Il
发明人： MOON, Woo-Chul , OH, Myung-Ryurl , YIM, Su-Bin , EUM, Tae-Han , LEE, Mi-Ae , JEON, Bu-Il
IPC分类号： C12N15/00
CPC分类号： C12Q1/6806 , C12N15/1003 , C12Q2527/125
摘要： If DNA of human, animal, plant or bacteria, or a bio-sample containing DNA such as blood is well mixed with a water-soluble chitosan, and stored as a liquid state or a solid state using a solid medium such as a paper, it is possible to store DNA stably at room temperature for a long time, and it is also useful for a gene assay henceforth. The DNA storage method is simple and economical, and a product prepared by applying the method such as a DNA card and a PCR kit can store, carry and collect multiple DNA samples, and it is also very useful for an automatic assay. In addition, the DNA ID card can play a role of DNA bank which stores personal DNAs, and it is helpful for personal identification and medical treatment by storing the personal genetic information as well.
摘要翻译：如果人，动物，植物或细菌的DNA或含有DNA的生物样品如血液与水溶性壳聚糖充分混合，并使用诸如纸的固体培养基作为液体状态或固态储存，可以长时间在室温下稳定存储DNA，此后也可用于基因测定。 DNA存储方法简单经济，通过应用DNA卡和PCR试剂盒等方法制备的产品可以存储，携带和收集多个DNA样品，对自动测定也非常有用。此外，DNA身份证可以起到存储个人DNA的DNA库的作用，也可以通过存储个人遗传信息对个人身份识别和医疗进行处理。

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