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1. 发明申请

WO2019222105A1 SMALL MOLECULE INHIBITORS OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER 审中-公开
公开(公告)号：WO2019222105A1
公开(公告)日：2019-11-21
申请号：PCT/US2019/032033
申请日：2019-05-13
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , WIPF, Peter , JOHNSON, James K. , SKODA, Erin M. , NELSON, Joel B. , WANG, Zhou , TAI, Serene , TAKUBO, Keita , MILLIGAN, John
发明人： WIPF, Peter , JOHNSON, James K. , SKODA, Erin M. , NELSON, Joel B. , WANG, Zhou , TAI, Serene , TAKUBO, Keita , MILLIGAN, John
IPC分类号： C07D295/185 , C07D209/52 , C07C49/563 , C07D409/02 , C07D207/06 , C07D207/08 , C07D233/61 , C07D487/04 , A61K31/12 , A61K31/165 , A61K31/40 , A61K31/403 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/498 , A61P35/00
摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R 20 –(Z) b –(Y) c –(R 21 ) a –(X) d –R 22 –R 23 wherein R 20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(=O), –S(=O)(=O)-, or NR 10 , wherein R 10 is H or alkyl; R 21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is ‑C(=O)-, ‑S(=O)(=O)-, or–N(H)C(=O)-; R 22 includes at least one divalent amino radical; R 23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.

2. 发明申请

WO2016046331A2 A HELMET AND A LIGHTING SYSTEM FOR A HELMET 审中-公开
标题翻译：一个HELMET和一个照明系统的HELMET
公开(公告)号：WO2016046331A2
公开(公告)日：2016-03-31
申请号：PCT/EP2015072009
申请日：2015-09-24
申请人： MILLIGAN JOHN , ERWIN WILLIAM ALEXANDER
发明人： MILLIGAN JOHN
IPC分类号： A42B3/04
CPC分类号： F21V23/045 , A42B3/044 , A42B3/0453 , B60Q1/2676 , B60Q1/34 , B60Q1/44 , F21V23/008 , F21V23/0492 , F21W2111/10 , H05B33/0803 , H05B33/0806 , H05B37/0236 , H05B37/0272
摘要： The present invention relates to a lighting system for a helmet of the type worn by a user of a vehicle, such as a motorbike, bicycle, moped or scooter. The system comprises an arrangement of a helmet and a vehicle mounted controller unit and transceiver means, the helmet mounting lighting functions comprising including left and right turning indicator lights, a brake light, and down light means and having a helmet mounted controller unit in communication with the lighting functions. The vehicle mounted controller unit is operable to generate triggering signals, and a transceiver means mounted to the vehicle is provided for transmission of the triggering signals to helmet mounted transceiver means, such that the helmet mounted controller unit is operable to activate lighting functions of the helmet in response to the triggering signals received by the helmet mounted transceiver means. The present invention further relates to a helmet comprising voice activated lighting functions.
摘要翻译：本发明涉及一种用于诸如摩托车，自行车，轻便摩托车或踏板车的车辆用户所佩戴的头盔的照明系统。该系统包括头盔和车载控制器单元和收发器装置的布置，头盔安装照明功能包括左右转向指示灯，制动灯和降灯装置，并具有与头盔安装的控制器单元通信照明功能。车载控制器单元可操作以产生触发信号，并且提供安装到车辆的收发器装置用于将触发信号传输到头盔安装的收发器装置，使得头盔安装的控制器单元可操作以激活头盔的照明功能响应于由头盔安装的收发器装置接收的触发信号。本发明还涉及一种包括声音激活照明功能的头盔。

3. 发明申请

WO2006069383A3 TIME ATTENDANCE CLOCK AND SYSTEM 审中-公开
标题翻译：时间出席时间和系统
公开(公告)号：WO2006069383A3
公开(公告)日：2007-10-18
申请号：PCT/US2005047136
申请日：2005-12-22
申请人： EXAKTIME INC , PAPPAS ANTHONY HENRYK , PREWETT SCOTT K , MILLIGAN JOHN L , KARTEN STUART A , DORAN VALERIA L
发明人： PAPPAS ANTHONY HENRYK , PREWETT SCOTT K , MILLIGAN JOHN L , KARTEN STUART A , DORAN VALERIA L
IPC分类号： G04B47/00
CPC分类号： G07C1/10
摘要： A time attendance system, including a time attendance clock, designed to be used in harsh conditions, such as outdoor job sites. A portable touch button, including a passively readable code, is brought into contact with the time attendance clock so as to create a time attendance record stored in the clock. Visual indicators and audible notification alert the employee of the acceptance of the act. Periodically, the time attendance records are retrieved from the time attendance clock, such as by using a hand-held electronic device which communicates in a wireless manner with the time attendance clock.
摘要翻译：一个考勤系统，包括一个设计在恶劣条件下使用的考勤时钟，如户外工作现场。包括被动读取代码的便携式触摸按钮与考勤时钟接触，以便创建存储在时钟中的考勤记录。视觉指标和听觉通知提醒员工接受该行为。周期性地，从考勤时钟检索考勤记录，例如通过使用以无线方式与考勤时钟进行通信的手持式电子设备。

4. 发明申请

WO2008127357A2 UPFLOW BIOREACTOR WITH SEPTUM AND PRESSURE RELEASE MECHANISM 审中-公开
标题翻译：具有压力和压力释放机制的UPFLOW生物反应器
公开(公告)号：WO2008127357A2
公开(公告)日：2008-10-23
申请号：PCT/US2007/080894
申请日：2007-10-10
申请人： UTAH STATE UNIVERSITY , HANSEN, Conly, L. , HANSEN, Carl, S. , PACK, Kevin , MILLIGAN, John , BENEFIEL, Bradley, C. , TOLMAN, Wayne, C. , TOLMAN, Kenneth, W.
发明人： HANSEN, Conly, L. , HANSEN, Carl, S. , PACK, Kevin , MILLIGAN, John , BENEFIEL, Bradley, C. , TOLMAN, Wayne, C. , TOLMAN, Kenneth, W.
IPC分类号： C02F3/12 , C02F9/00
CPC分类号： C02F3/2846 , C02F3/2886 , C02F2103/005 , C02F2103/20 , C12M21/04 , C12M21/16 , C12M23/34 , C12M29/02 , C12M33/16 , C12M33/20
摘要： An upflow bioreactor includes a vessel having an inlet and an outlet configured for upflow operation. A septum is positioned within the vessel and defines a lower chamber and an upper chamber. The septum includes an aperture that provides fluid communication between the upper chamber and lower chamber. The bioreactor also includes means for releasing pressure buildup in the lower chamber. In one configuration, the septum includes a releasable portion having an open position and a closed position. The releasable portion is configured to move to the open position in response to pressure buildup in the lower chamber. In the open position fluid communication between the lower chamber and the upper chamber is increased. Alternatively the lower chamber can include a pressure release line that is selectively actuated by pressure buildup. The pressure release mechanism can prevent the bioreactor from plugging and/or prevent catastrophic damage to the bioreactor caused by high pressures.
摘要翻译：上流式生物反应器包括具有入口和出口的容器，其构造成用于上流操作。隔膜位于容器内并限定下腔室和上腔室。隔膜包括在上室和下室之间提供流体连通的孔。生物反应器还包括用于释放下室中的压力累积的装置。在一种构造中，隔膜包括具有打开位置和闭合位置的可释放部分。可释放部分构造成响应于下室中的压力积累而移动到打开位置。在打开位置，下腔和上腔之间的流体连通增加。或者，下室可以包括通过压力累积选择性地致动的压力释放管线。压力释放机构可以防止生物反应器堵塞和/或防止由高压引起的生物反应器的灾难性损坏。

5. 发明申请

WO1991005588A1 COMPOSITE GOLF CLUB 审中-公开
标题翻译：复合高尔夫俱乐部
公开(公告)号：WO1991005588A1
公开(公告)日：1991-05-02
申请号：PCT/GB1990001535
申请日：1990-10-05
申请人： MILLIGAN, John, Reid
IPC分类号： A63B53/00
CPC分类号： A63B60/20 , A63B53/00
摘要： A single composite golf club (1) suitable for the pitching and putting of golf balls (9) comprising an elongate shaft (2) provided with, at respective ends (8 and 12), a putting head (4) suitable for use in the putting of golf balls (9) and a head (3) with a lofted contact face (10) suitable for the pitching of golf balls (9). The shaft (2) is provided with hand grips (5 and 6) at each end.

6. 发明申请

WO2017165822A1 SMALL MOLECULE INHIBITOR OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER 审中-公开
标题翻译：小分子抑制剂治疗抗雌激素前列腺癌的核移植雄激素受体
公开(公告)号：WO2017165822A1
公开(公告)日：2017-09-28
申请号：PCT/US2017/024105
申请日：2017-03-24
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , TAI, Serene , TAKUBO, Keita , MILLIGAN, John
发明人： TAI, Serene , TAKUBO, Keita , MILLIGAN, John , WIPF, Peter , JOHNSON, James, K. , SKODA, Erin, M. , NELSON, Joel, B. , WANG, Zhou
IPC分类号： C07D295/185 , C07D403/04 , C07D413/12 , C07D451/02 , C07D409/08 , C07D407/04 , C07D403/06 , C07D401/08 , C07D405/06 , C07D487/04 , C07D217/16 , C07C49/563 , A61K31/495 , A61K31/496 , A61K31/42 , A61K31/445 , A61K31/46 , A61K31/498 , A61K31/12 , A61K31/407 , A61K31/435 , A61K31/47 , A61P35/00
摘要： A compound, or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, according to formula (III) or according to Table A, a pharmaceutical composition comprising said compound and at least one pharmaceutically acceptable additive, and a method for treating prostate cancer in a subject, comprising administering to the subject a therapeutically effective amount of said compound.
摘要翻译：根据式（III）或根据表A的化合物或其立体异构体，药学上可接受的盐或酯，包含所述化合物和至少一种药学上可接受的添加剂的药物组合物，以及治疗受试者中的前列腺癌的方法，包括给予受试者治疗有效量的所述化合物。

7. 发明申请

WO2016046331A3 A HELMET AND A LIGHTING SYSTEM FOR A HELMET 审中-公开
公开(公告)号：WO2016046331A3
公开(公告)日：2016-03-31
申请号：PCT/EP2015/072009
申请日：2015-09-24
申请人： MILLIGAN, John , ERWIN, William Alexander
发明人： MILLIGAN, John
IPC分类号： A42B3/04
摘要： The present invention relates to a lighting system (100) for a helmet (1) of the type worn by a user of a vehicle, such as a motorbike, bicycle, moped or scooter. The system comprises an arrangement of a helmet and a vehicle mounted controller unit and transceiver means (110, 120, 130), the helmet mounting lighting functions comprising including left and right turning indicator lights (4), a brake light (5), and down light means (6) and having a helmet mounted controller unit in communication with the lighting functions. The vehicle mounted controller unit is operable to generate triggering signals, and a transceiver means mounted to the vehicle is provided for transmission of the triggering signals to helmet mounted transceiver means, such that the helmet mounted controller unit is operable to activate lighting functions of the helmet in response to the triggering signals received by the helmet mounted transceiver means. The present invention further relates to a helmet comprising voice activated lighting functions.

8. 发明申请

WO2008127357A3 UPFLOW BIOREACTOR WITH SEPTUM AND PRESSURE RELEASE MECHANISM 审中-公开
标题翻译：具有压力和压力释放机制的UPFLOW生物反应器
公开(公告)号：WO2008127357A3
公开(公告)日：2008-12-18
申请号：PCT/US2007080894
申请日：2007-10-10
申请人： UNIV UTAH STATE , HANSEN CONLY L , HANSEN CARL S , PACK KEVIN , MILLIGAN JOHN , BENEFIEL BRADLEY C , TOLMAN WAYNE C , TOLMAN KENNETH W
发明人： HANSEN CONLY L , HANSEN CARL S , PACK KEVIN , MILLIGAN JOHN , BENEFIEL BRADLEY C , TOLMAN WAYNE C , TOLMAN KENNETH W
IPC分类号： C02F3/00
CPC分类号： C02F3/2846 , C02F3/2886 , C02F2103/005 , C02F2103/20 , C12M21/04 , C12M21/16 , C12M23/34 , C12M29/02 , C12M33/16 , C12M33/20
摘要： An upflow bioreactor includes a vessel having an inlet and an outlet configured for upflow operation. A septum in the vessel defines a lower and an upper chamber. The septum includes an aperture for fluid communication between the chambers. The bioreactor includes means for releasing pressure buildup in the lower chamber. The septum can include a releasable portion having open and closed positions. The releasable portion moves to the open position in response to pressure buildup in the lower chamber. In the open position fluid communication between the chambers Is increased. Alternatively the lower chamber can include a pressure release line that Is selectively actuated by pressure buildup. The pressure release mechanism can prevent the bioreactor from plugging and/or prevent catastrophic damage to the bioreactor caused by high pressures.
摘要翻译：上流式生物反应器包括具有入口和出口的容器，其构造成用于上流操作。容器中的隔膜限定下室和上室。隔膜包括用于腔室之间的流体连通的孔。生物反应器包括用于释放下室中的压力累积的装置。隔膜可以包括具有打开和关闭位置的可释放部分。可释放部分响应于下室中的压力积累而移动到打开位置。在打开位置，腔室之间的流体连通增加。或者，下室可以包括通过压力积聚选择性地致动的压力释放管线。压力释放机构可以防止生物反应器堵塞和/或防止由高压引起的生物反应器的灾难性损坏。

9. 发明申请

WO2009155429A1 AUTOMATED MAT CLEANING AND HANDLING SYSTEM AND METHOD 审中-公开
标题翻译：自动磨床和处理系统及方法
公开(公告)号：WO2009155429A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/047812
申请日：2009-06-18
申请人： CINTAS CORPORATION , COTTER, Robert , POUND, Randy , MILLIGAN, John
发明人： COTTER, Robert , POUND, Randy , MILLIGAN, John
IPC分类号： A47L13/00
CPC分类号： D06G1/00 , D06F31/00
摘要： An automated system is configured to wash and dry mats. The system includes a number of modules, including a loading module, vibration module, washing module, vacuum module, and a discharge module. The disclosed system provides an opportunity for manual inspection of the mats, too. Because the mats that are fed into the system are jostled or shaken before they are washed, reduced amounts of chemicals, water, water pressure, drying energy, etc. are needed to clean the mats. The system may also optionally include a automatic rolling and sorting apparatus, which rolls a mat and sorts it according to weight, size, etc. after it is discharged from the discharge module. A method of cleaning mats is also disclosed.
摘要翻译：自动化系统被配置为洗涤和干燥垫子。该系统包括多个模块，包括加载模块，振动模块，清洗模块，真空模块和放电模块。所公开的系统也提供了用于手动检查垫子的机会。因为在洗涤之前将进料到系统中的垫子被推挤或摇动，所以需要减少化学品的量，水，水压，干燥能等来清洁垫子。该系统还可以任选地包括一个自动轧制和分选设备，该自动轧制和分选设备在从排出模块排出之后，滚动垫子并根据重量，尺寸等进行分类。还公开了一种清洁垫的方法。

10. 发明申请

WO2006069383A2 TIME ATTENDANCE CLOCK AND SYSTEM 审中-公开
标题翻译：时间出席时间和系统
公开(公告)号：WO2006069383A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/047136
申请日：2005-12-22
申请人： EXAKTIME, INC. , PAPPAS, Anthony Henryk , PREWETT, Scott K. , MILLIGAN, John L. , KARTEN, Stuart A. , DORAN, Valeria L.
发明人： PAPPAS, Anthony Henryk , PREWETT, Scott K. , MILLIGAN, John L. , KARTEN, Stuart A. , DORAN, Valeria L.
IPC分类号： G04B47/00
CPC分类号： G07C1/10
摘要： A time attendance system, including a time attendance clock, designed to be used in harsh conditions, such as outdoor job sites. A portable touch button, including a passively readable code, is brought into contact with the time attendance clock so as to create a time attendance record stored in the clock. Visual indicators and audible notification alert the employee of the acceptance of the act. Periodically, the time attendance records are retrieved from the time attendance clock, such as by using a hand-held electronic device which communicates in a wireless manner with the time attendance clock.
摘要翻译：一个考勤系统，包括一个设计在恶劣条件下使用的考勤时钟，如户外工作现场。包括被动读取代码的便携式触摸按钮与考勤时钟接触，以便创建存储在时钟中的考勤记录。视觉指标和听觉通知提醒员工接受该行为。周期性地，从考勤时钟检索考勤记录，例如通过使用以无线方式与考勤时钟进行通信的手持式电子设备。

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