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1. 发明申请

WO2010061165A1 COUPLER WITH COUPLING STATUS SENSORS 审中-公开
标题翻译：联轴器状态传感器
公开(公告)号：WO2010061165A1
公开(公告)日：2010-06-03
申请号：PCT/GB2009/002602
申请日：2009-11-03
申请人： MILLER INTERNATIONAL LIMITED , MILLER, Gary , MILLER, Ronald, Keith , MILLER, Doreen, Jacqueline
发明人： MILLER, Gary , MILLER, Ronald, Keith , MILLER, Doreen, Jacqueline
IPC分类号： E02F3/36 , E02F9/24
CPC分类号： E02F3/3663 , E02F3/365 , E02F9/26 , Y10T403/20
摘要： A coupler (24) for coupling an accessory (28) to an excavator arm (12) of an excavator (10), the coupler comprising a first jaw (30) that points in a generally longitudinal direction relative to the frame of the coupler (24), the jaw (30) being for receiving a first attachment pin of an accessory (28) and having a first sensor (40) for detecting the presence of an attachment pin therein, the coupler (24) further having a second jaw (32), or a latch (34), longitudinally spaced from the first jaw (30), and being for receiving a second attachment pin of the accessory (28), and having a second sensor (42) for detecting the presence of an attachment pin therein. The sensors (40, 42) transmit or send signals to a receiver (46, 48) for notifying the driver of the coupling status of the coupler (24) with respect to the accessory (28).
摘要翻译：一种用于将附件（28）联接到挖掘机（10）的挖掘机臂（12）的联接器（24），所述联接器包括相对于联接器的框架指向大致纵向的第一钳口（30） 24），用于接收附件（28）的第一附接销并具有用于检测其中存在附接销的第一传感器（40）的钳口（30），所述联接器（24）还具有第二钳口 32）或与第一钳口（30）纵向间隔开的闩锁（34），并且用于接收附件（28）的第二附接销，并且具有用于检测附件（28）的存在的第二传感器（42）销在其中。传感器（40,42）向接收器（46,48）发送或发送信号，用于通知驾驶员联接器（24）相对于附件（28）的联接状态。

2. 发明申请

WO2013050310A1 METHODS FOR THE PREPARATION OF 5-[2-[7-(TRIFLUOROMETHYL)-5-[4-(TRIFLUOROMETHYL)PHENYL]PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]ETHYNYL]-2-PYRIDINAMINE 审中-公开
标题翻译：制备5- [2- [7-（三氟甲基）-5- [4-（三氟甲基）苯基]吡唑并[1,5-A]嘧啶-3-基]乙基] -2-吡啶胺的方法
公开(公告)号：WO2013050310A1
公开(公告)日：2013-04-11
申请号：PCT/EP2012/069303
申请日：2012-10-01
申请人： F. HOFFMANN-LA ROCHE AG , BACHMANN, Stephan , BAILEY, Daniel , BRICE, Jodie , CEDILOTE, Miall , DONG, Zhiming , HILDBRAND, Stefan , MILLER, Doreen , SPURR, Paul , SRIVASTAVA, Amit , WICHMANN, Juergen , WOLTERING, Thomas , YANG, Jason , ZHANG, Pingsheng
发明人： BACHMANN, Stephan , BAILEY, Daniel , BRICE, Jodie , CEDILOTE, Miall , DONG, Zhiming , HILDBRAND, Stefan , MILLER, Doreen , SPURR, Paul , SRIVASTAVA, Amit , WICHMANN, Juergen , WOLTERING, Thomas , YANG, Jason , ZHANG, Pingsheng
IPC分类号： C07D487/04 , C07D213/73
CPC分类号： C07D487/04 , C07D213/73 , Y02P20/55
摘要： The present invention provides methods for preparing 5-[2-[7-(trifluoromethyl)-5-[4(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]-2-pyridinamine (compound A), which is useful for the treatment of depression and other CNS disorders. The present methods are useful for preparing compound A on large scale in manufacturing facilities.
摘要翻译：本发明提供了制备5- [2- [7-（三氟甲基）-5- [4-（三氟甲基）苯基]吡唑并[1,5-a]嘧啶-3-基]乙炔基] -2-吡啶胺（化合物 A），其可用于治疗抑郁症和其他CNS疾病。本发明的方法可用于在制造设备中大量制备化合物A.

3. 发明申请

WO2008074697A1 POLYMORPHS OF A MGLUR5 RECEPTOR ANTAGONIST 审中-公开
标题翻译： MGLUR5受体拮抗剂的多聚体
公开(公告)号：WO2008074697A1
公开(公告)日：2008-06-26
申请号：PCT/EP2007/063721
申请日：2007-12-11
申请人： F. HOFFMANN-LA ROCHE AG , CLEARY, Thomas P. , GLOMME, Alexander , GRASSMANN, Olaf , KUANG, Shan-Ming , MEIER, Roland , MILLER, Doreen , MOOG, Regina , ROHRER, Franziska E. , YANG, Jason
发明人： CLEARY, Thomas P. , GLOMME, Alexander , GRASSMANN, Olaf , KUANG, Shan-Ming , MEIER, Roland , MILLER, Doreen , MOOG, Regina , ROHRER, Franziska E. , YANG, Jason
IPC分类号： C07D401/06 , A61K31/4439 , A61P25/00
CPC分类号： C07D401/06
摘要： Present invention relates to mono-sulfate and hemi-sulfate salts of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine, to crystalline and amorphous forms thereof and to their use in pharmaceutical formulations. Present compounds are active on the mGluR5 receptor for the treatment of diseases, related to this receptor, such acute and/or chronic neurological disorders, in particular anxiety, or for the treatment of chronic and acute pain, protection against liver damage, failure whether drug or disease induced, urinary incontinence, obesity, Fragile-X or Autism.
摘要翻译：本发明涉及2-氯-4- [1-（4-氟 - 苯基）-2,5-二甲基-1H-咪唑-4-基乙炔基] - 吡啶的一硫酸盐和半硫酸盐，结晶和其无定形形式及其在药物制剂中的用途。本发明化合物在mGluR5受体上具有活性，用于治疗与该受体相关的疾病，如急性和/或慢性神经障碍，特别是焦虑症，或用于治疗慢性和急性疼痛，保护肝损伤，药物是否失效或疾病诱发，尿失禁，肥胖，脆性X或自闭症。

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