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1. 发明申请

WO2018067165A1 ENGINEERED ONCOLYTIC VIRUSES CONTAINING HYPER-BINDING SITES TO SEQUESTER AND SUPPRESS ACTIVITY OF ONCOGENIC TRANSCRIPTION FACTORS AS A NOVEL TREATMENT FOR HUMAN CANCER 审中-公开
标题翻译：工程化的包含超结合位点的溶瘤病毒对人类癌症的治疗作用和抑制癌症转录因子的活性
公开(公告)号：WO2018067165A1
公开(公告)日：2018-04-12
申请号：PCT/US2016/055896
申请日：2016-10-07
申请人： MIAMI UNIVERSITY , KENNEDY, Michael A.
发明人： KENNEDY, Michael A.
IPC分类号： C12N15/86 , A61K35/761 , C12N15/113
CPC分类号： C12N15/86 , A61K35/761 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343
摘要： In one or more embodiments, the present invention provides novel artificial, non-naturally-occurring double stranded DNA segments (and related methods) capable of acting as decoy binding sites for oncogenic transcription factors and a general method for suppressing aberrant activity of oncogenic transcription factors that promote cancer progression. In various embodiments, the present invention involves the sequestration of targeted oncogenic transcription factors at these artificial, non-naturally occurring engineered transcription factor binding sites, which have been introduced into the cells using oncolytic or other viruses that can be engineered to selectively target cancer cells. These artificial, non-naturally occurring engineered transcription factor binding sites act as decoys for binding so as to competitively sequester oncogenic transcription factors away from the host genomic DNA, thus abolishing or reducing oncogenic transcription factor activity and resulting in restored sensitivity to chemotherapy, increased apoptosis, and reduced cancer cell proliferation.
摘要翻译：在一个或多个实施方案中，本发明提供了能够充当致癌转录因子的诱饵结合位点的新型人工，非天然存在的双链DNA片段（和相关方法）以及一般方法用于抑制促进癌症进展的致癌转录因子的异常活性。在各种实施方案中，本发明涉及在这些人造，非天然存在的工程转录因子结合位点处螯合靶向致癌转录因子，所述工程转录因子结合位点已经使用溶瘤或其它可被工程化以选择性靶向癌细胞的病毒引入细胞。这些人工的，非天然存在的工程转录因子结合位点作为结合的诱饵以便竞争性地隔离宿主基因组DNA的致癌转录因子，从而消除或降低致癌转录因子活性并导致恢复对化学疗法的敏感性，增加凋亡，并减少癌细胞增殖。

2. 发明申请

WO2001034539A1 METHOD OF SATURATING OLEFINS 审中-公开
标题翻译：饱和脂蛋白的方法
公开(公告)号：WO2001034539A1
公开(公告)日：2001-05-17
申请号：PCT/US2000014512
申请日：2000-05-25
申请人： MIAMI UNIVERSITY
发明人： MIAMI UNIVERSITY , SHERMAN, Jeffrey, H. , HERSHBERGER, James, W.
IPC分类号： C07C7/163
CPC分类号： C10G27/10 , B01J23/72 , B01J31/10
摘要： A process for saturating olefins and alkynes in a hydrocarbon stream comprises mixing the hydrocarbon stream with a surfactant, hydrazine and an oxidizer. The resulting mixture is then directed through an ion exchange resin including a catalyst, preferably a copper (II) catalyst. Mixing of the hydrazine and the oxidizer in the presence of the catalyst forms diimide which saturates the olefins and the alkynes in the hydrocarbon stream.
摘要翻译：在烃流中饱和烯烃和炔烃的方法包括将烃流与表面活性剂，肼和氧化剂混合。然后将所得混合物引导通过包括催化剂，优选铜（II）催化剂的离子交换树脂。在催化剂存在下，肼和氧化剂的混合形成使烃流中的烯烃和炔烃饱和的二酰亚胺。

3. 发明申请

WO1987002396A1 PAPERMAKING PROCESS 审中-公开
标题翻译：造纸工艺
公开(公告)号：WO1987002396A1
公开(公告)日：1987-04-23
申请号：PCT/US1986002178
申请日：1986-10-15
申请人： MIAMI UNIVERSITY
发明人： MIAMI UNIVERSITY , TAGGART, Thomas, E. , NOE, Jeffrey, S. , SPRINGER, Allan, M.
IPC分类号： D21F11/00
CPC分类号： G01N33/343 , D21H23/08 , Y10S162/11
摘要： A method for controlling the addition (33) of cationic additive materials (28) to a paper mill slurry (22) used to neutralize the anionic contaminants in a papermaking process which utilizes total organic carbon measurements (32, 34) of samples of the slurry as an indicator of the cationic demand of the paper mill slurry. The method of the present invention discloses the discovery that measurements of the total organic carbon (32, 34) taken form filtered samples of the papermaking slurry correlate very well to cationic demand measurements of the papermaking slurry (22). Therefore, measurements of the total dissolved organic carbon content may be used to determine the desired addition rate of cationic additives (28) in a very convenient and reliable manner.

4. 发明申请

WO2022226493A1 OPTIMIZED METHODS FOR THE PRODUCTION OF PSILOCYBIN AND INTERMEDIATES OR SIDE PRODUCTS 审中-公开
公开(公告)号：WO2022226493A1
公开(公告)日：2022-10-27
申请号：PCT/US2022/071797
申请日：2022-04-19
申请人： MIAMI UNIVERSITY
发明人： JONES, John Andrew , O'DELL, Philip John
IPC分类号： C12P17/10 , C12N15/63 , C12N15/52
摘要： Provided are methods, host cells, transposons, transposomes, and kits for the optimized production of psilocybin or an intermediate or a side product thereof in a prokaryotic host cell. Also provided are methods, host cells, transposons, transposomes, and kits for the optimized production of norbaeocystin in a prokaryotic host cell. In certain embodiments, the prokaryotic host cell is selected from the group consisting of Escherichia coli, Corynebacterium glutamicum, Vibrio natriegens, Bacillus subtilis, Bacillus megaterium, Escherichia coli Nissle 1917, Clostridium acetobutlyicum, Streptomyces coelicolor, Lactococcus lactis, Pseudomonas putida, Streptomyces clavuligerus, and Streptomyces venezuelae.

5. 发明申请

WO2021086959A1 THERMAL SENSING WITH BLACKBODY RADIATION 审中-公开
公开(公告)号：WO2021086959A1
公开(公告)日：2021-05-06
申请号：PCT/US2020/057729
申请日：2020-10-28
申请人： MIAMI UNIVERSITY
发明人： WANG, Hui
IPC分类号： A61B5/00 , A61B5/01 , A61B8/00 , A61B18/14
摘要： A method and apparatus using radiation-based fiber-optic sensors and ultrasound thermometry to detect temperature before and during surgery. Ultrasound thermometry accurately measures temperature less than 50°C and requires calibration, which can be conducted in vivo with the disclosed fiber sensor based on blackbody radiation (BBR) and as an early step in the procedure. The monitored wavelength of BBR in a range between about 1.4pm and about 2.7 pm results in low attenuation for both water and a silica-based fiber. A thermal boundary map at and around the boundaries of the subsequently heated tissue in the region of interest (ROI) is displayed to the surgeon. The system accurately displays the temperature(s) in a thermal boundary map, thereby permitting the surgeon to determine when the ROI has been exposed to sufficient thermal energy to destroy it.

6. 发明申请

WO2012078982A3 XZH-5 INHIBITS CONSTITUTIVE AND INTERLEUKIN-6-INDUCED STAT3 PHOSPHORYLATION IN HUMAN HEPATOCELLULAR CARCINOMA CELLS 审中-公开
公开(公告)号：WO2012078982A3
公开(公告)日：2012-06-14
申请号：PCT/US2011/064152
申请日：2011-12-09
申请人： THE OHIO STATE UNIVERSITY , NATIONWIDE CHILDREN'S HOSPITAL, INC. , MIAMI UNIVERSITY , LI, Chenglong , LIN, Jiayuh , WANG, Hong
发明人： LI, Chenglong , LIN, Jiayuh , WANG, Hong
IPC分类号： A01N35/00 , A61K31/12
摘要： The present disclosure provides compounds, compositions of matter and methods related to XZH-5 and related chemical therapeutics. The inhibitory effects of a series of small molecules structurally related to XZH-5 on STAT3 phosphorylation is disclosed, as are the results of that inhibition, including induction of apoptosis, reduction of colony forming ability, inhibition of IL-6- induced STAT3 phosphorylation, and nuclear translocation and STAT3 DNA binding activity.

7. 发明申请

WO2023081842A2 ALTERNATIVE BIOSYNTHESIS PATHWAYS FOR THE PRODUCTION OF PSILOCYBIN AND INTERMEDIATES OR SIDE PRODUCTS 审中-公开
公开(公告)号：WO2023081842A2
公开(公告)日：2023-05-11
申请号：PCT/US2022/079329
申请日：2022-11-04
申请人： MIAMI UNIVERSITY
发明人： JONES, John Andrew , KANIS, Fiona
IPC分类号： C12N9/10 , A61K36/06 , A61K38/16 , C12N15/52 , C12N15/70
摘要： Provided are methods, prokaryotic host cells, expression vectors, and kits for the production of psilocybin or an intermediate or a side product thereof. In certain embodiments, the prokaryotic host cell is selected from the group consisting of Escherichia coli, Corynebacterium glutamicum, Vibrio natriegens, Bacillus subtilis, Bacillus megaterium, Escherichia coli Nissle 1917, Clostridium acetobutlyicum, Streptomyces coelicolor, Lactococcus lactis, Pseudomonas putida, Streptomyces clavuligerus, and Streptomyces venezuelae.

8. 发明申请

WO2023015279A1 METHODS FOR THE PRODUCTION OF METHYLATED TRYPTAMINE DERIVATIVES, INTERMEDIATES OR SIDE PRODUCTS 审中-公开
公开(公告)号：WO2023015279A1
公开(公告)日：2023-02-09
申请号：PCT/US2022/074579
申请日：2022-08-05
申请人： MIAMI UNIVERSITY
发明人： JONES, John Andrew , FRIEDBERG, Lucas
IPC分类号： C12P17/10 , C12N15/82 , C12N15/52 , C12N9/02 , C12N9/10
摘要： Provided are methods, prokaryotic host cells, expression vectors, and kits for the production of a methylated tryptamine or an intermediate or a side product thereof. In certain embodiments, the prokaryotic host cell is selected from the group consisting of Escherichia coli, Corynebacterium glutamicum, Vibrio natriegens, Bacillus subtilis, Bacillus megaterium, Escherichia coli Nissle 1917, Clostridium acetobutlyicum, Streptomyces coelicolor, Lactococcus lactis, Pseudomonas putida, Streptomyces clavuligerus, and Streptomyces venezuelae.

9. 发明申请

WO2022150840A1 PSILOCYBIN AND NORBAEOCYSTIN COMPOSITIONS AND METHODS OF TREATMENT 审中-公开
公开(公告)号：WO2022150840A1
公开(公告)日：2022-07-14
申请号：PCT/US2022/070094
申请日：2022-01-07
申请人： MIAMI UNIVERSITY
发明人： MCMURRAY, Matthew Stephen , JONES, John Andrew
IPC分类号： A61K36/07 , A61K31/405 , A61K31/675 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28
摘要： Provided is a pharmaceutical composition comprising two or more tryptamines that are present in Psilocybe magic mushrooms. Provided is a pharmaceutical composition comprising heterologously produced psilocybin and heterologously produced norbaeocystin. Also provided is a method of treating a neurological or psychological disorder or condition in a patient, comprising administering to the patient an effective amount of a pharmaceutical composition comprising psilocybin and an effective amount of a pharmaceutical composition comprising norbaeocystin. Also provided is a method of treating a neurological or psychological disorder or condition in a patient, comprising administering to the patient an effective amount of a pharmaceutical composition comprising psilocybin and an effective amount of a pharmaceutical composition comprising norbaeocystin. In some embodiments, the psilocybin is heterologously produced. In some embodiments, the norbaeocystin is heterologously produced.

10. 发明申请

WO2017218889A1 EUBACTERIUM PROBIOTICS AND METHODS OF TREATING OR PREVENTING HEART DISEASE 审中-公开
标题翻译： EUBACTERIUM益生菌和治疗或预防心脏病的方法
公开(公告)号：WO2017218889A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/037869
申请日：2017-06-16
申请人： OHIO STATE INNOVATION FOUNDATION , MIAMI UNIVERSITY
发明人： KRZYCKI, Joseph A. , KOUNTZ, Duncan , FERGUSON, JR., Donald J.
IPC分类号： A61K35/74
CPC分类号： A61K35/74
摘要： The present disclosure relates to probiotic compositions and methods of treating or preventing heart disease.
摘要翻译：本公开涉及益生菌组合物和治疗或预防心脏病的方法。

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