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1. 发明申请

WO2011131178A2 METHOD FOR DETECTING A SALMONELLA INFECTION 审中-公开
标题翻译：检测方法的沙门氏菌感染
公开(公告)号：WO2011131178A2
公开(公告)日：2011-10-27
申请号：PCT/DE2011000460
申请日：2011-04-14
申请人： BIOSERV ANALYTIK UND MEDIZINPRODUKTE GMBH , MEYER UDO AQUACONSULT GMBH , STEINMANN ALAIN , FAHLANDT HEIKE , SCHULZ BABETTE
发明人： MEYER UDO , STEINMANN ALAIN , FAHLANDT HEIKE , SCHULZ BABETTE
IPC分类号： C07K16/12
CPC分类号： C07K16/1235 , C07K2317/34 , C12Q1/689 , G01N33/56916 , G01N2333/255 , Y02A50/451
摘要： The invention relates to a diagnostic method for detecting a salmonella infection or salmonella contamination. The fields of application are medicine, veterinary medicine and various branches of industry. The object of the invention consists in developing a reliable test for detecting salmonella species. It is based on the object of establishing a method which makes possible as early as possible a detection and detects all important serovars. The diagnostic method according to the invention for detecting a salmonella infection/contamination is characterized in that the SipC of all known salmonella serovars is detected in excreta of patients/animals, carcasses, eggs and foodstuffs/feeding stuffs. The detection takes place by means of immunochemical systems exploiting monoclonal and polyclonal antibodies which are directed against the following peptide sequences: NH2-V-A-S-T-A-S-D-E-A-R-E-S-S-R-K-S-COOH, NH2-N-N-H-S-V-E-N-S-S-Q-T-A-S-Q-S-V-COOH, NH2-G-Q-Y-A-A-T-Q-E-R-S-E-Q-Q-I-S-COOH, NH2-L-G-I-K-D-S-N-K-Q-I-S-P-E-H-COOH and NH2-L-N-M-K-K-T-G-T-D-A-T-K-N-L-N-COOH.
摘要翻译：本发明涉及一种用于检测沙门氏菌感染或沙门氏菌污染的诊断方法。应用领域是医药，兽药和行业的各个分支。本发明的目的是开发用于检测沙门氏菌的一个可靠的测试。它是基于对象的开发方法，它允许尽早检测和每一个主要血清型。根据本发明用于检测沙门氏菌感染的诊断方法/ -kontamination的特征在于，所述通过所有已知血清型沙门氏菌的沙门氏菌SIPC排泄在患者/动物，动物尸体，鸡蛋和食品/饲料的排泄物检测。 NH2-VASTASDEARESSRKS-COOH，NH2-NNHSVENSSQTASQSV-COOH，NH2-GQYAATQERSEQQIS-COOH，NH2-LGIKDSNKQISPEH-COOH和NH 2 LNMKKTGTDATKNLN-COOH：检测是通过单 - 使用针对以下肽序列免疫系统和多克隆抗体进行，

2. 发明申请

WO2012025077A2 METHOD FOR THE FAST SEROLOGICAL DIAGNOSIS OF A SALMONELLA SUBTYPE 审中-公开
标题翻译：法快速血清学诊断沙门氏菌亚型
公开(公告)号：WO2012025077A2
公开(公告)日：2012-03-01
申请号：PCT/DE2011001409
申请日：2011-07-06
申请人： BIOSERV ANALYTIK UND MEDIZINPRODUKTE GMBH , MEYER UDO AQUACONSULT GMBH , STEINMANN ALAIN , FAHLANDT HEIKE , FIEDLER RAIMUND , MATSSON PER , SCHULZ BABETTE
发明人： MEYER UDO , STEINMANN ALAIN , FAHLANDT HEIKE , FIEDLER RAIMUND , MATSSON PER , SCHULZ BABETTE
CPC分类号： G01N33/56916 , G01N33/558 , G01N2333/255
摘要： The invention relates to a diagnostic method for detecting a salmonella infection or salmonella contamination. Said method can be used in medicine, veterinary medicine, and various sectors of industry. The objective of the invention is to develop a reliable test for detecting salmonellae. The invention is based on the aim of creating a method that enables the earliest possible detection and that detects all human-pathogenic serovars. The diagnostic method for detecting a salmonella subtype according to the invention is characterized in that the specific salmonella serotype is determined clearly and in a significantly shorter time than currently possible in excretions of patients/animals, carcasses, eggs, and food/feed by a combination of a multiple number of specific antibodies against H and O antigens in an immunological 1-/2-step method.
摘要翻译：本发明涉及一种用于检测沙门氏菌感染或沙门氏菌污染的诊断方法。应用领域是医药，兽药和行业的各个分支。本发明的目的是开发用于检测沙门氏菌的一个可靠的测试。它是基于在对象上开发一种方法，其允许尽可能早的检测和覆盖所有人类致病血清型。根据本发明的用于识别沙门氏菌亚型的诊断方法的特征在于，在患者/动物，动物尸体，鸡蛋和食品/饲料的排泄物，由特异性抗体的倍数数目的组合的特定的沙门氏菌血清型H-和O-抗原在显然免疫2分之1步骤过程，比在更短的时间是当前可能被确定。

3. 发明申请

WO0008463A3 IMMUNOADSORBER FOR REMOVING ENDOTOXINS 审中-公开
标题翻译： Immunoadsorber脱除ENDOTOXININ
公开(公告)号：WO0008463A3
公开(公告)日：2000-04-20
申请号：PCT/DE9902486
申请日：1999-08-05
申请人： PRIVATES INST BIOSERV GMBH , HEINRICH HANS WERNER , MEYER UDO AQUACONSULT GMBH , HLINAK ANDREAS , KRUSCHKE PETER , SASSE MIRKO
发明人： HEINRICH HANS-WERNER , MEYER UDO , HLINAK ANDREAS , KRUSCHKE PETER , SASSE MIRKO
IPC分类号： A61P37/00 , C07K16/12 , G01N33/53 , B01D15/00 , B01D15/08 , G01N33/569 , G01N33/579 , G01N33/92
CPC分类号： C07K16/1203 , C07K2317/11 , C07K2317/23
摘要： The invention relates to an immunoadsorber for specific removal of bacterial endotoxins from fluids or aqueous, crystalline and/or colloidal solutions, emulsions and body fluids (e.g. blood, plasma, lymph, cerebrospinal fluid) and/or fluids (e.g. serum, dialysate) obtained from body fluids. The endotoxins are bonded (in vitro, ex vivo or in situ) to avian endotoxin antibodies and eliminated from said fluid. A method for the production of the inventive immunoadsorber is also disclosed. The invention can be used in medicine, veterinary medicine, biomedicine, biomedical techniques, dentistry, pharmacy, biomedical research, pharmaceutical research, medical research, food production and, optionally, environmental protection.
摘要翻译：本发明描述了一种immunoadsorber用于具体从流体，水，晶体和/或胶体溶液，乳液，和体液（如血液，血浆，淋巴液，脑脊髓液）和/或流体从体液衍生（如血清，透析液中除去细菌内毒素）。的内毒素是（在体外，离体或原位）结合至抗viäreEndotoxinantikörper并因此从液体除去。同时，将描述用于制备免疫吸附的方法。应用本发明的，在医药，兽药，生物医药，生物医学工程，牙科，医药，生物，医药和医学研究，食品生产及可能对环境的地区。

4. 发明申请

WO0058005A3 IMMUNOADSORBER FOR USE IN SEPSIS THERAPY 审中-公开
标题翻译： Immunoadsorber败血症的治疗
公开(公告)号：WO0058005A3
公开(公告)日：2001-03-29
申请号：PCT/DE0000927
申请日：2000-03-23
申请人： BIOSERV AG , HEINRICH HANS WERNER , HAHN HANS JUERGEN , MEYER UDO AQUACONSULT GMBH , KRUSCHKE PETER , WAGNER HEINZ JUERGEN
发明人： HEINRICH HANS-WERNER , HAHN HANS-JUERGEN , MEYER UDO , KRUSCHKE PETER , WAGNER HEINZ-JUERGEN
IPC分类号： A61M1/36 , A61K35/16 , A61M1/02 , A61M1/34 , B01J20/26 , C07K16/18 , C07K16/24 , C07K17/02 , A61K39/44 , B01J20/22 , C07K1/22
CPC分类号： A61K35/16 , A61M1/3486 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/248 , C07K17/02 , C07K2317/11 , C07K2317/23
摘要： The invention relates to an immunoabsorber for use in sepsis therapy, especially for removing complement factors and lipopolysaccharides (LPS) and optionally other sepsis mediators such as TNF and interleukins from body fluids. The invention also relates to a method for producing said immunoadsorbers and to their use.
摘要翻译：本发明涉及免疫败血症治疗，特别是用于除去互补和脂多糖（LPS）和任选的进一步败血症介质，例如 TNF和白细胞介素体液，其制备方法及其用途。

5. 发明申请

WO0021981A2 TNF alpha BINDING PEPTIDES AND THEIR UTILIZATION FOR DETECTING, DEACTIVATING AND/OR REMOVING TNF alpha FROM BIOLOGICAL FLUIDS 审中-公开
标题翻译： TNFα结合肽及其用于从生物流体中检测，灭活和/或去除TNFα的应用
公开(公告)号：WO0021981A2
公开(公告)日：2000-04-20
申请号：PCT/DE9903256
申请日：1999-10-08
申请人： BIOSERV AG , WAGNER HEINZ JUERGEN , HEINRICH HANS WERNER , MEYER UDO AQUACONSULT GMBH
发明人： WAGNER HEINZ-JUERGEN , HEINRICH HANS-WERNER , MEYER UDO
IPC分类号： A61K38/00 , C07K7/06 , C07K7/00
CPC分类号： C07K7/06 , A61K38/00
摘要： The invention relates to peptides having formula NH2-IQTLHAQ-COOH and NH2-RLANTHFVY-COOH that specifically bind in vivo and ex vivo TNF alpha . Said peptides are suitable for producing TNF alpha test systems and/or for removing TNF alpha from body fluids, e.g. by means of plasmapheresis.
摘要翻译：具有式NH 2 -IQTLHAQ-COOH和NH 2 -RLANTFHVY-COOH的根据本发明的肽在体外和离体特异性结合TNFα。它们适用于制备TNFα的测试系统，TNFα的失活和/或其通过例如体液从体液中除去。血浆置换。

6. 发明申请

WO9714964A2 PATIENT-SPECIFIC IMMUNOADSORBENTS FOR EXTRACORPORAL APHERESIS AND METHODS OF PRODUCING SAID IMMUNO-ADSORBERS 审中-公开
标题翻译：用于体外单采和方法患者特异性的immunoadsorber生产同样
公开(公告)号：WO9714964A2
公开(公告)日：1997-04-24
申请号：PCT/DE9601910
申请日：1996-10-03
申请人： PRIVATES INST BIOSERV GMBH , HEINRICH HANS WERNER , RAMLOW WOLFGANG , BOEDEN HANS FRIEDRICH , NEUMANN HANS GEORG , MEYER UDO AQUACONSULT GMBH , TELLER JOACHIM
发明人： HEINRICH HANS-WERNER , RAMLOW WOLFGANG , BOEDEN HANS-FRIEDRICH , NEUMANN HANS-GEORG , MEYER UDO , TELLER JOACHIM
IPC分类号： G01N33/564 , A61K35/14 , A61K39/00 , A61K39/395 , A61M1/34 , A61M1/36 , A61P37/06 , B01J20/22 , B01J20/26 , G01N33/569 , G01N33/543 , G01N33/548
CPC分类号： A61M1/3679 , A61M1/3486 , B01J20/3212 , B01J20/3274 , B01J2220/4856 , C07K17/02 , Y10S436/824 , Y10S530/868
摘要： The invention relates to the production of multiple-application patient-specific immunoadsorbents which can be used for extracorporal apheresis in patients suffering from disorders caused by dysregulation of the immune system. Conventional methods are used to isolate the immune complexes from the patient's blood and appropriate methods are applied to separate the immune complexes into antigens and antibodies. The antigens and antibodies thus reactivated are coupled individually or as a mixture covalently to suitable carriers which are used as immunoadsorbents for the patient from whom the immune complexes originate. This facilitates production of specific immunoadsorbents even for patients suffering from rare auto-immune diseases.
摘要翻译：本发明涉及制备适用通用的，特定于患者的免疫吸附器，其可以在从该被免疫系统失调引起的疾病的患者使用用于体外血液分离到。通过常规方法来分离从患者的血液，其通过适当的方法抗原和抗体分离的免疫复合物。这样再活化抗原和抗体可以单独或作为混合物耦合共价合适的载体，其用作免疫用于从谁免疫复合物衍生的患者。因此特异性作用immunoadsorber也可以为从罕见的自身免疫性疾病的患者进行。

7. 发明申请

WO2012025077A4 METHOD FOR THE FAST SEROLOGICAL DIAGNOSIS OF A SALMONELLA SUBTYPE 审中-公开
标题翻译：快速诊断沙门氏菌亚型的方法
公开(公告)号：WO2012025077A4
公开(公告)日：2012-11-01
申请号：PCT/DE2011001409
申请日：2011-07-06
申请人： BIOSERV ANALYTIK UND MEDIZINPRODUKTE GMBH , MEYER UDO AQUACONSULT GMBH , STEINMANN ALAIN , FAHLANDT HEIKE , FIEDLER RAIMUND , MATSSON PER , SCHULZ BABETTE
发明人： MEYER UDO , STEINMANN ALAIN , FAHLANDT HEIKE , FIEDLER RAIMUND , MATSSON PER , SCHULZ BABETTE
IPC分类号： G01N33/569 , G01N33/558
CPC分类号： G01N33/56916 , G01N33/558 , G01N2333/255
摘要： The invention relates to a diagnostic method for detecting a salmonella infection or salmonella contamination. Said method can be used in medicine, veterinary medicine, and various sectors of industry. The objective of the invention is to develop a reliable test for detecting salmonellae. The invention is based on the aim of creating a method that enables the earliest possible detection and that detects all human-pathogenic serovars. The diagnostic method for detecting a salmonella subtype according to the invention is characterized in that the specific salmonella serotype is determined clearly and in a significantly shorter time than currently possible in excretions of patients/animals, carcasses, eggs, and food/feed by a combination of a multiple number of specific antibodies against H and O antigens in an immunological 1-/2-step method.
摘要翻译：本发明涉及用于检测沙门氏菌感染或沙门氏菌污染的诊断方法。应用领域是医药，兽药和各行业的分支机构。本发明的目的是开发用于检测沙门氏菌的可靠测试。它的基础是开发一种能够尽早检测和记录所有人类致病性血清型的方法。根据本发明的用于识别沙门氏菌亚型的诊断方法的特征在于，在患者/动物，动物尸体，鸡蛋和食品/饲料的排泄物，由特异性抗体的倍数数目的组合的特定的沙门氏菌血清型H-和O-抗原在确定了清晰且比目前可能的时间短得多的免疫学1/2步程序。

8. 发明申请

WO2011131178A3 METHOD FOR DETECTING A SALMONELLA INFECTION 审中-公开
标题翻译：检测沙门氏菌感染的方法
公开(公告)号：WO2011131178A3
公开(公告)日：2012-05-18
申请号：PCT/DE2011000460
申请日：2011-04-14
申请人： BIOSERV ANALYTIK UND MEDIZINPRODUKTE GMBH , MEYER UDO AQUACONSULT GMBH , STEINMANN ALAIN , FAHLANDT HEIKE , SCHULZ BABETTE
发明人： MEYER UDO , STEINMANN ALAIN , FAHLANDT HEIKE , SCHULZ BABETTE
IPC分类号： G01N33/569 , C07K16/12
CPC分类号： C07K16/1235 , C07K2317/34 , C12Q1/689 , G01N33/56916 , G01N2333/255 , Y02A50/451
摘要： The invention relates to a diagnostic method for detecting a salmonella infection or salmonella contamination. The fields of application are medicine, veterinary medicine and various branches of industry. The object of the invention consists in developing a reliable test for detecting salmonella species. It is based on the object of establishing a method which makes possible as early as possible a detection and detects all important serovars. The diagnostic method according to the invention for detecting a salmonella infection/contamination is characterized in that the SipC of all known salmonella serovars is detected in excreta of patients/animals, carcasses, eggs and foodstuffs/feeding stuffs. The detection takes place by means of immunochemical systems exploiting monoclonal and polyclonal antibodies which are directed against the following peptide sequences: NH2-V-A-S-T-A-S-D-E-A-R-E-S-S-R-K-S-COOH, NH2-N-N-H-S-V-E-N-S-S-Q-T-A-S-Q-S-V-COOH, NH2-G-Q-Y-A-A-T-Q-E-R-S-E-Q-Q-I-S-COOH, NH2-L-G-I-K-D-S-N-K-Q-I-S-P-E-H-COOH and NH2-L-N-M-K-K-T-G-T-D-A-T-K-N-L-N-COOH.
摘要翻译：本发明涉及用于检测沙门氏菌感染或沙门氏菌污染的诊断方法。应用领域是医药，兽药和各行业的分支机构。本发明的目的是开发用于检测沙门氏菌的可靠测试。它是基于对象的开发方法，它允许尽早检测和每一个主要血清型。根据本发明用于检测沙门氏菌感染的诊断方法/ -kontamination的特征在于，所述通过所有已知血清型沙门氏菌的沙门氏菌SIPC排泄在患者/动物，动物尸体，鸡蛋和食品/饲料的排泄物检测。 NH2-VASTASDEARESSRKS-COOH，NH2-NNHSVENSSQTASQSV-COOH，NH2-GQYAATQERSEQQIS-COOH，NH2-LGIKDSNKQISPEH-COOH和NH 2 LNMKKTGTDATKNLN-COOH：检测是通过单 - 使用针对以下肽序列免疫系统和多克隆抗体进行，

9. 发明申请

WO0014542A3 DIAGNOSTIC METHOD FOR DETECTING DISTURBANCES OF THE PANCREAS 审中-公开
标题翻译：诊断检测方法的胰腺功能障碍
公开(公告)号：WO0014542A3
公开(公告)日：2000-06-02
申请号：PCT/DE9902816
申请日：1999-09-03
申请人： PRIVATES INST BIOSERV GMBH , HEINRICH HANS WERNER , KLEINERT RAINER , MEYER UDO AQUACONSULT GMBH , WAGNER HEINZ JUERGEN
发明人： HEINRICH HANS-WERNER , KLEINERT RAINER , MEYER UDO , WAGNER HEINZ-JUERGEN
IPC分类号： G01N33/573 , C07K7/08 , C07K16/40 , C12N9/66 , C12P21/08 , C12Q1/28 , G01N33/577
CPC分类号： C12N9/6448 , C07K16/40
摘要： Disclosed is a method for detecting disturbances in the functioning of the pancreas, whereby parts of all elastase isoenzymes produced in the pancreas and synthetic amino acid sequences are used as antigens to obtain specific antibodies. The invention also relates to the use of said antibodies in immunochemical test methods.
摘要翻译：它是一种用于检测所述的胰腺病症的方法。根据本发明的目的是通过使用胰弹性蛋白酶和作为抗原的特异性抗体的产生及其在免疫化学试验使用合成的氨基酸序列的所有同功酶的部分的实现。

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