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1. 发明申请

WO2006081000A9 (POLYALKOXY)SULFONATE SURFACE MODIFIERS 审中-公开
标题翻译：（聚烷氧基）磺酸盐表面改性剂
公开(公告)号：WO2006081000A9
公开(公告)日：2006-08-31
申请号：PCT/US2005045321
申请日：2005-12-15
申请人： BAXTER INT , BAXTER HEALTHCARE SA , KIPP JAMES E , HAI TON THAT , MELNICK BENNETT P
发明人： KIPP JAMES E , HAI TON THAT , MELNICK BENNETT P
IPC分类号： C08G65/326 , C08G65/334 , C08L71/02
CPC分类号： C08G65/334 , A61K8/90 , A61K9/146 , A61K47/34 , A61Q19/00 , C08G65/326 , C08L71/02
摘要： The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof. The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use. The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent. Pharmaceutical compositions of the present invention can be used to treat amyriad of conditions and can be administered by many routes, including intravenous, intramuscular, subcutaneous, intrathecal, subdural, intracameral, intracerebral, intralesional, topical, oral, buccal, rectal, pulmonary, and nasal.
摘要翻译：本发明涉及新型化合物，制造方法和使用方法。本发明还涉及具有与其表面结合的一种或多种本发明化合物的固体药物/活性剂颗粒。本发明的化合物由与阴离子磺酸盐基团共价连接的非极性聚醚组成。这些化合物具有两亲性，并且优选具有表面活性。这些化合物优选用作表面活性剂以涂覆和稳定连续液体介质中的颗粒分散体。这些表面活性剂可以用于稳定用于药物，医学，化妆品或农业用途的悬浮液，乳液或脂质体制剂。可以通过多种方法制备并且优选包含药剂的颗粒。本发明的药物组合物可用于治疗多种病症，并可通过多种途径给药，包括静脉内，肌肉内，皮下，鞘内，硬膜下，前房内，脑内，病灶内，局部，口服，口腔，直肠，肺和鼻。

2. 发明申请

WO2006081000A3 (POLYALKOXY)SULFONATE SURFACE MODIFIERS 审中-公开
标题翻译：（POLYALKOXY）磺酸盐表面改性剂
公开(公告)号：WO2006081000A3
公开(公告)日：2006-09-28
申请号：PCT/US2005045321
申请日：2005-12-15
申请人： BAXTER INT , BAXTER HEALTHCARE SA , KIPP JAMES E , HAI TON THAT , MELNICK BENNETT P
发明人： KIPP JAMES E , HAI TON THAT , MELNICK BENNETT P
IPC分类号： C08G65/326 , C08G65/334 , C08L71/02
CPC分类号： C08G65/334 , A61K8/90 , A61K9/146 , A61K47/34 , A61Q19/00 , C08G65/326 , C08L71/02
摘要： The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof. The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use. The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent. Pharmaceutical compositions of the present invention can be used to treat amyriad of conditions and can be administered by many routes, including intravenous, intramuscular, subcutaneous, intrathecal, subdural, intracameral, intracerebral, intralesional, topical, oral, buccal, rectal, pulmonary, and nasal.
摘要翻译：本发明涉及新化合物，制备方法和使用方法。本发明还涉及具有一种或多种与其表面相关的本发明化合物的固体药物/活性剂颗粒。本发明的化合物由与阴离子磺酸盐基团共价连接的非极性聚醚组成。该化合物具有两性质量，优选表面活性。这些化合物优选用作表面活性剂以涂覆和稳定颗粒在连续液体介质中的分散体。这些表面活性剂可以用于稳定用于制药，医疗，化妆品或农业用途的悬浮液，乳剂或脂质体制剂。可以通过多种方法制备并且优选包含药剂的颗粒。本发明的药物组合物可用于治疗异常的病症，并且可以通过许多途径施用，包括静脉内，肌肉内，皮下，鞘内，硬膜下，阴道内，脑内，肠内，局部，口服，口腔，直肠，肺和鼻。

3. 发明申请

WO2006081000A2 (POLYALKOXY)SULFONATE SURFACE MODIFIERS 审中-公开
标题翻译：（聚烷氧基）磺酸盐表面改性剂
公开(公告)号：WO2006081000A2
公开(公告)日：2006-08-03
申请号：PCT/US2005/045321
申请日：2005-12-15
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , KIPP, James E. , HAI, Ton That , MELNICK, Bennett, P.
发明人： KIPP, James E. , HAI, Ton That , MELNICK, Bennett, P.
IPC分类号： C08G65/326 , C08G65/334 , C08L71/02
CPC分类号： C08G65/334 , A61K8/90 , A61K9/146 , A61K47/34 , A61Q19/00 , C08G65/326 , C08L71/02
摘要： The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof. The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use. The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent. Pharmaceutical compositions of the present invention can be used to treat amyriad of conditions and can be administered by many routes, including intravenous, intramuscular, subcutaneous, intrathecal, subdural, intracameral, intracerebral, intralesional, topical, oral, buccal, rectal, pulmonary, and nasal.
摘要翻译：本发明涉及新化合物，制造方法和使用方法。本发明还涉及具有与其表面结合的一种或多种本发明化合物的固体药物/活性剂颗粒。本发明的化合物由与阴离子磺酸盐基团共价连接的非极性聚醚组成。这些化合物具有两亲性，并且优选具有表面活性。这些化合物优选用作表面活性剂以涂覆和稳定连续液体介质中的颗粒分散体。这些表面活性剂可以用于稳定用于药物，医学，化妆品或农业用途的悬浮液，乳液或脂质体制剂。可以通过多种方法制备并且优选包含药剂的颗粒。本发明的药物组合物可用于治疗多种病症，并可通过多种途径给药，包括静脉内，肌肉内，皮下，鞘内，硬膜下，前房内，脑内，病灶内，局部，口服，口腔，直肠，肺和鼻

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