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1. 发明申请

WO0230457A2 MICROBES HAVING AN ATTENUATING MUTATION COMPRISING A TRANSCRIPTION TERMINATOR 审中-公开
标题翻译：具有包含转录终端机的衰减突变的微型计算机
公开(公告)号：WO0230457A2
公开(公告)日：2002-04-18
申请号：PCT/US0131606
申请日：2001-10-11
申请人： UNIV ST LOUIS , MEGAN HEALTH INC , CURTISS ROY III , TINGE STEVEN A
发明人： CURTISS ROY III , TINGE STEVEN A
IPC分类号： A61K39/00 , A61P37/02 , C12N15/74 , A61K39/02 , A61K39/108 , A61K39/112
CPC分类号： C12N15/74 , A61K39/0006 , A61K2039/522 , A61K2039/53
摘要： Compositions comprising a microbe having an attenuating mutation comprising a recombinant transcription terminator insertion in a chromosomal gene are disclosed. The compositions can be used as vaccines or carrier vehicles for delivering a desired protein to an individual. Also disclosed are methods for immunizing an individual and methods of delivering a desired gene product to an individual based upon administration of the compositions.
摘要翻译：公开了包含具有减毒突变的微生物的组合物，其包含染色体基因中的重组转录终止子插入物。组合物可以用作疫苗或载体载体，用于将期望的蛋白质递送给个体。还公开了用于免疫个体的方法和基于施用组合物将期望的基因产物递送给个体的方法。

2. 发明申请

WO0004919A2 LIVE ATTENUATED SALMONELLA VACCINES TO CONTROL AVIAN PATHOGENS 审中-公开
标题翻译：减毒沙门氏菌疫苗控制禽流感病毒
公开(公告)号：WO0004919A2
公开(公告)日：2000-02-03
申请号：PCT/US9915842
申请日：1999-07-13
申请人： MEGAN HEALTH INC , ROLAND KENNETH L
发明人： ROLAND KENNETH L
IPC分类号： A61K39/02 , A61K39/112 , A61K39/116 , A61P31/04 , C07K14/245 , C07K14/255 , A61K39/00
CPC分类号： C07K14/255 , A61K39/0258 , A61K39/0275 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/544 , A61K2039/552 , A61K2039/70 , C07K14/245
摘要： A vaccine for protecting birds against infection by avian pathogenic gram negative microbes is disclosed. The vaccine is a recombinant Salmonella strain expressing O-antigen of an avian pathogenic gram negative microbe such as an E. coli strain that is pathogenic in poultry. The recombinant Salmonella strain also does not express Salmonella O-antigen. Methods of using the vaccine to immunize birds are also disclosed.
摘要翻译：公开了一种用于保护禽类免受禽致病革兰氏阴性微生物感染的疫苗。该疫苗是表达禽致病性革兰氏阴性微生物的O-抗原的重组沙门氏菌菌株，例如在家禽中致病的大肠杆菌菌株。重组沙门氏菌菌株也不表达沙门氏菌O-抗原。还公开了使用疫苗免疫鸟类的方法。

3. 发明申请

WO0230457A9 MICROBES HAVING AN ATTENUATING MUTATION COMPRISING A TRANSCRIPTION TERMINATOR 审中-公开
标题翻译：具有包含转录终止子的衰减突变的微生物
公开(公告)号：WO0230457A9
公开(公告)日：2003-07-24
申请号：PCT/US0131606
申请日：2001-10-11
申请人： UNIV ST LOUIS , MEGAN HEALTH INC , CURTISS ROY III , TINGE STEVEN A
发明人： CURTISS ROY III , TINGE STEVEN A
IPC分类号： A61K39/00 , A61P37/02 , C12N15/74 , C12N1/36 , A61K35/74
CPC分类号： C12N15/74 , A61K39/0006 , A61K2039/522 , A61K2039/53
摘要： Compositions comprising a microbe having an attenuating mutation comprising a recombinant transcription terminator insertion in a chromosomal gene are disclosed. The compositions can be used as vaccines or carrier vehicles for delivering a desired protein to an individual. Also disclosed are methods for immunizing an individual and methods of delivering a desired gene product to an individual based upon administration of the compositions.
摘要翻译：公开了包含具有减毒突变的微生物的组合物，其包含染色体基因中的重组转录终止子插入。该组合物可以用作将所需蛋白质递送给个体的疫苗或运载体。还公开了用于免疫个体的方法和基于施用组合物将期望的基因产物递送至个体的方法。

4. 发明申请

WO0183785A3 REGULATED ANTIGEN DELIVERY SYSTEM (RADS) INVOLVING BACTERIA 审中-公开
标题翻译：涉及细菌的调节性抗原递送系统（RADS）
公开(公告)号：WO0183785A3
公开(公告)日：2002-06-13
申请号：PCT/US0113915
申请日：2001-04-30
申请人： UNIV WASHINGTON , MEGAN HEALTH INC , CURTISS ROY III , TINGE STEVEN A
发明人： CURTISS ROY III , TINGE STEVEN A
IPC分类号： C12N15/09 , A61K39/00 , A61K39/112 , A61P37/04 , C12N1/21 , C12N15/63 , C12N15/74 , C12P21/02 , C12R1/42 , A61K45/00
CPC分类号： C12N15/74 , A61K2039/523 , A61K2039/53 , C12N15/635
摘要： We describe a regulated antigen delivery system (RADS) that has (a) a vector that includes (1) a gene encoding a desired gene product operably linked to a control sequence, (2) an origin of replication conferring vector replication using DNA polymerase III, and (3) an origin of replication conferring vector replication using DNA polymerase I, where the second origin of replication is operably linked to a control sequence that is repressible by a repressor. The RADS microorganism also has a gene encoding a repressor, operably linked to an activatible control sequence. The RADS described provide high levels of the desired gene product after repression of the high copy number origin of replication is lifted. The RADS are particularly useful as live bacterial vaccines. Also described is a delayed RADS system, in which there is a delay before the high copy number origin is expressed after the repression is lifted. The delayed RADS is also particularly useful for live bacterial vaccines. Also described are several control elements useful for these systems, as well as methods for providing immunity to a pathogen in a vertebrate immunized with the RADS microorganisms.
摘要翻译：我们描述了一种调控抗原递送系统（RADS），其具有（a）载体，其包含（1）编码与控制序列可操作地连接的所需基因产物的基因，（2）使用DNA聚合酶III赋予载体复制的复制起点，和（3）使用DNA聚合酶I赋予载体复制的复制起点，其中第二复制起点可操作地连接于由阻遏物阻抑的控制序列。 RADS微生物还具有编码阻抑物的基因，可操作地连接于活化的对照序列。所述的RADS提供高水平的所需基因产物，在抑制高拷贝数复制起点解除之后。 RADS作为活细菌疫苗是特别有用的。还描述了延迟的RADS系统，其中在压制被解除之后表示高拷贝数原点之前存在延迟。延迟RADS对活细菌疫苗也特别有用。还描述了可用于这些系统的若干控制元件，以及用于用RADS微生物免疫的脊椎动物中的病原体提供免疫的方法。

5. 发明申请

WO2002030457A3 MICROBES HAVING AN ATTENUATING MUTATION COMPRISING A TRANSCRIPTION TERMINATOR 审中-公开
公开(公告)号：WO2002030457A3
公开(公告)日：2002-04-18
申请号：PCT/US2001/031606
申请日：2001-10-11
申请人： WASHINGTON UNIVERSITY IN ST. LOUIS , MEGAN HEALTH, INC. , CURTISS, Roy, III , TINGE, Steven, A.
发明人： CURTISS, Roy, III , TINGE, Steven, A.
IPC分类号： C12N1/36
摘要： Compositions comprising a microbe having an attenuating mutation comprising a recombinant transcription terminator insertion in a chromosomal gene are disclosed. The compositions can be used as vaccines or carrier vehicles for delivering a desired protein to an individual. Also disclosed are methods for immunizing an individual and methods of delivering a desired gene product to an individual based upon administration of the compositions.

6. 发明申请

WO0004920A3 METHOD OF VACCINATION OF NEWLY HATCHED POULTRY 审中-公开
标题翻译：新孵化家禽的接种方法
公开(公告)号：WO0004920A3
公开(公告)日：2000-04-27
申请号：PCT/US9915843
申请日：1999-07-13
申请人： MEGAN HEALTH INC , AEHLE SANDRA M
发明人： AEHLE SANDRA M
IPC分类号： A61K39/112 , A61K9/00 , A61P31/04 , A61K39/02
CPC分类号： A61K9/0017 , A61K39/0275 , A61K2039/552 , Y10S424/826 , Y10S424/829
摘要： A method of vaccinating poultry by spraying the poultry with an effective amount of a live avirulent derivative of an enteropathogenic enterobacteria is disclosed.
摘要翻译：公开了通过用有效量的肠致病性肠细菌的活无毒衍生物喷洒家禽来接种家禽的方法。

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