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1. 发明申请

WO2008116160A1 USE OF UMBILICAL CORD MATRIX CELLS 审中-公开
标题翻译：脐带脊髓细胞的使用
公开(公告)号：WO2008116160A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/057834
申请日：2008-03-21
申请人： KANSAS STATE UNIVERSITY RESEARCH FOUNDATION , COGNATE BIOSERVICES, INC. , WEISS, Mark , WEISS, Rita , ANDERSON, Cameron , MEDICETTY, Satish , VANDERWERFF, Irene , MCINTOSH, Kevin, R.
发明人： WEISS, Mark , WEISS, Rita , ANDERSON, Cameron , MEDICETTY, Satish , VANDERWERFF, Irene , MCINTOSH, Kevin, R.
IPC分类号： A61K35/50 , A61P37/02
CPC分类号： C12N5/0619 , A61K35/12 , C12N5/0605 , C12N5/0623 , C12N2501/115 , C12N2501/33 , C12N2501/39 , C12N2501/999 , C12N2506/02
摘要： The invention relates to the isolation and use of stem cells from amniote species (potentially any animal with an umbilical cord, including humans). More particularly the invention relates to obtaining stem cells that are at least multipotent and may be totipotent or nearly totipotent and are envisaged to have a variety of end uses. The cells of the present invention are immunosuppressive and may be used to inhibit the immune response in a subject.
摘要翻译：本发明涉及从羊膜ote属（潜在地任何具有脐带的动物，包括人）的干细胞的分离和使用。更具体地，本发明涉及获得至少多潜能的干细胞，并且可以是全能的或几乎全能的，并被设想具有各种最终用途。本发明的细胞是免疫抑制的，并且可以用于抑制受试者的免疫应答。

2. 发明申请

WO2011069121A1 MESENCHYMAL STEM CELLS (MSCS) ISOLATED FROM MOBILIZED PERIPHERAL BLOOD 审中-公开
标题翻译：从移动的外周血中分离出的MESENCHYMAL STEM CELLS（MSCS）
公开(公告)号：WO2011069121A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058980
申请日：2010-12-03
申请人： NEOSTEM, INC. , MARASCO, Wayne , MEDICETTY, Satish , JIANG, Yajuan
发明人： MARASCO, Wayne , MEDICETTY, Satish , JIANG, Yajuan
IPC分类号： C12N5/0775 , A61K35/14
CPC分类号： A61K35/28 , A61K38/193 , A61K38/20 , C12N5/0665
摘要： The present invention generally relates to methods of obtaining peripheral blood-derived MSCs (PB- derived MSCs) and bone-marrow derived MSC (BM-derived MSCs) from a peripheral blood sample obtained from a human subject. In particular, the present invention relates to the surprising discovery that the mobilization of MSC into the peripheral blood is temporally regulated and that the number of circulating MSCs in human peripheral blood peaks after at least 2 days post administration of a mobilizing agent, such as G-CSF or GM-CSF to a human subject. Accordingly, in some embodiments, the present invention relates to methods of obtaining PB-derived and BM-derived MSC from peripheral blood from a human subject in vivo and ex vivo using mobilizing agents, such as G-CSF or GM-CSF, where administration of G-CSF and/or GM-CSF are optimized to mobilize MSCs and enrich the number of MSCs in the peripheral blood as apposed to other stem cell populations, such as HSCs.
摘要翻译：本发明一般涉及从人受试者获得的外周血样品获得外周血来源的MSC（PB-衍生的MSC）和骨髓来源的MSC（BM-衍生的MSC）的方法。特别地，本发明涉及令人惊奇的发现，即临时调节MSC进入外周血中，并且在外周血中循环MSC的数量在给予移动剂至少2天后达到峰值，例如G -CSF或GM-CSF。因此，在一些实施方案中，本发明涉及从体外来自人受试者的外周血和离体使用动员剂例如G-CSF或GM-CSF获得PB-衍生和BM衍生的MSC的方法，其中给药的G-CSF和/或GM-CSF被优化以动员MSC并富集外周血中MSC的数量，如其他干细胞群体，如HSC。

3. 发明申请

WO2011069117A1 METHOD OF ISOLATION OF STEM CELL POPULATIONS FROM PERIPHERAL BLOOD USING SIZED-BASED SEPARATION (ELUTRIATION) 审中-公开
标题翻译：使用基于大小的分离（分离）从外周血中分离干细胞群体的方法
公开(公告)号：WO2011069117A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058974
申请日：2010-12-03
申请人： NEOSTEM, INC. , MARASCO, Wayne , MEDICETTY, Satish , JIANG, Yajuan
发明人： MARASCO, Wayne , MEDICETTY, Satish , JIANG, Yajuan
IPC分类号： A01N1/02
CPC分类号： C12N5/0647 , C12N5/0665
摘要： Disclosed is a method for isolating multiple populations of stem cells in at least one step from a peripheral blood sample without using positive selection, therefore enabling a "no-touch" method to isolate different stem cell populations without contaminating the stem cell populations with positive selection agents (e.g., antibodies, etc ) In particular, the present disclosure relates to flow-rate separation of stem cell populations using elutriation (sized-based separation) to negatively exclude cells based on size Different fractions or subfractions comprise an increase in yield of Very Small Embryonic-like Stem cells (VSELs), MSCs or HSCs as compared to non-fractionated apheresis product.
摘要翻译：公开了一种在不使用阳性选择的情况下在至少一个步骤中从外周血液样品中分离多个干细胞群的方法，因此能够实现“不接触”方法来分离不同的干细胞群体，而不会用阳性选择污染干细胞群体药剂（例如，抗体等）特别地，本公开涉及使用淘析（基于大小的分离）干细胞群体的流速分离，以基于大小不利地排除细胞。不同的级分或亚级分包括非常高的产量增加与非分级分离产物相比，小胚胎样干细胞（VSEL），MSC或HSC。

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