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1. 发明申请

WO2012065060A3 GAS-FILLED MICROBUBBLES AND SYSTEMS FOR GAS DELIVERY 审中-公开
公开(公告)号：WO2012065060A3
公开(公告)日：2012-05-18
申请号：PCT/US2011/060368
申请日：2011-11-11
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , KHEIR, John , MCGOWAN, Francis, X. , LOXLEY, Andrew , LEE, Robert
发明人： KHEIR, John , MCGOWAN, Francis, X. , LOXLEY, Andrew , LEE, Robert
IPC分类号： A61K47/48 , A61K47/30 , A61K9/127 , A61K9/46 , A61K9/24
摘要： Compressible and concentrated suspensions containing gas-filled microbubbles, uses thereof for delivering gas into a subject in need thereof, and systems for delivering the compressible suspensions. The gas-filled microbubbles each comprise a gas core surrounded by a lipid membrane, which includes (a) one or more lipids, such as 1,2-disteroyl- sn -glycero- 3-phosphocholine (DSPC) or dipalmitoylphosphatidylcholine (DPPC), and (b) one or more stabilizing detergents, such as poloxamer 188, Pluronic F108, Pluronic F127, polyoxyethylene (100) stearyl ether, cholesterol, gelatin, polyvinylpyrrolidone (PVP), and sodium deoxycholate (NaDoc).

2. 发明申请

WO2012065060A2 GAS-FILLED MICROBUBBLES AND SYSTEMS FOR GAS DELIVERY 审中-公开
标题翻译：用于气体输送的气体填充微生物和系统
公开(公告)号：WO2012065060A2
公开(公告)日：2012-05-18
申请号：PCT/US2011060368
申请日：2011-11-11
申请人： CHILDRENS MEDICAL CENTER , KHEIR JOHN , MCGOWAN FRANCIS X , LOXLEY ANDREW , LEE ROBERT
发明人： KHEIR JOHN , MCGOWAN FRANCIS X , LOXLEY ANDREW , LEE ROBERT
IPC分类号： A61K47/48 , A61K9/127 , A61K9/24 , A61K9/46 , A61K47/30
CPC分类号： A61K9/5015 , A01N1/021 , A61B5/029 , A61K9/0019 , A61K9/10 , A61K9/127 , A61K33/00 , A61K47/10 , A61M5/19 , A61M16/00
摘要： Compressible and concentrated suspensions containing gas-filled microbubbles, uses thereof for delivering gas into a subject in need thereof, and systems for delivering the compressible suspensions. The gas-filled microbubbles each comprise a gas core surrounded by a lipid membrane, which includes (a) one or more lipids, such as 1,2-disteroyl-sn-glycero- 3-phosphocholine (DSPC) or dipalmitoylphosphatidylcholine (DPPC), and (b) one or more stabilizing detergents, such as poloxamer 188, Pluronic F108, Pluronic F127, polyoxyethylene (100) stearyl ether, cholesterol, gelatin, polyvinylpyrrolidone (PVP), and sodium deoxycholate (NaDoc).
摘要翻译：含有充气微泡的可压缩和浓缩悬浮液，其用于将气体输送到有需要的受试者中，以及用于递送可压缩悬浮液的系统。充气微泡各自包含由脂质膜包围的气芯，其包括（a）一种或多种脂质，例如1,2-二甲酰基-sn-甘油-3-磷酸胆碱（DSPC）或二棕榈酰磷脂酰胆碱（DPPC），和（b）一种或多种稳定洗涤剂，如泊洛沙姆188，Pluronic F108，Pluronic F127，聚氧乙烯（100）硬脂醚，胆固醇，明胶，聚乙烯吡咯烷酮（PVP）和脱氧胆酸钠（NaDoc）。

3. 发明申请

WO2009043031A2 MICROBUBBLES AND METHODS FOR OXYGEN DELIVERY 审中-公开
标题翻译：微管和氧气输送方法
公开(公告)号：WO2009043031A2
公开(公告)日：2009-04-02
申请号：PCT/US2008/078167
申请日：2008-09-29
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , KHEIR, John , BORDEN, Mark, Andrew , MCGOWAN, Francis, X.
发明人： KHEIR, John , BORDEN, Mark, Andrew , MCGOWAN, Francis, X.
IPC分类号： A61K47/48 , A61P9/10
CPC分类号： A61K47/6925
摘要： Compositions containing a carrier and microbubbles encapsulating one or more gases, preferably oxygen, and methods for making and using the compositions are described herein. The microbubbles contain a lipid envelope formed of at least one base lipid and at least one emulsifying agent. The compositions may be administered to a patient to quickly deliver large amounts of oxygen to the patient's blood supply or directly to a tissue in need of oxygen. The compositions may be administered via injection or as a continuous infusion. The compositions contain a concentrated microbubble suspension, where the suspension contains at least 40 ml oxygen/dl suspension. The microbubbles are preferably less than 20 microns in diameter, more preferably less than 15 microns in diameter. The microbubbles described herein may be administered to a patient in an effective amount to increase in oxygen concentration in the patient's blood, and/or one or more tissues or organs. The microbubbles may be administered alone or in combination with other treatments as an adjunctive therapy.
摘要翻译：本文描述了含有包封一种或多种气体（优选氧气）的载体和微泡的组合物以及制备和使用该组合物的方法。微泡包含由至少一种基础脂质和至少一种乳化剂形成的脂质包膜。可将组合物给予患者以快速将大量氧气递送至患者的血液供应或直接输送至需要氧气的组织。该组合物可以通过注射或作为连续输注来施用。该组合物含有浓缩的微泡悬浮液，其中该悬浮液含有至少40ml氧/ dl悬浮液。微泡直径优选小于20微米，更优选直径小于15微米。本文所述的微泡可以以有效量施用给患者以增加患者血液和/或一种或多种组织或器官中的氧浓度。微泡可以单独使用或与其他治疗组合使用作为辅助治疗。

4. 发明申请

WO2009043031A3 MICROBUBBLES AND METHODS FOR OXYGEN DELIVERY 审中-公开
标题翻译：用于氧气输送的微生物和方法
公开(公告)号：WO2009043031A3
公开(公告)日：2009-09-03
申请号：PCT/US2008078167
申请日：2008-09-29
申请人： CHILDRENS MEDICAL CENTER , UNIV COLUMBIA , KHEIR JOHN , BORDEN MARK ANDREW , MCGOWAN FRANCIS X
发明人： KHEIR JOHN , BORDEN MARK ANDREW , MCGOWAN FRANCIS X
IPC分类号： A61K47/48 , A61P9/10
CPC分类号： A61K47/6925
摘要： Compositions containing a carrier and microbubbles encapsulating one or more gases, preferably oxygen, and methods for making and using the compositions are described herein. The microbubbles contain a lipid envelope formed of at least one base lipid and at least one emulsifying agent. The compositions may be administered to a patient to quickly deliver large amounts of oxygen to the patient's blood supply or directly to a tissue in need of oxygen. The compositions may be administered via injection or as a continuous infusion. The compositions contain a concentrated microbubble suspension, where the suspension contains at least 40 ml oxygen/dl suspension. The microbubbles are preferably less than 20 microns in diameter, more preferably less than 15 microns in diameter. The microbubbles described herein may be administered to a patient in an effective amount to increase in oxygen concentration in the patient's blood, and/or one or more tissues or organs. The microbubbles may be administered alone or in combination with other treatments as an adjunctive therapy.
摘要翻译：本文描述了包含载体和包封一种或多种气体（优选氧气）的微泡的组合物，以及用于制备和使用组合物的方法。微泡含有由至少一种碱性脂质和至少一种乳化剂形成的脂质包膜。组合物可以施用于患者以将大量氧气快速输送到患者的血液供应中，或者直接传递到需要氧气的组织。组合物可以通过注射或连续输注来施用。组合物含有浓缩微泡悬浮液，其中悬浮液含有至少40ml氧/ dl悬浮液。微泡的直径优选小于20微米，更优选直径小于15微米。本文所述的微泡可以有效量施用于患者以增加患者血液中的氧浓度，和/或一种或多种组织或器官。微泡可以单独施用或与其他治疗组合施用作为辅助治疗。

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