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1. 发明申请

WO2013041677A1 COMBINATION THERAPY USING IMMUNOGLOBULIN AND C1-INHIBITOR 审中-公开
标题翻译：使用免疫抑制剂和C1抑制剂组合治疗
公开(公告)号：WO2013041677A1
公开(公告)日：2013-03-28
申请号：PCT/EP2012/068643
申请日：2012-09-21
申请人： CSL BEHRING GMBH , BASTA, Milan , CHEN, Xinzhi , MATTSON, Mark
发明人： BASTA, Milan , CHEN, Xinzhi , MATTSON, Mark
IPC分类号： A61K39/395 , A61K38/55 , A61P9/10
CPC分类号： A61K39/39516 , A61K38/55 , A61K38/57 , A61K45/06 , A61K2039/505 , C07K16/06 , A61K2300/00
摘要： Methods are disclosed for treating cerebral ischemia using a combination of C1-INH and immunoglobulin, such as human plasma derived immunoglobulin (IVIG).
摘要翻译：公开了使用C1-INH和免疫球蛋白的组合（例如人血浆衍生的免疫球蛋白（IVIG））治疗脑缺血的方法。

2. 发明申请

WO2008024893A3 DERIVATIVES OF URIC AND THIOURIC ACID FOR OXIDATIVE STRESS-RELATED DISEASES 审中-公开
标题翻译：用于氧化应激相关疾病的尿酸和硫酸的衍生物
公开(公告)号：WO2008024893A3
公开(公告)日：2009-03-05
申请号：PCT/US2007076597
申请日：2007-08-23
申请人： US GOV HEALTH & HUMAN SERV , GREIG NIGEL H , MATTSON MARK P , HABERMAN FRANK , YU QIAN-SHENG , ARUMUGAM THIRUMA
发明人： GREIG NIGEL H , MATTSON MARK P , HABERMAN FRANK , YU QIAN-SHENG , ARUMUGAM THIRUMA
IPC分类号： A61K31/52 , A61K31/522 , A61P17/02 , A61P25/00
CPC分类号： A61K31/52 , A61K31/522
摘要： Disclosed is a method of treating or preventing an oxidative stress-related disease in a mammal in need thereof comprising administering an effective amount of a compound of formula (I) to the mammal, wherein R1-R4 and X1-X3 are as described herein. Examples of the oxidative stress-related diseases are a neurological disorder, a cardiovascular disorder, and a wound.
摘要翻译：公开了一种治疗或预防有需要的哺乳动物的氧化应激相关疾病的方法，包括向哺乳动物施用有效量的式（I）化合物，其中R 1 -R 4和X 1 -X 3如本文所述。氧化应激相关疾病的实例是神经障碍，心血管疾病和伤口。

3. 发明申请

WO2002070949A2 LIGHT TILTING APPARATUS 审中-公开
标题翻译：轻型倾斜装置
公开(公告)号：WO2002070949A2
公开(公告)日：2002-09-12
申请号：PCT/US2002/001558
申请日：2002-01-18
申请人： GENIE INDUSTRIES, INC. , ALLEN, Bradley , MATTSON, Mark
发明人： ALLEN, Bradley , MATTSON, Mark
IPC分类号： F21V21/14
CPC分类号： B60P3/18 , F21V21/14 , F21V21/22 , F21V21/30 , F21W2131/10
摘要： A light tilting apparatus usable with an extendable light. In one embodiment, a mobile lighting system includes a tiltable light assembly mounted to an extendable tower on a trailer. The tiltable light assembly comprises one or more lights fixedly mounted to a tilting member pivotably mounted to the extendable tower. A linkage operably connected to the tilting member at one end has a catch on a distal end. A linkage regulator attached to the extendable tower has a guide portion for the linkage to pass through as the extendable tower is extended and retracted. The linkage regulator is configured to engage the catch on the distal end of the linkage when the extendable tower reaches a preselected extension position restricting further motion of the linkage in the direction of tower extension. The linkage causes the tilting member to pivot and rotate the lights downward with continued extension of the extendable tower past the preselected extension position. Retraction of the extendable tower back to the preselected extension position, accordingly, results in causing rotation of the lights upwardly.
摘要翻译：一种可伸缩光使用的倾斜装置。在一个实施例中，移动照明系统包括安装到拖车上的可延伸塔的可倾斜的灯组件。可倾斜的灯组件包括固定地安装到可枢转地安装到可延伸塔的倾斜构件上的一个或多个灯。在一端可操作地连接到倾斜构件的连杆在远端具有卡扣。附接到可延伸塔的连杆调节器具有引导部分，用于当伸缩塔延伸和缩回时连杆通过。连杆调节器构造成当可伸缩塔达到限制连杆机构在塔架延伸方向上的进一步运动的预选延伸位置时，接合连杆的远端上的卡扣。该连杆导致倾斜构件枢转并且随着可延伸塔的延伸超过预选的延伸位置而使灯向下转动。因此，可延伸塔回缩到预选的延伸位置，导致光线向上旋转。

4. 发明申请

WO2008024893A2 METHOD OF TREATING OR PREVENTING OXIDATIVE STRESS-RELATED DISEASE 审中-公开
标题翻译：治疗或预防氧化应激相关疾病的方法
公开(公告)号：WO2008024893A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/076597
申请日：2007-08-23
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , GREIG, Nigel, H. , MATTSON, Mark, P. , HABERMAN, Frank , YU, Qian-sheng , ARUMUGAM, Thiruma
发明人： GREIG, Nigel, H. , MATTSON, Mark, P. , HABERMAN, Frank , YU, Qian-sheng , ARUMUGAM, Thiruma
IPC分类号： A61K31/52 , A61K31/522 , A61P17/02 , A61P25/00
CPC分类号： A61K31/52 , A61K31/522
摘要： Disclosed is a method of treating or preventing an oxidative stress-related disease in a mammal in need thereof comprising administering an effective amount of a compound of formula (I) to the mammal, wherein R 1 -R 4 and X 1 -X 3 are as described herein. Examples of the oxidative stress-related diseases are a neurological disorder, a cardiovascular disorder, and a wound.
摘要翻译：公开了一种在有需要的哺乳动物中治疗或预防氧化应激相关疾病的方法，包括向哺乳动物施用有效量的式（I）化合物，其中R 1〜 SUP 4+和X 1 -X 3如本文所述。氧化应激相关疾病的实例是神经障碍，心血管疾病和伤口。

5. 发明申请

WO02070949A3 LIGHT TILTING APPARATUS 审中-公开
标题翻译：轻型倾斜装置
公开(公告)号：WO02070949A3
公开(公告)日：2002-12-19
申请号：PCT/US0201558
申请日：2002-01-18
申请人： GENIE IND INC , ALLEN BRADLEY CO , MATTSON MARK
发明人： ALLEN BRADLEY , MATTSON MARK
IPC分类号： F21S8/00 , F21V21/14 , F21V21/22
CPC分类号： B60P3/18 , F21V21/14 , F21V21/22 , F21W2131/10
摘要： A light tilting apparatus usable with an extendable light. In one embodiment, a mobile lighting system (100) includes a tiltable light assembly (140) mounted to an extendable tower (120) on a trailer (160). The tiltable light assembly comprises one or more lights (142) fixedly mounted to a tilting member (212) pivotably mounted to the extendable tower. A linkage (214) operably connected to the tilting member at one end (215) has a catch (216) on a distal end. A linkage regulator (218) attached to the extendable tower has a guide portion for the linkage to pass through as the extendable tower is extended and retracted. The linkage regulator is configured to engage the catch on the distal end of the linkage when the extendable tower reaches a preselected extension position restricting further motion of the linkage in the direction of tower extension. The linkage causes the tilting member to pivot and rotate the lights downward with continued extension of the extendable tower past the preselected extension position. Retraction of the extendable tower back to the preselected extension position, accordingly, results in causing rotation of the lights upwardly.
摘要翻译：一种可伸缩光使用的倾斜装置。在一个实施例中，移动照明系统（100）包括安装到拖车（160）上的可延伸塔（120）的可倾斜的灯组件（140）。可倾斜的灯组件包括固定地安装到可枢转地安装到可延伸塔的倾斜构件（212）上的一个或多个灯（142）。在一端（215）处可操作地连接到倾斜构件的连杆（214）在远端具有挡块（216）。附接到可延伸塔的连杆调节器（218）具有引导部分，用于当伸缩塔伸展和缩回时连杆机构通过。连杆调节器构造成当可伸缩塔达到限制连杆机构在塔架延伸方向上的进一步运动的预选延伸位置时，接合连杆的远端上的卡扣。该连杆导致倾斜构件枢转并且随着可延伸塔的延伸超过预选的延伸位置而使灯向下转动。因此，可延伸塔回缩到预选的延伸位置，导致光线向上旋转。

6. 发明申请

WO2012125489A3 CAM DRIVEN WEDGE BRAKING SYSTEM FOR MULTI-STAGE LIFTS 审中-公开
公开(公告)号：WO2012125489A3
公开(公告)日：2012-09-20
申请号：PCT/US2012/028574
申请日：2012-03-09
申请人： LIFTSMART, LLC , BUSUTTIL, John Joseph , CITRON, Steven , MATTSON, Mark
发明人： BUSUTTIL, John Joseph , CITRON, Steven , MATTSON, Mark
IPC分类号： B66F9/075 , B66F9/08
摘要： Apparatus for braking relative vertical movement between two vertical members includes linkage connected either directly or indirectly to a cable pulley-mount that is spring loaded and moves cams that wedge in between two vertically moveable members when cable tension is not present at the pulley. A broken cable, for example, will create a situation where there is no cable tension between a plurality of cable pulleys, the lack of cable tension moves the mechanical cam style linkage to engage the braking members.

7. 发明申请

WO0204409A3 TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS 审中-公开
标题翻译：作为神经防护剂的四氢苯并噻唑类似物
公开(公告)号：WO0204409A3
公开(公告)日：2002-07-18
申请号：PCT/US0121504
申请日：2001-07-06
申请人： THE GOVERNMENT OF THE UNITED S , GREIG NIGEL H , MATTSON MARK , ZHU XIAOXIANG , YU QIAN-SHENG , HOLLOWAY HAROLD WAYNE
发明人： THE GOVERNMENT OF THE UNITED S , GREIG NIGEL H , MATTSON MARK , ZHU XIAOXIANG , YU QIAN-SHENG , HOLLOWAY HAROLD WAYNE
IPC分类号： A61P25/00 , A61P25/16 , A61P25/28 , C07D263/58 , C07D277/68 , C07D277/82 , C07D498/04 , C07D513/04 , A61K31/423 , A61K31/428 , C07D277/72
CPC分类号： C07D263/58 , C07D277/68 , C07D277/82 , C07D513/04
摘要： This invention relates generally to tetrahydrobenzothiazole analogues and tetrahydrobenzooxyzole analogues, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to methods of treatment using these compounds. The invention also encompasses pharmaceutically acceptable esters, amides, and salts of such compounds. The invention further provides a method of reducing or delaying apoptosis in a population of cells, comprising contacting the population of cells with a tetrahydrobenzothiazole analogue or a tetrahydrobenzooxyzole analogue, thereby reducing or delaying apoptosis in the population of cells.
摘要翻译：本发明一般涉及四氢苯并噻唑类似物和四氢苯并氧杂唑类似物，涉及包含这些化合物和药学上可接受的载体的药物组合物，以及使用这些化合物的治疗方法。本发明还包括药学上可接受的酯，酰胺和这些化合物的盐。本发明进一步提供了减少或延迟细胞群凋亡的方法，包括使细胞群与四氢苯并噻唑类似物或四氢苯并氧杂环庚烷类似物接触，由此减少或延迟细胞群中的细胞凋亡。

8. 发明申请

WO2012125489A2 CAM DRIVEN WEDGE BRAKING SYSTEM FOR MULTI-STAGE LIFTS 审中-公开
标题翻译： CAM DRIVEN WEDGE制动系统，用于多级升降机
公开(公告)号：WO2012125489A2
公开(公告)日：2012-09-20
申请号：PCT/US2012028574
申请日：2012-03-09
申请人： LIFTSMART LLC , BUSUTTIL JOHN JOSEPH , CITRON STEVEN , MATTSON MARK
发明人： BUSUTTIL JOHN JOSEPH , CITRON STEVEN , MATTSON MARK
IPC分类号： B66F9/075 , B66F9/08
CPC分类号： B66F9/07559 , B66F9/087 , B66F17/003
摘要： Apparatus for braking relative vertical movement between two vertical members includes linkage connected either directly or indirectly to a cable pulley-mount that is spring loaded and moves cams that wedge in between two vertically moveable members when cable tension is not present at the pulley. A broken cable, for example, will create a situation where there is no cable tension between a plurality of cable pulleys, the lack of cable tension moves the mechanical cam style linkage to engage the braking members.
摘要翻译：用于在两个垂直构件之间制动相对垂直运动的装置包括直接地或间接地连接到弹簧加载的电缆滑轮架上的联动装置，并且当皮带轮上不存在电缆张力时，移动楔形在两个可垂直移动的构件之间的凸轮。例如，断裂的电缆将产生在多个电缆滑轮之间不存在电缆张力的情况，缺少电缆张力使机械凸轮连杆机构移动以接合制动部件。

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