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1. 发明申请

WO2007034982A1 ENHANCER OF CHOLINESTERASE ACTIVITY 审中-公开
标题翻译： CHOLINESTERASE活性增强剂
公开(公告)号：WO2007034982A1
公开(公告)日：2007-03-29
申请号：PCT/JP2006/319219
申请日：2006-09-21
申请人： VERITRON LIMITED , MATSUDA, Hideaki , MIYAKE, Yoshimasa , HIRATA, Noriko
发明人： MATSUDA, Hideaki , MIYAKE, Yoshimasa , HIRATA, Noriko
IPC分类号： A61K36/48 , A61P1/16
CPC分类号： A61K36/48
摘要： The invention provides an enhancer for cholinesterase. An enhancer comprising Gam Arabic as an active ingredient is useful for preventing and/or treating a decreased cholinesterase activity due to liver damage or inhibition of cholinesterase as a side effect of various agents.
摘要翻译：本发明提供了胆碱酯酶的增强剂。包含阿拉伯胶作为活性成分的增强剂可用于预防和/或治疗由于肝脏损伤引起的胆碱酯酶活性降低或胆碱酯酶抑制作为各种药剂的副作用。

2. 发明申请

WO2008015575A2 MELANOGENESIS STIMULANT COMPOSITIONS DERIVED FROM EXTRACTS OF PLANTS OF THE GENUS NIGELLA 审中-公开
标题翻译：黑线虫属植物提取物产生的黑色素刺激性组合物
公开(公告)号：WO2008015575A2
公开(公告)日：2008-02-07
申请号：PCT/IB2007/003240
申请日：2007-05-09
申请人： UNISANTIS F Z E , KUBO, MICHINORI , MATSUDA, HIDEAKI
发明人： KUBO, MICHINORI , MATSUDA, HIDEAKI
CPC分类号： A61K36/71 , A61K8/02 , A61K8/97 , A61K2800/782 , A61K2800/91 , A61K2800/92 , A61Q5/065 , A61Q5/10
摘要： Disclosed are extracts and compositions containing the extracts useful for stimulating melanogenesis; the extracts are obtained from the plants of the genus Nigella (Ranunculaceae). The extracts and compositions are useful in personal care and pharmaceutical compositions for preventing, improving, or treating hair conditions and/or leukotrichia resulting from a reduction in or failure of melanin production. Such compositions may be applied topically or taken orally. The compositions stimulate melanin production as well as inhibit testosterone 5a-reductase, an indirect method to increase melanin production.
摘要翻译：公开了含有用于刺激黑素生成的提取物的提取物和组合物; 该提取物从奈杰菌属（毛茛科）的植物获得。提取物和组合物可用于个人护理和药物组合物中，用于预防，改善或治疗由黑素产生减少或失败导致的毛发状况和/或白血病。这种组合物可以局部应用或口服。该组合物刺激黑色素生成并抑制睾酮5α-还原酶，这是间接增加黑色素产生的方法。

3. 发明申请

WO2007094486A1 ACCELERATING AGENT OF CALCIUM ABSORPTION 审中-公开
标题翻译：加速吸收剂
公开(公告)号：WO2007094486A1
公开(公告)日：2007-08-23
申请号：PCT/JP2007/052906
申请日：2007-02-13
申请人： VERITRON LIMITED , MATSUDA, Hideaki , IWAKI, Masahiro , KAWASE, Atsushi
发明人： MATSUDA, Hideaki , IWAKI, Masahiro , KAWASE, Atsushi
IPC分类号： A61D9/00 , A23L1/304 , A23L2/52 , A61K33/06 , A61K33/10 , A61K33/14 , A61K47/12
CPC分类号： A23L2/52 , A23L33/16 , A23L33/21 , A23V2002/00 , A61K33/06 , A61K33/10 , A61K36/48 , A61K47/36 , Y02A50/411 , A61K2300/00 , A23V2200/306 , A23V2250/1578 , A23V2250/5028
摘要： The present invention provides an accelerating agent for calcium absorption comprising Gum Arabic, which is daily available while simultaneously taking dietary fiber.
摘要翻译：本发明提供了一种钙吸收促进剂，其包括阿拉伯胶，其在同时服用膳食纤维的同时每天使用。

4. 发明申请

WO1997033870A1 NOVEL PYRIDINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：新的吡啶衍生物和含有它们的药物作为活性成分
公开(公告)号：WO1997033870A1
公开(公告)日：1997-09-18
申请号：PCT/JP1997000712
申请日：1997-03-07
申请人： SS PHARMACEUTICAL CO., LTD. , HASEGAWA, Hiroshi , MIKAMI, Tadashi , TACHIBANA, Koichi , YAMAZAKI, Kazuo , KAWAMOTO, Noriyuki , SHIOIRI, Noriaki , KUSANO, Koji , SATO, Susumu , MATSUDA, Hideaki , YOKOYAMA, Toshio
发明人： SS PHARMACEUTICAL CO., LTD.
IPC分类号： C07D213/69
CPC分类号： C07D213/69 , C07D405/06 , C07D409/06 , Y10S514/885
摘要： Pyridine derivatives represented by general formula (1) and salts thereof, and medicines containing the same as the active ingredient, such as a cytokine production inhibitor, wherein R and R represent each H, alkyl, cycloalkyl, hydroxyalkyl, optionally substituted alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, optionally substituted aralkyl, phenacyl or acyl; R represents alkyl, optionally substituted phenyl, heteroaryl or cyclic amino; and X represents O or a combination of OH with H. These compounds have potent and highly specific and safe immune function regulating effects capable of suppressing excessive production of specified cytokines in various immunologic diseases.
摘要翻译：由通式（1）表示的吡啶衍生物及其盐，以及含有与活性成分相同的药物，例如细胞因子产生抑制剂，其中R 1和R 2各自表示H，烷基，环烷基，羟基烷基，任选取代的烷氧基烷基，羧基烷基，烷氧基羰基烷基，任选取代的芳烷基，苯甲酰甲酰基或酰基; R 3表示烷基，任选取代的苯基，杂芳基或环状氨基; 并且X表示O或OH与H的组合。这些化合物具有强力和高度特异性且安全的免疫功能调节作用，能够抑制各种免疫疾病中特定细胞因子的过量产生。

5. 发明申请

WO1995033726A1 4-QUINOLINONE DERIVATIVE OR SALT THEREOF 审中-公开
标题翻译： 4-喹啉酮衍生物或其盐
公开(公告)号：WO1995033726A1
公开(公告)日：1995-12-14
申请号：PCT/JP1995001118
申请日：1995-06-06
申请人： SS PHARMACEUTICAL CO., LTD. , YAMAZAKI, Kazuo , ADEGAWA, Shigeru , OGAWA, Yoichiro , MATSUDA, Hideaki , KURAISHI, Tadayuki
发明人： SS PHARMACEUTICAL CO., LTD.
IPC分类号： C07D215/58
CPC分类号： C07D401/12 , C07D215/58 , C07D405/12
摘要： A 4-quinolinone derivative represented by general formula (1) or a salt thereof, and an intermediate for use in the production thereof; and a medicinal composition containing the compound as the active ingredient: wherein R and R represent each H, halogen, cyano, optionally halogenated lower alkyl, lower alkylsulfonyl, lower alkylsulfinyl, lower alkylthio or lower alkoxy, or optionally substituted phenylsulfonyl, phenylsulfinyl or phenylthio; and R and R represent each H, optionally halogenated lower alkyl or cycloalkyl, or optionally substituted pyridyl, furanyl or phenyl, or R and R may be combined together to represent a four- to six-membered ring. The compound (1) and salt thereof have an excellent effect of potassium channel activation and are useful as a preventive and remedy for, for example, circulatory and bronchial diseases.
摘要翻译：由通式（1）表示的4-喹啉酮衍生物或其盐及其制备用的中间体; 和含有该化合物作为活性成分的药物组合物：其中R 1和R 2分别代表H，卤素，氰基，任选卤代的低级烷基，低级烷基磺酰基，低级烷基亚磺酰基，低级烷硫基或低级烷氧基，或任选取代苯基磺酰基，苯基亚磺酰基或苯硫基; R 3和R 4代表每个H，任选卤代的低级烷基或环烷基，或任选取代的吡啶基，呋喃基或苯基，或者R 3和R 4可以组合在一起代表四六元环。化合物（1）及其盐具有优异的钾通道活化作用，可用作例如循环和支气管疾病的预防和治疗。

6. 发明申请

WO1994027976A1 TRIAZOLE DERIVATIVE OR SALT THEREOF, AND FUNGICIDE CONTAINING THE SAME 审中-公开
标题翻译：三唑衍生物或其盐，以及含有其的杀真菌剂
公开(公告)号：WO1994027976A1
公开(公告)日：1994-12-08
申请号：PCT/JP1994000843
申请日：1994-05-27
申请人： SS PHARMACEUTICAL CO., LTD. , TOKIZAWA, Minoru , KANAMARU, Yoshihiko , KAWAMOTO, Noriyuki , NAKAZAWA, Hitoshi , NASHIMOTO, Koji , MAEBASHI, Kazuki , MATSUDA, Hideaki , KURAISHI, Tadayuki
发明人： SS PHARMACEUTICAL CO., LTD.
IPC分类号： C07D249/08
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： A triazole derivative represented by general formula (1) or a salt thereof, and a fungicide containing the same, wherein R and R represent each methyl, or R and R are combined together to represent ethylene. The compound (1) has a high fungicidal activity, and the fungicide containing the same as the active ingredient is useful for preventing and treating infectious diseases of mammals including humans caused by fungi.
摘要翻译：由通式（1）表示的三唑衍生物或其盐和含有它们的杀真菌剂，其中R 1和R 2各自表示甲基，或R 1和R 2组合在一起至代表乙烯。化合物（1）具有高杀真菌活性，并且含有与活性成分相同的杀真菌剂可用于预防和治疗包括真菌引起的人的哺乳动物的感染性疾病。

7. 发明申请

WO1992001676A1 QUINOLONECARBOXYLIC ACID DERIVATIVE 审中-公开
标题翻译：喹喔啉羧酸衍生物
公开(公告)号：WO1992001676A1
公开(公告)日：1992-02-06
申请号：PCT/JP1991000954
申请日：1991-07-17
申请人： SS PHARMACEUTICAL CO., LTD. , KONNO, Fujiko , SHIBATA, Akihiro , MATSUDA, Hideaki , ASAOKA, Takemitsu , KAWAHARA, Ryuichi , TAIDO, Naokata , KURAISHI, Tadayuki , TAKEDA, Sunao
发明人： SS PHARMACEUTICAL CO., LTD.
IPC分类号： C07D215/56
CPC分类号： C07D215/56 , C07D401/04 , C07D413/04 , C07D417/04
摘要： A quinolonecarboxylic acid derivative represented by general formula (1), its salt and an antibacterial agent containing the same as the active ingredient, wherein R1 represents hydrogen, alkyl, aralkyl or an ester residue which is hydrolyzable in vivo; R2 represents hydrogen or amino which may be substituted with one or two lower alkyl groups; X represents hydrogen or halogen; Y represents CH¿2?, O, S, SO, SO2 or NR?3¿, wherein R3 represents hydrogen or lower alkyl; and Z represents an oxygen atom or two hydrogen atoms. This compound develops a potent antibacterial activity particularly against gram-positive bacteria, so that it is useful in preventing and treating various infectious diseases clinically.

8. 发明申请

WO2006059764A3 ENHANCER OF THE EFFECT OF ADRENOCORTICOID, COMPRISING GUM ARABIC 审中-公开
标题翻译：加强阿拉伯胶囊的效果的增强
公开(公告)号：WO2006059764A3
公开(公告)日：2007-04-19
申请号：PCT/JP2005022267
申请日：2005-11-29
申请人： VERITRON LTD , KUBO YUMIKO , MATSUDA HIDEAKI
发明人： MATSUDA HIDEAKI , KUBO MICHINORI
IPC分类号： A61K31/57 , A61K31/573 , A61K31/58 , A61P13/12
CPC分类号： A61K31/573 , A61K31/57 , A61K31/58 , A61K36/48 , A61K2300/00
摘要： This invention provides an enhancer of the effect of adrenocorticoid on nephritis without enhancement of the undesirable side-effects of the said adrenocorticoid,comprising the water-soluble gum obtained from the stem and/or branch of Acacia species, e.g., Gum Arabic. The combination of the adrenocorticoid and the said water-soluble gum enhances the effect of the said adrenocorticoid on nephritis without enhancement of the undesirable side-effects of the hormone agent.
摘要翻译：本发明提供了增强肾上腺皮质激素对肾炎作用的增强剂，而不增强所述肾上腺皮质激素的不良副作用，其包含从相思树种的茎和/或分支获得的水溶性胶，例如阿拉伯胶。肾上腺皮质激素和所述水溶性胶的组合增强了所述肾上腺皮质激素对肾炎的作用，而不增加激素剂的不良副作用。

9. 发明申请

WO1993024460A1 5-AMINOQUINOLONECARBOXYLIC ACID DERIVATIVE AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：含有它们的5-氨基喹啉羧酸衍生物和抗菌剂作为活性成分
公开(公告)号：WO1993024460A1
公开(公告)日：1993-12-09
申请号：PCT/JP1993000694
申请日：1993-05-25
申请人： SS PHARMACEUTICAL CO., LTD. , KAIHO, Terumitsu , TAKEDA, Sunao , KONNO, Fujiko , SHIBATA, Akihiro , MATSUMOTO, Masaru , ASAOKA, Takemitsu , MATSUDA, Hideaki , KURAISHI, Tadayuki
发明人： SS PHARMACEUTICAL CO., LTD.
IPC分类号： C07D215/56
CPC分类号： C07D215/56 , A61K31/47 , A61K31/495 , C07D401/04
摘要： A 5-aminoquinolonecarboxylic acid derivative represented by general formula (1) or a salt thereof, and an antibacterial containing the same as the active ingredient, wherein R represents hydrogen, amino, C1-C5 linear or branched alkyl, or an alkylamino group having a C1-C5 linear or branched alkyl group; R represents hydrogen or C1-C5 linear or branched alkyl; X represents halogen; Y represents CH2, NH, CHR , NR (wherein R represents C1-C5 linear or branched alkyl) or oxygen; and Z represents an oxygen atom or two hydrogen atoms. It has a potent antibacterial activity against gram-positive bacteria including resistant strains and can be well absorbed in living organisms.
摘要翻译：由通式（1）表示的5-氨基喹诺酮羧酸衍生物或其盐，和含有与活性成分相同的抗菌剂，其中R 1表示氢，氨基，C 1 -C 5直链或支链烷基或烷基氨基具有C1-C5直链或支链烷基的基团; R 2表示氢或C 1 -C 5直链或支链烷基; X表示卤素; Y表示CH 2，NH，CHR 3，NR 3（其中R 3表示C 1 -C 5直链或支链烷基）或氧; Z表示氧原子或两个氢原子。它对革兰氏阳性菌（包括抗性菌株）具有很强的抗菌活性，可以很好的吸收生物体内。

10. 发明申请

WO1991001308A1 QUINOLONECARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：喹喔啉羧酸衍生物
公开(公告)号：WO1991001308A1
公开(公告)日：1991-02-07
申请号：PCT/JP1990000425
申请日：1990-03-29
申请人： SS PHARMACEUTICAL CO., LTD. , SHIBATA, Akihiro , MATSUDA, Hideaki , ASAOKA, Takemitsu , MATSUMOTO, Masaru , KAWAHARA, Ryuichi , KATORI, Tatsuhiko , TAIDO, Naokata , KURAISHI, Tadayuki
发明人： SS PHARMACEUTICAL CO., LTD.
IPC分类号： C07D215/56
CPC分类号： C07D215/56 , C07D401/04
摘要： Quinolonecarboxylic acid derivatives having an excellent antibacterial activity of general formula (I), their salts, antibacterial agents containing the same as the active ingredient, and intermediates therefor of general formula (V). In formula (I), R1 is lower alkyl, R2 is hydrogen or lower alkyl, R3 is hydrogen or halogen, and R4 and R5 are combined together to form an optionally substituted 5- or 6-membered ring which may contain other heteroatom(s), provided that the case where R1 is methyl, R2 and R3 are each hydrogen, and (a) is piperazinyl, is excluded. In formula (V), R1 is lower alkyl, R2-1 is lower alkyl, R3 is hydrogen or halogen, X is halogen, and R4 and R5 are combined together to form an optionally substituted 5- or 6-membered ring which may contain other heteroatom(s).

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