专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009127679A1 INDOLES AS MODULATORS OF NICOTICIC ACETYLCHOLINE RECEPTOR SUBTYPE ALPHA-7 审中-公开
标题翻译：作为尼古丁乙酰胆碱受体亚型ALPHA-7的调节剂
公开(公告)号：WO2009127679A1
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054495
申请日：2009-04-16
申请人： GLAXO GROUP LIMITED , DINNELL, Kevin , LIGHTFOOT, Andrew, P. , MARSHALL, Howard, Robert
发明人： DINNELL, Kevin , LIGHTFOOT, Andrew, P. , MARSHALL, Howard, Robert
IPC分类号： C07D401/12 , A61K31/4439 , A61P25/18
CPC分类号： C07D401/12
摘要： This invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of List A or a salt thereof which may be represented by N-[(2-Trifluoromethyl-1H-indol-5-yl)methyl]-5-(trifluoromethyl)-2-pyrimidinecarboxarnide.
摘要翻译：本发明涉及通过列举A或其盐的化合物调节a7烟碱乙酰胆碱受体（nAChR），其可以由N - [（2-三氟甲基-1H-吲哚-5-基）甲基] -5- （三氟甲基）-2- pyrimidinecarboxarnide。

2. 发明申请

WO2009127678A1 INDOLES AS MODULATORS OF NICOTINIC ACETYLCHOLIN RECEPTOR SUBTYPE ALPHA-71 审中-公开
标题翻译：作为尼古丁乙酰胆碱受体亚型ALPHA-71的调节剂
公开(公告)号：WO2009127678A1
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054493
申请日：2009-04-16
申请人： GLAXO GROUP LIMITED , DINNELL, Kevin , LIGHTFOOT, Andrew, P. , MARSHALL, Howard, Robert
发明人： DINNELL, Kevin , LIGHTFOOT, Andrew, P. , MARSHALL, Howard, Robert
IPC分类号： C07D401/12 , A61K31/4439 , A61P25/18
CPC分类号： C07D401/12
摘要： This invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof: Formula (I)
摘要翻译：本发明涉及通过式（I）化合物或其盐调节a7烟碱乙酰胆碱受体（nAChR）：式（I）

3. 发明申请

WO2008092877A2 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译： GLYT1运输商抑制剂及其在治疗神经病学和神经病学疾病中的应用
公开(公告)号：WO2008092877A2
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051083
申请日：2008-01-30
申请人： GLAXO GROUP LIMITED , UNIVERSITY OF NOTTINGHAM , AHMAD, Nadia Mamoona , LAI, Justine, Yeun Quai , MARSHALL, Howard, Robert , NASH, David, John , PORTER, Roderick, Alan
发明人： AHMAD, Nadia Mamoona , LAI, Justine, Yeun Quai , MARSHALL, Howard, Robert , NASH, David, John , PORTER, Roderick, Alan
IPC分类号： C07D471/10 , C07D491/10 , A61K31/438 , A61K31/4188 , A61P25/18 , A61P25/28
CPC分类号： C07D471/10 , C07D491/10
摘要： Compounds of formula (I) or a salt thereof are provided wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , X, n, p and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.
摘要翻译：提供式（I）化合物或其盐，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7，R 9，R 10， SUP>，X，n，p和m如说明书中所定义。还公开了化合物作为药物的用途，以及用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物的制备。本发明还公开了包含该化合物的药物组合物和组合。

4. 发明申请

WO2008092876A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译： GLYT1运输商抑制剂及其在治疗神经病学和神经病学疾病中的应用
公开(公告)号：WO2008092876A1
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051082
申请日：2008-01-30
申请人： GLAXO GROUP LIMITED , UNIVERSITY OF NOTTINGHAM , AHMAD, Nadia, Mamoona , LAI, Justine, Yeun Quai , ANDREOTTI, Daniele , MARSHALL, Howard, Robert , NASH, David, John , PORTER, Roderick, Alan
发明人： AHMAD, Nadia, Mamoona , LAI, Justine, Yeun Quai , ANDREOTTI, Daniele , MARSHALL, Howard, Robert , NASH, David, John , PORTER, Roderick, Alan
IPC分类号： C07D471/10 , A61K31/438 , A61P25/00 , A61P25/18 , A61P25/28
CPC分类号： C07D471/10
摘要： Compounds of formula (I) or a salt thereof are provided: wherein R 6 , R 7 , R 9 , R 10 , R 11 , X, n, p, Ar and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.
摘要翻译：提供式（I）化合物或其盐：其中R 6，R 7，R 9，R 10， R 11，R 11，X，n，p，Ar和m如说明书中所定义。还公开了化合物作为药物的用途，以及用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物的制备。本发明还公开了包含该化合物的药物组合物和组合。

5. 发明申请

WO2007104776A1 N-PHENYL-2-0X0-1,4-DIAZASPIR0 [4.5] DEC-3-EN-1-YL ACETAMIDE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS 审中-公开
标题翻译： N-PHENYL-2-0X0-1,4-DIAZASPIR0 [4.5] DEC-3-EN-1-YL乙酰胺衍生物及其作为甘氨酸运输抑制剂的用途
公开(公告)号：WO2007104776A1
公开(公告)日：2007-09-20
申请号：PCT/EP2007/052415
申请日：2007-03-14
申请人： GLAXO GROUP LIMITED , COULTON, Steven , MARSHALL, Howard , NASH, David, John , PORTER, Roderick, Alan
发明人： COULTON, Steven , MARSHALL, Howard , NASH, David, John , PORTER, Roderick, Alan
IPC分类号： C07D235/02 , A61K31/4184
CPC分类号： C07D235/02
摘要： Compounds of formula (I) and salts and solvates are provided: Formula (I) Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译：提供了式（I）化合物和盐和溶剂合物：式（I）化合物作为药物的用途，以及用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物的用途。本发明还包括制备这些化合物及其药物制剂的方法。

6. 发明申请

WO2006067417A1 GLYCINE TRANSPORT INHIBITORS 审中-公开
标题翻译：甘氨酸运输抑制剂
公开(公告)号：WO2006067417A1
公开(公告)日：2006-06-29
申请号：PCT/GB2005/004943
申请日：2005-12-21
申请人： GLAXO GROUP LIMITED , BRADLEY, Daniel, Marcus , BRANCH, Clive, Leslie , CHAN, Wai, Ngor , COULTON, Steven , GILPIN, Martin, Leonard , HARRIS, Andrew, Jonathan , LAI, Justine, Yeun, Quai , MARSHALL, Howard, Robert , MACRITCHIE, Jacqueline, Anne , NASH, David, John , PORTER, Roderick, Alan , SPADA, Simone , THEWLIS, Kevin, Michael , WARD, Simon, Edward
发明人： BRADLEY, Daniel, Marcus , BRANCH, Clive, Leslie , CHAN, Wai, Ngor , COULTON, Steven , GILPIN, Martin, Leonard , HARRIS, Andrew, Jonathan , LAI, Justine, Yeun, Quai , MARSHALL, Howard, Robert , MACRITCHIE, Jacqueline, Anne , NASH, David, John , PORTER, Roderick, Alan , SPADA, Simone , THEWLIS, Kevin, Michael , WARD, Simon, Edward
IPC分类号： C07C233/78 , A61K31/166 , C07C211/27
CPC分类号： C07C235/60 , C07C211/27 , C07C233/78 , C07C235/50 , C07C323/62
摘要： The present invention relates to compounds of Formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译：本发明涉及式（I）化合物或其盐或溶剂合物，它们在制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物中的用途。本发明还包括制备这些化合物及其药物制剂的方法。

7. 发明申请

WO2005058317A1 GLYCINE TRANSPORTER-1 INHIBIRORS 审中-公开
标题翻译：糖果运输机1号志愿者
公开(公告)号：WO2005058317A1
公开(公告)日：2005-06-30
申请号：PCT/EP2004/014472
申请日：2004-12-16
申请人： GLAXO GROUP LIMITED , BOZZOLI, Andrea , BRANCH, Clive, Leslie , MARSHALL, Howard , NASH, David, John , PORTER, Roderick, Alan
发明人： BOZZOLI, Andrea , BRANCH, Clive, Leslie , MARSHALL, Howard , NASH, David, John , PORTER, Roderick, Alan
IPC分类号： A61K31/439
CPC分类号： C07D451/02
摘要： The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R 1 , and R 3 and R 10 , X and Ar are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
摘要翻译：本发明提供式（I）化合物或其盐或溶剂合物：其中R 1和R 3和R 10，X和Ar如说明书中所定义，以及这些化合物的用途。该化合物抑制GlyT1转运蛋白并且可用于治疗某些神经和神经精神障碍，包括精神分裂症。

8. 发明申请

WO1989004790A1 PNEUMATIC SYSTEM 审中-公开
标题翻译：气动系统
公开(公告)号：WO1989004790A1
公开(公告)日：1989-06-01
申请号：PCT/GB1988001010
申请日：1988-11-17
申请人： MARSHALL, Howard, Robert, Philip
IPC分类号： B62L03/02
CPC分类号： B62L1/16 , B60T13/38 , B62L3/023
摘要： A pneumatic braking system for a cycle or a wheelchair wherein the braking system is adapted to receive a bottle (12) pre-charged with compressed gas. The system comprises a gas pressure operated cylinder (2, 7) for connection to a brake of a wheel of the cycle or wheelchair and a control means (21, 33) to apply gas pressure to the cylinder or vent gas from the cylinder to apply the brakes. The system also has a pressure regulator (26) to regulate the pressure of gas emerging from the outlet. The source of compressed gas is a pre-charged bottle similar to those used to pressurise a domestic or industrial beer barrel. It can be charged to around 6900 kNm and has been found to give a long-lasting supply of air. The gas pressure acts to release the brakes, and the cylinders have a spring (35, 36) to oppose this action and apply the brake. Thus a ''fail-safe'' mechanism is provided as the brakes are gradually applied when the gas pressure falls.
摘要翻译：一种用于循环或轮椅的气动制动系统，其中所述制动系统适于接收预先充满压缩气体的瓶子（12）。该系统包括用于连接到循环轮椅的轮子的制动器的气体压力操作缸（2,7）和用于将气体压力从气缸施加气体压力或从气缸排出气体的控制装置（21,33）制动器。该系统还具有压力调节器（26），以调节从出口排出的气体的压力。压缩气体的来源是与用于对家用或工业啤酒桶加压的那些类似的预充电瓶。它可以充电到6900 kNm左右，已经被发现能长时间供应空气。气体压力用于释放制动器，并且气缸具有与该动作相反的弹簧（35,36）并施加制动器。因此，当气体压力下降时，制动器逐渐被应用，因此提供了“故障安全”机构。

9. 发明申请

WO2008092877A3 8-OXA-1, 4-DIAZASPIRO [4,5] DEC-3-EN-1-YL AND 1,4, 8-TRIAZASPIRO [4,5] DEC- 3-EN-1-YL ACETAMIDES AS GLYTI TRANSPORTER INHIBITORS IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译： 8-OXA-1,4-DIAZASPIRO [4,5] DEC-3-EN-1-YL和1,4,8-三氮唑[4,5] DEC-3-EN-1-YL乙酰胺作为GLYTI运输机抑制剂治疗神经病学和神经功能障碍
公开(公告)号：WO2008092877A3
公开(公告)日：2008-10-02
申请号：PCT/EP2008051083
申请日：2008-01-30
申请人： GLAXO GROUP LTD , UNIV NOTTINGHAM , AHMAD NADIA MAMOONA , LAI JUSTINE YEUN QUAI , MARSHALL HOWARD ROBERT , NASH DAVID JOHN , PORTER RODERICK ALAN
发明人： AHMAD NADIA MAMOONA , LAI JUSTINE YEUN QUAI , MARSHALL HOWARD ROBERT , NASH DAVID JOHN , PORTER RODERICK ALAN
IPC分类号： C07D471/10 , A61K31/4188 , A61K31/438 , A61P25/18 , A61P25/28 , C07D491/10
CPC分类号： C07D471/10 , C07D491/10
摘要： Compounds of formula (I) or a salt thereof are provided wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , X, n, p and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.
摘要翻译：提供式（I）化合物或其盐，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7，R 9，R 10， SUP>，X，n，p和m如说明书中所定义。还公开了化合物作为药物的用途，以及用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物的制备。本发明还公开了包含该化合物的药物组合物和组合。

10. 发明申请

WO2007080159A3 PYRIDINE-, ISOXAZOLE, THIOPHENECARBOXAMIDE COMPOUNDS HAVING ACTIVITY AT THE GLYCINE TRANSPORTER GLYT1 AND USES THEREOF 审中-公开
标题翻译：吡咯烷，异噻唑，在GLYCINE TRANSPORTER GLYT1中具有活性的硫代酰胺化合物及其用途
公开(公告)号：WO2007080159A3
公开(公告)日：2008-01-17
申请号：PCT/EP2007050157
申请日：2007-01-08
申请人： GLAXO GROUP LTD , BRANCH CLIVE LESLIE , MARSHALL HOWARD , MCCRITCHIE JACKIE , PORTER RODERICK ALAN , SPADA SIMONE
发明人： BRANCH CLIVE LESLIE , MARSHALL HOWARD , MCCRITCHIE JACKIE , PORTER RODERICK ALAN , SPADA SIMONE
IPC分类号： C07D213/62 , C07D261/08 , C07D333/06
CPC分类号： C07D333/38 , C07D213/70 , C07D261/18
摘要： The present invention relates to compounds of formula (I), salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. Formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as defined in the description.
摘要翻译：本发明涉及式（I）化合物，其盐或溶剂化物，它们在制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物中的用途。本发明还包括制备这些化合物及其药物制剂的方法。式（I）其中R 1，R 2，R 3，R 4，R 4， 5，R 6和n如说明书中所定义。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式