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1. 发明申请

WO2013052158A3 TARGETED NANOVECTORS AND THEIR USE FOR TREATMENT OF BRAIN TUMORS 审中-公开
标题翻译：目标纳米颗粒及其用于治疗脑肿瘤的用途
公开(公告)号：WO2013052158A3
公开(公告)日：2014-05-01
申请号：PCT/US2012035267
申请日：2012-04-26
申请人： UNIV RICE WILLIAM M , TOUR JAMES M , BERLIN JACOB , MARCANO DANIELA , BASKIN DAVID S , SHARPE MARTYN A , METHODIST HOSPITAL RES INST
发明人： TOUR JAMES M , BERLIN JACOB , MARCANO DANIELA , BASKIN DAVID S , SHARPE MARTYN A
IPC分类号： A61K47/48
CPC分类号： A61K9/0085 , A61K9/5123 , A61K47/60 , A61K47/6925 , C12N15/87 , C12N2810/859
摘要： In some embodiments, the invention pertains to therapeutic compositions for treating a brain tumor. Such therapeutic compositions generally comprise: (1) a nanovector; (2) an active agent associated with the nanovector with activity against brain tumor cells; and (3) a targeting agent associated with the nanovector with recognition activity for a marker of the brain tumor cells. In some embodiments, the active agent and the targeting agent are non-covalently associated with the nanovector. Additional embodiments of the present invention pertain to methods of treating a brain tumor in a subject (e.g., a human being) by administering the aforementioned therapeutic compositions to the subject. Further embodiments of the present disclosure pertain to methods of formulating therapeutic compositions for treating a brain tumor in a subject in a personalized manner.
摘要翻译：在一些实施方案中，本发明涉及用于治疗脑肿瘤的治疗组合物。这样的治疗组合物通常包括：（1）纳维酮; （2）与具有针对脑肿瘤细胞活性的纳米动物相关的活性剂; 和（3）与具有脑肿瘤细胞标志物的识别活性的纳米动物相关的靶向剂。在一些实施方案中，活性剂和靶向剂与纳米活性剂非共价缔合。本发明的另外的实施方案涉及通过将上述治疗组合物给予受试者来治疗受试者（例如，人）中的脑肿瘤的方法。本公开的另外的实施方案涉及以个性化方式配制用于治疗受试者的脑肿瘤的治疗组合物的方法。

2. 发明申请

WO2013066398A1 USE OF CARBON NANOMATERIALS WITH ANTIOXIDANT PROPERTIES TO TREAT OXIDATIVE STRESS 审中-公开
标题翻译：使用碳纳米微粒与抗氧化性能来处理氧化应激
公开(公告)号：WO2013066398A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/035244
申请日：2012-04-26
申请人： WILLIAM MARSH RICE UNIVERSITY , TOUR, James, M. , BERLIN, Jacob , MARCANO, Daniela , LEONARD, Ashley , KENT, Thomas, A. , PAUTLER, Robia, G. , BITNER, Brittany , INOUE, Taeko , BAYLOR COLLEGE OF MEDICINE
发明人： TOUR, James, M. , BERLIN, Jacob , MARCANO, Daniela , LEONARD, Ashley , KENT, Thomas, A. , PAUTLER, Robia, G. , BITNER, Brittany , INOUE, Taeko
IPC分类号： A61K9/14 , A61P39/06 , B82Y5/00
CPC分类号： A61K33/44 , A61K9/0019 , A61K31/713 , A61K45/06 , A61K47/60 , A61K47/6925 , B82Y5/00 , A61K2300/00
摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.
摘要翻译：在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳黑色，氧化炭黑，亲水性碳簇及其组合。在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。

3. 发明申请

WO2013052158A2 TARGETED NANOVECTORS AND THEIR USE FOR TREATMENT OF BRAIN TUMORS 审中-公开
标题翻译：目标纳米颗粒及其用于治疗脑肿瘤的用途
公开(公告)号：WO2013052158A2
公开(公告)日：2013-04-11
申请号：PCT/US2012/035267
申请日：2012-04-26
申请人： WILLIAM MARSH RICE UNIVERSITY , TOUR, James, M. , BERLIN, Jacob , MARCANO, Daniela , BASKIN, David, S. , SHARPE, Martyn, A. , THE METHODIST HOSPITAL RESEARCH INSTITUTE
发明人： TOUR, James, M. , BERLIN, Jacob , MARCANO, Daniela , BASKIN, David, S. , SHARPE, Martyn, A.
IPC分类号： A61K48/00 , A61K9/51
CPC分类号： A61K9/0085 , A61K9/5123 , A61K47/60 , A61K47/6925 , C12N15/87 , C12N2810/859
摘要： In some embodiments, the invention pertains to therapeutic compositions for treating a brain tumor. Such therapeutic compositions generally comprise: (1) a nanovector; (2) an active agent associated with the nanovector with activity against brain tumor cells; and (3) a targeting agent associated with the nanovector with recognition activity for a marker of the brain tumor cells. In some embodiments, the active agent and the targeting agent are non-covalently associated with the nanovector. Additional embodiments of the present invention pertain to methods of treating a brain tumor in a subject (e.g., a human being) by administering the aforementioned therapeutic compositions to the subject. Further embodiments of the present disclosure pertain to methods of formulating therapeutic compositions for treating a brain tumor in a subject in a personalized manner.
摘要翻译：在一些实施方案中，本发明涉及用于治疗脑肿瘤的治疗组合物。这样的治疗组合物通常包括：（1）纳维酮; （2）与具有针对脑肿瘤细胞活性的纳米动物相关的活性剂; 和（3）与具有脑肿瘤细胞标志物的识别活性的纳米动物相关的靶向剂。在一些实施方案中，活性剂和靶向剂与纳米活性剂非共价缔合。本发明的另外的实施方案涉及通过将上述治疗组合物给予受试者来治疗受试者（例如，人）中的脑肿瘤的方法。本公开的另外的实施方案涉及以个性化方式配制用于治疗受试者的脑肿瘤的治疗组合物的方法。

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