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1. 发明申请

WO2003037383A1 AN ANTINEOPLASTIC- DENDRITIC POLYMER DRUG DELIVERY SYSTEM 审中-公开
标题翻译： ANTINEOPLASTIC-DENDRITIC聚合物药物递送系统
公开(公告)号：WO2003037383A1
公开(公告)日：2003-05-08
申请号：PCT/US2001/048568
申请日：2001-10-29
申请人： THE DOW CHEMICAL COMPANY , MALIK, Navid , DUNCAN, Ruth , TOMALIA, Donald, A. , ESFAND, Roseita
发明人： MALIK, Navid , DUNCAN, Ruth , TOMALIA, Donald, A. , ESFAND, Roseita
IPC分类号： A61K47/48
CPC分类号： A61K47/595
摘要： Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared. The antineoplastic agent is encapsulated within the dendritic polymer using an ionic charge shunt mechanism, whereby, the antineoplastic agent interacts with the anionic functional groups on the surface of the dendritic polymer allowing the antineoplastic agent to be uptaken by the dendritic polymer through an association with the functional groups of the interior of the dendritic polymer. The antineoplastic dendritic polymer conjugates may be administered intravenously, orally, parentally, subcutaneously, intraarterially or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The antineoplastic dendritic polymer conjugates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, and reduced toxicity.
摘要翻译：制备用于将抗肿瘤药物携带到恶性肿瘤中的有用的药物递送系统的抗肿瘤树突状聚合物缀合物。使用离子电荷分流机制将抗肿瘤剂包封在树突状聚合物内，由此，抗肿瘤剂与树突状聚合物表面上的阴离子官能团相互作用，允许抗肿瘤剂被树状聚合物吸收，通过与树枝状聚合物内部的官能团。抗肿瘤性树突状聚合物缀合物可以以有效抑制恶性肿瘤生长的量静脉内，口服，亲本，皮下，动脉内或局部给予具有恶性肿瘤的动物。抗肿瘤树突状聚合物缀合物具有药效高，药物携带能力强，水溶性好，储存稳定性好，毒性降低。

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