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1. 发明申请

WO2005037845A1 BENZOTHIAZOLE AND THIAZOLE’5,5-B!PYRIDINE COMPOSITIONS AND THEIR USE AS UBIQUITIN LIGASE INHIBITORS 审中-公开
标题翻译：苯并噻唑和噻唑-5,5-B！吡啶组合物及其作为UBIQUITIN LIGASE抑制剂的用途
公开(公告)号：WO2005037845A1
公开(公告)日：2005-04-28
申请号：PCT/US2004/034397
申请日：2004-10-18
申请人： RIGEL PHARMACEUTICALS, INC. , PARLATI, Francesco , RAMESH, Usha, V. , SINGH, Rajinder , PAYAN, Donald, G. , LOWE, Raymond , LOOK, Gary, Charles
发明人： PARLATI, Francesco , RAMESH, Usha, V. , SINGH, Rajinder , PAYAN, Donald, G. , LOWE, Raymond , LOOK, Gary, Charles
IPC分类号： C07D513/04
CPC分类号： C07D417/12 , A61K31/428 , A61K31/429 , C07D277/82 , C07D513/04 , Y02A50/411
摘要： This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a pharmaceutical composition according to the invention.
摘要翻译：本发明描述了可用作泛素抑制剂的化合物和药物组合物。本发明的化合物和药物组合物可用作涉及泛素化的生物体的生物化学途径的抑制剂。本发明还包括使用本发明的化合物和药物组合物来治疗需要抑制泛素化的病症。此外，本发明包括抑制细胞泛素化的方法，包括使其中需要泛素化抑制的细胞与根据本发明的药物组合物接触。

2. 发明申请

WO2010059763A1 COMPOSITIONS AND METHODS FOR THE ASSEMBLY OF POLYNUCLEOTIDES 审中-公开
标题翻译：多核苷酸组合物和方法
公开(公告)号：WO2010059763A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/065048
申请日：2009-11-19
申请人： AMYRIS BIOTECHNOLOGIES, INC. , SERBER, Zach , LOWE, Raymond , UBERSAX, Jeffrey, A. , CHANDRAN, Sunil, S. , DEAN, Erik, Jedediah , PLATT, Darren, M. , TAKEOKA, Kenneth, Toshiki
发明人： SERBER, Zach , LOWE, Raymond , UBERSAX, Jeffrey, A. , CHANDRAN, Sunil, S. , DEAN, Erik, Jedediah , PLATT, Darren, M. , TAKEOKA, Kenneth, Toshiki
IPC分类号： C12N15/06 , C12N15/10 , C40B40/06
CPC分类号： C12N15/1093 , C12N15/66 , C40B40/06 , C40B50/06
摘要： The present invention provides compositions and methods for rapid assembly of one or more assembled polynucleotides from a plurality of component polynucleotides. The methods of the invention utilize circular nucleic acid vectors that comprise a DNA segment D flanked by an annealable linker sequence, annealable linker sequence pairs LA and LB, or annealable linker sequence / primer binding segment pairs LA and PB or PA and LB. Restriction endonuclease digestion of a plurality of vectors containing the DNA segments to be assembled generates a plurality of DNA fragments comprising the elements PA-D-LB, LA-D-LB, and LA-D-PB or D-LB, LA-D-LB, and LA-D. The sequences of annealable linker sequences LA and LB provide complementary termini to the DNA fragments, which are utilized in host cell mediated homologous recombination or together with promer binding segments PA and PB in a polymerase cycling assembly reaction for the ordered assembly of the various DNA segments into one or more assembled polynucleotides.
摘要翻译：本发明提供了用于从多个组分多核苷酸快速装配一种或多种组装的多核苷酸的组合物和方法。本发明的方法利用环状核酸载体，其包含侧翼为可退火接头序列的DNA区段D，可退火接头序列对LA和LB，或可退火的接头序列/引物结合区段对LA和PB或PA和LB。含有待组装的DNA片段的多个载体的限制性内切酶消化产生多个包含元件PA-D-LB，LA-D-LB和LA-D-PB或D-LB，LA-D -LB和LA-D。可退火接头序列LA和LB的序列提供与DNA片段的互补末端，其用于宿主细胞介导的同源重组或与聚合酶循环组装反应中的promer结合片段PA和PB一起用于各种DNA片段的有序组装转化成一个或多个组装的多核苷酸。

3. 发明申请

WO2005037845A8 BENZOTHIAZOLE AND THIAZOLE[5,5-B] PYRIDINE COMPOSITIONS AND THEIR USE AS UBIQUITIN LIGASE INHIBITORS 审中-公开
标题翻译：苯并噻唑和噻唑[5,5-B]吡啶组合物及其作为UBIQUITIN LIGASE INHIBITORS的用途
公开(公告)号：WO2005037845A8
公开(公告)日：2006-08-17
申请号：PCT/US2004034397
申请日：2004-10-18
申请人： RIGEL PHARMACEUTICALS INC , PARLATI FRANCESCO , RAMESH USHA V , SINGH RAJINDER , PAYAN DONALD G , LOWE RAYMOND , LOOK GARY CHARLES
发明人： PARLATI FRANCESCO , RAMESH USHA V , SINGH RAJINDER , PAYAN DONALD G , LOWE RAYMOND , LOOK GARY CHARLES
IPC分类号： A61K31/428 , A61K31/429 , C07D277/82 , C07D417/12 , C07D513/04
CPC分类号： C07D417/12 , A61K31/428 , A61K31/429 , C07D277/82 , C07D513/04
摘要： This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a pharmaceutical composition according to the invention.
摘要翻译：本发明描述了可用作泛素抑制剂的化合物和药物组合物。本发明的化合物和药物组合物可用作涉及泛素化的生物体的生物化学途径的抑制剂。本发明还包括使用本发明的化合物和药物组合物来治疗需要抑制泛素化的病症。此外，本发明包括抑制细胞泛素化的方法，包括使其中需要泛素化抑制的细胞与根据本发明的药物组合物接触。

4. 发明申请

WO2013075138A1 SYSTEMS AND METHODS FOR IMPLEMENTING CROSS-FADING, INTERSTITIALS AND OTHER EFFECTS DOWNSTREAM 审中-公开
标题翻译：执行交叉渐变，间断和其他影响下降的系统和方法
公开(公告)号：WO2013075138A1
公开(公告)日：2013-05-23
申请号：PCT/US2012/065943
申请日：2012-11-19
申请人： SIRIUS XM RADIO INC. , LOWE, Raymond , WARD, Christopher , CHRISTINE, Charles, W.
发明人： LOWE, Raymond , WARD, Christopher , CHRISTINE, Charles, W.
IPC分类号： G11B20/10
CPC分类号： G10L19/167 , G06F9/5044 , G10L19/008 , G10L19/26 , G11B27/038 , H04H60/04
摘要： Systems and methods are presented for cross-fading (or other multiple clip processing) of information streams on a user or client device, such as a telephone, tablet, computer or MP3 player, or any consumer device with audio playback. Multiple clip processing can be accomplished at a client end according to directions sent from a service provider that specify a combination of (i) the clips involved; (ii) the device on which the cross-fade or other processing is to occur and its parameters; and (iii) the service provider system. For example, a consumer device with only one decoder, can utilize that decoder (typically hardware) to decompress one or more elements that are involved in a cross-fade at faster than real time, thus pre-fetching the next element(s) to be played in the cross-fade at the end of the currently being played element. The next elements(s) can, for example, be stored in an input buffer, then decoded and stored in a decoded sample buffer, all prior to the required presentation time of the multiple element effect. At the requisite time, a client device component can access the respective samples of the decoded audio clips as it performs the cross-fade, mix or other effect. Such exemplary embodiments use a single decoder and thus do not require synchronized simultaneous decodes.
摘要翻译：呈现用户或客户端设备（例如电话，平板电脑，计算机或MP3播放器）或具有音频播放的任何消费者设备的信息流的交叉衰落（或其他多个剪辑处理）的系统和方法。多个剪辑处理可以在客户端根据从服务提供者发送的指示来完成，该指示指定（i）涉及的剪辑的组合; （ii）要进行交叉淡入淡出或其他处理的设备及其参数; 和（iii）服务提供者系统。例如，仅具有一个解码器的消费者设备可以利用该解码器（通常是硬件）来以比实时更快的速度来解压缩交叉渐变中涉及的一个或多个元素，从而将下一个元素预取到在当前正在播放元素的末尾的交叉淡入淡出中播放。下一个元素可以例如存储在输入缓冲器中，然后解码并存储在解码的采样缓冲器中，全部在多重元素效应的所需呈现时间之前。在必要的时间，客户端设备组件可以在解码的音频剪辑执行交叉淡入淡出，混合或其他效果时访问相应的样本。这样的示例性实施例使用单个解码器，因此不需要同步的同步解码。

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