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1. 发明申请

WO2007134003A3 ORAL CARE REGIMEN 审中-公开
标题翻译：口腔护理
公开(公告)号：WO2007134003A3
公开(公告)日：2008-12-11
申请号：PCT/US2007068362
申请日：2007-05-07
申请人： COLGATE PALMOLIVE CO , PRENCIPE MICHAEL , VAN RYCKE ISABELLE , LOVELL RICHARD
发明人： PRENCIPE MICHAEL , VAN RYCKE ISABELLE , LOVELL RICHARD
IPC分类号： A61K8/04 , A61K8/25 , A61Q11/00
CPC分类号： A61K8/25 , A61K2800/28 , A61K2800/412 , A61K2800/88 , A61K2800/884 , A61Q11/00
摘要： The invention includes methods of cleaning an oral surface, maintaining oral health and/ or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, and contacting the oral surface with a periodic oral care composition at least once within a period of about 42 days. The periodic oral care compositions suitable for use in the method comprise a first abrasive having an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions and a second abrasive having an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. In the periodic oral care compositions, the ratio of the first abrasive to the second abrasive is about 1:1.6 to about 1.6:1. The periodic oral care compositions are characterized by a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200. Additionally or alternatively, the methods may include those where the second abrasive comprises silica and has an oil of absorption of greater than about 90 cm3/100g and/ or an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive may be about 1:1.6 to about 1.6:1. The total amount of the first and second abrasives present in the oral composition may be greater than about 25 % by weight of the composition and/ or the oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.
摘要翻译：本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。这样的方法包括使口腔表面与初级口腔护理组合物每天至少接触一次接触，并在约42天的时间内将口腔表面与周期性口腔护理组合物接触至少一次。适用于该方法的定期口腔护理组合物包括具有大于约5毫克损失/ 100,000次旋转的爱因纳氏硬度的第一研磨剂，以及每100,000次旋转具有小于约5毫克损失的爱因纳氏硬度的第二磨料。在定期口腔护理组合物中，第一研磨剂与第二研磨剂的比例为约1:1.6至约1.6:1。定期口腔护理组合物的特征在于大于约100的防护薄膜清洁率和小于约200的放射性牙本质磨损。另外或替代地，所述方法可以包括其中第二磨料包含二氧化硅并具有吸收油的那些大于约90cm 3 / 100g和/或Einlehner硬度小于每10万次转动约5mg的损失。第一研磨剂与第二研磨剂的比例可以为约1:1.6至约1.6:1。存在于口腔组合物中的第一和第二研磨剂的总量可以大于组合物的约25重量％，和/或口腔组合物具有大于约100的防护薄膜清洁率和低于约100的放射性牙本质磨损约200。

2. 发明申请

WO2009099450A1 ORAL CARE REGIMEN 审中-公开
标题翻译：口腔护理
公开(公告)号：WO2009099450A1
公开(公告)日：2009-08-13
申请号：PCT/US2008/058650
申请日：2008-03-28
申请人： COLGATE-PALMOLIVE COMPANY , ROBINSON, Richard, Scott , SULLIVAN, Richard, J. , PRENCIPE, Michael , VAN RYCKE, Isabelle , LOVELL, Richard , KOHLI, Rajnish , LEITE, Sergio , SIMON, Eric, A. , SANTARPIA, Ralph, Peter, III , CUMMINS, Diane , MELLO, Sarita, V. , CHOPRA, Suman, K. , DEPIERRO, Karen , ZAIDEL, Lynette , CHRISTOPOULOU, Constantina , SUBRAMANYAM, Ravi , WU, Donghui , MORGAN, Andre, M. , WANG, Qin , TAMBS, Gary, Edward , BARNES, Virginia, Monsul
发明人： ROBINSON, Richard, Scott , SULLIVAN, Richard, J. , PRENCIPE, Michael , VAN RYCKE, Isabelle , LOVELL, Richard , KOHLI, Rajnish , LEITE, Sergio , SIMON, Eric, A. , SANTARPIA, Ralph, Peter, III , CUMMINS, Diane , MELLO, Sarita, V. , CHOPRA, Suman, K. , DEPIERRO, Karen , ZAIDEL, Lynette , CHRISTOPOULOU, Constantina , SUBRAMANYAM, Ravi , WU, Donghui , MORGAN, Andre, M. , WANG, Qin , TAMBS, Gary, Edward , BARNES, Virginia, Monsul
IPC分类号： A61K8/44 , A61Q11/00 , A61K31/198 , A61P1/02
CPC分类号： A61K8/44 , A61K31/198 , A61Q11/00
摘要： The invention includes methods of cleaning an oral surface, maintaining oral health and/or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, contacting the oral surface with a periodic oral care maintenance composition at least once monthly, wherein the periodic oral care maintenance composition comprises a basic amino acid, in free or salt form and optionally contacting the oral surface with a periodic oral care cleaning composition at least once monthly. The periodic oral care cleaning compositions suitable for use in the method comprise an abrasive system.
摘要翻译：本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。这样的方法包括每天至少一次使口腔表面与主要口腔护理组合物接触，使口腔表面与定期的口腔护理维持组合物每月至少一次接触，其中定期口腔护理维持组合物包含游离或任选地使口腔表面与定期的口腔护理清洁组合物每月至少一次接触。适用于该方法的定期口腔护理清洁组合物包括研磨系统。

3. 发明申请

WO2007134003A2 ORAL CARE REGIMEN 审中-公开
标题翻译：口腔护理
公开(公告)号：WO2007134003A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/068362
申请日：2007-05-07
申请人： COLGATE-PALMOLIVE COMPANY , PRENCIPE, Michael , VAN RYCKE, Isabelle , LOVELL, Richard
发明人： PRENCIPE, Michael , VAN RYCKE, Isabelle , LOVELL, Richard
IPC分类号： A61K8/04 , A61K8/26 , A61Q11/00
CPC分类号： A61K8/25 , A61K2800/28 , A61K2800/412 , A61K2800/88 , A61K2800/884 , A61Q11/00
摘要： The invention includes methods of cleaning an oral surface, maintaining oral health and/ or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, and contacting the oral surface with a periodic oral care composition at least once within a period of about 42 days. The periodic oral care compositions suitable for use in the method comprise a first abrasive having an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions and a second abrasive having an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. In the periodic oral care compositions, the ratio of the first abrasive to the second abrasive is about 1:1.6 to about 1.6:1. The periodic oral care compositions are characterized by a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200. Additionally or alternatively, the methods may include those where the second abrasive comprises silica and has an oil of absorption of greater than about 90 cm 3 /100g and/ or an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive may be about 1:1.6 to about 1.6:1. The total amount of the first and second abrasives present in the oral composition may be greater than about 25 % by weight of the composition and/ or the oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.
摘要翻译：本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。这样的方法包括使口腔表面与初级口腔护理组合物每天至少接触一次，并使口腔表面与周期性口腔护理组合物在约42天的时间内至少一次接触。适用于该方法的定期口腔护理组合物包括具有每100,000次旋转大于约5毫克损失的爱因纳氏硬度的第一研磨剂，以及每100,000次旋转具有小于约5毫克损失的爱因纳氏硬度的第二磨料。在定期口腔护理组合物中，第一研磨剂与第二研磨剂的比例为约1:1.6至约1.6:1。定期口腔护理组合物的特征在于大于约100的防护薄膜清洁率和小于约200的放射性牙本质磨损。另外或替代地，所述方法可以包括其中第二磨料包含二氧化硅并具有吸收油的那些大于约90cm 3 / 100g和/或Einlehner硬度，每100,000次转动时损耗小于约5mg。第一研磨剂与第二研磨剂的比例可以为约1:1.6至约1.6:1。存在于口腔组合物中的第一和第二研磨剂的总量可以大于组合物的约25重量％，和/或口腔组合物具有大于约100的防护薄膜清洁率和小于约100的放射性牙本质磨损约200。

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