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1. 发明申请

WO2009003284A8 NOVEL PEPTIDES, USE THEREOF IN COSMETIC AND COSMECEUTIC APPLICATIONS, AND COMPOSITIONS COMPRISING SAME 审中-公开
标题翻译：新型肽，其在化妆品和成膜应用中的应用，以及包含其的组合物
公开(公告)号：WO2009003284A8
公开(公告)日：2010-03-04
申请号：PCT/CA2008001227
申请日：2008-06-30
申请人： INNOVACTIV INC , HOCQUAUX MICHEL , LOING ESTELLE , BEDOS PHILIPPE
发明人： HOCQUAUX MICHEL , LOING ESTELLE , BEDOS PHILIPPE
IPC分类号： C07K7/06 , A61K8/64 , A61K38/06 , A61K38/07 , A61K38/08 , A61P17/00 , A61P29/00 , A61Q19/10 , C07K5/083 , C07K5/11 , C07K5/117
CPC分类号： C07K5/1019 , A61K8/64 , A61K38/00 , A61Q17/04 , A61Q19/08 , C07K5/0806 , Y02P20/55
摘要： A peptide of formula I (SEQ ID NO: 1): Lip-A-Gly-His-B-R (I) wherein: Lip is a lipoyl residue of R or S configuration; A is absent or is a lysine residue of configuration L or D; GIy is a glycine residue; His is a histidine residue of configuration L or D; B is a lysine residue of configuration L or D, or a lysine residue of configuration L or D in which the NH2 group of the side chain comprises a modification, wherein said modification is (i) a replacement with a hydrogen or (ii) a modification with a protecting group selected from the group consisting of acetyl, benzoyl, tosyl, sulfonyl benzene, benzyloxycarbonyle and palmitoyl; wherein R is O(Z) or N(Z')(Z'), and wherein Z, Z' and Z' are independently of each other a hydrogen or a protecting group selected from the group consisting of methyl, ethyl, propyl, phenyl, hexyl, decyl and hexadecyl, or a racemate, an enantiomer or a diastereomer thereof, or a mixture thereof, or a salt thereof. A peptide of formula Il (SEQ ID NO: 2): Lip-A-His-B-C-Trp-R (II) wherein: Lip is a lipoyl residue of configuration R or S; His is a histidine residue of configuration L; Trp is a tryptophane residue of configuration L; A is absent, is an amino acid residue of configuration L or D selected from the group consisting of a lysine residue, an alanine residue, a glutamic acid residue and a glycine residue, or is a spacer of formula : NH-(CH2)n-CO- wherein n is an integer comprised between 2 and 14; B is an aromatic amino acid residue of configuration D selected from the group consisting of a phenylalanine residue, a homophenylalanine residue, a tryptophane residue, a ß-(1-Naphthyl)-alanine residue, a ß-(2-Naphthyl)-alanine residue and a phenylglycine residue; C is a basic amino acid residue of configuration L selected from the group consisting of an arginine residue, a lysine residue, an ornithine residue and a homoarginine residue; wherein R is O(Z) or N(Z')(Z'), and wherein Z, Z' and Z' are independently of each other a hydrogen or a protecting group selected from the group consisting of methyl, ethyl, propyl, phenyl, hexyl, decyl and hexadecyl, or a racemate, an enantiomer or a diastereomer thereof, or a mixture thereof, or a salt thereof.
摘要翻译：式I的肽（SEQ ID NO：1）：Lip-A-Gly-His-B-R（I）其中：Lip是R或S构型的脂酰基残基; A不存在或是L或D构型的赖氨酸残基; Gly是甘氨酸残基; His是构型L或D的组氨酸残基; B是构型L或D的赖氨酸残基或其中侧链的NH 2基团包含修饰的构型L或D的赖氨酸残基，其中所述修饰是（i）用氢取代或（ii）用选自乙酰基，苯甲酰基，甲苯磺酰基，磺酰基苯，苄氧基羰基和棕榈酰基的保护基改性; 其中R是O（Z）或N（Z'）（Z'），并且其中Z，Z'和Z'彼此独立地是氢或选自甲基，乙基，丙基，苯基，己基，癸基和十六烷基，或其外消旋物，对映异构体或非对映体，或其混合物，或其盐。式II（SEQ ID NO：2）的肽：Lip-A-His-B-C-Trp-R（II）其中：Lip是R或S构型的脂酰基残基; His是构型L的组氨酸残基; Trp是配置L的色氨酸残基; A不存在，是选自赖氨酸残基，丙氨酸残基，谷氨酸残基和甘氨酸残基的构型L或D的氨基酸残基，或者是下式的间隔基：NH-（CH 2）n -CO-，其中n是2至14之间的整数; B是配置D的芳族氨基酸残基，选自苯丙氨酸残基，高苯丙氨酸残基，色氨酸残基，β-（1-萘基） - 丙氨酸残基，β-（2-萘基） - 丙氨酸残基和苯基甘氨酸残基; C是选自精氨酸残基，赖氨酸残基，鸟氨酸残基和高精氨酸残基的构型L的碱性氨基酸残基; 其中R是O（Z）或N（Z'）（Z'），并且其中Z，Z'和Z'彼此独立地是氢或选自甲基，乙基，丙基，苯基，己基，癸基和十六烷基，或其外消旋物，对映异构体或非对映体，或其混合物，或其盐。

2. 发明申请

WO2010006412A1 COSMETIC COMPOSITIONS COMPRISING ASTEROIDEA BODY FLUID AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含ASTEROIDEA体液的化妆品组合物及其使用方法
公开(公告)号：WO2010006412A1
公开(公告)日：2010-01-21
申请号：PCT/CA2009/000878
申请日：2009-06-23
申请人： INNOVACTIV INC. , BEAULIEU, Martin , LOING, Estelle , FILLION, Catherine , DIONNE, Patrice , LAVOIE, Alain , THIBODEAU, Alain
发明人： BEAULIEU, Martin , LOING, Estelle , FILLION, Catherine , DIONNE, Patrice , LAVOIE, Alain , THIBODEAU, Alain
IPC分类号： A61K8/98 , A61P17/02 , A61Q19/00 , A61Q19/08
CPC分类号： A61Q19/08 , A61K8/987
摘要： A skin care composition comprising an isolated Asteroidea body fluid or extract thereof is described. Uses and methods of use of the composition for the prevention and/or treatment of a skin disorder or condition, such as skin- aging signs, are also described.
摘要翻译：描述了包含分离的Asteroidea体液或其提取物的护肤组合物。还描述了组合物用于预防和/或治疗皮肤病症或病症如皮肤老化征象的用途和方法。

3. 发明申请

WO9940113A9 LIPOPEPTIDES CONTAINING AN INTERFERON FRAGMENT AND USES THEREOF IN PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：含有干扰素片段的脂蛋白及其在药物组合物中的用途
公开(公告)号：WO9940113A9
公开(公告)日：1999-10-21
申请号：PCT/FR9900259
申请日：1999-02-05
申请人： INST NAT SANTE RECH MED , PASTEUR INSTITUT , CENTRE NAT RECH SCIENT , THIAM KADER , AURIAULT CLAUDE , GRAS MASSE HELENE , LOING ESTELLE , VERWAERDE CLAUDIE , GUILLET JEAN GERARD
发明人： THIAM KADER , AURIAULT CLAUDE , GRAS-MASSE HELENE , LOING ESTELLE , VERWAERDE CLAUDIE , GUILLET JEAN GERARD
IPC分类号： A61K9/107 , A61K38/21 , A61K39/00 , A61K39/39 , A61K47/48 , A61P37/02 , C07K14/57
CPC分类号： C07K14/57 , A61K9/1075 , A61K39/00 , A61K39/39 , A61K47/54 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/6018
摘要： The invention concerns any lipopeptide characterised in that it comprises: a peptide part comprising the peptide sequence consisting of about 30 to about 50 of the last contiguous amino acids of the interferon- gamma (IFN- gamma ) C-terminal end of mammals, whereof, if required, the last 3 to 20 amino acids have been suppressed; and one or several lipophilic parts comprising a C4-C20 chain of carbon atoms, saturated or unsaturated, linear or branched, or a steroid group. The invention also concerns any lipopeptide such as defined above containing one or several CD8, and/or CD4, and/or B epitopes. The invention further concerns medicines or vaccines containing any polypeptide such as defined above.
摘要翻译：本发明涉及任何脂肽，其特征在于其包含：肽部分，其包含由哺乳动物的干扰素-γ（IFN-γ）C-末端的最后连续氨基酸约30至约50个的肽序列，如果需要，最后3〜20个氨基酸被抑制; 和一个或多个亲油部分，其包含饱和或不饱和的直链或支链的碳原子的C 4 -C 20链或类固醇基团。本发明还涉及包含一种或几种CD8，和/或CD4和/或B表位的任何如上所定义的脂肽。本发明还涉及含有如上所定义的任何多肽的药物或疫苗。

4. 发明申请

WO2009127057A1 COSMETIC COMPOSITIONS COMPRISING EXOPOLYSACCHARIDES DERIVED FROM MICROBIAL MATS, AND USE THEREOF 审中-公开
标题翻译：包含从微生物物种衍生的异黄酮的化妆品组合物及其用途
公开(公告)号：WO2009127057A1
公开(公告)日：2009-10-22
申请号：PCT/CA2009/000493
申请日：2009-04-15
申请人： INNOVACTIV INC. , LOING, Estelle , BRIATTE, Sandrine , VAYSSIER, Catherine , BEAULIEU, Martin , DIONNE, Patrice
发明人： LOING, Estelle , BRIATTE, Sandrine , VAYSSIER, Catherine , BEAULIEU, Martin , DIONNE, Patrice
IPC分类号： A61K8/73 , A61K31/715 , A61K35/74 , A61K8/99 , A61Q19/08
CPC分类号： A61K31/715 , A61K8/73 , A61K8/99 , A61Q19/08
摘要： Disclosed herein is a skin care composition comprising at least one exopolysaccharide (EPS) originating from a microbial mat, wherein the EPS is in a concentration of about 0.001 % w/w to about 1.5 % w/w of the composition. Preferably, the EPS is derived from microorganism isolated from microbial mats found in French Polynesia. The composition is useful in reducing and preventing signs of skin aging and environmental damage by altering skin cell metabolism and improving hydration.
摘要翻译：本文公开了包含至少一种源自微生物垫的外多糖（EPS）的护肤组合物，其中所述EPS的浓度为所述组合物的约0.001％w / w至约1.5％w / w。优选地，EPS来源于从法属波利尼西亚发现的微生物垫分离的微生物。该组合物可用于通过改变皮肤细胞代谢和改善水合作用来减少和预防皮肤老化和环境损害的迹象。

5. 发明申请

WO2009003283A1 NOVEL COMPOUNDS, USE THEREOF IN COSMETIC AND COSMECEUTIC APPLICATIONS, AND COMPOSITIONS COMPRISING SAME 审中-公开
标题翻译：新化合物，其在化妆品和化妆品应用中的应用，以及包含其的组合物
公开(公告)号：WO2009003283A1
公开(公告)日：2009-01-08
申请号：PCT/CA2008/001226
申请日：2008-06-30
申请人： LES BIOTECHNOLOGIES OCEANOVA INC. , HOCQUAUX, Michel , LOING, Estelle , BEDOS, Philippe
发明人： HOCQUAUX, Michel , LOING, Estelle , BEDOS, Philippe
IPC分类号： C07K5/11 , A61K38/07 , A61K8/64 , A61P17/00 , A61Q19/08 , C07K5/10 , C07K5/113
CPC分类号： C07K5/1019 , A61K8/64 , A61K38/00 , A61Q19/08
摘要： A compound of the formula I: R-A-Gly-His-B (I) wherein: A and B are independently of each other a L-lysine residue, a D-lysine residue, or a L- or D- lysine residue in which the NH 2 group of the side chain comprises a modification, wherein said modification is (i) a replacement with a hydrogen, (ii) an acetylation, (iii) a benzoylation, or (iv) a palmitoylation; GIy is a glycine residue; His is a L- or D-histidine residue; R is CH 3 -(CH 2 ) n -CO-, wherein n = 2, 3, 4, 5, 6, 7 or 8; R' is a group of formula (II): N(Z)(Z') (II) wherein: Z and Z' is hydrogen, a methyl group, an ethyl group, a phenyl group, an hexyl group, a decyl group or an hexadecyl group; or a racemate, an enantiomer or a diastereomer thereof, or mixtures thereof, or a salt thereof.
摘要翻译：式I的化合物：其中：A和B彼此独立地为L-赖氨酸残基，D-赖氨酸残基或L-或D-赖氨酸残基，其中侧链的NH 2基团包括修饰，其中所述修饰是（i）用氢替代，（ii）乙酰化，（iii）苯甲酰化或（iv）棕榈酰化; Gly是甘氨酸残基; 他是一个L-或D-组氨酸残基; R是CH 3 - （CH 2）n -CO-，其中n = 2,3,4,5,6,7或8; R'是式（II）的基团：N（Z）（Z'）（II）其中：Z和Z'是氢，甲基，乙基，苯基，己基，癸基或十六烷基; 或其外消旋物，对映体或非对映异构体，或其混合物，或其盐。

6. 发明申请

WO2009003283A8 NOVEL COMPOUNDS, USE THEREOF IN COSMETIC AND COSMECEUTIC APPLICATIONS, AND COMPOSITIONS COMPRISING SAME 审中-公开
标题翻译：化妆品和化妆品应用中的新化合物，以及包含其的组合物
公开(公告)号：WO2009003283A8
公开(公告)日：2010-02-04
申请号：PCT/CA2008001226
申请日：2008-06-30
申请人： INNOVACTIV INC , HOCQUAUX MICHEL , LOING ESTELLE , BEDOS PHILIPPE
发明人： HOCQUAUX MICHEL , LOING ESTELLE , BEDOS PHILIPPE
IPC分类号： C07K5/11 , A61K8/64 , A61K38/07 , A61P17/00 , A61Q19/08 , C07K5/10 , C07K5/113
CPC分类号： C07K5/1019 , A61K8/64 , A61K38/00 , A61Q19/08
摘要： A compound of the formula I: R-A-Gly-His-B (I) wherein: A and B are independently of each other a L-lysine residue, a D-lysine residue, or a L- or D- lysine residue in which the NH2 group of the side chain comprises a modification, wherein said modification is (i) a replacement with a hydrogen, (ii) an acetylation, (iii) a benzoylation, or (iv) a palmitoylation; GIy is a glycine residue; His is a L- or D-histidine residue; R is CH3-(CH2)n-CO-, wherein n = 2, 3, 4, 5, 6, 7 or 8; R' is a group of formula (II): N(Z)(Z') (II) wherein: Z and Z' is hydrogen, a methyl group, an ethyl group, a phenyl group, an hexyl group, a decyl group or an hexadecyl group; or a racemate, an enantiomer or a diastereomer thereof, or mixtures thereof, or a salt thereof.
摘要翻译：式I的化合物：其中：A和B彼此独立地为L-赖氨酸残基，D-赖氨酸残基或L-或D-赖氨酸残基，其中侧链的NH 2基团包括修饰，其中所述修饰是（i）用氢替代，（ii）乙酰化，（iii）苯甲酰化或（iv）棕榈酰化; Gly是甘氨酸残基; 他是一个L-或D-组氨酸残基; R是CH 3 - （CH 2）n -CO-，其中n = 2,3,4,5,6,7或8; R'是式（II）的基团：N（Z）（Z'）（II）其中：Z和Z'是氢，甲基，乙基，苯基，己基，癸基或十六烷基; 或其外消旋物，对映体或非对映异构体，或其混合物，或其盐。

7. 发明申请

WO2009003284A1 NOVEL PEPTIDES, USE THEREOF IN COSMETIC AND COSMECEUTIC APPLICATIONS, AND COMPOSITIONS COMPRISING SAME 审中-公开
标题翻译：新型肽，其在化妆品和成膜应用中的应用，以及包含其的组合物
公开(公告)号：WO2009003284A1
公开(公告)日：2009-01-08
申请号：PCT/CA2008/001227
申请日：2008-06-30
申请人： LES BIOTECHNOLOGIES OCEANOVA INC. , HOCQUAUX, Michel , LOING, Estelle , BEDOS, Philippe
发明人： HOCQUAUX, Michel , LOING, Estelle , BEDOS, Philippe
IPC分类号： C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K8/64 , A61P17/00 , A61P29/00 , A61Q19/10 , C07K5/083 , C07K5/11 , C07K5/117
CPC分类号： C07K5/1019 , A61K8/64 , A61K38/00 , A61Q17/04 , A61Q19/08 , C07K5/0806 , Y02P20/55
摘要： A peptide of formula I (SEQ ID NO: 1): Lip-A-Gly-His-B-R (I) wherein: Lip is a lipoyl residue of R or S configuration; A is absent or is a lysine residue of configuration L or D; GIy is a glycine residue; His is a histidine residue of configuration L or D; B is a lysine residue of configuration L or D, or a lysine residue of configuration L or D in which the NH2 group of the side chain comprises a modification, wherein said modification is (i) a replacement with a hydrogen or (ii) a modification with a protecting group selected from the group consisting of acetyl, benzoyl, tosyl, sulfonyl benzene, benzyloxycarbonyle and palmitoyl; wherein R is O(Z) or N(Z')(Z"), and wherein Z, Z' and Z" are independently of each other a hydrogen or a protecting group selected from the group consisting of methyl, ethyl, propyl, phenyl, hexyl, decyl and hexadecyl, or a racemate, an enantiomer or a diastereomer thereof, or a mixture thereof, or a salt thereof. A peptide of formula Il (SEQ ID NO: 2): Lip-A-His-B-C-Trp-R (II) wherein: Lip is a lipoyl residue of configuration R or S; His is a histidine residue of configuration L; Trp is a tryptophane residue of configuration L; A is absent, is an amino acid residue of configuration L or D selected from the group consisting of a lysine residue, an alanine residue, a glutamic acid residue and a glycine residue, or is a spacer of formula : NH-(CH2)n-CO- wherein n is an integer comprised between 2 and 14; B is an aromatic amino acid residue of configuration D selected from the group consisting of a phenylalanine residue, a homophenylalanine residue, a tryptophane residue, a β-(1-Naphthyl)-alanine residue, a β-(2-Naphthyl)-alanine residue and a phenylglycine residue; C is a basic amino acid residue of configuration L selected from the group consisting of an arginine residue, a lysine residue, an ornithine residue and a homoarginine residue; wherein R is O(Z) or N(Z')(Z"), and wherein Z, Z' and Z" are independently of each other a hydrogen or a protecting group selected from the group consisting of methyl, ethyl, propyl, phenyl, hexyl, decyl and hexadecyl, or a racemate, an enantiomer or a diastereomer thereof, or a mixture thereof, or a salt thereof.
摘要翻译：式I的肽（SEQ ID NO：1）：Lip-A-Gly-His-B-R（I）其中：Lip是R或S构型的脂酰基残基; A不存在或是L或D构型的赖氨酸残基; Gly是甘氨酸残基; His是构型L或D的组氨酸残基; B是构型L或D的赖氨酸残基或其中侧链的NH 2基团包含修饰的构型L或D的赖氨酸残基，其中所述修饰是（i）用氢取代或（ii）用选自乙酰基，苯甲酰基，甲苯磺酰基，磺酰基苯，苄氧基羰基和棕榈酰基的保护基改性; 其中R是O（Z）或N（Z'）（Z“），并且其中Z，Z'和Z”彼此独立地是氢或选自甲基，乙基，丙基，苯基，己基，癸基和十六烷基，或其外消旋物，对映异构体或非对映体，或其混合物，或其盐。式II（SEQ ID NO：2）的肽：Lip-A-His-B-C-Trp-R（II）其中：Lip是R或S构型的脂酰基残基; His是构型L的组氨酸残基; Trp是配置L的色氨酸残基; A不存在，是选自赖氨酸残基，丙氨酸残基，谷氨酸残基和甘氨酸残基的构型L或D的氨基酸残基，或者是下式的间隔基：NH-（CH 2）n -CO-，其中n是2至14之间的整数; B是配置D的芳族氨基酸残基，选自苯丙氨酸残基，高苯丙氨酸残基，色氨酸残基，β-（1-萘基） - 丙氨酸残基，β-（2-萘基） - 丙氨酸残基和苯基甘氨酸残基; C是选自精氨酸残基，赖氨酸残基，鸟氨酸残基和高精氨酸残基的构型L的碱性氨基酸残基; 其中R是O（Z）或N（Z'）（Z“），并且其中Z，Z'和Z”彼此独立地是氢或选自甲基，乙基，丙基，苯基，己基，癸基和十六烷基，或其外消旋物，对映异构体或非对映体，或其混合物，或其盐。

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