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1. 发明申请

WO2017216289A1 COMPEPTIDE AND ANTIBODIES THERETO FOR DIAGNOSING OSTEOARTHRITIS 审中-公开
标题翻译：用于诊断骨关节炎的抗体和抗体
公开(公告)号：WO2017216289A1
公开(公告)日：2017-12-21
申请号：PCT/EP2017/064667
申请日：2017-06-15
申请人： SKIÖLDEBRAND, Eva , LINDAHL, Anders , EKMAN, Stina
发明人： SKIÖLDEBRAND, Eva , LINDAHL, Anders , EKMAN, Stina
IPC分类号： C07K16/18 , G01N33/68
摘要： There is provided a peptide comprising the amino acid sequence N-terminal-SGPTH and an antibody against this peptide. The peptide can be used for diagnosis in humans and animals, in particular horses. In particular the antibody can be used for diagnosis of a systemic low-grade chronic inflammatory disease such as osteoarthritis or atherosclerosis, or a neurodegenerative disease or neuroinflammatory disease.
摘要翻译：提供了包含氨基酸序列N末端-SGPTH的肽和针对该肽的抗体。该肽可用于人和动物，特别是马的诊断。特别地，抗体可用于诊断系统性低度慢性炎性疾病，例如骨关节炎或动脉粥样硬化，或神经退行性疾病或神经炎症疾病。

2. 发明申请

WO2012115575A1 DERIVATIVES FOR INDUCING OSTEOGENIC DIFFERENTIATION 审中-公开
标题翻译：诱导卵母细胞分化的衍生物
公开(公告)号：WO2012115575A1
公开(公告)日：2012-08-30
申请号：PCT/SE2012/050180
申请日：2012-02-20
申请人： BIOMATCELL AB , GRANELI, Cecilia , KARLSSON, Camilla , LINDAHL, Anders , THOMSEN, Peter
发明人： GRANELI, Cecilia , KARLSSON, Camilla , LINDAHL, Anders , THOMSEN, Peter
IPC分类号： A61K31/53 , A61K31/505 , A61P19/10 , C07D251/70 , C07D471/00 , C07D487/04
CPC分类号： C07D251/70 , A61K31/505 , A61K31/53 , C07D251/56 , C07D487/04
摘要： The present invention relates to a compound for use as a medicament, especially for treating bone, tooth and cartilage related diseases and damages. The compound has shown to be inducing and enhancing osteogenic differentiation. The present invention further relates to implants comprising said compound.
摘要翻译：本发明涉及用作药物，特别是用于治疗骨，牙齿和软骨相关疾病和损伤的化合物。该化合物显示出诱导和增强成骨分化。本发明还涉及包含所述化合物的植入物。

3. 发明申请

WO2020084113A1 SILDENAFIL FOR USE IN THE TREATMENT OF OSTEOARTHRITIS 审中-公开
公开(公告)号：WO2020084113A1
公开(公告)日：2020-04-30
申请号：PCT/EP2019/079170
申请日：2019-10-25
申请人： SKIÖLDEBRAND, Eva , HANSSON RÖNNBÄCK, Elisabeth , LINDAHL, Anders , ABRAHAMSSON AURELL, Kristin
发明人： SKIÖLDEBRAND, Eva , HANSSON RÖNNBÄCK, Elisabeth
IPC分类号： A61K31/519 , A61K31/445 , A61K31/7004 , A61K45/06 , A61K9/00 , A61P19/02 , A61K9/0019
摘要： There is provided a new treatment for osteoarthritis in horses, which involves the administration of a phosphodiesterase type 5 (PDE5) inhibitor, for example sildenafil in a low dose, to the patient. Preferably, sildenafil is combined with the local anaesthetic mepivacaine and with glucose.

4. 发明申请

WO2009151394A1 SUBLINGUAL COMPOSITIONS COMPRISING (2S) - (4E) -N-METHYL-5- (3- (5-ISOPROPOXYPYRIDIN) YL) -4-PENTEN-2-AMINE 审中-公开
标题翻译：包含（2S） - （4E）-N-甲基-5-（3-（5-异丙氧基吡啶））-L-丁烯-2-胺的亚组分
公开(公告)号：WO2009151394A1
公开(公告)日：2009-12-17
申请号：PCT/SE2009/050711
申请日：2009-06-11
申请人： ASTRAZENECA AB , LINDAHL, Anders X , RINGBERG, Anders
发明人： LINDAHL, Anders X , RINGBERG, Anders
IPC分类号： A61K9/20 , A61K31/4412 , A61P25/28
CPC分类号： A61K31/4412 , A61K9/0056
摘要： The present invention relates to sublingual compositions comprising (2S)-(4E)-N-methyl-5-(3-(5-isopropoxypyridin)yl)-4-penten-2-amine or pharmaceutically acceptable salts thereof, to the preparation of said compositions and the use of thereof in therapy.
摘要翻译：本发明涉及含有（2S） - （4E）-N-甲基-5-（3-（5-异丙氧基吡啶）基）-4-戊烯-2-胺或其药学上可接受的盐的制剂的舌下组合物所述组合物及其在治疗中的用途。

5. 发明申请

WO2005059116A1 METHODS FOR CLONAL DERIVATION OF HUMAN BLASTOCYST-DERIVED STEM CELL LINES 审中-公开
标题翻译：人造血干细胞移植细胞系的克隆方法
公开(公告)号：WO2005059116A1
公开(公告)日：2005-06-30
申请号：PCT/EP2004/014016
申请日：2004-12-08
申请人： CELLARTIS AB , LINDAHL, Anders , KARLSSON, Ulrika
发明人： LINDAHL, Anders , KARLSSON, Ulrika
IPC分类号： C12N5/02
CPC分类号： C12N5/0606 , C12N2501/115 , C12N2502/13 , C12N2509/00
摘要： Human blastocyst-derived stem cells (hBS) or hBS derived cells, such as, e.g., cells of endodermal, mesodermal, and ectodermal origin, are pluripotent cells with widespread potentials within the areas of e.g. therapeutic treatment, human developmental biology, and drug discovery processes. The present invention relates to a method for clonal derivation of human blastocyst-derived stem cells (hBS) or hBS derived cells. According to the present invention hBS cell colonies or hBS derived cell colonies are subjected to non-enzymatic treatment for dissociation of the cell colonies to one or more single cells, which are then separately cultivated in a serum based medium and/or serum based conditioned medium to obtain one or more cell clones capable of forming colonies.
摘要翻译：人胚泡来源的干细胞（hBS）或hBS衍生的细胞，例如内胚层，中胚层和外胚层来源的细胞，是具有广泛潜力的多能细胞。治疗性治疗，人类发育生物学和药物发现过程。本发明涉及一种用于人源胚泡干细胞（hBS）或hBS衍生细胞克隆衍生的方法。根据本发明，将hBS细胞集落或hBS衍生的细胞集落进行非酶处理以将细胞集落解离成一个或多个单细胞，然后将其单独培养在基于血清的培养基和/或血清基条件培养基以获得能够形成菌落的一个或多个细胞克隆。

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