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1. 发明申请

WO2015048728A1 METHODS FOR POST-FABRICATION FUNCTIONALIZATION OF POLY(ESTER UREAS) 审中-公开
标题翻译：聚酯（ESTER UREAS）后制备功能化方法
公开(公告)号：WO2015048728A1
公开(公告)日：2015-04-02
申请号：PCT/US2014/058264
申请日：2014-09-30
申请人： BECKER, Matthew , LIN, Fei , THE UNIVERSITY OF AKRON
发明人： BECKER, Matthew , LIN, Fei
IPC分类号： C07C229/00 , C08G63/91 , C08G75/02 , C08G77/04
CPC分类号： C08G71/02 , C07C227/18 , C07C229/34 , C07C247/04 , C07C275/16 , C08G2230/00 , C09D175/02
摘要： Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent "clickable" groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with Mw exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 30045 MPa; tensile stress: 8.51.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aqueous media.
摘要翻译：氨基酸类聚（酯尿素）（PEU）正在出现，这些聚合物在再生医学应用中已显示出希望。本发明的实施方案涉及在修饰的酪氨酸氨基酸上携带侧面的“可点击”基团的PEU的合成。悬挂物种包括炔烃，叠氮化物，烯烃，酪氨酸 - 苯酚和酮基团。通过界面缩聚方法得到Mw超过100kDa的PEU，通过共聚改变侧基的浓度。使用1 H NMR和UV-Vis光谱法证明可衍生化官能度的结合。使用静电纺丝制造直径范围为350nm至500nm的PEU纳米纤维。纳米纤维母材具有适用于组织工程的机械强度（杨氏模量：30045MPa;拉伸应力：8.51.2MPa）。在水性介质中使用生物正交反应进行静电纺丝后，将一系列生物活性肽和荧光分子缀合到纳米纤维的表面。

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