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1. 发明申请

WO2002068398A1 NEW CRYSTAL FORMS OF LAMOTRIGINE AND PROCESSES FOR THEIR PREPARATIONS 审中-公开
标题翻译： LAMOTRIGINE的新晶体形式及其制备方法
公开(公告)号：WO2002068398A1
公开(公告)日：2002-09-06
申请号：PCT/US2002/006160
申请日：2002-02-27
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , TEVA PHARMACEUTICALS USA, INC. , GARTI, Nissim , BERKOVICH, Yana , DOLITZKY, Ben-Zion , ARONHIME, Judith , SINGER, Claude , LIEBERMAN, Anita , GERSHON, Neomi
发明人： GARTI, Nissim , BERKOVICH, Yana , DOLITZKY, Ben-Zion , ARONHIME, Judith , SINGER, Claude , LIEBERMAN, Anita , GERSHON, Neomi
IPC分类号： C07D253/075
CPC分类号： C07D253/075
摘要： The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine containing molecules of the solvent in stoichiometric ratios are disclosed. The present invention also provides processes for preparing the new crystal forms of lamotrigine.
摘要翻译：拉莫三嗪本发明涉及抗癫痫的有用药物拉莫三嗪。公开了化学计量比的含有拉莫三嗪的溶剂分子的新晶体形式。本发明还提供了制备拉莫三嗪新晶型的方法。

2. 发明申请

WO2007109799A2 POLYMORPHS OF ESZOPICLONE MALATE 审中-公开
标题翻译：异黄酮黄酮的多聚体
公开(公告)号：WO2007109799A2
公开(公告)日：2007-09-27
申请号：PCT/US2007064825
申请日：2007-03-23
申请人： TEVA PHARMA , TEVA PHARMA , MAINFELD ALEX , WIZEL SCHLOMIT , MENDELOVICI MARIOARA , LIEBERMAN ANITA , KOLTAI TAMAS
发明人： MAINFELD ALEX , WIZEL SCHLOMIT , MENDELOVICI MARIOARA , LIEBERMAN ANITA , KOLTAI TAMAS
CPC分类号： C07D487/04
摘要： The present invention provides crystalline Eszopiclone malate form II, crystalline Eszopiclone form V, processes from preparing the crystalline Eszopiclone malate form II or V, pharmaceutical compositions comprising the crystalline Eszopiclone malate form II or V and methods of treating insomnia comprising administering the crystalline Eszopiclone malate form II or V.
摘要翻译：本发明提供结晶埃索替普罗苹果酸盐形式II，结晶埃索普洛尔形式V，从制备结晶依佐匹克隆苹果酸盐形式II或V的方法，包含结晶异山梨酸丙酮酸形式II或V的药物组合物和治疗失眠症的方法，包括施用结晶埃索普洛尔苹果酸盐形式 II或V.

3. 发明申请

WO02068398A9 NEW CRYSTAL FORMS OF LAMOTRIGINE AND PROCESSES FOR THEIR PREPARATIONS 审中-公开
标题翻译： LAMOTRIGINE的新型晶体形式及其制备方法
公开(公告)号：WO02068398A9
公开(公告)日：2002-11-21
申请号：PCT/US0206160
申请日：2002-02-27
申请人： TEVA PHARMA , TEVA PHARMA , GARTI NISSIM , BERKOVICH YANA , DOLITZKY BEN-ZION , ARONHIME JUDITH , SINGER CLAUDE , LIEBERMAN ANITA , GERSHON NEOMI
发明人： GARTI NISSIM , BERKOVICH YANA , DOLITZKY BEN-ZION , ARONHIME JUDITH , SINGER CLAUDE , LIEBERMAN ANITA , GERSHON NEOMI
IPC分类号： C07D253/06 , A61K31/53 , A61P25/08 , C07D253/075 , C30B7/14 , C30B29/58
CPC分类号： C07D253/075
摘要： The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine containing molecules of the solvent in stoichiometric ratios are disclosed. The present invention also provides processes for preparing the new crystal forms of lamotrigine.
摘要翻译：本发明涉及拉莫三嗪，其是抗癫痫的有用试剂。公开了含化学计量比的含有溶剂分子的拉莫三嗪的新结晶形式。本发明还提供了制备拉莫三嗪的新晶体形式的方法。

4. 发明申请

WO2004111029A2 PROCESS FOR PREPARING 2-[(PYRIDINYL)METHYL]SULFINYL-SUBSTITUTED BENZIMIDAZOLES AND NOVEL CHLORINATED DERIVATIVES OF PANTOPRAZOLE 审中-公开
标题翻译：制备2 - [（吡啶基）甲基]磺酰基取代苯并咪唑和新戊酰氯的衍生物的方法
公开(公告)号：WO2004111029A2
公开(公告)日：2004-12-23
申请号：PCT/US2004/019001
申请日：2004-06-10
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , TEVA PHARMACEUTICALS USA, INC. , LIEBERMAN, Anita , SINGER, Claude , RAIZI, Yuriy
发明人： LIEBERMAN, Anita , SINGER, Claude , RAIZI, Yuriy
IPC分类号： C07D401/00
CPC分类号： C07D401/12
摘要： The present invention provides a process comprising admixing a thioether with about 1.05 to about 1.6 molar equivalents of an active chlorine-containing oxidant, preferably sodium hypochlorite, and about 2.5 to about 5.0 molar equivalents of an alkali metal base; and recovering a sulfoxide that is preferably pantoprazole, lansoprazole, omeprazole, or rabeprazole. The process may further comprise contacting the sulfoxide with a source of sodium ions, preferably sodium hydroxide, to produce the sodium salt of the sulfoxide. The invention also relates to novel chlorinated derivatives of pantoprazole including 5(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chloromethyl]sulfinyl]-1H- benzimidazole and 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)chlorohydroxymethyl] sulfinyl]-1H-benzimidazole and processes for making them. The invention also relates to processes of quantifying and identifying a compound other than pantoprazole in a mixture of pantoprazole and at least one other compound.
摘要翻译：本发明提供了一种方法，其包括将硫醚与约1.05至约1.6摩尔当量的活性氯氧化剂，优选次氯酸钠和约2.5至约5.0摩尔当量碱金属碱混合; 并回收优选泮托拉唑，兰索拉唑，奥美拉唑或雷贝拉唑的亚砜。该方法可以进一步包括使亚砜与钠离子源（优选氢氧化钠）接触以产生亚砜的钠盐。本发明还涉及泮托拉唑的新型氯化衍生物，其包括5（二氟甲氧基）-2 - [[（3,4-二甲氧基-2-吡啶基） - 氯甲基]亚磺酰基] -1H-苯并咪唑和5-（二氟甲氧基）-2- [ [（3,4-二甲氧基-2-吡啶基）氯羟甲基]亚磺酰基] -1H-苯并咪唑及其制备方法。本发明还涉及在泮托拉唑和至少一种其它化合物的混合物中量化和鉴定泮托拉唑以外的化合物的方法。

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