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1. 发明申请

WO2008002956A3 THIAZOLINE AND OXAZOLINE DERIVATIVES AND THEIR METHODS OF USE 审中-公开
标题翻译：噻唑啉和氧杂环丁烷衍生物及其使用方法
公开(公告)号：WO2008002956A3
公开(公告)日：2008-07-03
申请号：PCT/US2007072185
申请日：2007-06-27
申请人： ABBOTT LAB , FAGHIH RAMIN , GFESSER GREGORY A , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI , GOPALAKRISHNAN SUJATHA , MALYSZ JOHN , GUBBINS EARL J , EL KOUHEN RACHID , LI JINHE , SARRIS KATHY A , MICHMERHUIZEN MELISSA J , WANG YING
发明人： FAGHIH RAMIN , GFESSER GREGORY A , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI , GOPALAKRISHNAN SUJATHA , MALYSZ JOHN , GUBBINS EARL J , EL KOUHEN RACHID , LI JINHE , SARRIS KATHY A , MICHMERHUIZEN MELISSA J , WANG YING
IPC分类号： C07D417/04 , A61K31/422 , A61K31/427 , C07D413/04 , C07D417/14
CPC分类号： C07D417/04 , C07D413/04 , C07D417/14
摘要： The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.
摘要翻译：本发明涉及选自化合物的式I化合物。式（I）化合物在治疗由烟碱乙酰胆碱受体调节的病症和病症中。

2. 发明申请

WO2009003074A8 CHOLINERGIC/SEROTONINERGIC RECEPTOR AND USES THEREOF 审中-公开
标题翻译：胆碱酯酶/受体受体及其用途
公开(公告)号：WO2009003074A8
公开(公告)日：2009-07-16
申请号：PCT/US2008068264
申请日：2008-06-26
申请人： ABBOTT LAB , GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
发明人： GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
IPC分类号： C07K14/435
CPC分类号： C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
摘要： The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.
摘要翻译：本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

3. 发明申请

WO1997007213A2 ASSAY FOR IDENTIFYING GENES CAUSING CHROMOSOME NON-DISJUNCTION 审中-公开
标题翻译：用于识别基因导致染色体不分离的测定
公开(公告)号：WO1997007213A2
公开(公告)日：1997-02-27
申请号：PCT/US1996013314
申请日：1996-08-15
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , POTTER, Huntington , LI, Jinhe
发明人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
IPC分类号： C12N15/12
CPC分类号： G01N33/5011 , A61K38/00 , C07K14/4711 , C12N15/10 , C12Q1/68 , C12Q1/6897 , G01N33/5008 , G01N33/502
摘要： Disclosed is a method of identifying genes whose gene products cause chromosome missegregation. The method involves transfecting a mammalian gene being assessed into a cell and then assessing whether the progeny cells have increased aneuploidy or increased chromosome breaks or translocations compared with cells that have not been transfected with the gene. Genes identified in this manner are likely to be involved in causing diseases such as cancer and Alzheimer's Disease, which result from improper chromosome segregation. Also disclosed is a method of identifying agents which can be used in the treatment of diseases caused by improper chromosome segregation. The method involves treating cells that have been transfected with a gene whose gene product causes improper chromosome segregation with an agent being assessed. Cells showing less aneuploidy or less chromosomal breakage or translocation compared with untreated cells indicate that the agent is useful in the treatment of diseases caused by improper chromosome segregation.
摘要翻译：公开了一种识别基因产物导致染色体错误分离的基因的方法。该方法涉及将待评估的哺乳动物基因转染到细胞中，然后评估与未用该基因转染的细胞相比，后代细胞是否增加非整倍体或增加的染色体断裂或易位。以这种方式鉴定的基因可能参与由于不适当的染色体分离而引起的癌症和阿尔茨海默病等疾病。还公开了一种鉴定可用于治疗由不适当的染色体分离引起的疾病的药剂的方法。该方法涉及用被评估的试剂处理基因产物导致不适当的染色体分离的基因转染的细胞。与未经处理的细胞相比，显示较少非整倍体或较少染色体断裂或易位的细胞表明该试剂可用于治疗由不适当的染色体分离引起的疾病。

4. 发明申请

WO2009003074A9 CHOLINERGIC/SEROTONINERGIC CHIMERIC RECEPTOR AND USES THEREOF 审中-公开
标题翻译： CHOLINERGIC / SERONONERGIC CHIMERIC RECEPTOR及其用途
公开(公告)号：WO2009003074A9
公开(公告)日：2010-10-28
申请号：PCT/US2008068264
申请日：2008-06-26
申请人： ABBOTT LAB , GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
发明人： GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
IPC分类号： C07K14/435
CPC分类号： C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
摘要： The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.
摘要翻译：本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

5. 发明申请

WO2009003074A2 CHOLINERGIC/SEROTONINERGIC RECEPTOR AND USES THEREOF 审中-公开
标题翻译：胆碱酯酶/受体受体及其用途
公开(公告)号：WO2009003074A2
公开(公告)日：2008-12-31
申请号：PCT/US2008068264
申请日：2008-06-26
申请人： ABBOTT LAB , GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
发明人： GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
IPC分类号： C07K14/435
CPC分类号： C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
摘要： The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.
摘要翻译：本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

6. 发明申请

WO2008002974A1 PYRROLE DERIVATIVES AND THEIR METHODS OF USE 审中-公开
标题翻译：吡咯衍生物及其使用方法
公开(公告)号：WO2008002974A1
公开(公告)日：2008-01-03
申请号：PCT/US2007/072228
申请日：2007-06-27
申请人： ABBOTT LABORATORIES , FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe
发明人： FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe
IPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , A61K31/402 , A61P25/00
CPC分类号： C07D207/34 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10
摘要： The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本发明涉及一系列取代的吡咯衍生物，包含其的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

7. 发明申请

WO2009067272A1 IMMUNOASSAY FOR DETECTION AND QUANTIFICATION OF AMYLOID-B PEPTIDES 审中-公开
标题翻译：免疫测定用于检测和定量AMYLOID-B肽
公开(公告)号：WO2009067272A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/057393
申请日：2008-03-19
申请人： ABBOTT LABORATORIES , LI, Jinhe , GOPALAKRISHNAN, Murali
发明人： LI, Jinhe , GOPALAKRISHNAN, Murali
IPC分类号： G01N33/50 , A61K31/00
CPC分类号： G01N33/5058 , C07D451/02 , C07D453/02 , C12N5/0618 , C12N2501/805 , G01N33/6896 , G01N2333/4709
摘要： The present invention provides a method for the detection and quantification of Ab1-40 produced in native cell types and tissues. Also provided are assays and kits to determine the effect of compounds on the production of amyloid b peptides.
摘要翻译：本发明提供了用于检测和定量在天然细胞类型和组织中产生的Ab1-40的方法。还提供了用于确定化合物对淀粉样蛋白b肽的产生的影响的测定和试剂盒。

8. 发明申请

WO2009003074A3 CHOLINERGIC/SEROTONINERGIC CHIMERIC RECEPTOR AND USES THEREOF 审中-公开
标题翻译：胆碱能/血清素能嵌合受体及其用途
公开(公告)号：WO2009003074A3
公开(公告)日：2008-12-31
申请号：PCT/US2008/068264
申请日：2008-06-26
申请人： ABBOTT LABORATORIES , GOPALAKRISHNAN, Murali , LI, Jinhe , CASSAR, Steven C , MALYSZ, John , ANDERSON, David J , GUBBINS, Earl J , BERTRAND, Daniel C
发明人： GOPALAKRISHNAN, Murali , LI, Jinhe , CASSAR, Steven C , MALYSZ, John , ANDERSON, David J , GUBBINS, Earl J , BERTRAND, Daniel C
IPC分类号： C07K14/435
摘要： The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.
摘要翻译：本发明描述了新的胆碱能/ 5-羟色胺能嵌合受体并提供了适于筛选配体的方法和组合物，所述配体例如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

9. 发明申请

WO2008002956A2 THIAZOLINE AND OXAZOLINE DERIVATIVES AND THEIR METHODS OF USE 审中-公开
标题翻译：噻唑啉和氧杂环丁烷衍生物及其使用方法
公开(公告)号：WO2008002956A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/072185
申请日：2007-06-27
申请人： ABBOTT LABORATORIES , FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe , SARRIS, Kathy A. , MICHMERHUIZEN, Melissa J. , WANG, Ying
发明人： FAGHIH, Ramin , GFESSER, Gregory A. , LYNCH, Christopher L. , GOPALAKRISHNAN, Murali , GOPALAKRISHNAN, Sujatha , MALYSZ, John , GUBBINS, Earl J. , EL KOUHEN, Rachid , LI, Jinhe , SARRIS, Kathy A. , MICHMERHUIZEN, Melissa J. , WANG, Ying
CPC分类号： C07D417/04 , C07D413/04 , C07D417/14
摘要： The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
摘要翻译：本发明涉及一系列噻唑啉和恶唑啉衍生物，其组合物，以及使用这些化合物治疗病症和病症的方法。

10. 发明申请

WO9707213A3 ASSAY FOR IDENTIFYING GENES CAUSING CHROMOSOME NON-DISJUNCTION 审中-公开
标题翻译：用于识别基因导致染色体非分离的测定
公开(公告)号：WO9707213A3
公开(公告)日：1997-05-22
申请号：PCT/US9613314
申请日：1996-08-15
申请人： HARVARD COLLEGE , POTTER HUNTINGTON , LI JINHE
发明人： POTTER HUNTINGTON , LI JINHE
IPC分类号： A61K38/00 , C07K14/47 , C12N15/10 , C12N15/12 , C12Q1/68 , G01N33/50 , C12N15/81
CPC分类号： G01N33/5011 , A61K38/00 , C07K14/4711 , C12N15/10 , C12Q1/68 , C12Q1/6897 , G01N33/5008 , G01N33/502
摘要： Disclosed is a method of identifying genes whose gene products cause chromosome missegregation. The method involves transfecting a mammalian gene being assessed into a cell and then assessing whether the progeny cells have increased aneuploidy or increased chromosome breaks or translocations compared with cells that have not been transfected with the gene. Genes identified in this manner are likely to be involved in causing diseases such as cancer and Alzheimer's Disease, which result from improper chromosome segregation. Also disclosed is a method of identifying agents which can be used in the treatment of diseases caused by improper chromosome segregation. The method involves treating cells that have been transfected with a gene whose gene product causes improper chromosome segregation with an agent being assessed. Cells showing less aneuploidy or less chromosomal breakage or translocation compared with untreated cells indicate that the agent is useful in the treatment of diseases caused by improper chromosome segregation.

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