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1. 发明申请

WO2010075521A1 COMPOSITIONS AND METHODS OF TREATING CANCER 审中-公开
标题翻译：治疗癌症的组合物和方法
公开(公告)号：WO2010075521A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069425
申请日：2009-12-23
申请人： CASE WESTERN RESERVE UNIVERSITY , SY, Man-Sun , XIN, Wei , LI, Chaoyang , YU, Shuiliang , YIN, Shaoman
发明人： SY, Man-Sun , XIN, Wei , LI, Chaoyang , YU, Shuiliang , YIN, Shaoman
IPC分类号： A61K38/00 , A61K31/7088
CPC分类号： A61K31/7088 , A61K31/00 , A61K38/1709 , A61K38/177
摘要： A method of inhibiting neoplastic, cancer, and/or tumorgenic cell proliferation, cell growth and motility in a subject includes administering to a cancer cell expressing Pro-PrP and FLNa a therapeutically effective amount of a Pro-PrP regulating agent.
摘要翻译：在受试者中抑制肿瘤，癌症和/或肿瘤细胞增殖，细胞生长和运动的方法包括向表达Pro-PrP和FLNa的癌细胞施用治疗有效量的Pro-PrP调节剂。

2. 发明申请

WO2012058393A3 DKK1 ANTIBODIES AND METHODS OF USE 审中-公开
标题翻译： DKK1抗体及其使用方法
公开(公告)号：WO2012058393A3
公开(公告)日：2012-10-04
申请号：PCT/US2011058025
申请日：2011-10-27
申请人： AMGEN INC , RICHARDS WILLIAM GLEASON , LU HSIENG SEN , KE HUA ZHU , LI CHAOYANG , JACOBSEN FREDERICK W
发明人： RICHARDS WILLIAM GLEASON , LU HSIENG SEN , KE HUA ZHU , LI CHAOYANG , JACOBSEN FREDERICK W
IPC分类号： C07K16/18 , C07K16/22
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
摘要翻译：本发明提供了特异性结合DKK1多肽的抗体及其免疫功能片段。还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。还公开了使用抗体和片段来治疗各种疾病。

3. 发明申请

WO2008070229A3 DETECTION OF PATHOGENIC AGGREGATES OF PROTEIN IN A SAMPLE BY HOMOLOGOUS ELISA 审中-公开
公开(公告)号：WO2008070229A3
公开(公告)日：2008-06-12
申请号：PCT/US2007/076986
申请日：2007-08-28
申请人： CASE WESTERN RESERVE UNIVERSITY , SY, Man-Sun , CHANG, Binggong , LI, Chaoyang
发明人： SY, Man-Sun , CHANG, Binggong , LI, Chaoyang
IPC分类号： G01N33/53 , C12P21/04
摘要： A method of detecting pathogenic aggregates of a protein in a sample comprises contacting the sample with a first monoclonal antibody or epitope binding fragment thereof, the first monoclonal antibody or an epitope binding fragment thereof being immunoreactive with the protein of the pathogenic aggregates, removing pathogenic aggregates of the protein not bound to the first monoclonal antibody or epitope binding fragment thereof, contacting the bound pathogenic aggregates of the protein with a second monoclonal antibody or epitope binding fragment thereof, the second monoclonal antibody or epitope binding fragment thereof being substantially identical to the first monoclonal antibody or epitope binding fragment thereof and being coupled to a detectable amplification module, amplifying the amplification module coupled to the second monoclonal antibody bound to the pathogenic aggregates, and detecting the amount of amplified amplification module to determine the presence of protein aggregates in the sample.

4. 发明申请

WO2008070229A2 DETECTION OF PATHOGENIC AGGREGATES OF PROTEIN IN A SAMPLE BY HOMOLOGOUS ELISA 审中-公开
标题翻译：同源ELISA法检测样品中蛋白质的致病凝集物
公开(公告)号：WO2008070229A2
公开(公告)日：2008-06-12
申请号：PCT/US2007076986
申请日：2007-08-28
申请人： UNIV CASE WESTERN RESERVE , SY MAN-SUN , CHANG BINGGONG , LI CHAOYANG
发明人： SY MAN-SUN , CHANG BINGGONG , LI CHAOYANG
IPC分类号： G01N33/53
CPC分类号： G01N33/537 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/2828
摘要： A method of detecting pathogenic aggregates of a protein in a sample comprises contacting the sample with a first monoclonal antibody or epitope binding fragment thereof, the first monoclonal antibody or an epitope binding fragment thereof being immunoreactive with the protein of the pathogenic aggregates, removing pathogenic aggregates of the protein not bound to the first monoclonal antibody or epitope binding fragment thereof, contacting the bound pathogenic aggregates of the protein with a second monoclonal antibody or epitope binding fragment thereof, the second monoclonal antibody or epitope binding fragment thereof being substantially identical to the first monoclonal antibody or epitope binding fragment thereof and being coupled to a detectable amplification module, amplifying the amplification module coupled to the second monoclonal antibody bound to the pathogenic aggregates, and detecting the amount of amplified amplification module to determine the presence of protein aggregates in the sample.
摘要翻译：检测样品中蛋白质的致病性聚集体的方法包括使样品与第一单克隆抗体或其表位结合片段接触，第一单克隆抗体或其表位结合片段与致病性聚集体的蛋白质发生免疫反应，除去致病性聚集体未与第一单克隆抗体或其表位结合片段结合的蛋白质，使蛋白质的结合致病性聚集体与第二单克隆抗体或其表位结合片段接触，第二单克隆抗体或其表位结合片段与第一单克隆抗体或其表位结合片段基本上相同单克隆抗体或其表位结合片段并与可检测的扩增模块偶联，扩增偶联于与致病性聚集体结合的第二单克隆抗体的扩增模块，并检测扩增扩增模块的量以确定蛋白质聚集体样本中的门。

5. 发明申请

WO2012058393A2 DKK1 ANTIBODIES AND METHODS OF USE 审中-公开
标题翻译： DKK1抗体和使用方法
公开(公告)号：WO2012058393A2
公开(公告)日：2012-05-03
申请号：PCT/US2011/058025
申请日：2011-10-27
申请人： AMGEN INC. , RICHARDS, William Gleason , LU, Hsieng Sen , KE, Hua Zhu , LI, Chaoyang , JACOBSEN, Frederick W.
发明人： RICHARDS, William Gleason , LU, Hsieng Sen , KE, Hua Zhu , LI, Chaoyang , JACOBSEN, Frederick W.
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
摘要翻译：本发明提供了特异性结合DKK1多肽的抗体及其免疫功能片段。还提供了制备这些抗体或其片段的方法以及含有该抗体或片段的生理学上可接受的组合物。还公开了使用抗体和片段来治疗各种疾病。

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