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1. 发明申请

WO9920305A8 VETERINARY VACCINES 审中-公开
标题翻译：兽医疫苗
公开(公告)号：WO9920305A8
公开(公告)日：1999-07-08
申请号：PCT/AU9800865
申请日：1998-10-16
申请人： FORT DODGE AUSTRALIA PTY LIMIT , BUCHTA RICHARD , SCHWARTZKOFF CHRISTOPHER LEIGH , LEHRBACH PHILIP RALPH
发明人： BUCHTA RICHARD , SCHWARTZKOFF CHRISTOPHER LEIGH , LEHRBACH PHILIP RALPH
IPC分类号： A61K9/00 , A61K9/107 , A61K39/08 , A61K39/39 , A61K47/06 , A61K47/14 , A61K47/44 , A61P31/04
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/107 , A61K39/08 , A61K47/06 , A61K47/14 , A61K2039/55566
摘要： The invention relates to vaccines which are suitable for the prevention of clostridial diseases of sheep (and lambs), providing an effective immunity for up to a year or more following a single injection or dose.
摘要翻译：本发明涉及适用于预防绵羊（和羔羊）梭菌病的疫苗，在单次注射或剂量后提供长达一年或更长时间的有效免疫力。

2. 发明申请

WO1987006590A1 IMMUNOPOTENTIATION 审中-公开
标题翻译：免疫增强
公开(公告)号：WO1987006590A1
公开(公告)日：1987-11-05
申请号：PCT/AU1987000107
申请日：1987-04-16
申请人： BIOENTERPRISES PTY. LTD. , BARNES, Thomas, Michael , LEHRBACH, Philip, Ralph , RUSSELL-JONES, Gregory, John
发明人： BIOENTERPRISES PTY. LTD.
IPC分类号： C07K15/04
CPC分类号： C07K14/005 , A61K38/00 , A61K39/385 , A61K2039/523 , A61K2039/6068 , A61K2039/627 , C07K14/245 , C07K14/445 , C07K14/8132 , C07K2319/00 , C07K2319/035 , C07K2319/40 , C12N15/62 , C12N2720/12322
摘要： A class of carrier molecules which when linked to an immunogen can enhance the host's immune response to that immunogen regardless of whether the complex of carrier and immunogen is administered parenterally, enterally or orally to the host. The invention also provides processes for production of complexes according to the invention, as well as hybrid DNA sequences encoding complexes according to the invention, recombinant DNA molecules bearing said hybrid DNA sequences, transformant hosts and vaccines comprising complexes of the invention as well as methods for production of said vaccines.
摘要翻译：当与免疫原连接时，一类载体分子可以增强宿主对该免疫原的免疫应答，而不管载体和免疫原的复合物是否肠胃外，肠道或口服给予宿主。本发明还提供了用于制备根据本发明的复合物的方法，以及编码根据本发明的复合物的杂交DNA序列，携带所述杂交DNA序列的重组DNA分子，转化体宿主和包含本发明复合物的疫苗以及用于生产所述疫苗。

3. 发明申请

WO2010022135A1 IMMUNOLOGICAL COMPOSITION 审中-公开
标题翻译：免疫组成
公开(公告)号：WO2010022135A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/054285
申请日：2009-08-19
申请人： WYETH , LEHRBACH, Philip, Ralph , CHESHIRE, William, John , XIN, Zhixian
发明人： LEHRBACH, Philip, Ralph , CHESHIRE, William, John , XIN, Zhixian
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/5252 , A61K2039/55505 , A61K2039/55577 , A61K2039/55583
摘要： The present invention relates to immunological compositions comprising sulpholipo-cyclodextrin (SL-CD) and, saponin or Quil A, and optionally at least one antigen The invention relates to methods and immunological compositions comprising at least one antigen, which may be a veterinary antigen The veterinary antigen in the methods and immunological compositions of the invention may be a bovine antigen The invention relates to methods and immunological compositions comprising bovine ephemeral fever virus (BEFV), bovine herpesvirus 1 (IBR) or bluetongue virus (BTV) The invention comprises methods for eliciting an immune response against BEFV, IBR, or BTV in an animal, which comprises administering to the animal a composition of the invention In the invention, particularly the immune response is a protective immune response The invention comprises a method for preparing an immunological composition comprising adding Quil A to a virus
摘要翻译：本发明涉及包含舒巴普罗 - 环糊精（SL-CD）和皂角苷或藜芦A和任选的至少一种抗原的免疫组合物。本发明涉及包含至少一种抗原的方法和免疫组合物，其可以是兽医抗原本发明的方法和免疫组合物中的兽医抗原可以是牛抗原。本发明涉及包含牛短暂热病毒（BEFV），牛疱疹病毒1（IBR）或蓝舌病毒（BTV））的方法和免疫组合物。本发明包括在动物中引发针对BEFV，IBR或BTV的免疫应答，其包括向动物施用本发明的组合物在本发明中，特别地，免疫应答是保护性免疫应答本发明包括一种制备免疫组合物的方法，其包含将Quil A添加到病毒中

4. 发明申请

WO1998027964A1 VETERINARY VACCINES 审中-公开
标题翻译：兽医疫苗
公开(公告)号：WO1998027964A1
公开(公告)日：1998-07-02
申请号：PCT/AU1997000871
申请日：1997-12-22
申请人： FORT DODGE AUSTRALIA PTY. LIMITED , BUCHTA, Richard , SCHWARTZKOFF, Christopher, Leigh , LEHRBACH, Philip, Ralph
发明人： FORT DODGE AUSTRALIA PTY. LIMITED
IPC分类号： A61K09/113
CPC分类号： A61K39/39 , A61K9/113 , A61K39/0225 , A61K39/08 , A61K2039/55566
摘要： Stable vaccine compositions allow safe and efficacious use of an oil emulsion vaccine for the initial single dose vaccination of previously unvaccinated animals and/or the subsequent annual booster vaccination. The vaccine compositions have a viscosity of 100m Pas or less and comprise multi-phase emulsions including an oil phase acting as adjuvant and preservative and an aqueous phase including one or more antigens selected from diseases of cattle or sheep. The oily adjuvant is acceptable for veterinary purposes and comprises a synthetic hydrocarbon being between 40 % and 60 % by weight of the emulsion and an emulsifier, selected so that the inversion point of the resulting emulsion is between 25 DEG C and 45 DEG C, and being between 2 % and 10 % by weight of the emulsion.
摘要翻译：稳定的疫苗组合物允许安全有效地使用油乳剂疫苗，用于先前未接种疫苗的动物的初始单剂量接种和/或随后的年加强免疫接种。疫苗组合物的粘度为100mPa·s以下，包含多相乳液，其包含作为佐剂和防腐剂的油相和含有选自牛或绵羊疾病的一种或多种抗原的水相。油性佐剂对于兽医目的是可接受的，并且包含合成烃占乳液重量的40％至60％，乳化剂选择为使得所得乳液的转化点在25至45℃之间，为乳液重量的2％至10％。

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