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1. 发明申请

WO2004096999A3 IN VITRO TRANSLATION SYSTEM 审中-公开
公开(公告)号：WO2004096999A3
公开(公告)日：2004-11-11
申请号：PCT/US2004/013110
申请日：2004-04-27
申请人： EXELIXIS, INC. , LEE, Jae, Moon , BUCKLEY, Douglas, Iwen , CANCILLA, Michael, Robert , CURTIS, Damian, E. , BOWMAN, Krista, K. , ZHAN, Hangjun , CIANCIO, Margie
发明人： LEE, Jae, Moon , BUCKLEY, Douglas, Iwen , CANCILLA, Michael, Robert , CURTIS, Damian, E. , BOWMAN, Krista, K. , ZHAN, Hangjun , CIANCIO, Margie
IPC分类号： C12P21/00
摘要： In vitro translation (IVT) systems and methods for increased expression of proteins from linear templates, using GamS, are provided. The proteins may be full length or protein fragments. The IVT system may be used in batch or continuous mode. The GamS may be used as GamS nucleic acid template, crude protein fraction, or purified protein product. The IVT system using GamS component may be employed in a high-throughput mode. The ability to predict expressible protein or fragments, and activity and solubility of a large-scale protein expression product based on the results obtained from high-throughput, small-scale IVT expression product is also provided.

2. 发明申请

WO2004096999A2 IN VITRO TRANSLATION SYSTEM 审中-公开
标题翻译：在体外翻译系统
公开(公告)号：WO2004096999A2
公开(公告)日：2004-11-11
申请号：PCT/US2004013110
申请日：2004-04-27
申请人： EXELIXIS INC , LEE JAE MOON , BUCKLEY DOUGLAS IWEN , CANCILLA MICHAEL ROBERT , CURTIS DAMIAN E , BOWMAN KRISTA K , ZHAN HANGJUN , CIANCIO MARGIE
发明人： LEE JAE MOON , BUCKLEY DOUGLAS IWEN , CANCILLA MICHAEL ROBERT , CURTIS DAMIAN E , BOWMAN KRISTA K , ZHAN HANGJUN , CIANCIO MARGIE
IPC分类号： C12N20060101 , C12N15/67 , C12P21/00 , C12P21/02 , C12Q1/68 , G01N33/53 , C12N
CPC分类号： C12P21/02 , C12N15/67
摘要： In vitro translation (IVT) systems and methods for increased expression of proteins from linear templates, using GamS, are provided. The proteins may be full length or protein fragments. The IVT system may be used in batch or continuous mode. The GamS may be used as GamS nucleic acid template, crude protein fraction, or purified protein product. The IVT system using GamS component may be employed in a high-throughput mode. The ability to predict expressible protein or fragments, and activity and solubility of a large-scale protein expression product based on the results obtained from high-throughput, small-scale IVT expression product is also provided.
摘要翻译：提供了体外翻译（IVT）系统和使用GamS从线性模板中增加蛋白质表达的方法。蛋白质可以是全长或蛋白质片段。 IVT系统可以分批或连续模式使用。 GAMS可用作GamS核酸模板，粗蛋白级分或纯化蛋白质产物。使用GamS组件的IVT系统可以以高通量模式使用。还提供了基于从高通量小规模IVT表达产物获得的结果来预测可表达蛋白质或片段的能力以及大规模蛋白质表达产物的活性和溶解度的能力。

3. 发明申请

WO2004015130A2 MODULATORS OF RABGGT AND METHODS OF USE THEREOF 审中-公开
标题翻译： RABGGT调节剂及其使用方法
公开(公告)号：WO2004015130A2
公开(公告)日：2004-02-19
申请号：PCT/US2003/025001
申请日：2003-08-07
申请人： EXELIXIS , BRISTOL-MYERS SQUIBB COMPANY , MANNE, Veeraswamy , LYNCH, Mark , ROSS-MACDONALD, Petra B. , STOUCH, Terry , LANGE, Naomi , CARROLL, Pamela , FITZGERALD, Kevin , COSTA, Michael, R. , MAXWELL, Mark E. , KINDT, Rachel M. , LACKNER, Mark R. , HUNG, Tak , O'BRIEN, Carol, L. , ZHANG, Hai Guang , BROWN, Katherine, S. , LEE, Jae Moon , LOMBARDO, Louis J.
发明人： MANNE, Veeraswamy , LYNCH, Mark , ROSS-MACDONALD, Petra B. , STOUCH, Terry , LANGE, Naomi , CARROLL, Pamela , FITZGERALD, Kevin , COSTA, Michael, R. , MAXWELL, Mark E. , KINDT, Rachel M. , LACKNER, Mark R. , HUNG, Tak , O'BRIEN, Carol, L. , ZHANG, Hai Guang , BROWN, Katherine, S. , LEE, Jae Moon , LOMBARDO, Louis J.
IPC分类号： C12Q
CPC分类号： C07K14/4747 , A61K31/00 , C12N9/1085 , C12N15/1137 , C12N2310/14 , C12Y205/0106 , G01N33/5011 , G01N2510/00 , G01N2800/52
摘要： The present invention provides methods for inducing apoptosis in a cell, the methods generally involving contacting the cell with an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for treating a disorder related to unwanted cell proliferation in an individual, the methods generally involving administering to the individual an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for reducing apoptosis in a cell, the methods generally involving increasing the level and/or activity of RabGGT in the cell. The present invention further provides methods for treating disorders associated with excessive apoptosis. The present invention further provides methods for identifying a cell that is amenable to treatment with the methods of the present invention. The present invention further provides methods for modulating a binding event between RabGGT and a RabGGT interacting protein. The present invention further provides a 3-dimensional structure of RabGGT, and methods of use of the structure to identify compounds that modulate RabGGT activity.
摘要翻译：本发明提供了诱导细胞凋亡的方法，所述方法通常包括使细胞与降低RabGGT水平和/或活性的试剂接触。本发明进一步提供了用于治疗个体中与有害细胞增殖有关的病症的方法，所述方法通常包括向个体施用降低RabGGT水平和/或活性的药剂。本发明还提供了减少细胞凋亡的方法，所述方法通常涉及提高细胞中RabGGT的水平和/或活性。本发明还提供了治疗与过度凋亡相关的疾病的方法。本发明进一步提供了用于鉴定可以用本发明的方法治疗的细胞的方法。本发明还提供了用于调节RabGGT和RabGGT相互作用蛋白之间的结合事件的方法。本发明进一步提供了RabGGT的三维结构，以及使用该结构鉴定调节RabGGT活性的化合物的方法。

4. 发明申请

WO2007046664A1 LIGHT DIFFUSION TYPE LIGHT EMITTING DIODE 审中-公开
标题翻译：光扩散型发光二极管
公开(公告)号：WO2007046664A1
公开(公告)日：2007-04-26
申请号：PCT/KR2006/004294
申请日：2006-10-20
申请人： KOREA PHOTONICS TECHNOLOGY INSTITUTE , KIM, Jae-Pil , PARK, Seung-Hyun , KIM, Tae-Hun , LEE, Jae-Moon , YU, Young-Moon
发明人： KIM, Jae-Pil , PARK, Seung-Hyun , KIM, Tae-Hun , LEE, Jae-Moon , YU, Young-Moon
IPC分类号： H01L33/00
CPC分类号： H01L33/56 , H01L33/501 , H01L2224/48091 , H01L2224/49107 , H01L2933/0091 , H01L2924/00014
摘要： The present invention relates to light diffusion type light emitting diodes, more particularly, to a light emitting device having a large divergence angle by widely spreading an emitted light from a single color to a white color and a method thereof. The light emitting diode including the encapsulating layer according to the present invention is characterized by including at least two materials with different characteristics. According to the present invention, an encapsulating material for light emitting diode is mixed with at least two materials with a different polarity or a refractive index to easily form a light emitting diode. In addition, the light emitting diode die is bonded on the bottom surface of a cup, and an encapsulating material and microspheres are dispersed in the vicinity and upper portion of the light emitting diode and the entire light emitting diode, therefore the light emitting diode has a large and uniform divergence angle due to a light uniformly scattered and refracted. Furthermore, the microsphere particles with similar density to the encapsulating layer exist, thereby solving a problem of precipitation of particles, which occurs when the existing inorganic particles are dispersed.
摘要翻译：本发明涉及光漫射型发光二极管，更具体地涉及通过广泛地将发射的光从单一颜色扩散到白色而具有大的发散角的发光器件及其方法。包括根据本发明的封装层的发光二极管的特征在于包括具有不同特性的至少两种材料。根据本发明，用于发光二极管的封装材料与具有不同极性或折射率的至少两种材料混合以容易地形成发光二极管。此外，发光二极管管芯结合在杯的底面上，并且封装材料和微球体分散在发光二极管的附近和上部以及整个发光二极管中，因此发光二极管具有由于光均匀分散和折射，发散角大而均匀。此外，存在与包封层密度相似的微球颗粒，从而解决了当现有的无机颗粒分散时发生的颗粒沉淀的问题。

5. 发明申请

WO2004015130A3 MODULATORS OF RABGGT AND METHODS OF USE THEREOF 审中-公开
标题翻译： RABGGT的调节剂及其使用方法
公开(公告)号：WO2004015130A3
公开(公告)日：2004-10-14
申请号：PCT/US0325001
申请日：2003-08-07
申请人： EXELIXIS , SQUIBB BRISTOL MYERS CO , MANNE VEERASWAMY , LYNCH MARK , ROSS-MACDONALD PETRA B , STOUCH TERRY , LAING NAOMI , CARROLL PAMELA , FITZGERALD KEVIN , COSTA MICHAEL R , MAXWELL MARK E , KINDT RACHEL M , LACKNER MARK R , HUNG TAK , O'BRIEN CAROL L , ZHANG HAI GUANG , BROWN KATHERINE S , LEE JAE MOON , LOMBARDO LOUIS J
发明人： MANNE VEERASWAMY , LYNCH MARK , ROSS-MACDONALD PETRA B , STOUCH TERRY , LAING NAOMI , CARROLL PAMELA , FITZGERALD KEVIN , COSTA MICHAEL R , MAXWELL MARK E , KINDT RACHEL M , LACKNER MARK R , HUNG TAK , O'BRIEN CAROL L , ZHANG HAI GUANG , BROWN KATHERINE S , LEE JAE MOON , LOMBARDO LOUIS J
IPC分类号： A61K31/00 , C07K14/47 , C12N9/10 , C12N15/113 , G01N33/50 , C12Q1/68 , A61K48/00
CPC分类号： C07K14/4747 , A61K31/00 , C12N9/1085 , C12N15/1137 , C12N2310/14 , C12Y205/0106 , G01N33/5011 , G01N2510/00 , G01N2800/52
摘要： The present invention provides methods for inducing apoptosis in a cell, the methods generally involving contacting the cell with an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for treating a disorder related to unwanted cell proliferation in an individual, the methods generally involving administering to the individual an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for reducing apoptosis in a cell, the methods generally involving increasing the level and/or activity of RabGGT in the cell. The present invention further provides methods for treating disorders associated with excessive apoptosis. The present invention further provides methods for identifying a cell that is amenable to treatment with the methods of the present invention. The present invention further provides methods for modulating a binding event between RabGGT and a RabGGT interacting protein. The present invention further provides a 3-dimensional structure of RabGGT, and methods of use of the structure to identify compounds that modulate RabGGT activity.
摘要翻译：本发明提供诱导细胞凋亡的方法，所述方法通常涉及使细胞与降低RabGGT的水平和/或活性的试剂接触。本发明还提供了治疗与个体中不需要的细胞增殖有关的病症的方法，所述方法通常涉及向个体施用降低RabGGT的水平和/或活性的药剂。本发明还提供减少细胞凋亡的方法，所述方法通常涉及增加细胞中RabGGT的水平和/或活性。本发明还提供了治疗与过度凋亡相关的疾病的方法。本发明还提供了用于鉴定可用本发明的方法治疗的细胞的方法。本发明还提供了调节RabGGT和RabGGT相互作用蛋白之间的结合事件的方法。本发明还提供了RabGGT的3维结构，以及使用该结构鉴定调节RabGGT活性的化合物的方法。

6. 发明申请

WO2019152546A3 SALT FORMS OF ORGANIC COMPOUND 审中-公开
公开(公告)号：WO2019152546A3
公开(公告)日：2019-08-08
申请号：PCT/US2019/015890
申请日：2019-01-30
申请人： KAINOS MEDICINE INC. , LEE, Jae Moon
发明人： LEE, Jae Moon , YOO, Sungeun , SHIN, Sunmi
IPC分类号： A61P9/10 , C07D207/16 , C07D401/12
摘要： A salt compound of 4-(2-((4-bromophenyl)thio)acetamido)-1-phenethyl-1H-pyrazole-3- carboxylic acid is disclosed. Also disclosed are methods for making the salt compound and formulations of the salt compound into dosage forms for clinical use.

7. 发明申请

WO2019152546A2 SALT FORMS OF ORGANIC COMPOUND 审中-公开
公开(公告)号：WO2019152546A2
公开(公告)日：2019-08-08
申请号：PCT/US2019/015890
申请日：2019-01-30
申请人： KAINOS MEDICINE INC. , LEE, Jae Moon
发明人： LEE, Jae Moon , YOO, Sungeun , SHIN, Sunmi
IPC分类号： C07D231/10
摘要： A salt compound of 4-(2-((4-bromophenyl)thio)acetamido)-1-phenethyl-1H-pyrazole-3- carboxylic acid is disclosed. Also disclosed are methods for making the salt compound and formulations of the salt compound into dosage forms for clinical use.

8. 发明申请

WO2018234864A3 MODULATORS OF ALPHA-SYNUCLEIN 审中-公开
公开(公告)号：WO2018234864A3
公开(公告)日：2018-12-27
申请号：PCT/IB2018/000766
申请日：2018-06-19
申请人： KAINOS MEDICINE INC. , LEE, Jae Moon
发明人： LEE, Jae Moon , KIM, Eunhee , JANG, Taeik , KIM, Boksuk , YU, Changsun , LEE, Jae Moon , YOO, Sungeun , CHUNG, Yeontae
IPC分类号： A61K31/415 , A61K31/4155 , A61K31/421 , A61K31/4439 , A61P25/28 , G01N33/68
摘要： The disclosure provides diagnostic methods and methods for treatment of conditions arising from alpha-synucleopathies. An aminopyrazole compound can be used for treatment of such conditions by lowering the amount of alpha-synuclein in cells of a subject.

9. 发明申请

WO2018234864A2 MODULATORS OF ALPHA-SYNUCLEIN 审中-公开
公开(公告)号：WO2018234864A2
公开(公告)日：2018-12-27
申请号：PCT/IB2018/000766
申请日：2018-06-19
申请人： KAINOS MEDICINE INC. , LEE, Jae Moon
发明人： LEE, Jae Moon , KIM, Eunhee , JANG, Taeik , KIM, Boksuk , YU, Changsun , LEE, Jae Moon , YOO, Sungeun , CHUNG, Yeontae
摘要： The disclosure provides diagnostic methods and methods for treatment of conditions arising from alpha-synucleopathies. An aminopyrazole compound can be used for treatment of such conditions by lowering the amount of alpha-synuclein in cells of a subject.

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